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https://www.readbyqxmd.com/read/28339441/the-role-of-the-ligamentum-flavum-area-as-a-morphological-parameter-of-lumbar-central-spinal-stenosis
#1
Young Uk Kim, Jun Young Park, Doo Hwan Kim, Myung-Hwan Karm, Jae-Young Lee, Jee In Yoo, Sung Won Chon, Jeong Hun Suh
BACKGROUND: Hypertrophy of the ligamentum flavum (LF) has been considered as a major cause of lumbar central spinal stenosis (LCSS). Previous studies have found that ligamentum flavum thickness (LFT) is correlated with aging, disc degeneration, and lumbar spinal stenosis. However, hypertrophy is different from thickness. Thus, to evaluate hypertrophy of the whole LF, we devised a new morphological parameter, called the ligamentum flavum area (LFA). OBJECTIVES: We hypothesized that the LFA is a key morphologic parameter in the diagnosis of LCSS...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28332140/interspinous-implants-are-the-new-implants-better-than-the-last-generation-a-review
#2
REVIEW
Michael Pintauro, Alexander Duffy, Payman Vahedi, George Rymarczuk, Joshua Heller
PURPOSE OF REVIEW: Interspinous process devices (IPDs) are used in the surgical treatment of lumbar spinal stenosis. The purpose of this review is to compare the first generation with the next-generation devices in terms of complications, device failure, reoperation rates, symptom relief, and outcome. RECENT FINDINGS: Thirty-seven studies were included from 2011 to 2016. Device failure occurred at a mean of 3.7%, with a lower tendency to happen with next-generation IPDs...
March 22, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28327950/a-new-classification-for-pathologies-of-spinal-meninges-part-2-primary-and-secondary-intradural-arachnoid-cysts
#3
Jörg Klekamp
BACKGROUND: Spinal intradural arachnoid cysts are rare causes of radiculopathy or myelopathy. Treatment options include resection, fenestration, or cyst drainage. OBJECTIVE: To classify intradural spinal arachnoid cysts and present results of their treatment. METHODS: Among 1519 patients with spinal space occupying lesions, 130 patients demonstrated intradural arachnoid cysts. Neuroradiological and surgical features were reviewed and clinical data analyzed...
March 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28327115/clinically-acceptable-agreement-between-the-vimove-wireless-motion-sensor-system-and-the-vicon-motion-capture-system-when-measuring-lumbar-region-inclination-motion-in-the-sagittal-and-coronal-planes
#4
Hanne Leirbekk Mjøsund, Eleanor Boyle, Per Kjaer, Rune Mygind Mieritz, Tue Skallgård, Peter Kent
BACKGROUND: Wireless, wearable, inertial motion sensor technology introduces new possibilities for monitoring spinal motion and pain in people during their daily activities of work, rest and play. There are many types of these wireless devices currently available but the precision in measurement and the magnitude of measurement error from such devices is often unknown. This study investigated the concurrent validity of one inertial motion sensor system (ViMove) for its ability to measure lumbar inclination motion, compared with the Vicon motion capture system...
March 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28326944/fatty-acid-binding-protein-inhibition-produces-analgesic-effects-through-peripheral-and-central-mechanisms
#5
Xiaoxue Peng, Keith Studholme, Martha P Kanjiya, Jennifer Luk, Diane Bogdan, Matthew W Elmes, Gregory Carbonetti, Simon Tong, Yu-Han Gary Teng, Robert C Rizzo, Huilin Li, Dale G Deutsch, Iwao Ojima, Mario J Rebecchi, Michelino Puopolo, Martin Kaczocha
Background Fatty-acid-binding proteins (FABPs) are intracellular carriers for endocannabinoids, N-acylethanolamines, and related lipids. Previous work indicates that systemically administered FABP5 inhibitors produce analgesia in models of inflammatory pain. It is currently not known whether FABP inhibitors exert their effects through peripheral or central mechanisms. Here, we examined FABP5 distribution in dorsal root ganglia and spinal cord and examined the analgesic effects of peripherally and centrally administered FABP5 inhibitors...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28323698/hypertrophy-and-fibrosis-of-the-ligamentum-flavum-in-lumbar-spinal-stenosis-is-associated-with-increased-expression-of-lpa-and-lpar1
#6
Kai Zhang, Wei Sun, Xin-Yu Liu, Chang-Qing Zhao, Hua Li, Xiao-Jiang Sun, Xie You-Zhuan, Wei Ding, Jie Zhao
STUDY DESIGN: Histologic, immunohistochemical (IHC), and enzyme-linked immunosorbent assay analysis of the human ligamentum flavum (LF). OBJECTIVE: The purpose of this study was to determine the level of expression of lysophosphatidic acid (LPA) in the LF from lumbar spinal stenosis (LSS) patients and to analyze the relationship among LPA, LPA receptors (LPARs), and LF hypertrophy. SUMMARY OF BACKGROUND DATA: LF hypertrophy and fibrosis are important causes of LSS...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28323696/a-new-angled-chisel-for-microendoscopic-decompressive-laminotomy
#7
Shu Nakamura, Motohide Shibayama, Fujio Ito, Yasushi Miura
STUDY DESIGN: A retrospective comparative series study. OBJECTIVE: The aim of the study was to describe a new angled chisel (NAC) that facilitates the osteotomy in microendoscopic decompressive laminotomy (MEDL), and to analyze the clinical and radiologic outcomes using the tool. SUMMARY OF BACKGROUND DATA: MEDL for lumbar spinal stenosis is a minimally invasive surgery. The paraspinous unilateral approach for bilateral decompression can preserve the posterior structure better than other methods...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28323693/assessment-of-vertebral-curves-using-the-manual-post-it-technique
#8
Brian P Gladnick, Joseph J Schreiber, Chad R Ishmael, Benjamin T Bjerke-Kroll, Matthew E Cunningham
STUDY DESIGN: A prospective study of a new technique. OBJECTIVE: The aims of this study were to report a manual technique for measuring vertebral curves on digital spine radiographs, and to assess the agreement of this technique with that of digital software for measuring vertebral curves. SUMMARY OF BACKGROUND DATA: Modern picture archiving and communication systems (PACS) typically include software for evaluating radiographic measurements...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28321409/could-the-topping-off-technique-be-the-preventive-strategy-against-adjacent-segment-disease-after-pedicle-screw-based-fusion-in-lumbar-degenerative-diseases-a-systematic-review
#9
REVIEW
Po-Hsin Chou, Hsi-Hsien Lin, Howard S An, Kang-Ying Liu, Wei-Ren Su, Cheng-Li Lin
The "topping-off" technique is a new concept applying dynamic or less rigid fixation such as hybrid stabilization device (HSD) or interspinous process device (IPD) for the purpose of avoiding adjacent segment disease (ASD) proximal to the fusion construct. A systematic review of the literature was performed on the effect of topping-off techniques to prevent or decrease the occurrence of ASD after lumbar fusion surgery. We searched through major online databases, PubMed and MEDLINE, using key words related to "topping-off" technique...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28320889/trunk-muscle-activation-during-movement-with-a-new-exercise-device-for-lumbo-pelvic-reconditioning
#10
Tobias Weber, Dorothée Debuse, Sauro E Salomoni, Edith L Elgueta Cancino, Enrico De Martino, Nick Caplan, Volker Damann, Jonathan Scott, Paul W Hodges
Gravitational unloading leads to adaptations of the human body, including the spine and its adjacent structures, making it more vulnerable to injury and pain. The Functional Re-adaptive Exercise Device (FRED) has been developed to activate the deep spinal muscles, lumbar multifidus (LM) and transversus abdominis (TrA), that provide inter-segmental control and spinal protection. The FRED provides an unstable base of support and combines weight bearing in up-right posture with side alternating, elliptical leg movements, without any resistance to movement...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28306640/cervical-alignment-variations-in-different-postures-and-predictors-of-normal-cervical-kyphosis-a-new-understanding
#11
Hwee Weng Dennis Hey, Eugene Tze-Chun Lau, Chengyuan Gordon Wong, Kimberly-Anne Tan, Gabriel Ka-Po Liu, Hee-Kit Wong
STUDY DESIGN: Prospective comparative study OBJECTIVE.: To predict physiological alignment of the cervical spine and study its morphology in different postures. SUMMARY OF BACKGROUND DATA: There is increasing evidence that normal cervical spinal alignment may vary from lordosis to neutral to kyphosis, or form S-shaped or reverse S-shaped curves. METHODS: Standing, erect sitting and natural sitting whole spine radiographs were obtained from 26 consecutive patients without cervical spine pathology...
March 16, 2017: Spine
https://www.readbyqxmd.com/read/28300721/characterization-of-facet-joint-cartilage-properties-in-the-human-and-interspecies-comparisons
#12
Siobhan A O'Leary, Jarrett M Link, Eric O Klineberg, Jerry C Hu, Kyriacos A Athanasiou
The facet joint, a synovial joint located on the posterior-lateral spine, is highly susceptible to degenerative changes and plays a significant role in back-related morbidities. Despite its significance, the facet is rarely studied and thus current treatment strategies are lacking. This study aimed to characterize, for the first time, the properties of human, pig, monkey, and rabbit lumbar facet cartilage providing much-needed design criteria for tissue engineering approaches. In this study, where possible, the facet's morphological, histological, mechanical, and biochemical properties were evaluated...
March 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28264978/deletion-of-the-fractalkine-receptor-cx3cr1-improves-endogenous-repair-axon-sprouting-and-synaptogenesis-after-spinal-cord-injury-in-mice
#13
Camila M Freria, Jodie C E Hall, Ping Wei, Zhen Guan, Dana M McTigue, Phillip G Popovich
Impaired signaling via CX3CR1, the fractalkine receptor, promotes recovery after traumatic spinal contusion injury in mice, a benefit achieved in part by reducing macrophage-mediated injury at the lesion epicenter. Here, we tested the hypothesis that CX3CR1-dependent changes in microglia and macrophage functions also will enhance neuroplasticity, at and several segments below the injury epicenter. New data show that in the presence of inflammatory stimuli, CX3CR1-deficient (CX3CR1(-/-)) microglia and macrophages adopt a reparative phenotype and increase expression of genes that encode neurotrophic and gliogenic proteins...
March 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28212183/cxcl12-cxcr4-signaling-contributes-to-the-pathogenesis-of-opioid-tolerance-a-translational-study
#14
Chih-Peng Lin, Kai-Hsiang Kang, Huang-Ju Tu, Ming-Yueh Wu, Tzu-Hung Lin, Houng-Chi Liou, Wei-Zen Sun, Wen-Mei Fu
BACKGROUND: Long-term opioid therapy for chronic pain may lead to analgesic tolerance, especially when administered intrathecally, thus preventing adequate pain relief. Discovering drug targets to treat opioid tolerance using a mechanism-based approach targeting opioid-induced neuroinflammation provides new therapeutic opportunities. In this study, we provide translational evidence that CXCL12/CXCR4 signaling contributes to the pathogenesis of opioid tolerance. METHODS: The CXCL12 levels in the cerebrospinal fluid of opioid-tolerant patients were compared with those of opioid-naive subjects...
March 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28207664/descriptive-analysis-of-spinal-neuroaxial-injections-surgical-interventions-and-physical-therapy-utilization-for-degenerative-lumbar-spondylolisthesis-within-medicare-beneficiaries-from-2000-to-2011
#15
Joseph A Sclafani, Alexandra Constantin, Pei-Shu Ho, Venu Akuthota, Leighton Chan
STUDY DESIGN: A retrospective, observational study. OBJECTIVE: The aim of this study was to determine the utilization of various treatment modalities in the management of degenerative spondylolisthesis within Medicare beneficiaries. SUMMARY OF BACKGROUND DATA: Degenerative lumbar spondylolisthesis is a condition often identified in symptomatic low back pain. A variety of treatment algorithms including physical therapy and interventional techniques can be used to manage clinically significant degenerative spondylolisthesis...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28207623/feasibility-of-percutaneous-posterolateral-spinal-fusion-with-recombinant-bone-morphogenetic-protein-2-rhbmp-2-a-comparison-with-standard-methods-using-an-animal-model-study
#16
Chris Yin Wei Chan, Mun Keong Kwan, Lim Beng Saw, Hussin Paisal
BACKGROUND CONTEXT: The clinical application of recombinant bone morphogenetic protein in spinal surgery has been shown to be safe and effective. However, its use in minimally invasive spine surgery has been limited to anterior interbody fusion procedures. To date, no study has evaluated the feasibility of percutaneous posterolateral fusion in the spine utilizing recombinant bone morphogenetic protein-2 (rhBMP-2). PURPOSE: To evaluate the feasibility of percutaneous posterolateral fusion in the spine utilizing rhBMP-2...
March 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28191306/chiropractic-management-of-post-spinal-cord-stimulator-spine-pain-a-case-report
#17
Rachel M Perrucci, Christopher M Coulis
BACKGROUND: A brief overview of failed back surgery syndrome, with emphasis on low back pain status post spinal cord stimulation, and post-surgical spinal manipulation is presented. CASE PRESENTATION: Four cases of patients within the VA Connecticut Health Care System presenting between July 2014 and July 2015 reporting low back pain after surgical insertion of spinal cord stimulators are discussed. This study describes the outcomes experienced by four patients with low back pain status post implanted spinal cord stimulators receiving manual therapy in the form of lumbar spine manipulation or mobilization...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/28185980/a-new-quantitative-measure-of-disc-degeneration
#18
Tapio Videman, Michele C Battié, Laura E Gibbons, Kevin Gill
BACKGROUND CONTEXT: The ability to adequately measure a phenomenon is critical to studying and understanding it. Since 1957, a variety of subjective visual grading methods have been used to assess disc degeneration, but these have been limited by gross ordinal scales and imprecision, as well as suboptimal reliability. Conceptually sound, objective, precise measurements are needed to advance knowledge of disc degeneration and its causes, progression, and consequences. PURPOSE: This study aimed to investigate the reliability and validity of a new system ("SpIn" for spine insight) to quantitatively measure lumbar disc degeneration or pathology...
February 6, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28168338/radiation-exposure-to-the-patients-in-thoracic-and-lumbar-spine-fusion-using-a-new-intraoperative-cone-beam-computed-tomography-imaging-technique-a-preliminary-study
#19
Ludovic Kaminski, V Cordemans, O Cartiaux, M Van Cauter
PURPOSE: The goals of this paper are to assess the ionizing radiation exposure to the patients during thoracic and lumbar spinal fusion using a new intraoperative 3D imaging system and to evaluate the factors that could explain the variability in the observed doses. METHOD: We retrospectively reviewed 97 patients who underwent posterior instrumented thoracic and/or lumbar spinal fusion from December 2013 to November 2014. Primary data were the total dose area product (total DAP, Gy cm(2)) and total skin dose (total SD, mGy)...
February 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28161752/reversibility-of-nerve-root-sedimentation-sign-in-lumbar-spinal-stenosis-patients-after-decompression-surgery
#20
Christian Barz, Markus Melloh, Lukas P Staub, Sarah J Lord, Harry R Merk, Thomas Barz
PURPOSE: The nerve root sedimentation sign (SedSign) is a magnetic resonance imaging (MRI) sign for the diagnosis of lumbar spinal stenosis (LSS). It is included in the assessment of LSS to help determine whether decompression surgery is indicated. Assessment of the reversibility of the SedSign after surgery may also have clinical implications for the decision about whether or not a secondary operation or revision is needed. This study investigated if lumbar decompression leads to a reversal of the SedSign in patients with LSS and a positive SedSign pre-operatively; and if a reversal is associated with more favourable clinical outcomes...
February 4, 2017: European Spine Journal
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