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https://www.readbyqxmd.com/read/29133001/effects-of-low-bone-mineral-status-on-biomechanical-characteristics-in-idiopathic-scoliotic-spinal-deformity
#1
Xiao-Xing Song, Lin-Yu Jin, Xin-Feng Li, Lie Qian, Hong-Xing Shen, Zu-De Liu, Bu-Wei Yu
BACKGROUND: Low bone mass in adolescent idiopathic scoliosis patients has been well reported. Poor bone quality was regarded as a new and unique prognostic factor in aggravating the curve progression. However, the potential biomechanical correlation between them remains unclear. METHODS: Three-dimensional finite element models of idiopathic scoliotic spine with different bone mineral status were created for axial loading simulation. Axial load of three different body weights were applied on different bone mineral mass models...
November 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29127093/development-of-the-ct-syndesmophyte-score-ctss-in-patients-with-ankylosing-spondylitis-data-from-the-sias-cohort
#2
Freek de Bruin, Anoek de Koning, Rosaline van den Berg, Xenofon Baraliakos, Juergen Braun, Sofia Ramiro, Floris A van Gaalen, Monique Reijnierse, Désirée van der Heijde
OBJECTIVES: To develop the CT Syndesmophyte Score (CTSS) for low-dose CT (ldCT) to assess structural damage in the spine of patients with ankylosing spondylitis (AS) and test its reliability. METHODS: Patientswith AS in the SIAS cohort had whole spine ldCT at baseline and 2 years. Syndesmophytes were scored in coronal and sagittal planes in eight quadrants per vertebral unit (VU) as absent=0, <50% of the intervertebral disc space (IDS)=1, ≥50%=2 or bridging the IDS=3 (range 0-552)...
November 10, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29114274/outcomes-of-minimally-invasive-surgery-compared-to-open-posterior-lumbar-instrumentation-and-fusion
#3
Low Yong Lee, Zamzuri Idris, Tan Boon Beng, Teo Yian Young, Wong Chung Chek, Jafri Malin Abdullah, Wong Sii Hieng
Introduction: Degenerative spine disease is increasingly common. There are many spinal fusion techniques used to treat degenerative spine disease. This study aims to compare the functional outcome of open versus minimally invasive surgery (MIS) technique in posterior lumbar instrumentation and fusion in degenerative spine disease and to evaluate the perioperative outcome and complications between MIS and open surgery. Materials and Methods: This is an observational cross-sectional study conducted on all degenerative spine disease patients who underwent both methods of posterior lumbar instrumentation and fusion from 2010 to 2014 by the Orthopedic and Neurosurgery Department, Sarawak General Hospital...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29099857/knockout-of-apolipoprotein-e-in-rabbit-promotes-premature-intervertebral-disc-degeneration-a-new-in-vivo-model-for-therapeutic-approaches-of-spinal-disc-disorders
#4
Anja Beierfuß, Hermann Dietrich, Christian Kremser, Monika Hunjadi, Andreas Ritsch, Thomas Rülicke, Claudius Thomé, Demissew Shenegelegn Mern
Intervertebral disc (IVD) degeneration that accelerates the loss of disc structural and functional integrities is recognized as one of the major factors of chronic back pain. Cardiovascular risk factors, such as deficits of apolipoproteins that elevate the levels of cholesterol and triglycerides, are considered critical for the progress of atherosclerosis; notably in the abdominal aorta and its lumbar branching arteries that supply lumbar vertebrae and IVDs. Obstruction of the lumbar arteries by atherosclerosis is presumed to promote lumbar disc degeneration and low back pain...
2017: PloS One
https://www.readbyqxmd.com/read/29095414/effects-of-combined-magnetic-fields-cmf-treatment-and-nano-hydroxyapatite-ha-coating-on-porous-biphasic-calcium-phosphate-bcp-bone-graft-in-rabbit-spinal-fusion-model
#5
Xianglong Zhuo, Chentian Li, Bing Li, Zhaoyang Li, Hongbin Lv, Jianjun Huang, Daqi Xu, Jian-Zhong Hu
STUDY DESIGN: An animal experimental study was designed to investigate the efficacy of combined magnetic fields (CMF) treatment and nano-hydroxyapatite (HA) coating in the biphasic calcium phosphate (BCP) graft in posterolateral lumbar fusion. OBJECTIVE: To evaluate the effects of CMF treatment and nano-HA/BCP and their combination effect in posterolateral lumbar fusion. SUMMARY OF BACKGROUND DATA: Enhancement of artificial bone graft bioeffects could improve spinal fusion outcomes...
October 31, 2017: Spine
https://www.readbyqxmd.com/read/29093781/efficacy-of-the-thoracolumbar-interfascial-plane-block-for-lumbar-laminoplasty-a-retrospective-study
#6
Hironobu Ueshima, Tomoyuki Ozawa, Tomoaki Toyone, Hiroshi Otake
Study Design: This paper was a single center-based retrospective study with prospective data collection. Purpose: Compared with other surgeries, limited options are available for perioperative pain management in spinal surgery. Therefore, we aimed to identify new pain management in this study. Overview of Literature: The thoracolumbar interfascial plane (TLIP) block has been reported to provide effective regional analgesia in the lumbar region...
October 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/29075135/dnmt3a-methylation-in-neuropathic-pain
#7
Cuijie Shao, Yong Gao, Dan Jin, Xin Xu, Shuying Tan, Hui Yu, Qingxiang Zhao, Li Zhao, Wansheng Wang, Deqiang Wang
BACKGROUND: Mu opioid receptor (MOR) plays a crucial role in mediating analgesic effects of opioids and is closely associated with the pathologies of neuropathic pain. Previous studies have reported that peripheral nerve injury downregulates MOR expression, but the epigenetic mechanisms remain unknown. OBJECTIVE: Therefore, we investigated DNA methyltransferase3a (DNMT3a) expression or methylation changes within MOR promoter in the spinal cord in a neuropathic pain induced by a chronic constriction injury (CCI) mouse model and further determined whether these injury-associated changes are reversible by pharmacological interventions...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29059193/safe-corridor-for-the-implantation-of-thoracolumbar-pedicle-screws-in-growing-pigs-a-morphometric-study
#8
Thibaut Cachon, Paul Pillard, Thierry Odent, Claude Carozzo, Eric Viguier
The pig spine is widely used as a large animal model for preclinical research in human medicine to test new spinal implants and surgical procedures. Among them, pedicle screw is one of the most common method of fixation of those implants. However, the pedicle of the porcine vertebra is not as well defined and not as large as the pedicle of the human vertebra. Therefore, the position of the screw should be adapted to the pig and not merely transposed based on the literature on humans. The purpose of this study is to determine the characteristics of the optimum implantation corridors for pedicle screws in the thoracolumbar spine of piglets of different ages using computed tomography (CT) and to determine the size and length of these corridors in pigs of different ages...
2017: PloS One
https://www.readbyqxmd.com/read/29057365/a-rare-case-of-intramedullary-solitary-juvenile-xanthogranuloma-of-the-lumbar-spine-in-the-adult-a-case-report
#9
Vania Pirillo, Andrea Prontera, Paolo Rizzo, Paolo Cipriano Cecchi, Martin Maffei, Andreas Schwarz
Solitary juvenile xanthogranuloma (SJX) of the spine is an extremely rare proliferative histiocytic disorder with only few cases reported in literature. We present the first case of intramedullary spinal SJX. A 22-year-old male presented with a nine-month history of progressively worsening sphincteric disturbances and saddle hypoesthesia. Magnetic resonance imaging showed an intra-axial lesion located in the conus medullaris; T1 hypointense, T2 iso-hyperintense and uniformly enhancing after contrast administration...
September 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29047242/effect-of-sagittal-balance-on-risk-of-falling-after-lateral-lumbar-interbody-fusion-surgery-combined-with-posterior-surgery
#10
Byung Ho Lee, Jae Ho Yang, Hak Sun Kim, Kyung Soo Suk, Hwan Mo Lee, Jin Oh Park, Seong Hwan Moon
PURPOSE: To demonstrate the impact of correcting sagittal balance (SB) on functional outcomes of surgical treatment for degenerative spinal disease and actual falls via utilization of new minimally invasive lumbar fusion techniques via a lateral approach. MATERIALS AND METHODS: From November 2011 to March 2015, we enrolled 56 patients who underwent minimally invasive lateral lumbar interbody fusion (LLIF) and matched 112 patients receiving decompression/postero-lateral fusion (PLF) surgery for lumbar spinal stenosis...
November 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29032887/virtual-simulation-in-enhancing-procedural-training-for-fluoroscopy-guided-lumbar-puncture-a-pilot-study
#11
Saad Ali, Monther Qandeel, Rishi Ramakrishna, Carina W Yang
RATIONALE AND OBJECTIVES: Fluoroscopy-guided lumbar puncture (FGLP) is a basic procedural component of radiology residency and neuroradiology fellowship training. Performance of the procedure with limited experience is associated with increased patient discomfort as well as increased radiation dose, puncture attempts, and complication rate. Simulation in health care is a developing field that has potential for enhancing procedural training. We demonstrate the design and utility of a virtual reality simulator for performing FGLP...
October 9, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29019807/pedicle-screw-insertion-accuracy-using-o-arm-robotic-guidance-or-freehand-technique-a-comparative-study
#12
Pietro Aniello Laudato, Katarzyna Pierzchala, Constantin Schizas
STUDY DESIGN: Retrospective radiological study OBJECTIVE.: To evaluate the accuracy of pedicle screw insertion using O-Arm navigation, Robotic assistance or a freehand fluoroscopic technique. SUMMARY OF BACKGROUND DATA: Pedicle screw insertion using either 'O-Arm' navigation or robotic devices is gaining popularity. Although several studies are available evaluating each of those techniques separately, no direct comparison has been attempted. METHODS: 84 patients undergoing implantation of 569 lumbar and thoracic screws were divided in three groups...
October 10, 2017: Spine
https://www.readbyqxmd.com/read/29016436/trends-and-disparities-in-cervical-spine-fusion-procedures-utilization-in-the-new-york-state
#13
Rui Feng, Mark Finkelstein, Khawaja Bilal, Eric K Oermann, Michael Palese, John Caridi
STUDY DESIGN: A retrospective review of the Statewide Planning and Research Cooperative System database of the New York State. OBJECTIVE: This study examined the rate of increase of cervical spine fusion procedures at low-, medium-, and high-volume hospitals, and analyzed racial and socioeconomic characteristics of the patient population treated at these three volume categories. SUMMARY OF BACKGROUND DATA: There has been a steady increase in spinal fusion procedures performed each year in the US, especially cervical and lumbar fusion...
October 9, 2017: Spine
https://www.readbyqxmd.com/read/28994028/treatment-for-degenerative-lumbar-spondylolisthesis-current-concepts-and-new-evidence
#14
REVIEW
Andre M Samuel, Harold G Moore, Matthew E Cunningham
PURPOSE OF REVIEW: Current guidelines for the optimal treatment degenerative spondylolisthesis are weak and based on limited high-quality evidence. RECENT FINDINGS: There is some moderate evidence that decompression alone may be a feasible treatment with lower surgical morbidity and similar outcomes to fusion when performed in a select population with a low-grade slip. Similarly, addition of interbody fusion may be best suited to a subset of patients with high-grade degenerative spondylolisthesis, although this remains controversial...
December 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28979853/lumbar-ganglion-cyst-nosology-surgical-management-and-proposal-of-a-new-classification-based-on-34-personal-cases-and-literature-review
#15
Maurizio Domenicucci, Alessandro Ramieri, Daniele Marruzzo, Paolo Missori, Massimo Miscusi, Roberto Tarantino, Roberto Delfini
AIM: To analyze different terms used in literature to identify lumbar extradural cysts and propose a common scientific terminology; to elaborate a new morphological classification of this pathology, useful for clinical and surgical purposes; and to describe the best surgical approach to remove these cysts, in order to avoid iatrogenic instability or treat the pre-existing one. METHODS: We retrospectively reviewed 34 patients with symptomatic lumbar ganglion cysts treated with spinal canal decompression with or without spinal fixation...
September 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28976431/global-alignment-and-proportion-gap-score-development-and-validation-of-a-new-method-of-analyzing-spinopelvic-alignment-to-predict-mechanical-complications-after-adult-spinal-deformity-surgery
#16
Caglar Yilgor, Nuray Sogunmez, Louis Boissiere, Yasemin Yavuz, Ibrahim Obeid, Frank Kleinstück, Francisco Javier Sánchez Pérez-Grueso, Emre Acaroglu, Sleiman Haddad, Anne F Mannion, Ferran Pellise, Ahmet Alanay
BACKGROUND: The restoration of normal sagittal alignment is a critical goal in adult spinal deformity surgery to achieve favorable outcomes and prevent mechanical complications. Schwab sagittal modifiers have been accepted as targets for appropriate alignment, but addressing these targets does not always prevent high mechanical complication or revision rates. This may be because the linear absolute numerical parameters do not cover the whole pelvic incidence spectrum and the distribution of lordosis, pelvic anteversion, and negative malalignment are not considered as potential causes of failure...
October 4, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28972129/camkii-regulates-synaptic-nmda-receptor-activity-of-hypothalamic-presympathetic-neurons-and-sympathetic-outflow-in-hypertension
#17
De-Pei Li, Jing-Jing Zhou, Jixiang Zhang, Hui-Lin Pan
NMDAR activity in the hypothalamic paraventricular nucleus (PVN) is increased and critically involved in heightened sympathetic vasomotor tone in hypertension. Calcium/calmodulin-dependent protein kinase II (CaMKII) binds to and modulates NMDAR activity. In this study, we determined the role of CaMKII in regulating NMDAR activity of PVN presympathetic neurons in male spontaneously hypertensive rats (SHRs). NMDAR-mediated EPSCs and puff NMDA-elicited currents were recorded in spinally projecting PVN neurons in SHRs and male Wistar-Kyoto (WKY) rats...
November 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28968836/limited-reliability-of-radiographic-assessment-of-spinal-progression-in-ankylosing-spondylitis
#18
Sibel Zehra Aydin, Esen Kasapoglu Gunal, Esra Kurum, Servet Akar, Halit Eyyup Mungan, Fatma Alibaz-Oner, Robert G Lambert, Pamir Atagunduz, Helena Marzo Ortega, Dennis McGonagle, Walter P Maksymowych
Objectives: Conventional radiography is key to assessing AS-related spinal involvement and has become increasingly important given that spinal fusion may continue under biologic therapy. We aimed to compare the reliability of radiographic scoring of the spine by using different approaches to understand how different readers agree on overall scores and on individual findings. Method: Six investigators scored 68 plain radiographs of the cervical and lumbar spine of 34 patients with a 2-year interval, for erosions, sclerosis, squaring, syndesmophytes and ankyloses using the Spondyloarthritis Radiography (SPAR) module...
September 15, 2017: Rheumatology
https://www.readbyqxmd.com/read/28960477/real-time-ultrasound-assessment-of-astronaut-spinal-anatomy-and-disorders-on-the-international-space-station
#19
Kathleen M Garcia, Michael F Harrison, Ashot E Sargsyan, Douglas Ebert, Scott A Dulchavsky
OBJECTIVES: Back pain is one of the most common conditions of astronauts during spaceflight and is hypothesized to be attributed to pathologic anatomic changes. Ultrasound (US) represents the only available imaging modality on the International Space Station, but a formal US protocol for imaging the structures of the spinal column does not exist. This investigation developed a method of acquiring diagnostic-quality images of the anterior lumbar and cervical regions of the spine during long-duration spaceflight...
September 29, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28949091/new-approach-for-the-treatment-of-neuropathic-pain-fibroblast-growth-factor-1-gene-transfected-adipose-derived-mesenchymal-stem-cells
#20
F Forouzanfar, B Amin, A Ghorbani, H Ghazavi, F Ghasemi, K Sadri, S Mehri, H R Sadeghnia, H Hosseinzadeh
BACKGROUND: Neuropathic pain triggered by peripheral nerve lesion is extremely difficult to manage with current approaches, hence the importance of exploring therapeutic alternatives. METHODS: We have analysed adipose-derived mesenchymal stem cells (AD-MSCs) and fibroblast growth factor 1 gene-transfected adipose-derived mesenchymal stem cells (AD-MSCs (FGF)(1) ) on chronic constriction injury (CCI). The mechanical and thermal hypersensitivity were assessed using the von Frey filament, radiant heat and acetone drop tests...
September 26, 2017: European Journal of Pain: EJP
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