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Unconventional therapies

Andrea Finaret, Paula Garber-Epstein
In recent decades there have been changes in the mental health feld that have also influenced the therapist-client relationship, which is seen as an essential element in the processes of recovery. Our purpose is to present a model of work reflected in therapeutic relationships in the feld of rehabilitation (RTR) that is guided by the principles of recovery. Therapeutic relationships are considered as a means through which it is possible to increase commitment and adherence of people to therapy and also participation in treatment and rehabilitation programs...
September 2017: Vertex: Revista Argentina de Psiquiatriá
Swechha Mishra, Sangeeta Singh
Background: In experimental therapy of cancer, survivin is considered to be one of the well-established targets. Studies have found that it is overexpression in most of the human tumors, but it is rarely found in normal tissues. It is having varied structural and functional role. It controls cell division and cellular stress response and also regulates metastasis and migration of cancerous cells. It has also been recognized as a biomarker which makes it unconventional drug target. In spite of being one of the centrally active components in metastasis and invasion, their clinical use is minimal...
January 2018: Pharmacognosy Magazine
Serena Gianfaldoni, Uwe Wollina, Michael Tirant, Georgi Tchernev, Jacopo Lotti, Francesca Satolli, Miriam Rovesti, Katlein França, Torello Lotti
An overview of unconventional therapies for vitiligo is presented. Some herbal compounds may be considered as valid therapeutic tools for the treatment of vitiligo.
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
Serena Gianfaldoni, Georgi Tchernev, Jacopo Lotti, Uwe Wollina, Francesca Satolli, Miriam Rovesti, Katlein França, Torello Lotti
The authors show a brief overview of the vitiligo's unconventional therapies. A part for well-documented effectiveness of L-phenylalanine, PGE2 and antioxidant agents in the treatment of vitiligo, for the other therapeutical approaches more investigations are needed.
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
Vrinda M, Arun S, Srikumar B N, Bindu M Kutty, Shankaranarayana Rao B S
Epilepsy is a neurological condition associated with seizures, neurodegeneration, circuit reorganization, and other structural and functional abnormalities. These elements ultimately lead to behavioural alterations such as anxiety, depression, and importantly cognitive impairment like learning disability and memory impairment. These factors can attribute to acceleration of aging and cognitive impairment in middle-aged people, which is otherwise evident in dementia and Alzheimer's disease among elderly people...
February 19, 2018: Journal of Chemical Neuroanatomy
Laurence Booth, Jane L Roberts, John Kirkwood, Andrew Poklepovic, Paul Dent
For several years, it has been known that histone deacetylase inhibitors have the potential to alter the immunogenicity of tumor cells exposed to checkpoint inhibitory immunotherapy antibodies. HDAC inhibitors can rapidly reduce expression of PD-L1 and increase expression of MHCA in various tumor types that subsequently facilitate the antitumor actions of checkpoint inhibitors. Recently, we have discovered that drug combinations which cause a rapid and intense autophagosome formation also can modulate the expression of HDAC proteins that control tumor cell immunogenicity via their regulation of PD-L1 and MHCA...
2018: Advances in Cancer Research
Jonathan Rick, Ankush Chandra, Manish K Aghi
Glioblastoma is an aggressive brain malignancy with poor outcomes. Current standard of care involves surgery, radiotherapy and chemotherapy. Even with optimal treatment, 5-year survival rates are low. Many patients are unable to tolerate the considerable side effects that therapy involves and suffer from low quality of life. Anti-mitotic tumor treating fields have shown potential in treating glioblastoma with data suggesting that they prolong disease-free survival and overall survival. Novocure has marketed a device that generates these fields via externally placed electrodes...
January 18, 2018: Journal of Neuro-oncology
Wei Wang, Dingfeng Shen, Xiao Li, Yuan Yao, Jiaping Lin, Aurelia Wang, Jiwoo Yu, Zhonglin Wang, Suck Won Hong, Shaoliang Lin, Zhiqun Lin
Here we report an unconventional strategy for crafting light-driven shape memory porous films (SMPFs) by judiciously constructing highly ordered porous films via a facile "breath figure" approach, followed by sequential vapor crosslinking and nondestructive directional light manipulation. The latter can conveniently and precisely transform round micropores into other shapes including round-rectangle, round-rhombus and size-reduced micropores at room temperature. Importantly, the transformed micropores can be perfectly reverted to original shapes by either thermal annealing or UV irradiation...
January 11, 2018: Angewandte Chemie
Li-Sen Lin, Jibin Song, Huang-Hao Yang, Xiaoyuan Chen
Yolk-shell nanostructures (YSNs) composed of a core within a hollow cavity surrounded by a porous outer shell have received tremendous research interest owing to their unique structural features, fascinating physicochemical properties, and widespread potential applications. Here, a comprehensive overview of the design, synthesis, and biomedical applications of YSNs is presented. The synthetic strategies toward YSNs are divided into four categories, including hard-templating, soft-templating, self-templating, and multimethod combination synthesis...
December 27, 2017: Advanced Materials
Natasha Atanaskova Mesinkovska
Alopecia areata is a prevalent autoimmune skin disease with no cure or indicated treatment options. In the absence of an approved treatment, some patients are eager to try unconventional therapies, despite the very limited research evaluating their safety and efficacy. Recently emerging unconventional therapies for alopecia areata discussed include antihistamines, cryotherapy, and low-dose naltrexone.
January 2018: Journal of Investigative Dermatology. Symposium Proceedings
R Saikant, Shilpa Ravindran, Ashitha Vijayan, Vani Maya, S Lakshmi, R Kartik, Manoj G
In a letter to the editor, Raineri SM et al. have given an insight of another dimension of procalcitonin (PCT) use as a diagnostic tool in invasive candidiasis. But based on our preliminary information, PCT is reported as unconventional modes of diagnosis approach which yet to prove its stand-alone biomarker properties for invasive candidiasis.
2017: Journal of Intensive Care
Jonas G Croissant, Yevhen Fatieiev, Abdulaziz Almalik, Niveen M Khashab
Predetermining the physico-chemical properties, biosafety, and stimuli-responsiveness of nanomaterials in biological environments is essential for safe and effective biomedical applications. At the forefront of biomedical research, mesoporous silica nanoparticles and mesoporous organosilica nanoparticles are increasingly investigated to predict their biological outcome by materials design. In this review, it is first chronicled that how the nanomaterial design of pure silica, partially hybridized organosilica, and fully hybridized organosilica (periodic mesoporous organosilicas) governs not only the physico-chemical properties but also the biosafety of the nanoparticles...
February 2018: Advanced Healthcare Materials
M Tazdait, L Mezquita, J Lahmar, R Ferrara, F Bidault, S Ammari, C Balleyguier, D Planchard, A Gazzah, J C Soria, A Marabelle, B Besse, C Caramella
BACKGROUND: Immune checkpoint inhibitors are an important tool in the therapeutic strategy against metastatic non-small cell lung cancer (NSCLC); however, radiological evaluation is challenging due to the emergence of atypical patterns of responses. Several evaluation criteria have been proposed, such as the Response Evaluation Criteria in Solid Tumours (RECIST), version 1.1, immune -related RECIST (irRECIST) and iRECIST, but have not been systematically compared in a homogeneous population...
January 2018: European Journal of Cancer
Jeffrey M Liebmann, Jeannie K Lee
Primary open angle glaucoma (POAG) is the most common type of glaucoma, and is responsible for approximately 90% of glaucoma cases in North America. POAG is characterized by an asymptomatic onset, where patients do not present with symptoms until significant visual loss occurs in late stages of the disease. Importantly, while glaucoma is associated with several risk factors that contribute to damage and disease progression, intraocular pressure (IOP) is the only proven modifiable risk factor at this time. Treatments for POAG include use of pharmacologic and surgical interventions...
September 2017: American Journal of Managed Care
Amara Ezeonyeji, Helen Baldwin, Milica Vukmanovic-Stejic, Michael R Ehrenstein
Dysregulation of interleukin-22 (IL-22) has been associated with autoimmune diseases but divergent effects upon inflammation have hampered efforts to define its contribution to pathogenesis. Here, we examined the role of IL-22 in patients with psoriatic arthritis (PsA). In the peripheral blood of PsA patients, there was a decrease in IL-22+ CD4+ T cells compared with healthy controls resulting in a heightened CD4+ IFNγ+ /IL-22+ ratio accompanied by diminished CCR6 expression. IL-22 expressing cells were depleted primarily from the central memory CD4 T-cell subset in PsA patients...
2017: Frontiers in Immunology
Jessica Graham, Michael Barberio, George Sam Wang
Cannabinoid hyperemesis syndrome (CHS) is an underrecognized diagnosis among adolescents. In the adult literature, it is characterized as nausea, vomiting, and abdominal pain in patients with chronic marijuana use. CHS is often refractory to the standard treatment of nausea and vomiting. Unconventional antiemetics, such as haloperidol, have been successful in alleviating symptoms; however, even 1 dose of haloperidol can lead to grave adverse effects, such as dystonia, extrapyramidal reactions, and neuroleptic malignant syndrome...
December 2017: Pediatrics
Razak Mohammed Gyasi, Kabila Abass, Samuel Adu-Gyamfi, Burnett Tetteh Accam
OBJECTIVE: The aim of this hospital-based, cross-sectional study was to examine nurses' knowledge, personal and professional practices and attitude towards complementary and alternative medical therapies in urban Ghana. METHOD: Using convenience sampling technique, cross-sectional data were collected from 210 registered and practicing nurses with self-administered questionnaire based on the Complementary and Alternative Medicine (CAM) Health Belief Questionnaire (CHBQ)...
November 2017: Complementary Therapies in Clinical Practice
E S Cannizzo, C Tincati, F Binda, P Ronzi, F A Cazzaniga, S Antinori, A d'Arminio Monforte, G Marchetti, L Milazzo
HBV eradication in chronic hepatitis B (CHB) subjects is rarely achieved with either nucleos(t)ide analogues (NA) or pegylated interferon (Peg-IFN), which both have a limited effect in restoring immune responses. Thirty CHB subjects on long-term treatment with tenofovir (TDF) and HBV suppression were enrolled and randomized 1:2 to either receive Peg-IFN-α-2a add-on therapy or continue TDF alone. We studied γδ T and iNKT frequency and function (by flow cytometry) at baseline, at 12 weeks and 12 weeks after the end of treatment...
November 1, 2017: Journal of Viral Hepatitis
José L Maravillas-Montero, Ernesto Acevedo-Ochoa
Although the production of antigen-specific antibodies has been the originally accepted function of B-cells during immune responses, specific subsets that can negatively regulate inflammation, designated regulatory B-cells (Bregs), have been identified recently. These immunosuppressive cells support tolerance, mainly through the production of interleukin 10 and other unconventional factors. There have been emerging data suggesting their importance in diverse normal and pathologic processes. Novel and in development B-cell targeted therapies seem to be ideal treatments for different types of diseasessuch as cancer and allergy...
September 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Martyna Tomczyk-Socha, Anna Turno-Kręcicka
Glaucoma is a heterogeneous group of ophthalmic diseases leading to irreversible damage to the optic nerve. While the overall mechanism responsible for glaucoma remains obscure, the most important risk factor is elevated intraocular pressure. The current therapies, whether pharmacological or surgical, are primarily symptomatic with the aim to lower the intraocular pressure (IOP). Poorer response to treatment is associated, for example, with pseudoexfoliation glaucoma, which is determined by blocking the trabecular meshwork (TM) both by pigment grains and the pseudoexfoliation material...
December 2017: Lymphatic Research and Biology
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