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https://www.readbyqxmd.com/read/29222749/the-mongoose-rational-arithmetic-toolbox
#1
Christopher Le, Leonid Chindelevitch
The modeling of metabolic networks has seen a rapid expansion following the complete sequencing of thousands of genomes. The constraint-based modeling framework has emerged as one of the most popular approaches to reconstructing and analyzing genome-scale metabolic models. Its main assumption is that of a quasi-steady-state, requiring that the production of each internal metabolite be balanced by its consumption. However, due to the multiscale nature of the models, the large number of reactions and metabolites, and the use of floating-point arithmetic for the stoichiometric coefficients, ensuring that this assumption holds can be challenging...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222530/seizure-rates-in-enzalutamide-treated-men-with-metastatic-castration-resistant-prostate-cancer-and-risk-of-seizure-the-upward-study
#2
Susan Slovin, William Clark, Joan Carles, Andrew Krivoshik, Jung Wook Park, Fong Wang, Daniel George
Importance: The androgen receptor inhibitor enzalutamide prolongs survival in men with metastatic castration-resistant prostate cancer (mCRPC). In controlled clinical studies, 0.5% (10 of 2051) of patients experienced seizure, but patients with a history of or risk factors for seizure were excluded. Men with mCRPC and seizure risk factors have an estimated seizure rate of 2.8 per 100 patient-years without enzalutamide exposure. Objective: To assess seizure incidence in patients with seizure risk factors who were receiving enzalutamide for mCRPC...
December 7, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29222393/protect-proximal-balloon-occlusion-together-with-direct-thrombus-aspiration-during-stent-retriever-thrombectomy-evaluation-of-a-double-embolic-protection-approach-in-endovascular-stroke-treatment
#3
Christian Maegerlein, Sebastian Moench, Tobias Boeckh-Behrens, Manuel Lehm, Dennis M Hedderich, Maria Teresa Berndt, Silke Wunderlich, Claus Zimmer, Johannes Kaesmacher, Benjamin Friedrich
PURPOSE: Stent retriever-based mechanical thrombectomy (MT) for emergent large vessel occlusions (ELVO) is often complicated by thrombus fragmentation causing distal embolization and embolization to new vascular territories. Well-established embolic protection approaches include proximal flow arrest and distal aspiration techniques during stent retriever maneuvers. Aiming at the reduction of thrombus fragmentation during MT we evaluated a technical approach combining proximal balloon occlusion together with direct thrombus aspiration during MT: the PROTECT technique...
December 8, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29222307/secondary-cns-relapse-in-diffuse-large-b-cell-lymphoma-defining-high-risk-patients-and-optimization-of-prophylaxis-strategies
#4
REVIEW
Kerry J Savage
Despite improvement in survival in diffuse large B-cell lymphoma (DLBCL) with the introduction of rituximab, central nervous system (CNS) relapse continues to represent a clinical challenge. A number of studies have evaluated clinical risk factors in an attempt to identify high-risk patients to direct CNS staging investigations and consider prophylaxis strategies. The CNS International Prognostic Index is a robust and reproducible risk model that can identity patients at high risk of CNS relapse, but its specificity remains limited...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222069/cooperativity-between-different-trna-modifications-and-their-modification-pathways
#5
REVIEW
Mikołaj Sokołowski, Roland Klassen, Alexander Bruch, Raffael Schaffrath, Sebastian Glatt
Ribonucleotide modifications perform a wide variety of roles in synthesis, turnover and functionality of tRNA molecules. The presence of particular chemical moieties can refine the internal interaction network within a tRNA molecule, influence its thermodynamic stability, contribute novel chemical properties and affect its decoding behavior during mRNA translation. As the lack of specific modifications in the anticodon stem and loop causes disrupted proteome homeostasis, diminished response to stress conditions, and the onset of human diseases, the underlying modification cascades have recently gained particular scientific and clinical interest...
December 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29221691/characteristics-and-outcomes-of-pediatric-heart-failure-related-emergency-department-visits-in-the-united-states-a-population-based-study
#6
Erika J Mejia, Matthew J O'Connor, Kimberly Y Lin, Lihai Song, Heather Griffis, Christopher E Mascio, Pirouz Shamszad, Aaron Donoghue, Chitra Ravishankar, Robert E Shaddy, Joseph W Rossano
OBJECTIVES: To describe the frequency, characteristics, and outcomes of heart failure-related emergency department (ED) visits in pediatric patients. We aimed to test the hypothesis that these visits are associated with higher admission rates, mortality, and resource utilization. STUDY DESIGN: A retrospective analysis of the Nationwide Emergency Department Sample for 2010 of patients ≤18 years of age was performed to describe ED visits with and without heart failure...
December 6, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29221534/on-becoming-a-global-citizen-transformative-learning-through-global-health-experiences
#7
Debra K Litzelman, Adrian Gardner, Robert M Einterz, Philip Owiti, Charity Wambui, Jordan C Huskins, Kathleen M Schmitt-Wendholt, Geren S Stone, Paul O Ayuo, Thomas S Inui, Rachel A Umoren
BACKGROUND: Globalization has increased the demand for international experiences in medical education. International experiences improve medical knowledge, clinical skills, and self-development; influence career objectives; and provide insights on ethical and societal issues. However, global health rotations can end up being no more than tourism if not structured to foster personal transformation and global citizenship. OBJECTIVE: We conducted a qualitative assessment of trainee-reported critical incidents to more deeply understand the impact of our global health experience on trainees...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29221450/peer-feedback-for-examiner-quality-assurance-on-mrcgp-international-south-asia-a-mixed-methods-study
#8
D P Perera, Marie Andrades, Val Wass
BACKGROUND: The International Membership Examination (MRCGP[INT]) of the Royal College of General Practitioners UK is a unique collaboration between four South Asian countries with diverse cultures, epidemiology, clinical facilities and resources. In this setting good quality assurance is imperative to achieve acceptable standards of inter rater reliability. This study aims to explore the process of peer feedback for examiner quality assurance with regard to factors affecting the implementation and acceptance of the method...
December 8, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29221333/successful-treatment-of-a-ruptured-left-internal-mammary-artery-aneurysm-with-a-delayed-diagnosis-of-type-i-neurofibromatosis
#9
Do Wan Kim, In Seok Jeong, Kook Joo Na, Bong Suk Oh, Byung Hee Ahn, Sang Yun Song
Neurofibromatosis type I (NF-1) induced vasculopathy is rare but catastrophic complication after aneurysmal rupture. We present the case of a 55-year-old female who developed hypovolemic shock because of left internal mammary artery (IMA) pseudoaneurysm rupture associated with NF-1. Even she was not detected NF-1 at the time of arrival in emergency room. We decided to perform percutaneous embolization instead of surgical approach. In this case, after intervention, the ruptured left IMA aneurysm was well treated...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221329/inter-hospital-transports-on-extracorporeal-membrane-oxygenation-in-different-health-care-systems
#10
Lars Mikael Broman
The feasibility and the recognition of the possibility to transport patients on extracorporeal membrane oxygenation (ECMO) aroused in the 1970s. The number of transporting facilities worldwide was less than 20 in the beginning of the second Millennium. In 2009 the H1N1 pandemic and a publication showing survival benefit for adult patients transported to a hospital with ECMO resource increased both awareness and interest for ECMO treatment. The number of transport organizations increased rapidly. As of today, the number of transport organizations increases world-wide, though some centers where ECMO is an established treatment report decreasing numbers of transports...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29220165/photo-triggered-n2-generating-submicron-particles-for-selective-killing-of-cancer-cells
#11
Huiying Li, Wenbo Zhang, Ning He, Weijun Tong, Changyou Gao
Killing of cancer cells by applying mechanical disruption is an appealing emerging strategy for cancer treatment in recent years. In this study, photo-responsive submicron particles based on diazo-resin (DZR) which are able to release N2 under UV irradiation were prepared through a polyamine-salt aggregation method. After surface modification with hyaluronic acid (HA), the particles could be internalized selectively by cancer cells and mainly located in lysosomes after 6 h incubation. The viability of cancer cells decreased obviously after co-cultured with photo-responsive particles and UV irradiation due to the integrity damage of lysosomes by photo-triggered N2 generation and the subsequential increased reactive oxygen species...
December 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29219140/-near-miss-obstetric-events-and-maternal-mortality-in-a-tertiary-care-hospital
#12
Shravya Tallapureddy, Revathi Velagaleti, Himabindu Palutla, Chaitanya Venkata Satti
Obstetric near-miss or severe acute maternal morbidity is gaining interest internationally as a new indicator of the quality of obstetric care. This is a retrospective study conducted using "The WHO Near-Miss Approach" to provide insight into obstetric emergencies, near-miss cases, and maternal deaths in our hospital. The maternal near-miss ratio was 8.4/1000 live births, maternal near-miss to mortality ratio was 5.3:1. Hemorrhage was the leading cause (43.7%) of morbidity in near-miss cases while hypertensive disorders were the leading cause in maternal deaths (66...
October 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/29219105/impact-of-extreme-weather-events-and-climate-change-for-health-and-social-care-systems
#13
REVIEW
Sarah Curtis, Alistair Fair, Jonathan Wistow, Dimitri V Val, Katie Oven
This review, commissioned by the Research Councils UK Living With Environmental Change (LWEC) programme, concerns research on the impacts on health and social care systems in the United Kingdom of extreme weather events, under conditions of climate change. Extreme weather events considered include heatwaves, coldwaves and flooding. Using a structured review method, we consider evidence regarding the currently observed and anticipated future impacts of extreme weather on health and social care systems and the potential of preparedness and adaptation measures that may enhance resilience...
December 5, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29218519/glucose-transport-activity-measured-in-giant-vesicles
#14
Jesper S Hansen, Karin Lindkvist-Petersson
Incorporation of membrane proteins and internal reporter systems directly into giant vesicles, during their formation from a hydrogel surface, has emerged as a promising new concept in membrane protein characterization. Here, we provide the detailed protocol for a glucose transporter activity assay based on giant vesicles containing a fluorescent enzyme-linked reporter system internally. This assay is applicable for the functional analysis of a variety of hexose-transporting proteins. We furthermore believe that it can aid in the development of drugs targeting hexose transporters...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29218114/comparative-transcriptome-analysis-of-the-global-circular-rnas-expression-profiles-between-shee-and-sheec-cell-lines
#15
Jiachun Sun, Xiaozhi Yuan, Xiangming Li, Dengkui Wang, Tanyou Shan, Wei Wang, Qiuyan Wan, Xinshuai Wang, Junqiang Yan, Shegan Gao
Esophageal squamous cell carcinoma (ESCC) is widely regarded as one of the most lethal types of cancer around the world. The fact that early detection of ESCC could dramatically improve the treatment outcome of the patients has sparked considerable interest in searching for reliable and accurate diagnostic biomarkers. Recently, circular RNAs (circRNA) have emerged as a new type of non-coding RNAs with significant RNase resistance, wide abundance and remarkable internal diversity. There is also increasing evidence suggesting that circRNAs could be implicated in the pathogenesis of cancer and other diseases...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29217396/a-2018-horizon-scan-of-emerging-issues-for-global-conservation-and-biological-diversity
#16
REVIEW
William J Sutherland, Stuart H M Butchart, Ben Connor, Caroline Culshaw, Lynn V Dicks, Jason Dinsdale, Helen Doran, Abigail C Entwistle, Erica Fleishman, David W Gibbons, Zhigang Jiang, Brandon Keim, Xavier Le Roux, Fiona A Lickorish, Paul Markillie, Kathryn A Monk, Diana Mortimer, James W Pearce-Higgins, Lloyd S Peck, Jules Pretty, Colleen L Seymour, Mark D Spalding, Femke H Tonneijck, Rosalind A Gleave
This is our ninth annual horizon scan to identify emerging issues that we believe could affect global biological diversity, natural capital and ecosystem services, and conservation efforts. Our diverse and international team, with expertise in horizon scanning, science communication, as well as conservation science, practice, and policy, reviewed 117 potential issues. We identified the 15 that may have the greatest positive or negative effects but are not yet well recognised by the global conservation community...
November 27, 2017: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/29216533/assessing-the-zoonotic-potential-of-arboviruses-of-african-origin
#17
REVIEW
Marietjie Venter
Several African arboviruses have emerged over the past decade in new regions where they caused major outbreaks in humans and/or animals including West Nile virus, Chikungunya virus and Zika virus. This raise questions regarding the importance of less known zoonotic arboviruses in local epidemics in Africa and their potential to emerge internationally. Syndromic surveillance in animals may serve as an early warning system to detect zoonotic arbovirus outbreaks. Rift Valley fever and Wesselsbronvirus are for example associated with abortion storms in livestock while West Nile-virus, Shuni virus and Middelburg virus causes neurological disease outbreaks in horses and other animals...
December 4, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/29216349/developing-a-standard-set-of-patient-centred-outcomes-for-inflammatory-bowel-disease-an-international-cross-disciplinary-consensus
#18
Andrew H Kim, Charlotte Roberts, Brian G Feagan, Rupa Banerjee, Willem Bemelman, Keith Bodger, Marc Derieppe, Axel Dignass, Richard Driscoll, Ray Fitzpatrick, Janette Gaarentstroom-Lunt, Peter D Higgins, Paulo Gustavo Kotze, Jillian Meissner, Marian O'Connor, Zhi-Hua Ran, Corey A Siegel, Helen Terry, Welmoed K van Deen, C Janneke van der Woude, Alandra Weaver, Suk-Kyun Yang, Bruce E Sands, Séverine Vermeire, Simon Pl Travis
Background and Aims: Success in delivering value-based healthcare involves measuring outcomes that matter most to patients. Our aim was to develop a minimum Standard Set of patient-centred outcome measures for inflammatory bowel disease (IBD), for use in different healthcare settings. Methods: An international working group (n=25) representing patients, patient associations, gastroenterologists, surgeons, specialist nurses, IBD registries and patient-reported outcome measure (PROM) methodologists participated in a series of teleconferences incorporating a modified Delphi process...
December 5, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29216331/combined-short-and-long-axis-ultrasound-guided-central-venous-catheterization-is-superior-to-conventional-techniques-a-cross-over-randomized-controlled-manikin-trial
#19
Jun Takeshita, Kei Nishiyama, Satoru Beppu, Nozomu Sasahashi, Nobuaki Shime
OBJECTIVES: Visualizing the needle tip using the short-axis (SA) ultrasound-guided central venous catheterization approach can be challenging. It has been suggested to start the process with the SA approach and then switch to the long-axis (LA); however, to our knowledge, this combination has not been evaluated. We compared the combined short- and long-axis (SLA) approach with the SA approach in a manikin study. METHODS: We performed a prospective randomized controlled cross-over study in an urban emergency department and intensive care unit...
2017: PloS One
https://www.readbyqxmd.com/read/29215711/triage-tools-for-detecting-cervical-spine-injury-in-pediatric-trauma-patients
#20
REVIEW
Annelie Slaar, M M Fockens, Junfeng Wang, Mario Maas, David J Wilson, J Carel Goslings, Niels Wl Schep, Rick R van Rijn
BACKGROUND: Pediatric cervical spine injury (CSI) after blunt trauma is rare. Nonetheless, missing these injuries can have severe consequences. To prevent the overuse of radiographic imaging, two clinical decision tools have been developed: The National Emergency X-Radiography Utilization Study (NEXUS) criteria and the Canadian C-spine Rule (CCR). Both tools are proven to be accurate in deciding whether or not diagnostic imaging is needed in adults presenting for blunt trauma screening at the emergency department...
December 7, 2017: Cochrane Database of Systematic Reviews
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