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https://www.readbyqxmd.com/read/29770280/effect-of-body-mass-index-on-perioperative-outcomes-in-minimally-invasive-oblique-lateral-lumbar-interbody-fusion-versus-open-fusions-a-multivariant-analysis
#1
Hamid Abbasi, Alex Grant
Background Obesity is an increasing public health concern associated with increased perioperative complications and expense in lumbar spine fusions. While open and mini-open fusions such as transforaminal lumbar interbody fusion (TLIF) and minimally invasive TLIF (MIS-TLIF) are more challenging in obese patients, new MIS procedures like oblique lateral lumbar interbody fusion (OLLIF) may improve perioperative outcomes in obese patients relative to TLIF and MIS-TLIF. Purpose The purpose of this study is to determine the effects of obesity on perioperative outcomes in OLLIF, MIS-TLIF, and TLIF...
March 8, 2018: Curēus
https://www.readbyqxmd.com/read/29766758/anti-inflammatory-peptide-attenuates-edema-and-promotes-bmp-2-induced-bone-formation-in-spine-fusion
#2
Juliane D Glaeser, Khosrowdad Salehi, Linda Kanim, Dmitriy Sheyn, Zachary NaPier, Phillip Behrens, Leslie Garcia, Jason M Cuéllar, Hyun W Bae
Recombinant human bone morphogenic protein-2 (BMP-2) loaded absorbable collagen sponges (ACS) have been successfully used to enhance bone formation and to induce spinal fusion in humans. However, side effects, such as soft-tissue edema and inflammation, have been reported. NEMO binding domain peptide (NBD) inhibits activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a central regulator of immune response. In this study, we investigated NBD's potential to reduce BMP-2-induced soft-tissue inflammation without affecting BMP-2-mediated spinal fusion in rat...
May 16, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29748903/sagittal-classification-in-adolescent-idiopathic-scoliosis-original-description-and-therapeutic-implications
#3
K Abelin-Genevois, D Sassi, S Verdun, P Roussouly
INTRODUCTION: Surgical treatment of AIS aims to correct the coronal and sagittal alignment of the spine. The global alignment of the spine may be normalized through reciprocal changes between the fused spine and adjacent segments. We propose a new classification system describing the specific sagittal patterns induced by AIS to define reproducible guidelines for the surgical strategy. METHODS: We analyzed 100 consecutive AIS patients aged between 12 and 18 years candidate for spinal fusion...
May 10, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29747017/a-novel-association-between-intrathecal-drug-administration-and-arachnoiditis-ossificans
#4
Max Ward, Antonios Mammis, Maureen T Barry, Robert F Heary
We present a case of delayed progression of adhesive arachnoiditis to arachnoiditis ossificans (AO) in a patient being treated with a high dose polypharmaceutical intrathecal regimen. The patient is a 39-year-old Caucasian male who was implanted with an intrathecal pump in 2006 to control severe low back pain and administered intrathecal pain medication for a period of 10 years. In 2016, he developed new onset radicular pain and worsened sensation in his lower extremities. A CT scan of the lumbar spine at that time demonstrated profound calcification of the arachnoid consistent with a diagnosis of AO...
May 7, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29742708/the-effectiveness-and-safety-of-nonsurgical-integrative-interventions-for-symptomatic-lumbar-spinal-spondylolisthesis-a-randomized-controlled-multinational-multicenter-trial-protocol
#5
Kiok Kim, Yousuk Youn, Sang Ho Lee, Jung Chul Choi, Jae Eun Jung, Jaehong Kim, Wenchun Qu, Jason Eldrige, Tae-Hun Kim
BACKGROUND: Surgery is generally accepted as the main therapeutic option for symptomatic lumbar spondylolisthesis. However, new nonsurgical therapeutic options need to be explored for this population. OBJECTIVES: The objective of this study is to assess the effectiveness and safety of a 5-week Mokhuri treatment program compared with conventional nonsurgical treatments for symptomatic lumbar spondylolisthesis. METHODS: This is a study protocol for a multinational, multicenter clinical randomized controlled trial comparing the effectiveness and safety of 5 weeks of nonsurgical integrative treatments (a Mokhuri treatment program consisting of Chuna, acupuncture, and patient education) with nonsurgical conventional treatments (drugs for pain relief, epidural steroid injections, and physical therapy)...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29738366/effects-of-combined-magnetic-fields-treatment-and-nano-hydroxyapatite-coating-on-porous-biphasic-calcium-phosphate-bone-graft-in-rabbit-spinal-fusion-model
#6
Xianglong Zhuo, Chentian Li, Bing Li, Zhaoyang Li, Hongbin Lv, Jianjun Huang, Daqi Xu, Jianzhong Hu
STUDY DESIGN: An animal experimental study was designed to investigate the efficacy of combined magnetic fields (CMF) treatment and nano-hydroxyapatite (HA) coating in the biphasic calcium phosphate (BCP) graft in posterolateral lumbar fusion. OBJECTIVE: To evaluate the effects of CMF treatment and nano-HA/BCP and their combination effect in posterolateral lumbar fusion. SUMMARY OF BACKGROUND DATA: Enhancement of artificial bone graft bioeffects could improve spinal fusion outcomes...
June 1, 2018: Spine
https://www.readbyqxmd.com/read/29736360/metachronous-bilateral-painless-foot-drop-secondary-to-spinal-stenosis-case-report
#7
Luis A Robles
Foot drop (FD) is an uncommon manifestation of nerve root compression secondary to lumbar degenerative disease (LDD). In most of these patients, FD is unilateral and is associated with low back pain and leg pain. A small number of cases have been described with bilateral FD, which is reported to occur simultaneously in a synchronous fashion. A 63-year-old male with a remote history of spinal surgery due to left painless FD presented with a new episode of right FD, this new FD initiated suddenly and it was not associated with low back pain or radicular pain...
March 5, 2018: Curēus
https://www.readbyqxmd.com/read/29735128/the-relationship-between-apical-vertebral-rotation-and-truncal-rotation-in-adolescent-idiopathic-scoliosis-using-3d-reconstructions
#8
Pawel P Jankowski, Burt Yaszay, Krishna R Cidambi, Carrie E Bartley, Tracey P Bastrom, Peter O Newton
STUDY DESIGN: Retrospective review of prospective data. OBJECTIVES: To evaluate the relationship between absolute apical vertebral rotation (AVR) evaluated with upright 3D imaging and angle of trunk rotation (ATR) before and after surgery for thoracic and lumbar curves in adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: New imaging technology allows for improved radiographic assessment of the degree of AVR pre- and postoperatively through 3D spine models created from biplanar, simultaneous spine radiographs...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29721356/accuracy-of-percutaneous-pedicle-screw-insertion-in-spinal-fixation-of-traumatic-thoracic-and-lumbar-spine-fractures
#9
Tamer Orief, Mohammad Alfawareh, Mohammad Halawani, Walid Attia, Khaled Almusrea
Background: Percutaneous insertion of pedicle screws was developed as a minimally invasive alternative to the different open spinal procedures. Here, we determined the accuracy of percutaneous pedicle screw insertion. Methods: For 60 consecutive patients with thoracic/lumbar spine fractures, computed tomography (CT) studies were utilized to assess the accuracy of percutaneous pedicle screw positioning. A screw was identified as cortical encroachment if the pedicle cortex could not be visualized, while Frank penetration was defined if screw trajectory being located obviously outside the pedicle boundaries [e...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29718432/impact-of-h3-3-k27m-mutation-on-prognosis-and-survival-of-grade-iv-spinal-cord-glioma-on-the-basis-of-new-2016-world-health-organization-classification-of-the-central-nervous-system
#10
Seong Yi, Sunkyu Choi, Dong Ah Shin, Du Su Kim, Junjeong Choi, Yoon Ha, Keung Nyun Kim, Chang-Ok Suh, Jong Hee Chang, Se Hoon Kim, Do Heum Yoon
BACKGROUND: Spinal cord glioma grade IV is a rare, diffuse midline glioma. H3 K27M-mutant was classified in a different entity in the 2016 World Health Organization (WHO) classification recently. No reports about prognosis of spinal cord glioma grade IV are available yet. OBJECTIVE: To analyze the prognostic factors for spinal cord glioma grade IV. METHODS: Twenty-five patients with spinal cord glioma of grade IV who underwent surgery in a single institute were selected...
May 1, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29680509/opioids-delay-healing-of-spinal-fusion-a-rabbit-posterolateral-lumbar-fusion-model
#11
Nikhil Jain, Khaled Himed, Jeffrey M Toth, Karen C Briley, Frank M Phillips, Safdar N Khan
BACKGROUND CONTEXT: Opioid use is prevalent for management of pre- and post-operative pain in patients undergoing spinal fusion. There is evidence that opioids downregulate osteoblasts in-vitro, and one previous study found that morphine delays the maturation and remodeling of callus in a rat femur fracture model. However, the effect of opioids on healing of spinal fusion has not been investigated before. Isolating the effect of opioid exposure in humans would be limited by the numerous confounding factors that affect fusion healing...
April 19, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29680304/spinal-dural-arteriovenous-fistula-assumed-to-be-symptomatic-after-placement-of-lumbar-cerebrospinal-fluid-drain
#12
Senshu Nonaka, Hidenori Oishi, Satoshi Tsutsumi, Koichiro Sakamoto, Hidehiro Okura, Takamoto Suzuki, Hisato Ishii, Yukimasa Yasumoto
A 69-year-old man presented with severe headache. Cranial computed tomography revealed diffuse subarachnoid hemorrhage. An anterior communicating artery aneurysm was identified and successfully obliterated by open microsurgery on the same day. Following placement of a continuous lumbar cerebrospinal fluid drain on hospitalization day 7, the patient developed a severe paraplegia and sensory loss below T6. Cerebral magnetic resonance imaging did not identify a responsible lesion. Spinal magnetic resonance imaging, however, showed extensive intramedullary hyperintensity on T2-weighted sequences...
April 18, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29679729/a-longitudinal-study-of-disc-height-narrowing-and-facet-joint-osteoarthritis-at-the-thoracic-and-lumbar-spine-evaluated-by-computed-tomography-the-framingham-study
#13
Mohamed Jarraya, Ali Guermazi, Amanda L Lorbergs, Elana Brochin, Douglas P Kiel, Mary L Bouxsein, L Adrienne Cupples, Elizabeth J Samelson
BACKGROUND CONTEXT: Prevalence and progression of disc height narrowing (DHN) and facet joint osteoarthritis (FJOA) in the thoracic and lumbar regions in non-clinical populations are not well-established. PURPOSE: Use computed tomography (CT) images to determine prevalence and progression of DHN and FJOA according to age, sex, and spinal region. STUDY DESIGN: Six-year longitudinal study SAMPLE: 1,196 members of the Framingham Study (mean baseline age 61 ±9 years) OUTCOME MEASURES: We compared prevalence and progression (new or worsening) of moderate-to-severe DHN and FJOA by age, sex, and spinal region...
April 18, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29669030/the-efficacy-of-intraoperative-neurophysiological-monitoring-to-detect-postoperative-neurological-deficits-in-transforaminal-lumbar-interbody-fusion-surgery
#14
Joung Heon Kim, Svetlana Lenina, Grace Mosley, Joshua Meaike, Benjamin Tran, Jun S Kim, Samuel K Cho
BACKGROUND: Despite the extensive use of intraoperative neurophysiological monitoring (IONM) in spinal procedures, there is no standard guideline for what types of IONM tests should be monitored during lumbar procedures with instrumentation. Moreover, the efficacy of IONM during transforaminal lumbar interbody fusion (TLIF) surgery in detecting postoperative neurological deficits has not been well described. OBJECTIVE: To analyze waveform changes from individual IONM tests (somatosensory evoked potentials [SSEP], motor evoked potentials [MEP], and electromyography [EMG]) during TLIF and compare the sensitivity and specificity of these tests in order to determine the best combination to detect postoperative neurological deficits...
April 13, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29662769/human-and-bovine-spinal-disc-mechanics-subsequent-to-trypsin-injection
#15
Jeremy Alsup, Timothy Bishop, Dennis Eggett, Anton E Bowden
Objective: To investigate the biomechanical effects of injections of a protease on the characteristics of bovine coccygeal and human lumbar disc motion segments. Methods: Mechanics of treated tissues were measured immediately after injection and 3 h after injection. Motion segments underwent axial rotation and flexion-extension loading. Results: Stiffness and neutral zone parameters experienced significant changes over time, with bovine tissues more strongly affected than human cadaver tissues...
October 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29643759/changes-in-h-reflex-recruitment-after-trans-spinal-direct-current-stimulation-with-multiple-electrode-configurations
#16
Alexander Kuck, Dick F Stegeman, Herman van der Kooij, Edwin H F van Asseldonk
Trans-spinal direct current stimulation (tsDCS) is an electro-modulatory tool with possible application in the rehabilitation of spinal cord injury. TsDCS generates a small electric field, aiming to induce lasting, functional neuromodulation in the targeted neuronal networks. Earlier studies have shown significant modulatory effects after application of lumbar tsDCS. However, for clinical application, a better understanding of application specific factors is required. Our goal was to investigate the effect of different electrode configurations using lumbar spinal tsDCS on spinal excitability...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29618366/bisphosphonate-therapy-for-spinal-osteoporosis-in-hajdu-cheney-syndrome-new-data-and-literature-review
#17
James F H Pittaway, Christopher Harrison, Yumie Rhee, Muriel Holder-Espinasse, Alan E Fryer, Tim Cundy, William M Drake, Melita D Irving
BACKGROUND: Hajdu-Cheney syndrome (HCS) (#OMIM 102500) is a rare, autosomal dominant condition that presents in early childhood. It is caused by mutations in the terminal exon of NOTCH2, which encodes the transmembrane NOTCH2 receptor. This pathway is involved in the coupled processes of bone formation and resorption. The skeletal features of HCS include acro-osteolysis of the digits and osteoporosis commonly affecting vertebrae and long bones. Fractures are a prominent feature and are associated with significant morbidity...
April 4, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29588241/facet-joint-fixation-and-alif-dlif-or-tlif-for-treatment-of-degenerative-lumbar-disc-diseases-retrospective-cohort-study-of-a-new-minimally-invasive-technique
#18
Evgenii Belykh, Andrey A Kalinin, Nikolay L Martirosyan, Talgat Kerimbayev, Nicholas Theodore, Mark C Preul, Vadim A Byvaltsev
BACKGROUND: Anterior, direct lateral and transforaminal lumbar interbody fusions (ALIF, DLIF, and TLIF) are usually combined with posterior fixation to treat degenerative spinal diseases. Outcomes of ALIF, TLIF, or DLIF combined with a new wedge-shaped, interfacet cage-plate have not been reported. We assessed early clinical outcomes of patients treated with interbody fusion and facet fixation using a titanium wedge-shaped cage-plate. METHODS: This retrospective observational cohort study included patients (n=80) who underwent 1-level interbody fusion and facet joint fixation via ALIF (n=24) or DLIF (n=26) with bilateral facet fixation or TLIF with ipsilateral pedicle screws and contralateral facet fixation (n=30)...
March 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29581018/application-of-morphometrics-as-a-predictor-for-survival-in-patients-with-prostate-cancer-metastasis-to-the-spine
#19
Hesham Mostafa Zakaria, Lara Massie, Azam Basheer, Erinma Elibe, David Boyce-Fappiano, Lonni Shultz, Ian Lee, Brent Griffith, Farzan Siddiqui, Victor Chang
BACKGROUND: Surgery for spinal metastases can improve survival, but has high morbidity that can potentially diminish any benefit. New objective methods of predicting overall survival would be beneficial for surgical decision making. Morphometrics quantifies patient frailty and has been successfully used to predict overall survival in lung cancer patients with spine metastases. This study evaluates whether morphometrics can predict survival in patients with prostate cancer spinal metastases...
March 23, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29576907/spinal-case-of-the-month-with-short-perspective-how-would-you-treat-this-l3-l4-synovial-cyst
#20
REVIEW
Nancy E Epstein
Background: In this new section, Case of the Month with Short Perspective from Surgical Neurology International, we want to see how various spine surgeons would approach different spinal pathologies. In this first case, an elderly male presented with 3 years of lower back pain and progressive neurogenic claudication with bilateral radiculopathy that had exacerbated over the prior 6 months. An outside physician performed a magnetic resonance (MR) study of the lumbar spine that showed a massive synovial cyst filling the spinal canal (e...
2018: Surgical Neurology International
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