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Astaxanthin

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https://www.readbyqxmd.com/read/29050210/astaxanthin-acts-via-lrp-1-to-inhibit-inflammation-and-reverse-lipopolysaccharide-induced-m1-m2-polarization-of-microglial-cells
#1
Xiaojun Wen, Lijiao Xiao, Zhuoyan Zhong, Limin Wang, Ze Li, Xiaoping Pan, Zhonglin Liu
Microglia become activated during neuroinflammation and produce neurotoxic and neurotrophic factors, depending on whether they acquire M1 proinflammatory or M2 anti-inflammatory phenotypes. Astaxanthin (ATX), a natural carotenoid, has anti-inflammatory and neuroprotective effects. We investigated whether ATX could reverse M1/M2 polarization and suppress neuroinflammation via low-density lipoprotein receptor-related protein-1 (LRP-1). We observed increased expression of M1 (TNF-α, IL-1β, and CD86) and decreased expression of M2 (Arg-1, IL-10, and CD206) markers in BV2 microglial cells stimulated with lipopolysaccharide (LPS)...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29044575/investigation-of-the-effect-of-astaxanthin-on-alveolar-bone-loss-in-experimental-periodontitis
#2
H Balci Yuce, A Lektemur Alpan, F Gevrek, H Toker
BACKGROUND AND OBJECTIVE: Astaxanthin is a keto-carotenoid that has a strong antioxidant effect. The purpose of this study was to evaluate the effects of astaxanthin on alveolar bone loss and histopathological changes in ligature-induced periodontitis in rats. MATERIAL AND METHODS: Wistar rats were divided into four experimental groups: non-ligated (C, n = 6); ligature only (L, n = 6); ligature and astaxanthin (1 mg/kg/day astaxanthin, AS1 group, n = 8); ligature and astaxanthin (5 mg/kg/day astaxanthin, AS5 group, n = 8)...
October 17, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29039023/astaxanthin-ameliorates-doxorubicin-induced-cognitive-impairment-chemobrain-in-experimental-rat-model-impact-on-oxidative-inflammatory-and-apoptotic-machineries
#3
Sara Emad El-Agamy, Amal Kamal Abdel-Aziz, Sara Wahdan, Ahmed Esmat, Samar S Azab
Chemobrain refers to a common sequelae experienced by 15-80% of cancer patients exposed to chemotherapeutics. The antineoplastic agent doxorubicin (DOX) has been implicated in a strenuous neurotoxicity manifested as decline in cognitive functions, most probably via cytokine-induced oxidative and nitrosative damage to brain tissues. Astaxanthin (AST), a naturally occurring carotenoid, is reputable for its outstanding antioxidant, anti-inflammatory, and antiapoptotic activities. Therefore, the aim of the current study was to investigate the potential neuroprotective and memory-enhancing effects of AST against DOX-induced behavioral and neurobiological abnormalities...
October 16, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29028078/a-natural-pharma-standard-supplement-formulation-to-control-treatment-related-toxicity-and-oxidative-stress-in-genitourinary-cancer-a-preliminary-study
#4
A Ledda, G Belcaro, M Dugall, R Luzzi, M Hosoi, B Feragalli, R Cotellese, V Cosentino, M Cosentino, R Eggenhoffner, M Pellizzato, A Fratter, L Giacomelli
OBJECTIVE: Oncological treatments are associated with toxicities that may decrease compliance to treatment in most genitourinary cancer patients. Supplementation with pharmaceutical-standardized supplement may be a supplementary method to control the side effects after chemo- and radiotherapy and the increased oxidative stress associated to treatments. This registry study evaluated a natural combination of supplements containing curcumin, cordyceps, and astaxanthin (Oncotris™) used as supplementary management in genitourinary cancer patients who had undergone oncological therapy...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29019908/sequencing-and-characterization-of-novel-pii-signaling-protein-gene-in-microalga-haematococcus-pluvialis
#5
Ruijuan Ma, Yan Li, Yinghua Lu
The PII signaling protein is a key protein for controlling nitrogen assimilatory reactions in most organisms, but little information is reported on PII proteins of green microalga Haematococcus pluvialis. Since H. pluvialis cells can produce a large amount of astaxanthin upon nitrogen starvation, its PII protein may represent an important factor on elevated production of Haematococcus astaxanthin. This study identified and isolated the coding gene (HpGLB1) from this microalga. The full-length of HpGLB1 was 1222 bp, including 621 bp coding sequence (CDS), 103 bp 5' untranslated region (5' UTR), and 498 bp 3' untranslated region (3' UTR)...
October 11, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29017370/valorization-of-raw-materials-from-agricultural-industry-for-astaxanthin-and-%C3%AE-carotene-production-by-xanthophyllomyces-dendrorhous
#6
Teresa Gervasi, Vito Pellizzeri, Qada Benameur, Claudio Gervasi, Antonello Santini, Nicola Cicero, Giacomo Dugo
Waste deriving from food and agro-industries is a growing problem in our modern society. In order to reduce food waste and its associated impacts over the environment and public health, innovative strategies for the conversion of food wastes in added value products are studied. Whey is one of the prominent waste deriving from Sicilian diary industry. The growth and the carotenoid biosynthesis of the yeast Xanthophyllomyces dendrorhous by its cultivation in pre-treated whey were studied. The study showed the possibility of increasing the astaxanthin productivity from X...
October 11, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28985609/inhibition-of-autophagy-modulates-astaxanthin-and-total-fatty-acid-biosynthesis-in-chlorella-zofingiensis-under-nitrogen-starvation
#7
Zhao Zhang, Dongzhe Sun, Ka-Wing Cheng, Feng Chen
The present study showed that inhibition of autophagy significantly increased cellular levels of reactive oxygen species in Chlorella zofingiensis under nitrogen starvation. This was accompanied with increased expression of PSY, and enhanced accumulation of astaxanthin after 48h of cultivation. Nevertheless, the proportion of astaxanthin in secondary carotenoids remained unchanged. Meanwhile, the expression level of ACCase was also elevated in the 3-MA-treated cells compared to the control despite a >20% lower content of fatty acid in the former than the latter...
September 21, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28983979/effect-of-marine-by-product-meals-on-hen-egg-production-parameters-yolk-lipid-composition-and-sensory-quality
#8
E Toyes-Vargas, R Ortega-Pérez, J L Espinoza-Villavicencio, M Arellano-Pérez, R Civera, E Palacios
The effect of including 5% marine by-product meals in feeds of laying hens on egg production, composition and sensory characteristics was tested. Marine by-product meals were prepared using two methods: (i) cooking (100°C/10 min) followed by drying (60°C/24 hr) or (ii) grinding followed by drying. The raw materials used for meal production were scallop or squid viscera, shrimp heads or whole mackerel. A total of 108 laying hens were allocated to nine diet treatments; one control diet (corn and soya bean based) and eight experimental diets, containing 95% of the control feed and 5% of the experimental meal for three weeks...
October 6, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28983399/carotenoids-as-potential-antioxidant-agents-in-stroke-prevention-a-systematic-review
#9
REVIEW
Ahmad Bahonar, Mohammad Saadatnia, Fariborz Khorvash, Mohammadreza Maracy, Alireza Khosravi
Stroke and other cerebrovascular diseases are among the most common causes of death worldwide. Prevention of modifiable risk factors is a cost-effective approach to decrease the risk of stroke. Oxidative stress is regarded as the major flexible operative agent in ischemic brain damage. This review presents recent scientific advances in understanding the role of carotenoids as antioxidants in lowering stroke risk based on observational studies. We searched Medline using the following terms: (Carotenoids [MeSH] OR Carotenes [tiab] OR Carotene [tiab] OR "lycopene [Supplementary Concept]" [MeSH] OR lycopene [tiab] OR beta-Carotene [tiab]) AND (stroke [MeSH] OR stroke [tiab] OR "Cerebrovascular Accident" [tiab] OR "Cerebrovascular Apoplexy" [tiab] OR "Brain Vascular Accident" [tiab] OR "Cerebrovascular Stroke" [tiab]) AND ("oxidative stress" [MeSH] OR "oxidative stress"[tiab])...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28982597/chronic-trans-astaxanthin-treatment-exerts-antihyperalgesic-effect-and-corrects-co-morbid-depressive-like-behaviors-in-mice-with-chronic-pain
#10
Xi Jiang, Qizhi Yan, Fuhe Liu, Changfeng Jing, Lianshu Ding, Lijin Zhang, Cong Pang
Patients suffering from chronic neuropathic pain are at high risk of co-morbid depression, which burdens healthcare. Trans-astaxanthin has been shown in our previous studies to exert antidepressant-like effect. This work aimed to investigate the effects of trans-astaxanthin on pain-related depressive-like behaviors in mice and explored the mechanism(s). Chronic constriction injury (CCI) model was used in this research. Chronic pain was evaluated by thermal hyperalgesia in Hargreaves test and mechanical allodynia in von Frey test, depressive-like behaviors were evaluated by immobility time in forced swim test and tail suspension test...
October 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28981670/antioxidant-protection-by-astaxanthin-in-the-citrus-red-mite-acari-tetranychidae
#11
Makoto Atarashi, Yuki Manabe, Hidenari Kishimoto, Tatsuya Sugawara, Masahiro Osakabe
Solar ultraviolet-B (UVB) radiation and radiant heat have lethal effects on plant-dwelling mites, including spider mites, and their natural enemies, such as phytoseiid mites, leading them to reside on lower leaf surfaces. Panonychus spider mites are outcompeted by Tetranychus spider mites and thus exploit upper leaf surfaces, where they are exposed to both UVB radiation and radiant heat. Panonychus spider mites are thought to produce astaxanthin constitutionally. In this study, we compared carotenoid components, antioxidant capacity, lipid peroxidation, survival, and egg production in wild-type (WTS) and albino-type strains (ATS) of Panonychus citri (McGregor)...
July 8, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28974798/stability-of-astaxanthin-loaded-nanostructured-lipid-carriers-as-affected-by-ph-ionic-strength-heat-treatment-simulated-gastric-juice-and-freeze-thawing
#12
Fardin Tamjidi, Mohammad Shahedi, Jaleh Varshosaz, Ali Nasirpour
Nanostructured lipid carriers (NLCs) offer many potential benefits for incorporating lipophilic molecules into clear/opaque food systems. In this study, the influence of pH, ionic strength, thermal treatment, simulated gastric juice (SGJ), and freeze-thawing on the stability of astaxanthin-loaded NLCs (Ax-NLCs) was examined. Ax-NLCs (containing α-tocopherol and ethylenediaminetetraacetic acid as antioxidants) were stabilized with Tween 80 and lecithin (Z-average size: 94 nm), and studied for the above mentioned purpose...
September 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28974791/astaxanthin-stability-and-color-change-of-krill-during-subcritical-water-treatment
#13
Intira Koomyart, Hironori Nagamizu, Pramote Khuwijitjaru, Takashi Kobayashi, Hirokazu Shiga, Hidefumi Yoshii, Shuji Adachi
Pacific krill (Euphausia pacifica) contains high amounts of astaxanthin, a carotenoid pigment with strong antioxidative activities. In this study, the effects of subcritical water temperatures (100-180 °C) and times (0-10 min) on color changes (L*, a*, and b*) and astaxanthin degradation in Pacific krill were investigated. In addition, an aqueous solution of pure astaxanthin and that of crude astaxanthin from Pacific krill, both at a concentration of 5 mg/L, were subjected to treatment under subcritical water conditions using a flow-type reactor to compare the degradation of free astaxanthin and astaxanthin fatty acid esters...
September 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28973873/engineering-of-tomato-for-the-sustainable-production-of-ketocarotenoids-and-its-evaluation-in-aquaculture-feed
#14
Marilise Nogueira, Eugenia M A Enfissi, Maria E Martínez Valenzuela, Guillaume N Menard, Richard L Driller, Peter J Eastmond, Wolfgang Schuch, Gerhard Sandmann, Paul D Fraser
Ketocarotenoids are high-value pigments used commercially across multiple industrial sectors as colorants and supplements. Chemical synthesis using petrochemical-derived precursors remains the production method of choice. Aquaculture is an example where ketocarotenoid supplementation of feed is necessary to achieve product viability. The biosynthesis of ketocarotenoids, such as canthaxanthin, phoenicoxanthin, or astaxanthin in plants is rare. In the present study, complex engineering of the carotenoid pathway has been performed to produce high-value ketocarotenoids in tomato fruit (3...
September 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28963510/a-dietary-carotenoid-reduces-immunopathology-and-enhances-longevity-through-an-immune-depressive-effect-in-an-insect-model
#15
Julien Dhinaut, Aude Balourdet, Maria Teixeira, Manon Chogne, Yannick Moret
Immunopathology corresponds to self-damage of the inflammatory response, resulting from oxidizing molecules produced when the immune system is activated. Immunopathology often contributes to age-related diseases and is believed to accelerate ageing. Prevention of immunopathology relies on endogenous antioxidant enzymes and the consumption of dietary antioxidants, including carotenoids such as astaxanthin. Astaxanthin currently raises considerable interest as a powerful antioxidant and for its potential in alleviating age-related diseases...
September 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28944426/experimental-evaluation-of-the-efficiency-of-lipid-module-enriched-with-docosahexaenoic-acid-and-astaxantin
#16
Yu S Sidorova, V А Sarkisyan, N A Petrov, A A Kochetkova, V K Mazo
Rats of the experimental group for 30 days received a ration in which the fat component (sunflower oil) was completely substituted with a lipid module enriched with docosahexaenoic acid and astaxanthin. Anxiety of animals in elevated plus-maze test and muscle tone in the grip strength test were evaluated before and after the experiment. Exhausting treadmill exercise was simulated after 30 days of feeding the lipid module. Modification of the lipid component of the diet (enrichment with docosahexaenoic acid and astaxanthin) reduced fatigue during exhausting physical exercise, increased muscle tone, and produced an anxiolytic effect...
September 25, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28943084/horizontal-transfer-of-a-synthetic-metabolic-pathway-between-plant-species
#17
Yinghong Lu, Sandra Stegemann, Shreya Agrawal, Daniel Karcher, Stephanie Ruf, Ralph Bock
Transgene expression from the plastid (chloroplast) genome provides unique advantages, including high levels of foreign protein accumulation, convenient transgene stacking in operons, and increased biosafety due to exclusion of plastids from pollen transmission [1, 2]. However, applications in biotechnology and synthetic biology are severely restricted by the very small number of plant species whose plastid genomes currently can be transformed [3, 4]. Here we report a simple method for the introduction of useful plastid transgenes into non-transformable species...
October 9, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28937591/metabolic-engineering-of-escherichia-coli-for-producing-astaxanthin-as-the-predominant-carotenoid
#18
Qian Lu, Yi-Fan Bu, Jian-Zhong Liu
Astaxanthin is a carotenoid of significant commercial value due to its superior antioxidant potential and wide applications in the aquaculture, food, cosmetic and pharmaceutical industries. A higher ratio of astaxanthin to the total carotenoids is required for efficient astaxanthin production. β-Carotene ketolase and hydroxylase play important roles in astaxanthin production. We first compared the conversion efficiency to astaxanthin in several β-carotene ketolases from Brevundimonas sp. SD212, Sphingomonas sp...
September 22, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28936571/effect-of-dietary-astaxanthin-on-the-growth-performance-non-specific-immunity-and-antioxidant-capacity-of-pufferfish-takifugu-obscurus-under-high-temperature-stress
#19
Chang-Hong Cheng, Zhi-Xun Guo, Chao-Xia Ye, An-Li Wang
The present study was conducted to investigate the effects of astaxanthin on growth performance, biochemical parameters, ROS production, and immune-related gene expressions of the pufferfish (Takifugu obscurus) under high temperature stress. The experimental basal diets supplemented with astaxanthin at the rates of 0 (control), 20, 40, 80, 160, and 320 mg kg(-1) were fed to fish for 8 weeks. The results showed that the fish fed diet with 80, 160, and 320 mg kg(-1) astaxanthin significantly improved weight gain and specific growth rate...
September 21, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28933728/the-effect-of-astaxanthin-rich-microalgae-haematococcus-pluvialis-and-wholemeal-flours-incorporation-in-improving-the-physical-and-functional-properties-of-cookies
#20
A K M Mofasser Hossain, Margaret A Brennan, Susan L Mason, Xinbo Guo, Xin An Zeng, Charles S Brennan
Marine-based food supplements can improve human nutrition. In an effort to modulate glycaemic response and enhance nutritional aspects, marine-derived algal food rich in astaxanthin was used in the formulation of a model food (wholemeal cookie). Astaxanthin substitution of cookies made from three flours (wheat, barley and oat) demonstrated a significant reduction in the rate of glucose released during in vitro digestion together with an increase in the total phenolic content (TPC) and antioxidant capacity of the food...
July 26, 2017: Foods (Basel, Switzerland)
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