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https://www.readbyqxmd.com/read/29433708/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-for-diagnosis-and-staging-of-lung-cancer
#1
REVIEW
David Fielding, Noriaki Kurimoto
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS TBNA) is fundamental to the diagnosis of lung cancer, as many patients present with more advanced stages of lung cancer, with enlarged hilar and mediastinal lymph nodes. It also represents a way to sample pulmonary masses directly to make the diagnosis, whereby no other accessible tissue is present and the mass sits adjacent to a large central airway. Very importantly also, EBUS TBNA is the widely accepted first procedure in lung cancer staging...
March 2018: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/29424404/-endobronchial-ultrasound-guided-transbronchial-needle-aspiration
#2
Gonzalo Labarca, Iván Caviedes, Erik Folch, Adnan Majid, Sebastián Fernández-Bussy
In the last years, several techniques have been developed to obtain a prompt diagnosis or rule out lung cancer. Endobronchial ultrasound- guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure with a high diagnostic yield for mediastinal and central pulmonary lesions. This procedure is especially useful for lung cancer diagnosis and mediastinal staging. Two different types of EBUS are currently available: Radial EBUS and lineal EBUS. Each one has technical differences together with a range of clinical indications...
September 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29424124/can-a-postnasal-drip-can-be-aspirated-into-the-lungs
#3
EDITORIAL
Peter-John Wormald
No abstract text is available yet for this article.
February 9, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29420904/unstable-inflation-causing-injury-insight-from-prone-position-and-paired-ct-scans
#4
Yi Xin, Maurizio Cereda, Hooman Hamedani, Mehrdad Pourfathi, Sarmad Siddiqui, Natalie Meeder, Stephen Kadlecek, Ian Duncan, Harrilla Profka, Jennia Rajaei, Nicholas J Tustison, James C Gee, Brian P Kavanagh, Rahim R Rizi
BACKGROUND: It remains unclear how prone positioning improves survival in acute respiratory distress syndrome (ARDS). Using serial computed tomography (CT), we previously reported that 'unstable' inflation, i.e. partial aeration with large tidal density swings (indicating increased local strain) is associated with injury progression. We prospectively tested whether prone position contains the early propagation of experimental lung injury by stabilizing inflation. METHODS: Injury was induced by tracheal hydrochloric acid (HCl) in rats; after randomization to supine or prone position, injurious ventilation was commenced using high tidal volume and low PEEP...
February 8, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29420583/controlled-hypothermia-may-improve-surfactant-function-in-asphyxiated-neonates-with-or-without-meconium-aspiration-syndrome
#5
Chiara Autilio, Mercedes Echaide, Daniele De Luca, Jesús Pérez-Gil
BACKGROUND: Whole-body hypothermia (WBH) is used to improve neurological outcomes in perinatal asphyxia. Recent studies suggested a beneficial effect of hypothermia for some types of acute respiratory failure. However, no data are available about the biophysical function of human surfactant during WBH. We investigated whether WBH improves surfactant biophysical properties in asphyxiated neonates with or without meconium aspiration syndrome (MAS). METHODS: Non-bronchoscopic bronchoalveolar lavage (BAL) has been collected from 10 asphyxiated neonates (2 with MAS, 8 with no lung disease (NLD)) at different time-points (pre-WBH, 24h, 48h, 72h of WBH and post-WBH)...
2018: PloS One
https://www.readbyqxmd.com/read/29416730/neutrophil-extracellular-traps-contribute-to-the-pathogenesis-of-acid-aspiration-induced-ali-ards
#6
Haitao Li, Xiaoting Zhou, Hongyi Tan, Yongbin Hu, Lemeng Zhang, Shuai Liu, Minhui Dai, Yi Li, Qian Li, Zhi Mao, Pinhua Pan, Xiaoli Su, Chengpin Hu
Background: Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a manifestation of systemic inflammation in the lungs, but the factors that trigger inflammation in ALI/ARDS are unclear. We hypothesized that neutrophil extracellular traps (NETs) contribute to the pathogenesis of acid aspiration-induced ALI/ARDS. Results: Analysis of bronchial aspirates from ARDS patients showed that NETs were significantly correlated with the degree of ARDS (r = -0...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29406183/efficacy-of-a-new-dual-channel-laryngeal-mask-airway-the-lma%C3%A2-gastro%C3%A2-airway-for-upper-gastrointestinal-endoscopy-a-prospective-observational-study
#7
N C S Terblanche, C Middleton, D L Choi-Lundberg, M Skinner
BACKGROUND: Significant cardiorespiratory events are frequent in patients undergoing gastrointestinal endoscopy. Central to the occurrence of respiratory events is an unsecured airway. This study sought to determine the efficacy of a new laryngeal mask airway, the LMA®GastroTM Airway (Teleflex Medical, Athlone, Ireland), in patients undergoing upper gastrointestinal endoscopy. New design features include a dedicated channel for oesophageal intubation and separate channel with terminal cuff for lung ventilation...
February 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29405663/cytologic-histologic-correlation-of-programmed-death-ligand-1-immunohistochemistry-in-lung-carcinomas
#8
Eleanor Russell-Goldman, Sasha Kravets, Suzanne E Dahlberg, Lynette M Sholl, Marina Vivero
BACKGROUND: Programmed cell death protein 1 inhibitors increasingly are being used to treat patients with advanced lung carcinomas. Programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) in tumor cells (TCs) and tumor-infiltrating immune cells (ICs) is used to select patients for programmed cell death protein 1 inhibition, but few studies have evaluated PD-L1 IHC in cytology specimens. The objective of the current study was to compare PD-L1 IHC in cytology cell blocks and matched surgical specimens...
February 5, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29399198/combined-small-cell-carcinoma-with-giant-cell-carcinoma-component-of-the-lung-a-case-successfully-diagnosed-by-computed-tomography-guided-fine-needle-aspiration-cytology
#9
Yusuke Ebisu, Mitsuaki Ishida, Tomohito Saito, Tomohiro Murakawa, Yoshiko Uemura, Koji Tsuta
Combined small cell lung carcinoma (SCLC) is a rare variant of SCLC and is defined as a mixture of SCLC and non-SCLC components. Although any histopathological subtype may be present as a non-SCLC component, the presence of pleomorphic carcinoma components are extremely rare. The present report describes the first documented cytological features of combined SCLC with a giant cell carcinoma component. A 50-year-old Japanese female with a history of smoking presented with a mass lesion in the left lung. Computed tomography-guided fine-needle aspiration cytology and needle biopsy were performed, followed by a lobectomy...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29395562/-endobronchial-ultrasound-with-transbronchial-needle-aspiration-evaluation-of-clinical-practice
#10
D Basille, C Hybiak, C Dayen, B Toublanc, Y Douadi, G Francois, I Rault, C Andrejak, P Berna, V Jounieaux
INTRODUCTION: Endobronchial ultrasound with transbronchial needle aspiration (EBUS-TBNA) has undergone a large increase in France since 2007. The aim is to study the evolution of the indications for EBUS-TBNA in our region during the period 2008-2013. MATERIAL AND METHODS: We conducted a retrospective observational study including all the patients who underwent an EBUS-TBNA procedure in Picardie from 2008 to 2013. The respective proportion for each indication was noted...
January 23, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29383040/a-prospective-study-on-the-diagnosis-of-peripheral-lung-cancer-using-endobronchial-ultrasonography-with-a-guide-sheath-and-computed-tomography-guided-transthoracic-needle-aspiration
#11
Jun Zhu, Feng Tang, Ye Gu
Background: It is difficult to collect peripheral lung cancer samples. This study analyzed the applicability of endobronchial ultrasonography with a guide sheath (EBUS-GS) and computed tomography-guided transthoracic needle aspiration (CT-TTNA) for the diagnosis of peripheral lung cancer. Methods: A prospective analysis of peripheral lung cancer patients was performed. The study included 150 cases in the EBUS-GS group and 177 cases in the CT-TTNA group. The diagnostic rate, pathological type, genetic status and complications were analyzed...
2018: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29381987/a-case-report-and-literature-review-of-barium-sulphate-aspiration-during-upper-gastrointestinal-examination
#12
Gao-Wu Yan, Jiang-Fa Deng, Anup Bhetuwal, Guo-Qing Yang, Quan-Shui Fu, Hong Chen, Na Hu, Hao Zeng, Xiao-Ping Fan, Gao-Wen Yan, Xiao-Lin Wu
RATIONALE: Even though barium sulphate aspiration during upper gastrointestinal examination is a well-known phenomenon, complication such as long-term lung injury and death may still occur. This may depend upon the concentration, amount, anatomy, or certain predisposing factors. PATIENT CONCERNS: A 47-year-old woman who had a barium swallow to screen for foreign body in esophagus. DIAGNOSES: Chest radiographs demonstrated massive barium sulphate depositions in her trachea and inferior lobe of right lung...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29377878/implementing-endobronchial-ultrasound-guided-ebus-for-staging-and-diagnosis-of-lung-cancer-a-cost-analysis
#13
Catalina Lizama, Neli S Slavova-Azmanova, Martin Phillips, Michelle L Trevenen, Ian W Li, Claire E Johnson
BACKGROUND Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and guide sheath (EBUS-GS) are gaining popularity for diagnosis and staging of lung cancer compared to CT-guided transthoracic needle aspiration (CT-TTNA), blind fiber-optic bronchoscopy, and mediastinoscopy. This paper aimed to examine predictors of higher costs for diagnosing and staging lung cancer, and to assess the effect of EBUS techniques on hospital cost. MATERIAL AND METHODS Hospital costs for diagnosis and staging of new primary lung cancer patients presenting in 2007-2008 and 2010-2011 were reviewed retrospectively...
January 29, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29372844/molecular-testing-of-non-small-cell-lung-carcinoma-diagnosed-by-endobronchial-ultrasound-guided-transbronchial-fine-needle-aspiration
#14
Erika E Doxtader, Yu-Wei Cheng, Yaxia Zhang
CONTEXT: - Given the increasing demand for molecular testing of non-small cell lung carcinoma specimens to guide therapeutic decision-making, and the trend toward minimally invasive techniques for obtaining diagnostic tissue, cytopathology laboratories must devise strategies to maximize DNA yield for necessary molecular testing. OBJECTIVE: - To describe our experience at Cleveland Clinic with epidermal growth factor receptor ( EGFR) mutation testing by next-generation sequencing and anaplastic lymphoma kinase ( ALK) gene rearrangement testing by fluorescence in situ hybridization of non-small cell lung carcinomas diagnosed by cytology, with an emphasis on specimens obtained by endobronchial ultrasound-guided transbronchial fine-needle aspiration...
January 26, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29372563/cladosporium-cladosporioides-complex-infection-in-a-mixed-breed-dog
#15
Matteo Spano, Zuliani Davide, Peano Andrea, Bertazzolo Walter
A 3-year-old female mixed-breed dog was referred with a 2-day history of serious dyspnea, coughing, lethargy, anorexia, and a low-grade right anterior lameness. At presentation, the dog had an increased respiratory rate, dull heart and lung sounds, and cyanotic mucous membranes. It was hyperthermic and slightly dehydrated. Laboratory findings showed mild neutrophilia with a left shift, while serum biochemistry variables were in the normal range. However, urinalysis revealed mild proteinuria and rare erythrocytes and leukocytes on sediment examination...
January 25, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29368549/instillation-of-hyaluronan-reverses-acid-instillation-injury-to-the-mammalian-blood-gas-barrier
#16
Ting Zhou, Zhihong Yu, Ming-Yuan Jian, Israr Ahmad, Carol S Trempus, Brant M Wagener, Jean-Francois Pittet, Saurabh Aggarwal, Stavros Garantziotis, Weifeng Song, Sadis Matalon
Acid (HCl) aspiration during anesthesia may lead to acute lung injury. There is no effective therapy. We hypothesized that HCl, instilled intratracheally in C57BL/6 mice results in the formation of low molecular weight hyaluronan (L-HA), which activates RhoA and ROCK, causing airway hyperresponsiveness (AHR) and increased permeability. Furthermore, instillation of high molecular weight hyaluronan (H-HA; Yabro®), will reverse lung injury. We instilled HCl in C57BL/6 wild type, MPO-/- and CD44-/- mice. WT mice were also instilled intranasally with H-HA (Yabro®) at 1 and 23 h post HCl...
January 25, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29365641/myeloid-but-not-epithelial-tissue-factor-exerts-protective-anti-inflammatory-properties-in-acid-aspiration-induced-acute-lung-injury
#17
Gernot Schabbauer, Julia Kral-Pointner, Waltraud Schrottmaier, Vera Horvath, Hannes Datler, Lena Hell, Cihan Ay, Birgit Niederreiter, Bernd Jilma, Johannes Schmid, Alice Assinger, Nigel Mackman, Sylvia Knapp
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29364576/simultaneous-detection-of-single-nucleotide-variant-deletion-insertion-and-fusion-in-lung-and-thyroid-carcinoma-using-cytology-specimen-and-an-rna-based-next-generation-sequencing-assay
#18
Natalya V Guseva, Omar Jaber, Aaron A Stence, Krishnaveni Sompallae, Amani Bashir, Ramakrishna Sompallae, Aaron D Bossler, Chris S Jensen, Deqin Ma
BACKGROUND: Molecular testing for epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) and ROS proto-oncogene 1, receptor tyrosine kinase (ROS1) fusion is routinely performed in patients with stage IV lung adenocarcinoma to assess their eligibility for targeted therapy. Fine-needle aspiration (FNA)-derived material frequently is the only pathologic material available. The identification of genomic aberrations in thyroid nodules from FNA smears may help stratify cancer risk and spare patients from a second surgery...
January 24, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29361809/-the-prevalence-of-nontuberculous-mycobacterial-lung-disease-with-orwithout-reflux-esophagitis
#19
Jae Bin Kang, Dong Ho Lee, Soo Hoon Kwon, Nayoung Kim, Young Soo Park, Hyuk Yoon, Cheol Min Shin, Yoon Jin Choi
Background/Aims: Gastrointestinal reflux disease (GERD) is defined as 'a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications'. It is associated with various lung diseases, including bronchial asthma, chronic bronchitis, and bronchiectasis. GERD may also affect nontuberculous mycobacterial (NTM) lung disease. We presumed that the normal mucosal barrier of the bronchial epithelium is broken due to the aspiration of gastric juice and consequent chronic bronchial inflammation...
January 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29346251/combined-endosonography-reduces-time-to-diagnose-pulmonary-coccidioidomycosis
#20
Raj A Shah, Jose J Vempilly, Shaikh M Noor Ul Husnain, Pravachan Hegde
Coccidioidomycosis causes significant morbidity in endemic areas. In the absence of sensitive diagnostic serologic testing, clinicians have increasingly relied on lung and lymph node biopsies for diagnosis. Recently, endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) has been shown to be an excellent sampling method for the diagnosis and staging of lung cancers, especially when combined with endoscopic ultrasound guided fine needle aspiration (EUS-FNA). We present 13 consecutive cases where EBUS-TBNA and/or EUS-FNA of pulmonary lymph nodes were performed as part of the workup for pulmonary coccidioidomycosis...
January 16, 2018: Journal of Bronchology & Interventional Pulmonology
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