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lumbar spinal new

Dennis Hey, Eugene Tze Chun Lau, Joel-Louis Lim, Denise Choong, Chuen-Seng Tan, Gabriel Ka-Po Liu, Hee-Kit Wong
BACKGROUND CONTEXT: Flexion radiographs have been used to identify cases of spinal instability. However, current methods are not standardized and are not sufficiently sensitive/specific to identify instability. PURPOSE: Introduction of a new slump sitting method for performing lumbar spine flexion radiographs and comparison of the angular range of motions and displacements between the conventional method and this new method. STUDY DESIGN: Prospective study on radiologic evaluation of the lumbar spine flexion range of motions and displacements using dynamic radiographs PATIENT SAMPLE: 60 patients were recruited from a single spine tertiary centre...
October 17, 2016: Spine Journal: Official Journal of the North American Spine Society
Zhuofeng Ding, Wei Xu, Jie Zhang, Wangyuan Zou, Qulian Guo, Changsheng Huang, Chang Liu, Tao Zhong, Jun-Ming Zhang, Zongbin Song
Bone cancer pain (BCP) is the most common complication in patients with bone cancer. Glial cell line-derived neurotrophic factor (GDNF) is believed to be involved in chronic pain conditions. In this article, the expression and roles of GDNF were studied in a rat model of BCP induced by tibia injection of Walker 256 rat mammary gland carcinoma cells. Significant mechanical and thermal hyperalgesia and ongoing pain were observed beginning as early as day 5 post injection. The expression level of GDNF protein examined on day 16 after tibia injection was decreased in the L3 dorsal root ganglion (DRG) and lumbar spinal cord, but not in other spinal levels or the anterior cingulate cortex...
September 22, 2016: International Journal of Cancer. Journal International du Cancer
Sean D Rundell, Karen J Sherman, Patrick J Heagerty, Charles N Mock, Nathan J Dettori, Bryan A Comstock, Andrew L Avins, Srdjan S Nedeljkovic, David R Nerenz, Jeffrey G Jarvik
OBJECTIVE:  To identify predictors of persistent disability and back pain in older adults. DESIGN:  Prospective cohort study. SETTING:  Back pain outcomes using longitudinal data registry. SUBJECTS:  Five thousand two hundred twenty adults age 65 years and older with a new primary care visit for back pain. METHODS:  Baseline measurements included: demographics, health, and back pain characteristics...
September 28, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Krista J Spiller, Clark R Restrepo, Tahiyana Khan, Anna M Stieber, Linda K Kwong, John Q Trojanowski, Virginia M-Y Lee
In order to treat progressive paralysis in ALS patients, it is critical to develop a mouse that closely models human ALS in both pathology and also in the timing of these events. We have recently generated new TDP-43 bigenic mice (called rNLS8) with doxycycline (Dox)-suppressible expression of human TDP-43 (hTDP-43) harboring a defective nuclear localization signal (hTDP-43∆NLS) under the control of the NEFH promoter. Our previous studies characterized the pathology and disease course in young rNLS8 mice following induction of neuronal hTDP-43ΔNLS...
September 29, 2016: Acta Neuropathologica Communications
Emmanuelle Chaleat-Valayer, Agnès Troncy, Marion Montané, Soline Bellaiche, Eric Berthonnaud
OBJECTIVE: The goal of this preliminary study is to analyze the biomechanical strategies of spine, pelvis and lower limbs (LL) with tridimensional motion analysis during stand-to-sit task, an understudied movement in the literature, however, source of questioning in clinical practice. OBSERVATIONS: One female and one male, healthy participants, (respectively 28 and 48 years old) were included without history of pathology and with normal pelvic incidences. Participants performed stand-to-sit movements on a stool without using their hands...
September 2016: Annals of Physical and Rehabilitation Medicine
Jean-Claude Bernard, Eric Berthonnaud, Nuria Rodriguez-Martinez, Julie Deceuninck, Emmanuelle Chaleat-Valayer
OBJECTIVE: Three-dimensional imaging was performed to identify if Lenke 1A curves could be reclassified in subgroups to improved orthopedic or surgical treatment of adolescent idiopathic scoliosis. It seems that multitude of 3D reconstructions can exist in Lenke 1A curves. With his classification Lenke introduces new parameters in radiographic analysis of idiopathic scoliosis like frontal lumbar and thoracic sagittal modifiers. Scoliosis is defined as a three dimensional deformity in frontal, sagittal and horizontal plane...
September 2016: Annals of Physical and Rehabilitation Medicine
Laure Mathevon, Nicolas Leroux, Céline Piscicelli, Emmanuelle Clarac, Shenhao Dai, Patrice Davoine, Paul Krack, Dominic Perennou
OBJECTIVE: To take care of postural disorders is a major issue in Parkinson's disease (PD). We present a documented observation suggesting the existence of a biased representation of verticality in PD, resulting in a severe retropulsion and recurrent falls. A rehabilitation program aimed to modulate verticality perception dramatically improved the postural perception of the vertical, trunk posture and balance abilities, and reduced retropulsion as well as lastingly fall frequency. OBSERVATIONS: A 68 year-old patient with Parkinson's disease fall backward 3 times a day...
September 2016: Annals of Physical and Rehabilitation Medicine
Daniel D Bohl, Fady Y Hijji, Dustin H Massel, Benjamin C Mayo, William W Long, Krishna D Modi, Ankur S Narain, Blaine T Manning, Junyoung Ahn, Philip K Louie, Kern Singh
BACKGROUND CONTEXT: Spine surgeons employ a high volume of imaging in the diagnosis and evaluation of spinal pathology. However, little is known regarding patients' knowledge of the radiation exposure associated with these imaging techniques. PURPOSE: To characterize spine patients' knowledge regarding radiation exposure from various imaging modalities. STUDY DESIGN/SETTING: A cross-sectional survey study. PATIENT SAMPLE: One hundred patients at their first clinic visit with a single spine surgeon at an urban institution...
September 21, 2016: Spine Journal: Official Journal of the North American Spine Society
Christopher S Graffeo, Avital Perry, Eelco F M Wijdicks
BACKGROUND: Intracranial subarachnoid hemorrhage (SAH) and spinal subdural hematoma (SDH) are rare complications of spine surgery, thought to be precipitated by cerebrospinal fluid (CSF) hypotension in the setting of an intraoperative durotomy or postoperative CSF leak. Considerable clinical variability has been reported, requiring a high level of clinical suspicion in patients with a new, unexplained neurologic deficit after spine surgery. METHODS: Case report...
September 22, 2016: Neurocritical Care
M Lefranc, J Peltier
The ROSA® robot (Medtech, Montpellier, France) is a new medical device designed to assist the surgeon during minimally invasive spine procedures. The device comprises a patient-side cart (bearing the robotic arm and a workstation) and an optical navigation camera. The ROSA® Spine robot enables accurate pedicle screw placement. Thanks to its robotic arm and navigation abilities, the robot monitors movements of the spine throughout the entire surgical procedure and thus enables accurate, safe arthrodesis for the treatment of degenerative lumbar disc diseases, exactly as planned by the surgeon...
October 2016: Expert Review of Medical Devices
Yi-Ren Chen, Sayantan Deb, Lan Pham, Harminder Singh
OBJECTIVE: Our study aims to evaluate the clinical outcomes of cortical screws in regards to postoperative pain. BACKGROUND: Pedicle screw fixation is the current mainstay technique for posterior spinal fusion. Over the past decade, a new technique called cortical screw fixation has been developed, which allows for medialized screw placement through stronger cortical bone. There have been several studies that showed either biomechanical equivalence or superiority of cortical screws...
2016: Curēus
Jung Wook Park, Min Woo Cheon, Min Hong Lee
OBJECTIVE: To compare the visibility and procedural parameters between a standard spinal needle and a new laser-etched needle (LEN) in real-time ultrasonography guided lumbar medial branch access in a phantom of the lumbosacral spine. METHODS: We conducted a prospective single-blinded observational study at a rehabilitation medicine center. A new model of LEN was manufactured with a standard 22-gauge spinal needle and a laser etching machine. Thirty-two inexperienced polyclinic medical students performed ultrasonography-guided lumbar medial branch access using both a standard spinal needle and a LEN with scanning protocol...
August 2016: Annals of Rehabilitation Medicine
Yoshihito Sakai, Sadayuki Ito, Tetsuro Hida, Kenyu Ito, Atsushi Harada, Ken Watanabe
BACKGROUND: The ligamentum flavum hypertrophy is considered to be one of the important causes of development of lumbar spinal stenosis (LSS). Several histologic and biologic mechanisms in hypertrophied flavum have proposed. However, no study that investigated the relationship between clinical outcome and ligamentum flavum hypertrophy has been published. The purpose of this study was to identify a new classification of LSS, in ligamentous and nonligamentous stenosis, according to the cutoff value of the area proportion of the ligamentum flavum in the spinal canal, and to assess the value of surgical and conservative treatments for LSS based on the classification of the ligamentous stenosis...
August 28, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Nilam J Soni, Ricardo Franco-Sadud, Daniel Schnobrich, Ria Dancel, David M Tierney, Gerard Salame, Marcos I Restrepo, Paul McHardy
PURPOSE OF REVIEW: To review the literature and describe techniques to use ultrasound to guide performance of lumbar puncture (LP). RECENT FINDINGS: Ultrasound evaluation of the lumbar spine has been shown in randomized trials to improve LP success rates while reducing the number of attempts and the number of traumatic taps. SUMMARY: Ultrasound mapping of the lumbar spine reveals anatomical information that is not obtainable by physical examination, including depth of the ligamentum flavum, width of the interspinous spaces, and spinal bone abnormalities, including scoliosis...
August 2016: Neurology. Clinical Practice
Jean Yves Lazennec, Dominique Folinais, Samy Bendaya, Marc Antoine Rousseau, Aidin Eslam Pour
Lumbar stenosis is frequently observed and treated by spine surgeons. The extent of neurological decompression and the potential spinal fixation are the basic concerns when surgery is planned. But this segmented approach to the problem is sometimes insufficient due to the complex functional situations induced by a sagittal imbalance of the patient and the combination of pathologies known as hip-spine or knee-spine syndromes. A total of 373 consecutive patients included from our EOS and clinical data base. Patients were divided in two groups...
October 2016: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Hwee Weng Dennis Hey, Chengyuan Gordon Wong, Eugene Tze-Chun Lau, Kimberly-Anne Tan, Leok-Lim Lau, Ka-Po Gabriel Liu, Hee-Kit Wong
BACKGROUND CONTEXT: Sitting spinal alignment is increasingly recognized as a factor influencing strategy for deformity correction. Considering that most individuals sit for longer hours in a "slumped" rather than in an erect posture, greater understanding of the natural sitting posture is warranted. PURPOSE: This study aimed to investigate the differences in sagittal spinal alignment between two common sitting postures: a natural, patient-preferred posture; and an erect, investigator-controlled posture that is commonly used in alignment studies...
August 22, 2016: Spine Journal: Official Journal of the North American Spine Society
Dae-Jung Choi, Chang-Myong Choi, Je-Tea Jung, Sang-Jin Lee, Yong-Sang Kim
STUDY DESIGN: Descriptions of technical strategies to overcome pitfalls associated with early learning periods in biportal endoscopic spinal surgery (BESS). PURPOSE: To introduce BESS for lumbar spinal diseases (LSDs) and to inform certain challenges to be overcome in mastering the technique. OVERVIEW OF LITERATURE: BESS has shown superior benefits including excellent magnification, a wider range of view by dynamic handling of an endoscope and instruments...
August 2016: Asian Spine Journal
Christopher H Wise, Ronald J Schenk, Jill Black Lattanzi
BACKGROUND: Despite emerging evidence to support the use of high velocity thrust manipulation in the management of lumbar spinal conditions, utilization of thrust manipulation among clinicians remains relatively low. One reason for the underutilization of these procedures may be related to disparity in training in the performance of these techniques at the professional and post professional levels. PURPOSE: To assess the effect of using a new model of active learning on participant confidence in the performance of spinal thrust manipulation and the implications for its use in the professional and post-professional training of physical therapists...
July 2016: Journal of Manual & Manipulative Therapy
Toshimi Aizawa, Yasuhisa Tanaka, Toru Yokoyama, Yoichi Shimada, Ken Yamazaki, Hiroshi Takei, Shin-Ichi Konno, Chikashi Kawahara, Eiji Itoi, Shoichi Kokubun
BACKGROUND: There are no diagnostic support tools composed of a simple, single-sheet, self-administered, self-reported history questionnaire (SSHQ) for patients with leg symptoms caused by either lumbar spinal stenosis (LSS) or lumbar disc herniation (LDH), at the same time, can discriminate the two diseases. METHODS: We conducted retrospective and prospective derivation studies and a prospective validation study. Based on data from 137 patients with LSS and 206 with LDH, we identified key prediction factors to establish the diagnosis of LSS and LDH, which became the basis of a temporary SSHQ...
September 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Karen S Coughlan, Luise Halang, Ina Woods, Jochen H M Prehn
Transgenic transactivation response DNA-binding protein 43 (TDP-43) mice expressing the A315T mutation under control of the murine prion promoter progressively develop motor function deficits and are considered a new model for the study of amyotrophic lateral sclerosis (ALS); however, premature sudden death resulting from intestinal obstruction halts disease phenotype progression in 100% of C57BL6/J congenic TDP-43(A315T) mice. Similar to our recent results in SOD1(G93A) mice, TDP-43(A315T) mice fed a standard pellet diet showed increased 5' adenosine monophosphate-activated protein kinase (AMPK) activation at postnatal day (P)80, indicating elevated energetic stress during disease progression...
September 1, 2016: Disease Models & Mechanisms
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