Osteoathritis

BACKGROUND: Many international clinical guidelines recommend therapeutic exercise as a core treatment for knee and hip osteoarthritis. We aimed to identify individual patient-level moderators of the effect of therapeutic exercise for reducing pain and improving physical function in people with knee osteoarthritis, hip osteoarthritis, or both. METHODS: We did a systematic review and individual participant data (IPD) meta-analysis of randomised controlled trials comparing therapeutic exercise with non-exercise controls in people with knee osteoathritis, hip osteoarthritis, or both...

INTRODUCTION: Osteoarthritis (OA) as the most common joint disease is a major public health concern. AIM: To investigate the effect of multimorbidity on functional and quality of life outcomes in women with generalized osteoathritis (hand and knee arthritis, GOA). METHOD: In this cross-sectional study, patients according to the American College of Rheumatology (ACR) criteria for OA were invited. The control group consisted of subjects without any musculoskeletal symptoms, osteoarthritis or inflammatory rheumatic disease...

Synovial inflammation is observed in patients with osteoathritis (OA) and likely contributed to its exacerbation. Regulatory B (Breg) cells are shown to suppress inflammation in various diseases, including rheumatoid arthritis (RA). To examine whether Breg cells also participated in OA, we examined the synovial fluid from OA patients, and compared with that in RA patients. In OA synovial fluid, IL-10-producing B cells were present directly ex vivo and were increased upon stimulation, indicating that B cells were a source of IL-10 directly at the affected site of OA patients...

Osteoathritis (OA) of the knee is common, and the chances of suffering from OA increase with age. Its treatment should be initially nonoperative-and requires both pharmacological and nonpharmacological treatment modalities. If conservative therapy fails, surgery should be considered. Surgical treatments for knee OA include arthroscopy, cartilage repair, osteotomy, and knee arthroplasty. Determining which of these procedures is most appropriate depends on several factors, including the location, stage of OA, comorbidities on the one side and patients suffering on the other side...

One of the fundamental problem to solved, connected with a way of proceeding in hip osteoarthritis is appropriate selection of diagnosis methods. Various scores helps in assessment of functional efficiency of the hip. They are applied on variable stages of diagnosis process, assumed way of treatment included physiotherapy and to analysis achieved results of treatment. Universal applied scores are: HHS, WOMAC, Merle D'Aubigne-Postel, Mayo. The purpose of this study was to compare methods mentioned above. The special attention was paid to an assessment of usefulness of scores in treatment process...

INTRODUCTION: The development of glenohumeral osteoarthritis is sufficiently described after instability and rotator cuff pathologies. The purpose of this work was to evaluate a coherency between glenohumeral osteoarthritis and SLAP lesions by means of MR arthrography which has not been described up to now in the literature. MATERIAL AND METHODS: 20 patients with a SLAP lesion type II were treated with arthroscopic SLAP repair. MR arthrography was performed after intra-articular administration of diluted gadolinium (after positive vote of the ethics committee) after a mean FU of 36 months (26 to 54 months)...

BACKGROUND: Osteoarthritis is a multifactorial disease characterized by destruction of the articular cartilage due to genetic, mechanical and environmental components affecting more than 100 million individuals all over the world. Despite the high prevalence of the disease, the absence of large-scale molecular studies limits our ability to understand the molecular pathobiology of osteoathritis and identify targets for drug development. METHODOLOGY/PRINCIPAL FINDINGS: In this study we integrated genetic, bioinformatic and proteomic approaches in order to identify new genes and their collaborative networks involved in osteoarthritis pathogenesis...

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The Ibadan Knee Hip osteoarthritis Outcome measure (IKHOAM) was developed for patients with Knee/Hip Osteoarthritis in the Nigerian and similar environments. The Yoruba Version was developed to encourage its use in the Southwestern region of Nigeria. The IKHOAM was translated into Yoruba in four separate processes of translation, back translation, committee review and pre-testing. It was administered to a cohort of 164 outpatients with symptomatic OA of the knee and or Hip who attended physiotherapy units in selected hospitals from Southwestern region of Nigeria...

OBJECTIVE: Increasing bone mineral density (BMD) has been found in several studies in patients with osteoarthritis (OA). Therefore, the simultaneous occurrence of osteoporosis (OP) and OA is denied by many clinicians. Because of our clinical impression, however, we suggest that we have to consider a common occurrence. In the present study we have examined the relationship between osteoathritis of the knee or the hip and osteoporosis. METHOD: The BMD of the lumbar spine and the proximal femur of 117 OA patients (82 postmenopausal female patients aged 50-83 and 35 male patients aged 36-86 years) who subsequently required hip or knee replacements, but were otherwise healthy, was measured by dual-energy X-ray absorptiometry (DXA; Hologic QDR-2000)...

BACKGROUND AND PURPOSE: Pain during activities of daily living is a common presenting complaint of individuals with knee osteoarthritis and anterior cruciate ligament injury. Knee pain is also associated with a decrease in quality of life for people with osteoarthritis. The purpose of the present study was to examine the dose-response relationship between knee joint forces and painful symptoms, and whether the acute symptoms, were associated with individuals' quality of life. METHOD: This was a cross-sectional cohort correlation study...

Articular cartilage has only a small capacity for regneration. This makes the repair of articular surfaces difficult. In 1959 Pridie described his method of resurfacing osteoarthritic knee joints. This operation is still in widespread use today. Pridie introduced the principle of drilling exposed subchondral bone with the objective of encouraging a fibro-cartilaginous repair. The newly formed fibrocartilaginous layer that develops over the lesion in osteoarthritis may be enough to decrease patients symptoms...