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https://www.readbyqxmd.com/read/28819424/circulating-tumor-cells-and-microemboli-can-differentiate-malignant-and-benign-pulmonary-lesions
#1
Mario Mascalchi, Cristina Maddau, Lapo Sali, Elena Bertelli, Francesca Salvianti, Stefania Zuccherelli, Marzia Matucci, Alessandra Borgheresi, Claudio Raspanti, Monica Lanzetta, Massimo Falchini, Ernesto Mazza, Alessandra Vella, Michaela Luconi, Pamela Pinzani, Mario Pazzagli
The presence of circulating tumor cells (CTC) or microemboli (CTM) in the peripheral blood can theoretically anticipate malignancy of solid lesions in a variety of organs. We aimed to preliminarily assess this capability in patients with pulmonary lesions of suspected malignant nature. We used a cell-size filtration method (ScreenCell) and cytomorphometric criteria to detect CTC/CTM in a 3 mL sample of peripheral blood that was taken just before diagnostic percutaneous CT-guided fine needle aspiration (FNA) or core biopsy of the suspicious lung lesion...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28794637/the-role-of-mediastinoscopy-in-the-diagnosis-of-non-lung-cancer-diseases
#2
Serdar Onat, Gungor Ates, Alper Avcı, Tekin Yıldız, Ali Birak, Cihan Akgul Ozmen, Refik Ulku
BACKGROUND: Mediastinoscopy is a good method to evaluate mediastinal lesions. We sought to determine the current role of mediastinoscopy in the investigation of non-lung cancer patients with mediastinal lymphadenopathy. MATERIALS AND METHODS: We retrospectively reviewed clinical parameters (age, gender, histological diagnosis, morbidity, mortality) of all patients without lung cancer who consecutively underwent mediastinoscopy in Hospital of Faculty of Medicine of Dicle University between June 2003 and December 2016...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28794143/differential-diagnosis-of-granulomatous-lung-disease-clues-and-pitfalls-number-4-in-the-series-pathology-for-the-clinician-edited-by-peter-dorfm%C3%A3-ller-and-alberto-cavazza
#3
Shinichiro Ohshimo, Josune Guzman, Ulrich Costabel, Francesco Bonella
Granulomatous lung diseases are a heterogeneous group of disorders that have a wide spectrum of pathologies with variable clinical manifestations and outcomes. Precise clinical evaluation, laboratory testing, pulmonary function testing, radiological imaging including high-resolution computed tomography and often histopathological assessment contribute to make a confident diagnosis of granulomatous lung diseases. Differential diagnosis is challenging, and includes both infectious (mycobacteria and fungi) and noninfectious lung diseases (sarcoidosis, necrotising sarcoid granulomatosis, hypersensitivity pneumonitis, hot tub lung, berylliosis, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, rheumatoid nodules, talc granulomatosis, Langerhans cell histiocytosis and bronchocentric granulomatosis)...
September 30, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28777908/carboxyhemoglobin-half-life-during-hyperbaric-oxygen-in-a-patient-with-lung-dysfunction-a-case-report
#4
Lindell K Weaver, Kayla Deru
INTRODUCTION: The carboxyhemoglobin half-life (COHb t1/2) during hyperbaric oxygen (HBO₂) is often quoted as 23 minutes, derived from the average of two adult male volunteers breathing HBO₂ at 3 atmospheres absolute (ATA). However, the mean COHb t1/2 of 12 male volunteer smokers was 26.3 minutes at 1.58 ATA and in 12 non-intubated carbon monoxide (CO) poisoned patients treated at 3 ATA, was 43 minutes. CASE REPORT: An 81-year old male, poisoned by an improperly ventilated natural gas heater, was intubated for coma, then treated with HBO₂...
March 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28772352/cytologic-characteristics-of-thymic-adenocarcinoma-with-enteric-differentiation-a-study-of-four-fine-needle-aspiration-specimens
#5
Ah-Young Kwon, Joungho Han, Hae-Yon Cho, Seokhwi Kim, Heejin Bang, Jiyeon Hyeon
Thymic adenocarcinoma is extremely rare. Although its histologic features have been occasionally reported, a lack of description of the cytologic features has hampered the prompt and accurate diagnosis of this condition. Herein, we describe the cytologic findings and histology of four aspiration cytology specimens of thymic adenocarcinoma. The specimens were obtained from primary tumors, metastatic lymph nodes, and pericardial effusions. All four specimens showed three-dimensional glandular clusters with a loss of polarity and nuclear overlapping...
August 4, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28765893/endothelial-semaphorin-7a-promotes-seawater-aspiration-induced-acute-lung-injury-through-plexin-c1-and-%C3%AE-1-integrin
#6
Minlong Zhang, Xue Yan, Wei Liu, Ruilin Sun, Yonghong Xie, Faguang Jin
Inflammation and edema are two main characteristics in seawater aspiration‑induced acute lung injury (ALI). In a previous study of the authors, it was demonstrated that endothelial semaphorin 7A (SEMA7A) serves an important role in the development of seawater‑induced inflammation and edema. However, the mechanism of endothelial SEMA7A‑mediated ALI remains unclear. Therefore, the authors explored the effect of SEMA7A in rat pulmonary microvascular endothelial cells (RPMVECs) and the interaction between endothelial SEMA7A and alveolar macrophages during seawater aspiration‑induced ALI...
July 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28765480/tuberculosis-presenting-as-broncho-oesophageal-fistula-in-a-young-healthy-man
#7
Ahmed Sayeed, Eid Humaid Alqurashi, Adnan B Alzanbagi, Nabil Abdulwadod Badr Ghaleb
A 21-year-old Saudi man presented with a history of dysphagia and choking. CT scan of the chest showed clear evidence of chronic recurrent aspiration pneumonia in the left lung. It also showed a fistula connecting the left main bronchus to the oesophagus. Endoscopy showed clear opening on the oesophageal side. Bronchoscopy also confirmed the presence of a broncho-oesophageal fistula on the left bronchial side with the presence of secretions on swallowing. Bronchoalveolar lavage (BAL) was done and sent for mycobacterial tuberculosis culture...
July 31, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28764230/pulmonary-actinomycosis-in-a-patient-with-aids-hcv
#8
Payam Tabarsi, Sootiya Yousefi, Sayena Jabbehdari, Majid Marjani, Parvaneh Baghaei
Pulmonary actinomycosis is a rare bacterial lung infection which is caused mainly by Actinomyces israelii. This non contagious infection can destroy parts of the lungs. There are variable presentations of pulmonary actinomycosis with similarity in manifestations to other infectious diseases of the lungs. Pulmonary actinomycosis is diagnosed by fine needle aspiration, bronchoscopy and finding of typical sulfur granules. We present a case of pulmonary actinomycosis in a middle aged (AIDS/HCV) man with massive hemoptysis and progressive dyspnoea...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28764225/an-unusual-cause-of-organizing-pneumonia-hydrocarbon-pneumonitis
#9
Kuruswamy Thurai Prasad, Sahajal Dhooria, Amanjit Bal, Ritesh Agarwal, Inderpaul Singh Sehgal
Hydrocarbon pneumonitis is a type of acute exogenous lipoid pneumonia due to the aspiration of petroleum products. The clinical and radiological features of this condition are non-specific and the diagnosis is usually missed if a careful history is not taken. Herein, we describe a 24-year-old male who was referred to us with a diagnosis of Interstitial Lung Disease (ILD) and was later found to have hydrocarbon pneumonitis.
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28762784/next-generation-sequencing-of-endobronchial-ultrasound-transbronchial-needle-aspiration-specimens-in-lung-cancer
#10
David Fielding, Andrew J Dalley, Farzad Bashirzadeh, Mahendra Singh, Lakshmy Nandakumar, Amy E McCart Reed, Debra Black, Stephen Kazakoff, Katia Nones, John Pearson, Nic Waddell, Sunil R Lakhani, Peter T Simpson
No abstract text is available yet for this article.
August 1, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28758151/the-effect-of-diet-induced-serum-hypercholesterolemia-on-the-surfactant-system-and-the-development-of-lung-injury
#11
Scott Milos, Joshua Qua Hiansen, Brandon Banaschewski, Yi Y Zuo, Li-Juan Yao, Lynda A McCaig, James Lewis, Cory M Yamashita, Ruud A W Veldhuizen
Acute respiratory distress syndrome (ARDS) is a pulmonary disorder associated with alterations to the pulmonary surfactant system. Recent studies showed that supra-physiological levels of cholesterol in surfactant contribute to impaired function. Since cholesterol is incorporated into surfactant within the alveolar type II cells which derives its cholesterol from serum, it was hypothesized that serum hypercholesterolemia would predispose the host to the development of lung injury due to alterations of cholesterol content in the surfactant system...
September 2016: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28748094/metastatic-squamous-cell-carcinoma-of-the-lung-mimicking-multiple-bone-abscesses
#12
Yuki Haruta, Yuki Kataoka, Hiroshi Ito, Taro Mori, Masaki Matsuo
Squamous cell carcinoma of the lung is known to metastasize to the bones, but a presentation similar to bone abscess is rare. We encountered a case with bone metastases that mimicked bone abscess, which delayed the diagnosis of squamous cell lung carcinoma. A 67-year-old man presented with a left upper lung infiltrate and lytic lesions on the left first rib and right fifth rib. In consideration of a possible infectious process, cultures of the aspirate from the right fifth rib lesion and blood were taken; however, results were non-specific...
September 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28741603/role-of-the-lung-microbiome-in-the-pathogenesis-of-chronic-obstructive-pulmonary-disease
#13
REVIEW
Lei Wang, Ke Hao, Ting Yang, Chen Wang
OBJECTIVE: The development of culture-independent techniques for microbiological analysis shows that bronchial tree is not sterile in either healthy or chronic obstructive pulmonary disease (COPD) individuals. With the advance of sequencing technologies, lung microbiome has become a new frontier for pulmonary disease research, and such advance has led to better understanding of the lung microbiome in COPD. This review aimed to summarize the recent advances in lung microbiome, its relationships with COPD, and the possible mechanisms that microbiome contributed to COPD pathogenesis...
July 24, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28738709/nebulized-hypertonic-saline-to-prevent-ventilator-associated-pneumonia-in-premature-infants-a-randomized-trial
#14
Zahra Ezzeldin, Yasmeen Mansi, Mervat Gaber, Rania Zakaria, Rehab Fawzy, Mohamed A Mohamed
BACKGROUND/OBJECTIVES: Ventilator associated pneumonia (VAP) is a leading cause of death. Nebulized hypertonic saline solution (HSS) has been used to improve pulmonary clearance and reduce infection in intubated patients. This study examines whether nebulized HSS may reduce VAP in intubated premature infants. METHODS: We analyzed results of 100 intubated premature infants who completed the study. Infants were divided into the "Control" group where VAP prevention protocol was implemented and the "Intervention" group where nebulized HSS twice daily was added to the package of care...
July 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28734808/-congenital-cytomegalovirus-infection-manifesting-as-neonatal-respiratory-distress-in-an-hiv-exposed-uninfected-newborn
#15
A Pham, H El Mjati, N Nathan, F Kieffer, D Mitanchez
BACKGROUND: Cytomegalovirus (CMV) is one of the most common intrauterine infections, affecting approximately 1% of all live births. There are few reports on congenital CMV infections manifesting as isolated pneumonitis. CASE REPORT: We report a case of congenital CMV with neonatal respiratory distress affecting an HIV-exposed uninfected infant. This infant required noninvasive ventilation beginning within the first 15min of life. The initial chest X-ray showed diffuse bilateral ground-glass opacifications...
July 19, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28731666/pulmonary-complications-of-chemical-pneumonia-a-case-report
#16
Semiha Bahceci Erdem, Hikmet T Nacaroglu, Rana Isgüder, Canan S Unsal Karkiner, Hüdaver Alper, Demet Can
Hydrocarbon aspiration (HA) can cause significant lung disease by inducing an inflammatory response, hemorrhagic exudative alveolitis, and loss of surfactant function. The most serious side effect of HA is aspiration pneumonia. Pneumothorax, pneumatocele, acute respiratory distress syndrome (ARDS), pulmonary abscess, bronchopleural fistula, bilateral hemorrhagic pleural effusion and pyopneumothorax were previously reported. Hereby we report a patient hospitalized due to aspiration pneumonia who developed pleurisy and pneumothorax after drinking paint thinner...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28730738/the-effects-of-aspirated-thickened-water-on-survival-and-pulmonary-injury-in-a-rabbit-model
#17
Nogah Nativ-Zeltzer, Maggie A Kuhn, Denise M Imai, Ryan P Traslavina, Amanda S Domer, Juliana K Litts, Brett Adams, Peter C Belafsky
OBJECTIVES/HYPOTHESIS: Liquid thickeners are one of the most frequently utilized treatment strategies for persons with oropharyngeal swallowing dysfunction. The effect of commercially available thickeners on lung injury is uncertain. The purpose of this study was to compare the effects of aspiration of water alone, xanthan gum (XG)-thickened water, and cornstarch (CS)-thickened water on survival and lung morphology in a rabbit model. STUDY DESIGN: Animal model. Prospective small animal clinical trial...
July 21, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28730709/the-role-of-the-cytopathologist-in-subtyping-and-epidermal-growth-factor-receptor-testing-in-non-small-cell-lung-cancer-an-institutional-experience
#18
A Sekar, N Gupta, A Rajwanshi, R Chaturvedi, N Singh, A Lal
OBJECTIVE: Approximately 10% of non-small-cell lung cancer (NSCLC) remains unclassifiable as NSCLC-not otherwise specified (NOS), after using a panel of immunomarkers. The present study was undertaken to assess sensitivity and specificity of immunomarkers in sub-typing NSCLC on fine needle aspiration cytology (FNAC). Epidermal growth factor receptor (EGFR) mutations were also detected in these samples. METHODS: Sixty cases of NSCLC including 15 squamous cell carcinoma (SCC), 15 adenocarcinomas (ADC) and 30 NSCLC-NOS reported on FNAC were included in the study...
July 21, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28729039/congenital-myopathy-due-to-myosin-heavy-chain-2-mutation-presenting-as-chronic-aspiration-pneumonia-in-infancy
#19
R Tsabari, H Daum, E Kerem, Y Fellig, T Dor
A 7-week-old infant presented with persistent noisy breathing and aspirations during swallowing. Neurological examination and brain MRI were normal. His 12-year-old brother underwent pneumonectomy at the age of 10 years due to recurrent aspirations leading to severe lung damage. The older brother developed subsequently ophthalmoplegia and nystagmus along with mild weakness of the neck flexors and proximal muscles. Exome analysis revealed homozygosity for a novel truncating mutation p.G800fs27* in the Myosin Heavy Chain 2 (MYH2) gene in both brothers, while parents and an unaffected sibling were heterozygous...
June 27, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28719983/neonatal-lemierre-syndrome-youngest-reported-case-and-literature-review
#20
Blake S Raggio, Maria C Grant, Kimsey Rodriguez, Patrick J Cripe
A previously healthy 5-week-old female was admitted for sepsis secondary to methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. After several days of hospitalization, she experienced acute decompensation in mental status despite having received targeted antibiotic therapy. Imaging revealed left peritonsillar/parapharyngeal space abscess, left venous thrombophlebitis of the internal jugular vein, and septic emboli of the lungs and brain consistent with Lemierre syndrome. Bedside needle aspiration of the parapharyngeal abscess confirmed MRSA involvement...
July 1, 2017: Clinical Pediatrics
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