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Astaxanthin

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https://www.readbyqxmd.com/read/28230827/astaxanthin-modifies-clastogenic-effects-of-ionizing-radiation-in-vitro-in-peripheral-blood-lymphocytes-of-the-persons-recovered-from-acute-radiation-sickness
#1
D А Kurinnyi, S R Rushkovsky, O B Dybska, G V Dubrovina, M А Pilinska
AIM: To assess radioprotective activity of astaxanthin toward radiation-induced in vitro cytogenetic effects in human peripheral blood lymphocytes (PBL). MATERIALS AND METHODS: PBL from the cleanup workers exposed to ionizing radiation at high doses in 1986 during accident on Chornobyl nuclear power plant and who were diagnosed with acute radiation sickness of the first and second degrees, were cultured in vitro. Astaxanthin was added into the culture medium at a final concentration of 20...
December 2016: Experimental Oncology
https://www.readbyqxmd.com/read/28193580/astaxanthin-inhibits-inflammation-and-fibrosis-in-the-liver-and-adipose-tissue-of-mouse-models-of-diet-induced-obesity-and-nonalcoholic-steatohepatitis
#2
Bohkyung Kim, Callie Farruggia, Chai Siah Ku, Tho X Pham, Yue Yang, Minkyung Bae, Casey J Wegner, Nicholas J Farrell, Ellen Harness, Young-Ki Park, Sung I Koo, Ji-Young Lee
The objective of this study was to determine if astaxanthin (ASTX), a xanthophyll carotenoid, can prevent obesity-associated metabolic abnormalities, inflammation and fibrosis in diet-induced obesity (DIO) and nonalcoholic steatohepatitis (NASH) mouse models. Male C57BL/6J mice were fed a low-fat (6% fat, w/w), a high-fat/high-sucrose control (HF/HS; 35% fat, 35% sucrose, w/w), or a HF/HS containing ASTX (AHF/HS; 0.03% ASTX, w/w) for 30 weeks. To induce NASH, another set of mice was fed a HF/HS diet containing 2% cholesterol (HF/HS/HC) a HF/HS/HC with 0...
March 2, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28193431/a-comparative-study-of-diploid-versus-triploid-atlantic-salmon-salmo-salar-l-the-effects-of-rearing-temperatures-5-10-and-15%C3%A2-c-on-raw-material-characteristics-and-storage-quality
#3
Jørgen Lerfall, Pål Rune Hasli, Even Flønes Skare, Rolf Erik Olsen, Bjørn Tore Rotabakk, Bjørn Roth, Erik Slinde, Bjørg Egelandsdal
Several major market operators argue that the current level of knowledge about quality is too scant to justify a switch to a large-scale production of triploid salmon. The aim of the present study was, therefore, to elucidate how rearing conditions (5, 10 and 15°C) affect the flesh quality of triploid Atlantic salmon (Salmo salar L., 1.6±0.3kg). As a reference, diploid salmon kept under equal conditions and with equal genetics were used. The main design discriminant was the holding temperature; increased temperature gave increased blood lactate, rigor index (Ir), drip loss (DL), content of astaxanthin and intensity of redness, but reduced muscle pH, cathepsin activity and fillet lightness...
June 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28193419/chemical-stability-of-astaxanthin-integrated-into-a-food-matrix-effects-of-food-processing-and-methods-for-preservation
#4
REVIEW
Alejandra Anahí Martínez-Delgado, Sanghamitra Khandual, Socorro Josefina Villanueva-Rodríguez
Astaxanthin is a carotenoid pigment found in numerous organisms ranging from bacteria to algae, yeasts, plants, crustaceans and fish such as salmon. Technological importance of this pigment emerged from various studies demonstrating that it is a powerful antioxidant, even with higher activity than alpha-tocopherol and other carotenoids. It has been included in various pharmaceutical products because of several beneficial properties. By its nature, astaxanthin is susceptible to degradation and can undergo chemical changes during food processing...
June 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28179080/simultaneous-determination-of-13-carotenoids-by-a-simple-c18-column-based-ultra-high-pressure-liquid-chromatography-method-for-carotenoid-profiling-in-the-astaxanthin-accumulating-haematococcus-pluvialis
#5
Hui Jin, Yong Min Lao, Jin Zhou, Huai Jin Zhang, Zhong Hua Cai
A simple ultra-high-pressure liquid chromatography (UHPLC) method for rapidly and simultaneously identifying thirteen carotenoids in Haematococcus pluvialis was developed in this study. The method is capable of effectively separating two astaxanthin isomers, two ζ-carotene isomers, and three phytoene isomers on two simple C18 columns within 9 and 12min only by using methanol and acetonitrile, respectively. To our best knowledge, this is the rapidest method for these carotenoid isomers, currently. Using this method, carotenoid profiling in the astaxanthin-accumulating H...
March 10, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28170435/preventive-effect-of-dietary-astaxanthin-on-uva-induced-skin-photoaging-in-hairless-mice
#6
Toshiyuki Komatsu, Suguru Sasaki, Yuki Manabe, Takashi Hirata, Tatsuya Sugawara
Astaxanthin, a carotenoid found mainly in seafood, has potential clinical applications due to its antioxidant activity. In this study, we evaluated the effect of dietary astaxanthin derived from Haematococcus pluvialis on skin photoaging in UVA-irradiated hairless mice by assessing various parameters of photoaging. After chronic ultraviolet A (UVA) exposure, a significant increase in transepidermal water loss (TEWL) and wrinkle formation in the dorsal skin caused by UVA was observed, and dietary astaxanthin significantly suppressed these photoaging features...
2017: PloS One
https://www.readbyqxmd.com/read/28161193/preventive-treatment-of-astaxanthin-provides-neuroprotection-through-suppression-of-reactive-oxygen-species-and-activation-of-antioxidant-defense-pathway-after-stroke-in-rats
#7
Lei Pan, Ying Zhou, Xiu-Fang Li, Qing-Jia Wan, Le-Hua Yu
Astaxanthin, a natural antioxidant carotenoid, has been shown to reduce cerebral ischemic injury in rodents. However, there have not been any studies specifically addressing whether preventive administration of astaxanthin can protect against cerebral ischemia. The purpose of this study was to examine whether pretreatment of astaxanthin can protect against ischemic injuries in the adult rats. The rats were pre-administered intragastrically with astaxanthin for seven days (once a day), and middle cerebral artery occlusion was performed at 1h after the final administration...
February 1, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28153925/the-formation-and-sequestration-of-non-endogenous-ketocarotenoids-in-transgenic-nicotiana-glauca
#8
Cara Louise Mortimer, Norihiko Misawa, Laura Perez-Fons, Francesca Pamela Robertson, Hisashi Harada, Peter M Bramley, Paul David Fraser
Ketolated and hydroxylated carotenoids are high-value compounds with industrial, food and feed applications. Chemical synthesis is presently the production method of choice for these compounds, with no amenable plant sources readily available. In the present study, the 4, 4' β-oxygenase (crtW) and 3, 3' β-hydroxylase (crtZ) genes from Brevundimonas sp SD-212. have been expressed under constitutive transcriptional control in Nicotiana glauca, which has an emerging potential as biofuel and biorefining feedstock...
January 30, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28152447/astaxanthin-pretreatment-attenuates-acetaminophen-induced-liver-injury-in-mice
#9
Jingyao Zhang, Simin Zhang, Jianbin Bi, Jingxian Gu, Yan Deng, Chang Liu
BACKGROUND: Acetaminophen (APAP) is a conventional drug widely used in the clinic because of its antipyretic-analgesic effects. However, accidental or intentional APAP overdoses induce liver injury and even acute liver failure (ALF). Astaxanthin (ASX) is the strongest antioxidant in nature that shows preventive and therapeutic properties, such as ocular protection, anti-tumor, anti-diabetes, anti-inflammatory, and immunomodulatory effects. The aim of present study was to determine whether ASX pretreatment provides protection against APAP-induced liver failure...
January 31, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28145851/the-influence-of-dietary-antioxidant-on-ovarian-eggs-and-levels-of-vitamin-e-c-a-astaxanthin-%C3%AE-carotene-and-oxidative-stres-in-tissues-of-astacus-leptodactylus-eschscholtz-during-reproduction
#10
O Barim-Oz, H Sahin
The experiment was conducted to determine the most effective antioxidant (among the vitamin E (VE), vitamin C (VC), vitamin A (VA), astaxanthine (AX), β-carotene (βC)) on the ovarian egg number and size, level of VE, VC, VA, AX, βC and oxidative stress (as malondialdehyde (MDA)) in the hepatopancreas, ovarian, gills and muscle tissue during ovarian development of Astacus leptodactylus. One control (C) and five experimental diets (EE, EC, EA, EAX and EβC) were prepared. The EE, EC, EA, EAX and EβC groups were formed by added 150 mg kg-1 VE, 200 mg kg-1 VC, 240 mg kg-1 VA, 200 mg kg-1 AX and 200 mg kg-1 βC to diet C, respectively...
December 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28128352/astaxanthin-protects-against-early-burn-wound-progression-in-rats-by-attenuating-oxidative-stress-induced-inflammation-and-mitochondria-related-apoptosis
#11
Quan Fang, Songxue Guo, Hanlei Zhou, Rui Han, Pan Wu, Chunmao Han
Burn-wound progression can occur in the initial or peri-burn area after a deep burn injury. The stasis zone has a higher risk of deterioration mediated by multiple factors but is also considered salvageable. Astaxanthin (ATX), which is extracted from some marine organisms, is a natural compound with a strong antioxidant effect that has been reported to attenuate organ injuries caused by traumatic injuries. Hence, we investigated the potential effects of ATX on preventing early burn-wound progression. A classic "comb" burn rat model was established in this study for histological and biological assessments, which revealed that ATX, particularly higher doses, alleviated histological deterioration in the stasis zone...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28124844/effects-of-astaxanthin-on-oxidative-stress-induced-by-cu-2-in-prostate-cells
#12
Hong-Zhou Meng, Xiao-Feng Ni, Hai-Ning Yu, Shan-Shan Wang, Sheng-Rong Shen
Astaxanthin (AST), a carotenoid molecule extensively found in marine organisms and increasingly used as a dietary supplement, has been reported to have beneficial effects against oxidative stress. In the current paper, the effects of AST on viability of prostate cells were investigated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay; cell apoptosis and intracellular reactive oxygen species (ROS) levels were determined by flow cytometry; the mitochondrial membrane potential (MMP) was measured by fluorospectrophotometer; and activities of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) were evaluated by a detection kit...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28115908/raw-glycerol-and-parboiled-rice-effluent-for-carotenoid-production-effect-of-the-composition-of-culture-medium%C3%A2-and-initial-ph
#13
Carolina Moroni Silva, Thais de Matos de Borba, Susana Juliano Kalil, Janaína Fernandes de Medeiros, Burkert
Search for naturally grown food has stimulated the biotechnological production of carotenoids. Therefore, the use of the yeast Xanthophyllomonas dendrorhous has been researched due to its abilities to assimilate different sources as substrates and to produce high amounts of carotenoids. Furthermore, alternative sources have been used as the culture medium to reduce costs and environmental impact. A potent carotenoid is astaxanthin in view of its health-promoting and antioxidative properties. It consists of different geometrical isomers with trans and cis configuration...
December 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/28115023/astaxanthin-attenuates-total-body-irradiation-induced-hematopoietic-system-injury-in-mice-via-inhibition-of-oxidative-stress-and-apoptosis
#14
Xiao-Lei Xue, Xiao-Dan Han, Yuan Li, Xiao-Fei Chu, Wei-Min Miao, Jun-Ling Zhang, Sai-Jun Fan
BACKGROUND: The hematopoietic system is especially sensitive to total body irradiation (TBI), and myelosuppression is one of the major effects of TBI. Astaxanthin (ATX) is a powerful natural anti-oxidant with low toxicity. In this study, the effect of ATX on hematopoietic system injury after TBI was investigated. METHODS: Flow cytometry was used to detect the proportion of hematopoietic progenitor cells (HPCs) and hematopoietic stem cells (HSCs), the level of intracellular reactive oxygen species (ROS), expression of cytochrome C, cell apoptosis, and NRF2-related proteins...
January 23, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28071055/rapid-and-efficient-conversion-of-all-e-astaxanthin-to-9z-and-13z-isomers-and-assessment-of-their-stability-and-antioxidant-activities
#15
Cheng Yang, Lianfu Zhang, Hua Zhang, Qingrui Sun, Ronghua Liu, Jing Li, Leiyan Wu, Rong Tsao
An optimized isomerization method was developed by heating all-E-astaxanthin in ethyl acetate (70 °C) with I-TiO2 catalyst, yielding 22.7% and 16.9% of 9Z- and 13Z-astaxanthin, respectively, in 2 h, with 92-95% purity after semipreparative HPLC purification. 13Z-Astaxanthin had higher antioxidant activity than all-E- and 9Z-astaxanthins in oxygen radical absorbing capacity assay for lipophilic compounds, photochemiluminescence, and cellular antioxidant activity (CAA) assays, and 9Z-astaxanthin was higher in DPPH radical-scavenging activity assay and lower in CAA assay...
February 1, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28061399/transcriptome-sequencing-and-metabolic-pathways-of-astaxanthin-accumulated-in-haematococcus-pluvialis-mutant-under-15-co2
#16
Jun Cheng, Ke Li, Yanxia Zhu, Weijuan Yang, Junhu Zhou, Kefa Cen
Transcriptome sequencing and annotation was performed on Haematococcus pluvialis mutant red cells induced with high light under 15% CO2 to demonstrate why astaxanthin yield of the mutant was 1.7 times higher than that of a wild strain. It was found that 56% of 1947 differentially expressed genes were upregulated in mutant cells. Most significant differences were found in unigenes related to photosynthesis, carotenoid biosynthesis and fatty acid biosynthesis pathways. The pyruvate kinase increased by 3.5-fold in mutant cells...
March 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28048972/astaxanthin-improves-cognitive-performance-in-mice-following-mild-traumatic-brain-injury
#17
Xinran Ji, Dayong Peng, Yiling Zhang, Jun Zhang, Yuning Wang, Yuan Gao, Ning Lu, Peifu Tang
[BACKGROUND]: Traumatic brain injury (TBI) produces lasting neurological deficits that plague patients and physicians. To date, there is no effective method to combat the source of this problem. Here, we utilized a mild, closed head TBI model to determine the modulatory effects of a natural dietary compound, astaxanthin (AST). AST is centrally active following oral administration and is neuroprotective in experimental brain ischemia/stroke and subarachnoid hemorrhage (SAH) models. We examined the effects of oral AST on the long-term neurological functional recovery and histological outcomes following moderate TBI in a mice model...
December 31, 2016: Brain Research
https://www.readbyqxmd.com/read/28040647/comparative-transcriptomic-analysis-reveals-phenol-tolerance-mechanism-of-evolved-chlorella-strain
#18
Lin Zhou, Dujia Cheng, Liang Wang, Juan Gao, Quanyu Zhao, Wei Wei, Yuhan Sun
The growth of microalgae is inhibited by high concentration phenol due to reactive oxygen species. An evolved strain tolerated to 500mg/L phenol, Chlorella sp. L5, was obtained in previous study. In this study, comparative transcriptomic analysis was performed for Chlorella sp. L5 and its original strain (Chlorella sp. L3). The tolerance mechanism of Chlorella sp. L5 for high concentration phenol was explored on genome scale. It was identified that the up-regulations of the related genes according to antioxidant enzymes (SOD, APX, CAT and GR) and carotenoids (astaxanthin, lutein and lycopene) biosynthesis had critical roles to tolerate high concentration phenol...
March 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28035956/changes-of-photosynthetic-behaviors-and-photoprotection-during-cell-transformation-and-astaxanthin-accumulation-in-haematococcus-pluvialis-grown-outdoors-in-tubular-photobioreactors
#19
Litao Zhang, Fang Su, Chunhui Zhang, Fengying Gong, Jianguo Liu
The cell transformation from green motile cells to non-motile cells and astaxanthin accumulation can be induced in the green alga Haematococcus pluvialis cultured outdoors. In the initial 3 d of incubation (cell transformation phase), light absorption and photosynthetic electron transport became more efficient. After five days of incubation (astaxanthin accumulation phase), the light absorption per active reaction center (ABS/RC) increased, but the efficiency of electron transport (ψo) and the quantum yield of electron transport (φEo) decreased with increased time, indicating that the capacity of photosynthetic energy utilization decreased significantly during astaxanthin accumulation, leading to an imbalance between photosynthetic light absorption and energy utilization...
December 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28028106/imaginal-feeding-for-progression-of-diapause-phenotype-in-the-two-spotted-spider-mite-acari-tetranychidae
#20
Shoko Kawaguchi, Yuki Manabe, Tatsuya Sugawara, Masahiro Osakabe
Adult females of the two-spotted spider mite (Tetranychus urticae Koch) enter diapause under conditions of short-day length and low temperature. A conspicuous body color change, from greenish yellow to bright orange, accompanies diapause induction. This pigmentation is attributed to accumulation of keto-carotenoids produced internally from β-carotene, which is a precursor of vitamin A essential for inducing diapause. The quantity of β-carotene transferred from females to eggs has been considered sufficient to induce diapause...
December 2016: Environmental Entomology
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