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Tienrat Tangchaikeeree, Duangporn Polpanich, Abdelhamid Elaissari, Kulachart Jangpatarapongsa
Colloidal magnetic particles (MPs) have been developed in association with molecular diagnosis for several decades. MPs have the great advantage of easy manipulation using a magnet. In nucleic acid detection, these particles can act as a capture support for rapid and simple biomolecule separation. The surfaces of MPs can be modified by coating with various polymer materials to provide functionalization for different applications. The use of MPs enhances the sensitivity and specificity of detection due to the specific activity on the surface of the particles...
June 22, 2017: Colloids and Surfaces. B, Biointerfaces
R T Krediet, A C Abrahams, C W H de Fijter, M G H Betjes, W H Boer, B C van Jaarsveld, C J A M Konings, F W Dekker
The share of peritoneal dialysis (PD) in the spectrum of chronic dialysis has decreased markedly in the Netherlands in the last 15 years. Consequently, the knowledge of nephrologists and nursing staff on PD has declined leading to a negative spiral in which loss of experience resulted in loss of enthusiasm to offer PD to patients and also in less interest in the new PD developments. All these changes took place while the results of PD improved and patient survival was at least similar to that on haemodialysis...
June 2017: Netherlands Journal of Medicine
Xinzuo Fang, Long Jiao, Rui Zhang, Hai-Long Jiang
The low kinetics of oxygen evolution reaction (OER) hampers the H2 production by H2O electrolysis and it is of great importance to develop efficient and low-cost OER catalysts. Herein, a representative metalloporphyrinic MOF, PCN-600-Ni, integrating with graphene oxide (GO), is served as an ideal precursor and template to afford bimetallic iron-nickel phosphide/reduced graphene oxide composite (denoted as Fe-Ni-P/rGO-T, T represents pyrolysis temperature) via pyrolysis and subsequent phosphidation process. Thanks to the highly porous structure, synergetic effect of Fe and Ni elements in bimetallic phosphide as well as the good conductivity endowed by rGO, the optimized Fe-Ni-P/rGO-400 exhibits remarkable catalytic performance for OER in 1...
June 27, 2017: ACS Applied Materials & Interfaces
Mizuki Nishino, Nikhil H Ramaiya, Hiroto Hatabu, F Stephen Hodi
Cancer immunotherapy using immune-checkpoint blockade (ICB) has created a paradigm shift in the treatment of advanced-stage cancers. The promising antitumour activity of monoclonal antibodies targeting the immune-checkpoint proteins CTLA-4, PD-1, and PD-L1 led to regulatory approvals of these agents for the treatment of a variety of malignancies. Patients might experience clinical benefits from treatment with these agents, despite unconventional patterns of tumour response that can be misinterpreted as disease progression, warranting a new, specific approach to evaluate responses to immunotherapy...
June 27, 2017: Nature Reviews. Clinical Oncology
Rodolphe Clerac, Kasper Pedersen, Daniel Wooddruff, Saurabh Kumar Singh, Alain Tressaud, Etienne Durand, Mihail Atanasov, Panagiota Perlepe, Katharina Ollefs, Fabrice Wilhelm, Corine Mathonière, Frank Neese, Andrei Rogalev, Jesper Bendix
Heavy 5d elements, like osmium, feature strong spin-orbit interaction which is at the origin of exotic physical behaviors. Revealing the full potential of e.g. novel osmium oxide materials ("osmates") is however contingent upon a detailed understanding of the local single-ion properties. Herein, we report on two molecular osmate analogues, [OsF6]2- and [OsF6]-, as model systems for Os4+ and Os5+ centres found in oxides. Using X-ray absorption spectroscopy (XAS) and X-ray magnetic circular dichroism (XMCD) techniques combined with state-of-the-art ab initio calculations, we elucidate their ground state, which is mirroring the osmium electronic structure in osmates...
June 26, 2017: Chemistry: a European Journal
Marco Caminati, Veronica Giorgis, Boaz Palterer, Francesca Racca, Chiara Salvottini, Oliviero Rossi
The exact prevalence of hypersensitivity reactions related to sexual behaviours is not known; however, they heavily impact on the quality of life and of sex life of affected patients. In fact, not only common respiratory and skin allergies, such as asthma, rhinitis, urticaria and atopic dermatitis, but also food and drug allergy have been found to negatively affect the quality of sex life. Allergic diseases impact on the sexual function in both physical and psychological ways, representing one of the main complaints of a considerable proportion of patients...
June 26, 2017: Clinical Reviews in Allergy & Immunology
César Muñoz-Fontela, Anita K McElroy
Viruses of the Ebolavirus genus cause sporadic epidemics of severe and systemic febrile disease that are fueled by human-to-human transmission. Despite the notoriety of ebolaviruses, particularly Ebola virus (EBOV), as prominent viral hemorrhagic fever agents, and the international concern regarding Ebola virus disease (EVD) outbreaks, very little is known about the pathophysiology of EVD in humans and, in particular, about the human immune correlates of survival and immune memory. This lack of basic knowledge about physiological characteristics of EVD is probably attributable to the dearth of clinical and laboratory data gathered from past outbreaks...
June 27, 2017: Current Topics in Microbiology and Immunology
Pilar Amellali Badillo-Suárez, Maricela Rodríguez-Cruz, Xóchitl Nieves-Morales
Obesity is the most common metabolic disease whose prevalence is increasing worldwide. This condition is considered a serious public health problem due to associated comorbidities such as diabetes mellitus and hypertension. Perinatal morbidity related to obesity does not end with birth; this continues affecting the mother/infant binomial and could negatively impact on metabolism during early infant nutrition. Nutrition in early stages of growth may be essential in the development of obesity in adulthood, supporting the concept of "nutritional programming"...
June 27, 2017: Journal of Mammary Gland Biology and Neoplasia
Hao Su, Iulian I Iordachita, Junichi Tokuda, Nobuhiko Hata, Xuan Liu, Reza Seifabadi, Sheng Xu, Bradford Wood, Gregory S Fischer
Magnetic Resonance Imaging (MRI) provides both anatomical imaging with excellent soft tissue contrast and functional MRI imaging (fMRI) of physiological parameters. The last two decades have witnessed the manifestation of increased interest in MRI-guided minimally invasive intervention procedures and fMRI for rehabilitation and neuroscience research. Accompanying the aspiration to utilize MRI to provide imaging feedback during interventions and brain activity for neuroscience study, there is an accumulated effort to utilize force sensors compatible with the MRI environment to meet the growing demand of these procedures, with the goal of enhanced interventional safety and accuracy, improved efficacy and rehabilitation outcome...
April 1, 2017: IEEE Sensors Journal
Hyojin Lee, Chloe Kim, Dongjin Lee, Jea Ho Park, Peter C Searson, Kwan Hyi Lee
Recent studies have found that prostate cancer expresses abnormal genetic markers including multiple types of TMPRSS2-ERG fusion genes. The expression level of different TMPRSS2-ERG fusion genes is correlated to pathologic variables of aggressive prostate cancer and disease progression. State-of-the-art methods for detection of TMPRSS2-ERG fusion genes include reverse transcription polymerase chain reaction (RT-PCR) with a detection limit of 1 fmol at urinary condition. RT-PCR is time consuming, costly, and inapplicable for multiplexing...
2017: International Journal of Nanomedicine
Oksana Gorobets, Svitlana Gorobets, Marceli Koralewski
The discovery of biogenic magnetic nanoparticles (BMNPs) in the human brain gives a strong impulse to study and understand their origin. Although knowledge of the subject is increasing continuously, much remains to be done for further development to help our society fight a number of pathologies related to BMNPs. This review provides an insight into the puzzle of the physiological origin of BMNPs in organisms of all three domains of life: prokaryotes, archaea, and eukaryotes, including humans. Predictions based on comparative genomic studies are presented along with experimental data obtained by physical methods...
2017: International Journal of Nanomedicine
David Cooper, Nicolas Bernier, Jean-Luc Rouvière, Yun-Yu Wang, Weihao Weng, Anita Madan, Shogo Mochizuki, Hemanth Jagannathan
Precession electron diffraction has been used to systematically measure the deformation in Si/SiGe blanket films and patterned finFET test structures grown on silicon-on-insulator type wafers. Deformation maps have been obtained with a spatial resolution of 2.0 nm and a precision of ±0.025%. The measured deformation by precession diffraction for the blanket films has been validated by comparison to energy dispersive x-ray spectrometry, X-Ray diffraction, and finite element simulations. We show that although the blanket films remain biaxially strained, the patterned fin structures are fully relaxed in the crystallographic planes that have been investigated...
May 29, 2017: Applied Physics Letters
Alessio Mattesini, Serafina Valente, Carlotta Sorini Dini, Simone Bartolini, Gianluca Caiazzo, Giorgio Baldereschi, Alfredo Galassi, Carlo Di Mario
Successful percutaneous coronary intervention of chronic total occlusions (CTO) is associated with favorable clinical outcomes in selected subsets of patients. The success rate of CTO interventions greatly increased over the last decades, thanks to the development of dedicated materials and interventional strategies. Nevertheless, CTO interventions are still challenging with higher complication rates and lower success rates compared to standard percutaneous coronary interventions. Dedicated CTO operators are warranted in order to minimize the rate of complications and to achieve a success rate near to 90%...
June 2017: Giornale Italiano di Cardiologia
Miki Nonaka, Nagomi Kurebayashi, Takashi Murayama, Masami Sugihara, Kiyoshi Terawaki, Seiji Shiraishi, Kanako Miyano, Hiroshi Hosoda, Shosei Kishida, Kenji Kangawa, Takashi Sakurai, Yasuhito Uezono
Cancer was considered an incurable disease for many years; however, with the development of anticancer drugs and state-of-the art technologies, it has become curable. Cardiovascular diseases in patients with cancer or induced by cancer chemotherapy have recently become a great concern. Certain anticancer drugs and molecular targeted therapies cause cardiotoxicity, which limit the widespread implementation of cancer treatment and decrease the quality of life in cancer patients significantly. The anthracycline doxorubicin (DOX) causes cardiotoxicity...
2017: Endocrine Journal
Jan-Kai Chang, Hui Fang, Christopher A Bower, Enming Song, Xinge Yu, John A Rogers
Foundry-based routes to transient silicon electronic devices have the potential to serve as the manufacturing basis for "green" electronic devices, biodegradable implants, hardware secure data storage systems, and unrecoverable remote devices. This article introduces materials and processing approaches that enable state-of-the-art silicon complementary metal-oxide-semiconductor (CMOS) foundries to be leveraged for high-performance, water-soluble forms of electronics. The key elements are (i) collections of biodegradable electronic materials (e...
June 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
Letian Dou, Minliang Lai, Christopher S Kley, Yiming Yang, Connor G Bischak, Dandan Zhang, Samuel W Eaton, Naomi S Ginsberg, Peidong Yang
Halide perovskites are promising semiconductor materials for solution-processed optoelectronic devices. Their strong ionic bonding nature results in highly dynamic crystal lattices, inherently allowing rapid ion exchange at the solid-vapor and solid-liquid interface. Here, we show that the anion-exchange chemistry can be precisely controlled in single-crystalline halide perovskite nanomaterials when combined with nanofabrication techniques. We demonstrate spatially resolved multicolor CsPbX3 (X = Cl, Br, I, or alloy of two halides) nanowire heterojunctions with a pixel size down to 500 nm with the photoluminescence tunable over the entire visible spectrum...
June 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
Chengzhi Shi, Marc Dubois, Yuan Wang, Xiang Zhang
Long-range acoustic communication is crucial to underwater applications such as collection of scientific data from benthic stations, ocean geology, and remote control of off-shore industrial activities. However, the transmission rate of acoustic communication is always limited by the narrow-frequency bandwidth of the acoustic waves because of the large attenuation for high-frequency sound in water. Here, we demonstrate a high-throughput communication approach using the orbital angular momentum (OAM) of acoustic vortex beams with one order enhancement of the data transmission rate at a single frequency...
June 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
Jose Coelho-Lima, Ioakim Spyridopoulos
Prevalence of age-associated cardiovascular diseases (CVD) has dramatically increased as a result of improvements in life expectancy. Chronic inflammation is a shared pathophysiological feature of age-associated CVDs, indicating a role for the immune system in the onset and development of CVDs. Indeed, ageing elicits profound changes in both the cardiovascular and immune system, especially in the T cell compartment. Although such changes have been well described at the cellular level, the molecular mechanisms underlying immune-mediated cardiovascular ageing remain largely unexplored...
June 23, 2017: Experimental Gerontology
Javier González Lagunas
Piezoelectric devices are commonly used in all areas of maxillofacial surgery. Initially applied in preprosthetic surgery, they have steadily become a common practice in major surgery of the facial skeleton, including maxillary and mandibular osteotomies, temporomandibular joint surgery, orbital surgery, craniofacial procedures and rhinoplasty. We will review the current medical literature and establish the "state of the art" of piezosurgery in orthognathic surgery, TMJ surgery and rhinoplasty.
June 23, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
Fabio Baselice
Ultrasound images are affected by the speckle phenomenon, a multiplicative noise that degrades image quality. Several methods for denoising have been proposed in recent years, based on different approaches. The so-called non-local mean is considered the state-of-the-art method; the idea is to find similar patches across the image and exploit them to regularize the image. The method proposed here is in the non-local family, although instead of partitioning the target image in patches, it works pixelwise. The similarity between pixels is evaluated by analyzing their statistical behavior, in particular, by measuring the Kolmogorov-Smirnov distance between their distributions...
June 23, 2017: Ultrasound in Medicine & Biology
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