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Unconventional therapies

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https://www.readbyqxmd.com/read/28507799/characterization-of-a-human-anti-tumoral-nk-cell-population-expanded-after-bcg-treatment-of-leukocytes
#1
Eva M García-Cuesta, Gloria Esteso, Omodele Ashiru, Sheila López-Cobo, Mario Álvarez-Maestro, Ana Linares, Mei M Ho, Luis Martínez-Piñeiro, Hugh T Reyburn, Mar Valés-Gómez
Immunotherapy, via intra-vesical instillations of BCG, is the therapy of choice for patients with high-risk non-muscle invasive bladder cancer. The subsequent recruitment of lymphocytes and myeloid cells, as well as the release of cytokines and chemokines, is believed to induce a local immune response that eliminates these tumors, but the detailed mechanisms of action of this therapy are not well understood. Here, we have studied the phenotype and function of the responding lymphocyte populations as well as the spectrum of cytokines and chemokines produced in an in vitro model of human peripheral blood mononuclear cells (PBMCs) co-cultured with BCG...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28498291/multi-level-3d-printing-implant-for-reconstructing-cervical-spine-with-metastatic-papillary-thyroid-carcinoma
#2
Xiucan Li, Yiguo Wang, Yongfei Zhao, Jianheng Liu, Songhua Xiao, Keya Mao
STUDY DESIGN: A unique case report. OBJECTIVE: A three-dimensional (3D) printing technology is proposed for reconstructing multi-level cervical spine (C2-C4) after resection of metastatic papillary thyroid carcinoma in a middle-age female patient. SUMMARY OF BACKGROUND DATA: Papillary thyroid carcinoma is a malignant neoplasm with a relatively favorable prognosis. A metastatic lesion in multi-level cervical spine (C2-C4) destroys neurological functions and causes local instability...
May 11, 2017: Spine
https://www.readbyqxmd.com/read/28491241/fifteen-years-of-bone-marrow-mononuclear-cell-therapy-in-acute-myocardial-infarction
#3
REVIEW
Miruna Mihaela Micheu, Maria Dorobantu
In spite of modern treatment, acute myocardial infarction (AMI) still carries significant morbidity and mortality worldwide. Even though standard of care therapy improves symptoms and also long-term prognosis of patients with AMI, it does not solve the critical issue, specifically the permanent damage of cardiomyocytes. As a result, a complex process occurs, namely cardiac remodeling, which leads to alterations in cardiac size, shape and function. This is what has driven the quest for unconventional therapeutic strategies aiming to regenerate the injured cardiac and vascular tissue...
April 26, 2017: World Journal of Stem Cells
https://www.readbyqxmd.com/read/28484598/the-evidence-on-tiotropium-bromide-in-asthma-from-the-rationale-to-the-bedside
#4
REVIEW
Dejan Radovanovic, Pierachille Santus, Francesco Blasi, Marco Mantero
Severe and poorly controlled asthma still accounts for a great portion of the patients affected. Disease control and future risk management have been identified by international guidelines as the main goals in patients with asthma. The need for new treatment approaches has led to reconsider anticholinergic drugs as an option for asthma treatment. Tiotropium is the first anticholinergic drug that has been approved for children and adults with poorly controlled asthma and is currently considered as an option for steps 4 and 5 of the Global Initiative for Asthma...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28468249/unconventional-secretion-of-heat-shock-proteins-in-cancer
#5
REVIEW
Tiago Góss Santos, Vilma Regina Martins, Glaucia Noeli Maroso Hajj
Heat shock proteins (HSPs) are abundant cellular proteins involved with protein homeostasis. They have both constitutive and inducible isoforms, whose expression levels are further increased by stress conditions, such as temperature elevation, reduced oxygen levels, infection, inflammation and exposure to toxic substances. In these situations, HSPs exert a pivotal role in offering protection, preventing cell death and promoting cell recovery. Although the majority of HSPs functions are exerted in the cytoplasm and organelles, several lines of evidence reveal that HSPs are able to induce cell responses in the extracellular milieu...
April 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28397295/role-of-nail-bed-methotrexate-injections-in-isolated-nail-psoriasis-conventional-drug-via-an-unconventional-route
#6
D Daulatabad, C Grover, A Singal
Nail psoriasis can be a debilitating condition; however, in patients with isolated nail involvement, the use of toxic systemic therapies such as methotrexate may not be justified. We report on 4 patients (30 involved nails between them), who were treated with injections of methotrexate (0.1 mL of a 25 mg/mL solution) into the nail bed at 3-weekly intervals. Mean baseline Nail Psoriasis Severity Index (NAPSI) was 4.77 (range 2-8, cumulative score 143; n = 30); dropping successively at each visit to 2.43 (range 0-4, cumulative score 73; n = 30) at 15 weeks...
April 10, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28383639/immune-checkpoint-inhibitors-in-advanced-renal-cell-carcinoma-experience-to-date-and-future-directions
#7
M B Atkins, J I Clark, D I Quinn
In recent years, there has been dramatic expansion of the treatment armamentarium for patients with advanced renal cell carcinoma (aRCC), including drugs targeting vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR) pathways. Despite these advances, patient outcomes remain suboptimal, underscoring the need for therapeutic interventions with novel mechanisms of action. The advent of immunotherapy with checkpoint inhibitors has led to significant changes in the treatment landscape for several solid malignancies...
April 5, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28365442/loss-of-cln3-impacts-protein-secretion-in-the-social-amoeba-dictyostelium
#8
Robert J Huber
Neuronal ceroid lipofuscinosis (NCL), also referred to as Batten disease, is the most common form of childhood neurodegeneration. Mutations in CLN3 cause the most prevalent subtype of the disease, which manifests during early childhood and is currently untreatable. The precise function of the CLN3 protein is still not known, which has inhibited the development of targeted therapies. In the social amoeba Dictyostelium discoideum, loss of the CLN3 homolog, Cln3, reduces adhesion during early development, which delays streaming and aggregation...
March 29, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28349508/targeting-schlemm-s-canal-in-the-medical-therapy-of-glaucoma-current-and-future-considerations
#9
REVIEW
Vanessa Andrés-Guerrero, Julián García-Feijoo, Anastasios Georgios Konstas
Schlemm's canal (SC) is a unique, complex vascular structure responsible for maintaining fluid homeostasis within the anterior segment of the eye by draining the excess of aqueous humour. In glaucoma, a heterogeneous group of eye disorders afflicting approximately 60 million individuals worldwide, the normal outflow of aqueous humour into SC is progressively hindered, leading to a gradual increase in outflow resistance, which gradually results in elevated intraocular pressure (IOP). By and large available antiglaucoma therapies do not target the site of the pathology (SC), but rather aim to decrease IOP by other mechanisms, either reducing aqueous production or by diverting aqueous flow through the unconventional outflow system...
March 27, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28342084/the-transplantation-of-mesenchymal-stem-cells-derived-from-unconventional-sources-an-innovative-approach-to-multiple-sclerosis-therapy
#10
REVIEW
Sabrina Giacoppo, Placido Bramanti, Emanuela Mazzon
In recent years, in the effort to find a potential innovative therapy for multiple sclerosis (MS), researchers focused on transplantation of mesenchymal stem cells (MSCs) due to their well-recognized ability to suppress inflammatory/autoimmune responses and exert neuroregenerative properties. MSCs are a heterogeneous subset of pluripotent non-hematopoietic stromal cells that can be isolated from many different adult tissues, characterized by the capability to differentiate into various cell lineages, and to translocate into damaged areas, providing immunomodulatory effects...
March 25, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28330617/cd54-mediated-interaction-with-pro-inflammatory-macrophages-increases-the-immunosuppressive-function-of-human-mesenchymal-stromal-cells
#11
Nicolas Espagnolle, Adélie Balguerie, Emmanuelle Arnaud, Luc Sensebé, Audrey Varin
Mesenchymal stromal cells (MSCs) sense and modulate inflammation and represent potential clinical treatment for immune disorders. However, many details of the bidirectional interaction of MSCs and the innate immune compartment are still unsolved. Here we describe an unconventional but functional interaction between pro-inflammatory classically activated macrophages (M1MΦ) and MSCs, with CD54 playing a central role. CD54 was upregulated and enriched specifically at the contact area between M1MФ and MSCs. Moreover, the specific interaction induced calcium signaling and increased the immunosuppressive capacities of MSCs dependent on CD54 mediation...
April 11, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28320360/a-prospective-analysis-of-pinch-grafting-of-chronic-leg-ulcers-in-a-series-of-elderly-patients-in-rural-cameroon
#12
Benjamin Momo Kadia, Christian Akem Dimala, Desmond Aroke, Cyril Jabea Ekabe, Reine Suzanne Mengue Kadia, Alain Chichom Mefire
BACKGROUND: Chronic leg ulcers (CLUs) pose serious public health concerns worldwide. They mainly affect the elderly population. Pinch grafting (PG) could be used to treat a variety of CLUs. However, in Cameroon, there is scarce data on the outcome of PG of CLUs in elderly patients in rural hospitals where most of these patients seek for medical attention and where clinicians rely on unconventional wound dressing methods to treat CLUs. Our objective was to describe the outcome of PG of CLUs in elderly patients in rural Cameroon...
March 20, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/28303236/treating-the-critically-ill-with-radiotherapy-lessons-learned-from-a-young-woman-with-cardiac-angiosarcoma
#13
Emma C Fields, Bryan Squires, Harry Lomas
BACKGROUND: Treating patients who are critically ill with radiotherapy (RT) brings a unique set of challenges as it involves treating patients who require mechanical life support, unconventional positioning, and a multidisciplinary team approach to ensure safety. However, when the benefits of such treatment outweigh the risks, the challenges can be overcome, as demonstrated in this unique case of cardiac angiosarcoma. CASE DESCRIPTION: This is a case of a 42-year-old female with a right sided cardiac angiosarcoma who quickly developed cardiac tamponade and respiratory failure related to compression of her right heart by the tumor...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28287518/isolation-and-flow-cytometric-analysis-of-human-endocervical-gamma-delta-t-cells
#14
Natasa Strbo, Laura Romero, Maria Alcaide, Margaret Fischl
The female reproductive tract (FRT) mucosal immune system serves as the first line of defense. Better knowledge of the genital mucosa is therefore essential for understanding pathogenicity of different pathogens including HIV. Gamma delta (GD) T cells are the prototype of 'unconventional' T cells and represent a relatively small subset of T cells defined by their expression of heterodimeric T-cell receptors (TCRs) composed of gamma and delta chains. This sets them apart from the classical and much better known CD4(+) helper T cells and CD8(+) cytotoxic T cells that are defined by alpha-beta TCRs...
February 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28287179/novel-computational-method-for-predicting-polytherapy-switching-strategies-to-overcome-tumor-heterogeneity-and-evolution
#15
Vanessa D Jonsson, Collin M Blakely, Luping Lin, Saurabh Asthana, Nikolai Matni, Victor Olivas, Evangelos Pazarentzos, Matthew A Gubens, Boris C Bastian, Barry S Taylor, John C Doyle, Trever G Bivona
The success of targeted cancer therapy is limited by drug resistance that can result from tumor genetic heterogeneity. The current approach to address resistance typically involves initiating a new treatment after clinical/radiographic disease progression, ultimately resulting in futility in most patients. Towards a potential alternative solution, we developed a novel computational framework that uses human cancer profiling data to systematically identify dynamic, pre-emptive, and sometimes non-intuitive treatment strategies that can better control tumors in real-time...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28282810/neuropathological-staging-of-brain-pathology-in-sporadic-parkinson-s-disease-separating-the-wheat-from-the-chaff
#16
Heiko Braak, Kelly Del Tredici
A relatively small number of especially susceptible nerve cell types within multiple neurotransmitter systems of the human central, peripheral, and enteric nervous systems (CNS, PNS, ENS) become involved in the degenerative process underlying sporadic Parkinson's disease (sPD). The six-stage model we proposed for brain pathology related to sPD (Neurobiol Aging 2003) was a retrospective study of incidental and clinically diagnosed cases performed on unconventionally thick tissue sections (100 μm) from a large number of brain regions...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28279411/dialysis-catheter-placement-in-patients-with-exhausted-access
#17
Syed Rahman, Joshua D Kuban
Patients with end-stage renal disease undergo renal transplant, peritoneal dialysis, or intermittent hemodialysis for renal replacement therapy. For hemodialysis, native fistulas or grafts are preferred but hemodialysis catheters are often necessary. Per KDOQI, the right jugular vein is the preferred vessel of access for these catheters. However, in patients with long-standing end-stage renal disease vein thrombosis, stenosis and occlusion occurs. In these patients with end-stage vascular access, unconventional routes of placement of dialysis catheters are needed...
March 2017: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/28261025/the-use-of-isotretinoin-in-low-doses-and-unconventional-treatment-regimens-in-different-types-of-acne-a-literature-review
#18
REVIEW
Jolanta D Torzecka, Bożena Dziankowska-Bartkowiak, Zofia Gerlicz-Kowalczuk, Anna Wozniacka
High effectiveness of isotretinoin treatment for severe types of acne resistant to antibiotics has been widely recognized. However, the recommended doses in conventional therapy, according to consensus of the Polish Dermatological Society, may cause serious adverse effects. Thus, research into less stressful, alternative treatment regimens with the use of low doses of isotretinoin has been carried out. The aim of the paper was to review the selected papers where authors present the results of their studies on different regimens with the use of isotretinoin in low doses in patients with acne, evaluate their efficacy, patient satisfaction, frequency of adverse effects, recurrences and also treatment costs...
February 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28150122/use-of-non-conventional-medicine-two-years-after-cancer-diagnosis-in-france-evidence-from-the-vican-survey
#19
Aline Sarradon-Eck, Anne-Déborah Bouhnik, Dominique Rey, Marc-Karim Bendiane, Laetitia Huiart, Patrick Peretti-Watel
PURPOSE: The purpose of this study was to assess the use of non-conventional medicine (NCM) in a representative sample of French patients 2 years after cancer diagnosis. METHODS: The study was based on data obtained in the VICAN survey (2012) on a representative sample of 4349 patients 2 years after cancer diagnosis. Self-reported data were collected at telephone interviews with patients. The questionnaire addressed the various types of non-conventional treatments used at the time of the survey...
February 1, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28138194/efficacy-and-safety-concerns-regarding-complementary-and-alternative-medicine-use-among-diabetes-patients
#20
Jothydev Kesavadev
There has been an ever increasing rise in the use of Complementary and Alternative Medicinal (CAM) practices among general populations during past few decades. Individuals with diabetes being prone to an array of related health complications, demand special attention concerning their interest towards different CAM practices. Apart from clinical practitioner and patient based awareness programmes regarding the safety and efficacy implications of CAM therapies, stringent regulations should also be imposed on these unconventional health practices so as to strike off any major adverse events...
February 2017: JPMA. the Journal of the Pakistan Medical Association
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