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https://www.readbyqxmd.com/read/29667626/eus-fna-in-cystic-pancreatic-lesions-where-are-we-now-and-where-are-we-headed-in-the-future
#1
REVIEW
Jose Lariño-Noia, Julio Iglesias-Garcia, Daniel de la Iglesia-Garcia, J Enrique Dominguez-Muñoz
EUS-FNA is often performed in the evaluation of Cystic Pancreatic Lesions (CPL) for a better preoperative characterization. The objective is to identify premalignant lesions as Mucinous Cystic Neoplasms, and/or a malignant transformation of them (adenocarcinoma). The role of cytological evaluation in this setting is discouraging and intracystic markers analysis, mainly CEA, lacks of a good specificity for the detection of mucinous neoplasms. New devices and approaches have emerged to overcome these problems as the cytology brush (Echobrush), the small mini-biopsy foceps, the cystoscopy and the needle Confocal LASER Endomicroscopy (nCLE), showing in some studies good rates of accuracy for distinguishing among mucinosus and non-mucinous neoplasms...
March 2018: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29667289/endosomal-receptor-trafficking-retromer-and-beyond
#2
REVIEW
Jing Wang, Alina Fedoseienko, Bayou Chen, Ezra Burstein, Da Jia, Daniel D Billadeau
The tubular endolysosomal network is a quality control system that ensures the proper delivery of internalized receptors to specific subcellular destinations in order to maintain cellular homeostasis. Although retromer was originally described in yeast as a regulator of endosome-to-Golgi receptor recycling, mammalian retromer has emerged as a central player in endosome-to-plasma membrane recycling of a variety of receptors. Over the past decade, information regarding the mechanism by which retromer facilitates receptor trafficking has emerged, as has the identification of numerous retromer-associated molecules including the WASH complex, sorting nexins and TBC1d5...
April 18, 2018: Traffic
https://www.readbyqxmd.com/read/29666691/internal-laryngocele-unusual-onset-in-a-91-year-old-female-patient
#3
Maria C Spinosi, Chiara Mezzedimi, Giovanni Monciatti, Desiderio Passali
While internal laryngoceles rarely cause major clinical complaints, they may lead to airway obstruction and require emergency intervention on rare occasions. We report a 91-year-old patient who was referred to the Ear, Nose & Throat Clinic of the Policlinico Santa Maria alle Scotte, Siena, Italy, in 2017 due to recurrent episodes of severe dyspnoea. A flexible nasopharyngolaryngoscopic examination revealed an internal laryngocele of approximately 1.5 cm in diameter that moved up and down the glottic plane, occasionally invading the subglottic space during inspiration and impeding airflow...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29666309/hospital-admissions-associated-with-medication-non-adherence-a-systematic-review-of-prospective-observational-studies
#4
Pajaree Mongkhon, Darren M Ashcroft, C Norman Scholfield, Chuenjid Kongkaew
BACKGROUND: Medication non-adherence in ambulatory care has received substantial attention in the literature, but less so as it affects acute care. Accordingly, we aimed to estimate the frequency with which non-adherence to medication contributes to hospital admissions. METHODS: We searched the Cochrane Library, EMBASE, Cumulative Index to Nursing and Allied Health Literature, International Pharmaceutical Abstracts and PubMed (until December 2017) to identify prospective observational studies that examined prevalence rates of hospital admissions associated with medication non-adherence...
April 17, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29666157/cd30-expression-and-its-correlation-with-myc-and-bcl2-in-de-novo-diffuse-large-b-cell-lymphoma
#5
Qi-Xing Gong, Zhen Wang, Chong Liu, Xiao Li, Ting-Xun Lu, Jin-Hua Liang, Wei Xu, Jian-Yong Li, Zhi-Hong Zhang
AIM: CD30+ diffuse large B-cell lymphoma (DLBCL) has emerged as a new immunophenotypic variant of de novo DLBCLs. However, the prevalence of CD30 positivity is variable according to different studies, and the prognostic significance of CD30 is also controversial. This study aimed to investigate the positive expression rate and prognostic impact of CD30 in de novo DLBCLs and try to find the correlated influences. METHODS: A total of 241 patients with de novo DLBCL in east China from 2008 to 2015 were included to investigate the prevalence, clinicopathological features and outcomes of CD30+ de novo DLBCLs...
April 17, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29665949/current-status-of-pharmacokinetic-and-safety-studies-of-multidrug-resistant-tuberculosis-treatment-in-children
#6
A J Garcia-Prats, E M Svensson, E D Weld, H S Schaaf, A C Hesseling
After decades of neglect, data are finally becoming available on the appropriate, safe dosing of key second-line anti-tuberculosis drugs used for treating multidrug-resistant tuberculosis (MDR-TB) in children, including levofloxacin (LVX), moxifloxacin (MFX), linezolid (LZD) and delamanid (DLM). Much needed data on some novel and repurposed drugs are still lacking, including for bedaquiline (BDQ), pretomanid (PTM) and clofazimine (CFZ). We review the status of pharmacokinetic (PK) and safety studies of key anti-tuberculosis medications in children with MDR-TB, identify priority knowledge gaps and note ongoing work to address those gaps, in the context of planning for an efficacy trial in children with MDR-TB...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29665568/a-small-proportion-of-litter-derived-nitrogen-is-assimilated-by-plant-biomass-or-immobilized-in-sediments-regardless-of-harvest-management-as-detected-by-15-n-labeled-phragmites-litter-in-a-constructed-wetland
#7
Takashi S T Tanaka, Chagan Irbis, Yuki Hama, Pengyun Wang, Kunzhi Li, Tatsuya Inamura
Emergent aquatic macrophytes play an important role in the removal of nutrients in constructed wetlands (CWs). However, plant biomass supplies litter after the onset of senescence. Although litter-derived nitrogen (N) has been considered a nutrient source for the internal loading that may reduce CW performance, little is known about the quantitative N dynamics associated with litter decomposition. Thus, a controversial question remains about whether plant harvest is needed to manage CWs. In this study, we evaluated the decomposition and the fate of N derived from 15 N-labeled Phragmites litter in a CW for 1 year...
April 14, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29664808/trends-in-pharmacological-emergency-treatment-of-patients-suffering-from-schizophrenia-over-a-16-year-observation-period
#8
Monika Edlinger, Anna-Sophia Welte, Nursen Yalcin-Siedentopf, Georg Kemmler, Felix Neymeyer, W Wolfgang Fleischhacker, Alex Hofer
Patients suffering from schizophrenia are often treated in locked psychiatric units because of psychomotor agitation, hostility and aggressive behavior, or suicidality. Because of legal conditions, investigations on these acutely ill patients are difficult, and many studies do not represent 'real-life psychiatry'. This retrospective survey was conducted at the Department of Psychiatry, Psychotherapy and Psychosomatics of the Medical University, Innsbruck, Austria. Data were collected from the records of all adult inpatients suffering from a schizophrenia spectrum disorder according to the International Classification of Diseases, 10th ed...
April 16, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29664651/nanocomposite-membrane-with-polyethylenimine-grafted-graphene-oxide-as-a-novel-additive-to-enhance-pollutant-filtration-performance
#9
Lina Zhang, Baoliang Chen, Abdul Ghaffar, Xiaoying Zhu
Synthetic membranes often suffer ubiquitous fouling as well as a trade-off between permeability and selectivity. However, emerging materials which are able to mitigate membrane fouling and break the permeability and selectivity trade-off are urgently needed. A novel additive, GO-PEI, bearing a positive charge and hydrophilic nature was prepared by the covalent grafting of polyethylenimine (PEI) molecules with graphene oxide (GO) nanosheets, which later was blended with bulk polyethersulfone (PES) to fabricate the graphene containing nanocomposite membranes (NCMs)...
April 17, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29664347/which-melodic-universals-emerge-from-repeated-signaling-games-a-note-on-lumaca-and-baggio-2017-%C3%A2
#10
Andrea Ravignani, Tessa Verhoef
Music is a peculiar human behavior. While very common in our species, we still know very little as to why and how music emerged. For centuries, the study of music has been the sole prerogative of the humanities. Lately, however, music is being increasingly investigated by psychologists, neuroscientists, biologists, and computer scientists. One possible approach to study the origins of music is to hypothesize and empirically test the mechanisms behind this structured behavior. Recent experiments in the lab have shown how musical rhythm and melody can emerge via the process of cultural transmission...
April 17, 2018: Artificial Life
https://www.readbyqxmd.com/read/29663840/compliance-with-standards-of-practice-for-health-related-rehabilitation-in-low-and-middle-income-settings-development-and-implementation-of-a-novel-scoring-method
#11
Wesley Pryor, Pushpak Newar, Chiara Retis, Isabelle Urseau
PURPOSE: To (A) develop a method for measuring compliance with standards, and (B) implementation of the method in 12 rehabilitation centers in six low and middle-income countries (LMICs). METHODS: In part A, existing standards were compiled and operationalized into scores, organized into 5 'scorecards' and 15 'sub-scorecards', then tested and refined in an iterative process. In part B, 12 rehabilitation centers in 6 countries implemented the standards using the new method, revealing relative performance between centers, and across different standards...
April 17, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29663648/sensory-strategies-in-adult-mental-health-a-qualitative-exploration-of-staff-perspectives-following-the-introduction-of-a-sensory-room-on-a-male-adult-acute-ward
#12
Angus S Forsyth, Rebecca Trevarrow
In recent years, there has been growing interest in the use of sensory techniques to help with emotional regulation in adult mental health populations. This is against a backdrop of international policies aimed at reducing restrictive interventions and improving the effectiveness of de-escalation techniques. A sensory room was designed and implemented on a male adult acute psychiatric ward. Staff perspectives were sought to evaluate the effectiveness of the room in managing emotional distress by exploring staff awareness of a broader range of de-escalation strategies and by exploring what effect the room had on staff behaviours with respect to sensory interventions...
April 16, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29662831/the-asia-pacific-consensus-statement-on-laparoscopic-liver-resection-for-hepatocellular-carcinoma-a-report-from-the-7th-asia-pacific-primary-liver-cancer-expert-meeting-held-in-hong-kong
#13
Tan To Cheung, Ho-Seong Han, Wong Hoi She, Kuo-Hsin Chen, Pierce K H Chow, Boon Koon Yoong, Kit Fai Lee, Shoji Kubo, Chung Ngai Tang, Go Wakabayashi
Background: Laparoscopic liver resection has been gaining momentum, and it has become an accepted practice after the two international consensus conferences where experts worked up guidelines to standardize this approach and improve its safety. However, most laparoscopic hepatectomies were performed in patients with liver metastases. The concurrent presence of liver cirrhosis with hepatocellular carcinoma (HCC) poses a great challenge to clinicians trying to establish a routine use of laparoscopic liver resection for HCC...
March 2018: Liver Cancer
https://www.readbyqxmd.com/read/29662732/institutional-review-of-hemorrhagic-pelvic-emergencies-effectively-managed-with-percutaneous-arterial-embolization
#14
Muhammad Azeemuddin, Raza Sayani, Nauman Turab, Syed M Mustahsan, Mohammad Hasan, Dawar B Khan, Fatima Mubarak
OBJECTIVE: Our aim was to review the results of pelvic arterial embolization (PAE) performed in the interventional radiology suite. METHOD: The data of all patients in whom pelvic angioembolization was performed was collected from July 2011 to June 2017. Procedures were performed by an experienced interventional radiologist. The clinical and laboratory data, as well as the outcome data, were obtained from the medical records of our hospital. The following parameters were collected for each patient, including the age, gender, presenting symptoms, site of bleeding, catheters used for embolization, material used for embolization, previous computed tomography (CT) scan and/or focused assessment with sonography for trauma (FAST) ultrasound, average hemoglobin before the procedure, and patient clinical status on discharge...
February 15, 2018: Curēus
https://www.readbyqxmd.com/read/29661239/neonatal-care-practices-in-sub-saharan-africa-a-systematic-review-of-quantitative-and-qualitative-data
#15
REVIEW
Margaret Bee, Anushree Shiroor, Zelee Hill
BACKGROUND: Recommended immediate newborn care practices include thermal care (immediate drying and wrapping, skin-to-skin contact after delivery, delayed bathing), hygienic cord care and early initiation of breastfeeding. This paper systematically reviews quantitative and qualitative data from sub-Saharan Africa on the prevalence of key immediate newborn care practices and the factors that influence them. METHODS: Studies were identified by searching relevant databases and websites, contacting national and international academics and implementers and hand-searching reference lists of included articles...
April 16, 2018: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/29660733/an-analysis-of-belgian-cannabis-social-clubs-supply-practices-a-shapeshifting-model
#16
Mafalda Pardal
BACKGROUND AND RESEARCH QUESTIONS: Cannabis Social Clubs (CSCs) are associations of cannabis users that collectively organize the cultivation and distribution of cannabis. As this middle ground supply model has been active in Belgium for over a decade, this paper aims to examine CSCs' supply practices, noting any shifts from previously reported features of the model. METHODS: We draw on interviews with directors of seven currently active Belgian CSCs (n = 21) and their cannabis growers (n = 23)...
April 13, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29659599/profiling-extracellular-vesicle-release-by-the-filarial-nematode-brugia-malayi-reveals-sex-specific-differences-in-cargo-and-a-sensitivity-to-ivermectin
#17
Hiruni Harischandra, Wang Yuan, Hannah J Loghry, Mostafa Zamanian, Michael J Kimber
The filarial nematode Brugia malayi is an etiological agent of Lymphatic Filariasis. The capability of B. malayi and other parasitic nematodes to modulate host biology is recognized but the mechanisms by which such manipulation occurs are obscure. An emerging paradigm is the release of parasite-derived extracellular vesicles (EV) containing bioactive proteins and small RNA species that allow secretion of parasite effector molecules and their potential trafficking to host tissues. We have previously described EV release from the infectious L3 stage B...
April 16, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29658829/playground-love-sex-work-pleasure-and-self-affirmation-in-the-urban-nightlife-of-indonesian-waria
#18
Terje Toomistu
Indonesian transgender women, locally and internationally recognised as waria, share some lifestyle patterns that have emerged under conditions of limited social acceptance. These patterns include involvement in sex work. The high number of waria who are sex workers is usually explained in economic terms. However, their presence in certain locations around the city known for waria sex work is not only for work, and quite often not even for sex. Waria street nightlife fosters waria agency, which emerges from self-affirmation through pleasurable bodily practices involving intimate (sexual partners) and both proximate (other waria and men nearby) and distant others (structuring ideals)...
April 16, 2018: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/29658770/the-new-mandate-and-work-of-icrp-committee-4
#19
D A Cool
Committee 4 of the International Commission on Radiological Protection (ICRP) is charged with the development of principles and recommendations on radiological protection of people and the environment in all exposure situations. For the term beginning in July 2017, the Committee has a total of 18 members from 12 countries. The programme of work includes a wide range of activities in five major thematic areas. The first is the consolidation and preparation of reports elaborating application of the system of protection in existing exposure situations...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29657730/lemierre-s-syndrome-presented-with-acute-pancreatitis
#20
Laura Garcia, Kaori Ito
Case: Lemierre's syndrome is a rare clinical condition that is characterized by infected internal jugular vein thrombosis with metastatic septicemia. The most common causative agent is Fusobacterium necrophorum . A previously healthy 37-year-old woman presented to our emergency department with nausea, vomiting, and diarrhea. She was admitted to the general practice unit with a diagnosis of acute pancreatitis then was subsequently transferred to the intensive care unit due to shock. Physical examination revealed tenderness on right side of the neck...
April 2018: Acute Medicine & Surgery
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