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https://www.readbyqxmd.com/read/28098745/effect-of-freeze-dried-allograft-bone-with-human-basic-fibroblast-growth-factor-containing-a-collagen-binding-domain-from-clostridium-histolyticum-collagenase-on-bone-formation-after-lumbar-posterolateral-fusion-surgery-in-rats
#1
Gen Inoue, Kentaro Uchida, Osamu Matsushita, Hisako Fujimaki, Wataru Saito, Masayuki Miyagi, Hiroyuki Sekiguchi, Nozomu Nishi, Seiji Ohtori, Mizuki Yogoro, Masashi Takaso
STUDY DESIGN: An experimental study. OBJECTIVE: To evaluate the effectiveness of freeze-dried bone allograft (FDBA) with basic fibroblast growth factor (bFGF) fused with the polycystic kidney disease domain (PKD) and the collagen-biding domain (CBD) of Clostridium histolyticum collagenase, for the acceleration of lumbar posterolateral fusion in rats. SUMMARY OF BACKGROUND DATA: Reports indicate bFGF is an effective growth factor with osteogenic potential for promoting bone regeneration, although its efficiency decreases rapidly following its diffusion in body fluid from the host site...
January 16, 2017: Spine
https://www.readbyqxmd.com/read/28089323/neurophysiological-monitoring-of-lumbar-spinal-nerve-roots-a-case-report-of-postoperative-deficit-and-literature-review
#2
Yuguang Chen, Baoqing P Wang, Junlin Yang, Yaolong Deng
INTRODUCTION: Intraoperative neurophysiological monitoring (IONM) has proven to help reduce the probability of postoperative neurological deficit for spinal deformity correctional surgeries. However, in rare cases new deficits may still happen. We report a surgical case in which the patient had postoperative paralysis. We would like to call for more case reports with postoperative neurological deficits as they present difficult clinical cases. PRESENTATION OF CASE: A 61-year-old male patient with severe thoracolumbar kyphoscoliosis underwent posterior spinal correction and fusion with segmental T10-L5 pedicle screws and rods instrumentation with IONM...
November 19, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28063076/automatic-detection-of-vertebral-number-abnormalities-in-body-ct-images
#3
Shouhei Hanaoka, Yoshiyasu Nakano, Mitsutaka Nemoto, Yukihiro Nomura, Tomomi Takenaga, Soichiro Miki, Takeharu Yoshikawa, Naoto Hayashi, Yoshitaka Masutani, Akinobu Shimizu
PURPOSE: The anatomical anomaly of the number of vertebral bones is one of the major anomalies in the human body, which can cause confusion of the spinal level in, for example, surgery. The aim of this study is to develop an automatic detection system for this type of anomaly. METHODS: We utilized our previously reported anatomical landmark detection system for this anomaly detection problem. This system uses a landmark point distribution model (L-PDM) to find multiple landmark positions...
January 6, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28045856/a-multiparametric-alarm-criterion-for-motor-evoked-potential-monitoring-during-spine-deformity-surgery
#4
Martín J Segura, María E Talarico, Mariano A Noel
PURPOSE: This is a pilot study to compare changes in the amplitude, area below the curve, number of phases, duration, and latency of the intraoperative transcranial motor evoked potentials (TcMEP) for early detection of impending spinal cord injury. An empirical ratio calculated by a combination of the above-mentioned parameters was also assessed. METHODS: Intraoperative TcMEP recordings from five patients presenting with neuromuscular kyphoscoliosis, idiopathic scoliosis, achondroplasia and lumbar kyphosis, congenital kyphosis, and achondroplasia with cervical instability were reviewed...
January 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28043422/extent-ii-thoracoabdominal-aortic-aneurysm-repair-how-i-do-it
#5
Joseph S Coselli, Kim I de la Cruz, Ourania Preventza, Scott A LeMaire, Scott A Weldon
The primary risks associated with thoracoabdominal aortic aneurysm (TAAA) repair-namely operative death, paraplegia, and renal failure necessitating dialysis-are commonly related to the distal ischemia that occurs during aortic clamping and the disruption of vital branching arteries. Our technique for open TAAA repair has evolved over the course of 3 decades, from the unheparinized, simple "clamp-and-sew" approach learned directly from E. Stanley Crawford himself to a contemporary, multimodal strategy that uses an array of surgical adjuncts...
July 2016: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28038690/the-development-of-a-representative-porcine-early-onset-scoliosis-model-with-a-standalone-posterior-spinal-tether
#6
R Bogie, A K Roth, P C Willems, Vd W Weegen, J J Arts, L W van Rhijn
STUDY DESIGN: In vivo analysis in a porcine model. OBJECTIVES: To develop a porcine experimental scoliosis model representative of early-onset scoliosis (EOS) with the use of a radiopaque ultra-high molecular weight polyethylene (UHMWPE) posterior spinal tether. SUMMARY OF BACKGROUND DATA: Large animal experimental scoliosis models with substantial growth potential are needed to test new fusionless scoliosis correction techniques. Previously described scoliosis models involve rib procedures, which violate the thoracic cage and affect subsequent corrective procedures...
January 2017: Spine Deformity
https://www.readbyqxmd.com/read/28025800/intrathecal-delivery-of-ssaav9-dao-extends-survival-in-sod1-g93a-als-mice
#7
Wan Wang, Weisong Duan, Ying Wang, Di Wen, Yakun Liu, Zhongyao Li, Haojie Hu, Hongying Cui, Can Cui, Huiqian Lin, Chunyan Li
Amyotrophic lateral sclerosis (ALS) is an adult-onset, irreversible neurodegenerative disease that leads to progressive paralysis and inevitable death 3-5 years after diagnosis. The mechanisms underlying this process remain unknown, but new evidence indicates that accumulating levels of D-serine result from the downregulation of D-amino acid oxidase (DAO) and that this is a novel mechanism that leads to motoneuronal death in ALS via N-methyl-D-aspartate receptor-mediated cell toxicity. Here, we explored a new therapeutic approach to ALS by overexpressing DAO in the lumbar region of the mouse spinal cord using a single stranded adeno-associated virus serotype 9 (ssAAV9) vector...
December 26, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/28017709/anatomical-analysis-of-the-relation-between-human-ligamentum-flavum-and-posterior-spinal-bony-prominence
#8
Javid Akhgar, Hidetomi Terai, Mohammad Suhrab Rahmani, Koji Tamai, Akinobu Suzuki, Hiromitsu Toyoda, Masatoshi Hoshino, Mitsuhiko Ikebuchi, Sayed Abdullah Ahmadi, Kazunori Hayashi, Hiroaki Nakamura
BACKGROUND: Posterior spinal bony prominences are commonly used as landmarks during posterior spinal surgery; however, the exact relationship of these structures with ligamentum flavum (LF) borders and attachments has not been clarified. MATERIALS AND METHODS: Whole spines were removed en bloc from 20 embalmed human cadavers. Plain radiographs and computed tomography (CT) scans of each whole spine were taken, and then the spine was divided in two parts along the pedicle bases...
December 22, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28009223/development-of-an-enhanced-recovery-after-surgery-eras-approach-for-lumbar-spinal-fusion
#9
Michael Y Wang, Peng-Yuan Chang, Jay Grossman
OBJECTIVE Over the past decade, Enhancing Recovery After Surgery (ERAS) programs have been implemented throughout the world across multiple surgical disciplines. However, to date no spinal surgery equivalent has been described. In this report the authors review the development and implementation of a "fast track" surgical approach for lumbar fusion. METHODS The first 42 consecutive cases in which patients were treated with the new surgical procedure were reviewed. A combination of endoscopic decompression, expandable cage deployment, and percutaneous screw placement were performed with liposomal bupivacaine anesthesia to allow the surgery to be performed without general endotracheal anesthesia...
December 23, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28003887/histological-evaluation-of-hydroxyapatite-granules-with-and-without-platelet-rich-plasma-versus-an-autologous-bone-graft-comparative-study-of-biomaterials-used-for-spinal-fusion-in-a-new-zealand-white-rabbit-model
#10
Zamzuri Zakaria, Che N Z C Seman, Zunariah Buyong, Mohd A Sharifudin, Ahmad H Zulkifly, Kamarul A Khalid
OBJECTIVES: Hydroxyapatite (HA) has osteoconductive properties and is widely used as a bone graft substitute. Platelet-rich plasma (PRP) is an autologous product with osteoinductive effects. Hypothetically, a combination of both would augment the bone formation effect of HA and widen its application in spinal fusion surgeries. This study aimed to compare new bone formation with HA granules alone and in combination with PRP versus an autologous bone graft during a lumbar intertransverse process spinal fusion...
November 2016: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/27999308/downregulation-of-homer1b-c-in-sod1-g93a-models-of-als-a-novel-mechanism-of-neuroprotective-effect-of-lithium-and-valproic-acid
#11
Hai-Zhi Jiang, Shu-Yu Wang, Xiang Yin, Hong-Quan Jiang, Xu-Dong Wang, Jing Wang, Tian-Hang Wang, Yan Qi, Yue-Qing Yang, Ying Wang, Chun-Ting Zhang, Hong-Lin Feng
BACKGROUND: Mutations in the Cu/Zn superoxide dismutase (SOD1) gene have been linked to amyotrophic lateral sclerosis (ALS). However, the molecular mechanisms have not been elucidated yet. Homer family protein Homer1b/c is expressed widely in the central nervous system and plays important roles in neurological diseases. In this study, we explored whether Homer1b/c was involved in SOD1 mutation-linked ALS. RESULTS: In vitro studies showed that the SOD1 G93A mutation induced an increase of Homer1b/c expression at both the mRNA and protein levels in NSC34 cells...
December 17, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27996077/hybrid-rigid-deformable-model-for-prediction-of-neighboring-intervertebral-disc-loads-during-flexion-movement-after-lumbar-interbody-fusion-at-l3-4-level
#12
Tien Tuan Dao
Knowledge of spinal loads in neighboring discs after interbody fusion plays an important role in the clinical decision of this treatment as well as in the elucidation of its effect. However, controversial findings are still noted in the literature. Moreover, there are no existing models for efficient prediction of intervertebral disc stresses within annulus fibrosus (AF) and nucleus pulposus (NP) regions. In this present study, a new hybrid rigid-deformable modeling workflow was established to quantify the mechanical stress behavior within AF and NP regions of the L4-5, L2-3, and L1-2 discs after interbody fusion at L3-4 level...
December 20, 2016: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/27990418/finite-element-study-of-a-lumbar-intervertebral-disc-nucleus-replacement-device
#13
Jessica S Coogan, W Loren Francis, Travis D Eliason, Todd L Bredbenner, Brian D Stemper, Narayan Yoganandan, Frank A Pintar, Daniel P Nicolella
Nucleus replacement technologies are a minimally invasive alternative to spinal fusion and total disc replacement that have the potential to reduce pain and restore motion for patients with degenerative disc disease. Finite element modeling can be used to determine the biomechanics associated with nucleus replacement technologies. The current study focuses on a new nucleus replacement device designed as a conforming silicone implant with an internal void. A validated finite element model of the human lumbar L3-L4 motion segment was developed and used to investigate the influence of the nucleus replacement device on spine biomechanics...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27938483/transplantation-of-mesenchymal-stromal-cells-in-patients-with-amyotrophic-lateral-sclerosis-results-of-phase-i-iia-clinical-trial
#14
Eva Syková, Petr Rychmach, Ivana Drahorádová, Šimona Konrádová, Kateřina Růžičková, Ivan Voříšek, Serhiy Forostyak, Aleš Homola, Martin Bojar
Amyotrophic lateral sclerosis (ALS) is a progressive untreatable neurodegenerative disorder, leading to the death of the cortical and spinal motoneurons (MN). Bone marrow mesenchymal stem cells (BM-MSC) may represent a new approach to slowing down the progression of ALS, by providing neurotrophic support to host MN, and by having an antiinflammatory effect. We have designed a prospective, non-randomized, open-label clinical trial (phase I/IIa, EudraCT No. 2011-000362-35) to assess the safety and efficacy of autologous multipotent BM-MSC in ALS treatment...
7, 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27933388/digital-tomosynthesis-as-a-new-diagnostic-tool-for-evaluation-of-spine-damage-in-patients-with-ankylosing-spondylitis
#15
Young Bin Joo, Tae-Hwan Kim, Jina Park, Kyung Bin Joo, Yoonah Song, Seunghun Lee
We aimed to compare digital tomosynthesis (DTS) with radiographs for the assessment of spinal bone damage in patients with ankylosing spondylitis (AS). The study comprised 68 patients with AS who underwent both DTS and radiographs of the cervical and lumbar spine on the same day. Spinal bone damage was assessed using the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) and the presence of facet joint damage. The Wilcoxon signed-rank test and McNemar's test were used to compare spinal bone damage between the two modalities...
December 8, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27931946/multifidus-degeneration-a-new-risk-factor-for-lumbar-spinal-stenosis-a-case-control-study
#16
Jiayao Jiang, Haibin Wang, Liang Wang, Bangke Zhang, Qunfeng Guo, Wen Yuan, Xuhua Lu
No abstract text is available yet for this article.
December 5, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27927546/new-eos-imaging-protocol-allows-a-substantial-reduction-in-radiation-exposure-for-scoliosis-patients
#17
Peter O Newton, Yash Khandwala, Carrie E Bartley, Fredrick G Reighard, Tracey P Bastrom, Burt Yaszay
STUDY DESIGN: Prospective. OBJECTIVE: To evaluate the reliability of three-dimensional (3D) spinal models from Micro Dose EOS x-rays compared to standard, Low Dose EOS x-rays utilized for evaluating patients with adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: There is a strong suggestion that radiation exposure to scoliosis patients can be further reduced. METHODS: Sixty AIS patients who received biplanar, posteroanterior, and lateral standard Low Dose spine x-rays in our EOS imaging unit (∼0...
March 2016: Spine Deformity
https://www.readbyqxmd.com/read/27897305/-cervical-ischaemic-neuronopathy-and-cardioembolism-another-cause-of-man-in-the-barrel-syndrome
#18
H Gonzalez-Usigli, A Gandarilla, J J Garcia, J Serrato, N Estrada
INTRODUCTION: Spinal infarction accounts for 1% of all strokes. Cardioembolism is a rare cause. Common areas of ischemic spinal damage are watershed in the dorsal or lumbar regions; however cervical spinal cord infarction has been reported previously. CASE REPORT: We present a new case of a man-in-the-barrel syndrome produced by cardiac embolization associated with atrial fibrillation during an acute myocardial infarction, which caused cervical ischemic neuronopathy (infarction of the anterior horn)...
December 16, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27879570/bone-turnover-markers-as-a-new-predicting-factor-for-non-union-after-spinal-fusion-surgery
#19
Hiroyuki Inose, Tsuyoshi Yamada, Mieradili Mulati, Takashi Hirai, Shuta Ushio, Toshitaka Yoshii, Tsuyoshi Kato, Shigenori Kawabata, Atsushi Okawa
STUDY DESIGN: Retrospective observational study. OBJECTIVE: We investigated whether bone turnover markers could be a useful indicator for prediction of nonunion. SUMMARY OF BACKGROUND DATA: Nonunion is a major complication of lumbar spinal fusion surgery. However, the involvement of bone turnover in the process of bony union in spinal fusion surgery is poorly understood. METHODS: Of the 74 patients analyzed, 13 were diagnosed with nonunion...
November 22, 2016: Spine
https://www.readbyqxmd.com/read/27875927/what-is-being-trained-how-divergent-forms-of-plasticity-compete-to-shape-locomotor-recovery-after-spinal-cord-injury
#20
J Russell Huie, Kazuhito Morioka, Jenny Haefeli, Adam R Ferguson
Spinal cord injury (SCI) is a devastating syndrome that produces dysfunction in motor and sensory systems, manifesting as chronic paralysis, sensory changes, and pain disorders. The multi-faceted and heterogeneous nature of SCI has made effective rehabilitative strategies challenging. Work over the last 40 years has aimed to overcome these obstacles by harnessing the intrinsic plasticity of the spinal cord to improve functional locomotor recovery. Intensive training after SCI facilitates lower extremity function and has shown promise as a tool for retraining the spinal cord by engaging innate locomotor circuitry in the lumbar cord...
January 13, 2017: Journal of Neurotrauma
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