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https://www.readbyqxmd.com/read/28549320/light-emission-miracle-in-the-sea-and-preeminent-applications-of-bioluminescence-in-recent-new-biotechnology
#1
Sana Sharifian, Ahmad Homaei, Roohullah Hemmati, Khosro Khajeh
Bioluminescence is referred to the light emission by a living organism due to a specific biochemical reaction. This interesting feature of the organisms could highly influences behavioral and ecosystem dynamics. Luminescence, mostly observed in marine species, is generally higher in deep-living genera than in benthic or shallow organisms. However, among creatures living in land, fireflies, beetles, springtails and fungi have shown some bioluminescent activities. Classically, the emission of light is catalyzed by luciferase from a substrate...
May 17, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28548302/fast-computation-of-full-density-matrix-of-multispin-systems-for-spatially-localized-in-vivo-magnetic-resonance-spectroscopy
#2
Yan Zhang, Li An, Jun Shen
PURPOSE: Numerical simulations of three-dimensionally localized MRS spectra have been very time-consuming for multi-spin systems because the current state-of-the-art requires computation of a large ensemble of spins pixel-by-pixel in three dimensional space. This paper describes a highly accelerated technique for computing spatially localized MRS spectra using the full solution to the Liouville-von Neumann equation. METHODS: The time evolution of spatially localized multispin density matrix as the full solution to the Liouville-von Neumann equation was analyzed...
May 26, 2017: Medical Physics
https://www.readbyqxmd.com/read/28547752/development-and-psychometric-validation-of-pukat-2%C3%A2-0-a-knowledge-assessment-tool-for-pressure-ulcer-prevention
#3
Bénédicte Manderlier, Nele Van Damme, Katrien Vanderwee, Sofie Verhaeghe, Ann Van Hecke, Dimitri Beeckman
The aim of this study was to develop a tool to measure the knowledge of nurses on pressure ulcer prevention. PUKAT 2·0 is a revised and updated version of the Pressure Ulcer Knowledge Assessment Tool (PUKAT) developed in 2010 at Ghent University, Belgium. The updated version was developed using state-of-the-art techniques to establish evidence concerning validity and reliability. Face and content validity were determined through a Delphi procedure including both experts from the European Pressure Ulcer Advisory Panel (EPUAP) and the National Pressure Ulcer Advisory Panel (NPUAP) (n = 15)...
May 26, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28546862/block-sparsity-based-joint-compressed-sensing-recovery-of-multi-channel-ecg-signals
#4
Anurag Singh, Samarendra Dandapat
In recent years, compressed sensing (CS) has emerged as an effective alternative to conventional wavelet based data compression techniques. This is due to its simple and energy-efficient data reduction procedure, which makes it suitable for resource-constrained wireless body area network (WBAN)-enabled electrocardiogram (ECG) telemonitoring applications. Both spatial and temporal correlations exist simultaneously in multi-channel ECG (MECG) signals. Exploitation of both types of correlations is very important in CS-based ECG telemonitoring systems for better performance...
April 2017: Healthcare Technology Letters
https://www.readbyqxmd.com/read/28546838/dmap-assisted-sulfonylation-as-an-efficient-step-for-the-methylation-of-primary-amine-motifs-on-solid-support
#5
Johnny N Naoum, Koushik Chandra, Dorit Shemesh, R Benny Gerber, Chaim Gilon, Mattan Hurevich
Several multistep strategies were developed to ensure single methylation of amines on solid support. These strategies rely on the introduction of the o-NBS protecting/activating group as a key step. We found that the state-of-the-art strategies fail for the methylation of several primary amine motifs, largely due to inefficient sulfonylation. Here we show that using the superior nucleophilic base DMAP instead of the commonly used base collidine as a sulfonylation additive is essential for the introduction of the o-NBS group to these amine motifs...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28546634/high-gain-graphene-transistors-with-a-thin-alox-top-gate-oxide
#6
Erica Guerriero, Paolo Pedrinazzi, Aida Mansouri, Omid Habibpour, Michael Winters, Niklas Rorsman, Ashkan Behnam, Enrique A Carrion, Amaia Pesquera, Alba Centeno, Amaia Zurutuza, Eric Pop, Herbert Zirath, Roman Sordan
The high-frequency performance of transistors is usually assessed by speed and gain figures of merit, such as the maximum oscillation frequency f max, cutoff frequency f T, ratio f max/f T, forward transmission coefficient S 21, and open-circuit voltage gain A v. All these figures of merit must be as large as possible for transistors to be useful in practical electronics applications. Here we demonstrate high-performance graphene field-effect transistors (GFETs) with a thin AlOx gate dielectric which outperform previous state-of-the-art GFETs: we obtained f max/f T > 3, A v > 30 dB, and S 21 = 12...
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28546568/textured-nise2-film-bifunctional-electrocatalyst-for-full-water-splitting-at-remarkably-low-overpotential-with-high-energy-efficiency
#7
Abdurazag T Swesi, Jahangir Masud, Wipula P R Liyanage, Siddesh Umapathi, Eric Bohannan, Julia Medvedeva, Manashi Nath
Herein we have shown that electrodeposited NiSe2 can be used as a bifunctional electrocatalyst under alkaline conditions to split water at very low potential by catalyzing both oxygen evolution and hydrogen evolution reactions at anode and cathode, respectively, achieving a very high electrolysis energy efficiency exceeding 80% at considerably high current densities (100 mA cm(-2)). The OER catalytic activity as well as electrolysis energy efficiency surpasses any previously reported OER electrocatalyst in alkaline medium and energy efficiency of an electrolyzer using state-of-the-art Pt and RuO2 as the HER and OER catalyst, respectively...
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28546061/primary-biliary-cholangitis-advances-in-management-and-treatment-of-the-disease
#8
Pietro Invernizzi', Annarosa Floreani, Marco Carbone, Marco Marzioni, Antonio Craxi, Luigi Muratori, Umberto Vespasiani Gentilucci, Ivan Gardini, Antonio Gasbarrini, Paola Krugeri, Francesco Saverio Mennini, Virginia Ronco, Elena Lanati, Pier Luigi Canonico, Domenico Alvaro
Primary Biliary Cholangitis, previously known as Primary Biliary Cirrhosis, is a rare disease, which mainly affects women in their fifth to seventh decades of life. It is a chronic autoimmune disease characterized by a progressive damage of interlobular bile ducts leading to ductopenia, chronic cholestasis and bile acids retention. Even if the disease usually presents a long asymptomatic phase and a slow progression, in many patients it may progress faster toward cirrhosis and its complications. The 10year mortality is greater than in diseases such as human immunodeficiency virus/Hepatitis C Virus coinfection and breast cancer...
May 8, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28546054/moving-towards-shared-decision-making-in-the-physician-patient-encounter-in-france-state-of-the-art-and-future-prospects
#9
Nora Moumjid, Julien Carretier, Giovanna Marsico, François Blot, Christine Durif-Bruckert, Franck Chauvin
In this paper we present the evolution of shared decision-making since the mid-nineties in terms of legislation, official statements and guidelines. We outline the goals and declarations of the French Ministry of Health and the French National Authority for Health, for whom informing patients and shared decision-making are central concerns. Finally, we discuss research projects and clinical initiatives in shared decision-making in France and provide a general overview of progress and barriers to progress.
May 22, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28546050/shared-decision-making-in-argentina-in-2017
#10
Mariela Barani, Karin Kopitowski, Carolina Carrara, María Victoria Ruiz Yanzi
Argentina is a high-middle income country located in Southern South America with an estimated population of 44 million inhabitants. The epidemiological profile of the population is characterised by an increase of non-communicable diseases. The health system is heterogeneous, fragmented and loosely integrated. There are no unified research agenda or government initiatives encouraging the implementation of and research on Shared Decision-Making (SDM). Progress has been made lately to respect patient autonomy through the enactment of the 'Patients' Rights Act', which expressly enshrines the right of patients to get information as a key element of decision-making...
May 22, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28545872/imaging-of-liver-transplantation
#11
Rossano Girometti, Martina Pancot, Giuseppe Como, Chiara Zuiani
Liver transplantation (LT) is the treatment of choice for end-stage chronic liver disease, fulminant liver failure and early stage hepatocellular carcinoma. As discussed in this review, state-of-the-art imaging modalities including ultrasonography (US), computed tomography (CT) and magnetic resonance imaging (MRI) play a pivotal role in the selection of patients and donors, as well as in early detection of those complications at risk of impairing graft function and/or survival. We also illustrate main imaging findings related to the wide spectrum of clinical problems raised by LT...
May 15, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28545607/dynamically-weighted-evolutionary-ordinal-neural-network-for-solving-an-imbalanced-liver-transplantation-problem
#12
Manuel Dorado-Moreno, María Pérez-Ortiz, Pedro A Gutiérrez, Rubén Ciria, Javier Briceño, César Hervás-Martínez
OBJECTIVE: Create an efficient decision-support model to assist medical experts in the process of organ allocation in liver transplantation. The mathematical model proposed here uses different sources of information to predict the probability of organ survival at different thresholds for each donor-recipient pair considered. Currently, this decision is mainly based on the Model for End-stage Liver Disease, which depends only on the severity of the recipient and obviates donor-recipient compatibility...
March 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/28545390/mqaprank-improved-global-protein-model-quality-assessment-by-learning-to-rank
#13
Xiaoyang Jing, Qiwen Dong
BACKGROUND: Protein structure prediction has achieved a lot of progress during the last few decades and a greater number of models for a certain sequence can be predicted. Consequently, assessing the qualities of predicted protein models in perspective is one of the key components of successful protein structure prediction. Over the past years, a number of methods have been developed to address this issue, which could be roughly divided into three categories: single methods, quasi-single methods and clustering (or consensus) methods...
May 25, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28545366/role-of-positron-emission-tomography-for-central-nervous-system-involvement-in-systemic-autoimmune-diseases-status-and-perspectives
#14
Daniele Mauro, Gaetano Barbagallo, Salvatore D'Angelo, Sannino Pasqualina, Saverio Naty, Caterina Bruno, Ignazio Olivieri, Rosa Daniela Grembiale, Francesco Ursini
In the last years, an increasing interest in molecular imaging has been raised by the extending potential of positron emission tomography (PET). The role of PET imaging, originally confined to the oncology setting, is continuously extending thanks to the development of novel radiopharmaceutical and to the implementation of hybrid imaging techniques, where PET scans are combined with computed tomography (CT) or magnetic resonance imaging(MRI) in order to improve spatial resolution. Early preclinical studies suggested that 18F-FDG PET can detect neuroinflammation; new developing radiopharmaceuticals targeting more specifically inflammation-related molecules are moving in this direction...
May 23, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28544652/brownmillerite-type-ca2fecoo5-as-a-practicable-oxygen-evolution-reaction-catalyst
#15
Etsushi Tsuji, Teruki Motohashi, Hiroyuki Noda, Damian Kowalski, Yoshitaka Aoki, Hajime Tanida, Junji Niikura, Yukinori Koyama, Masahiro Mori, Hajime Arai, Tsutomu Ioroi, Naoko Fujiwara, Yoshiharu Uchimoto, Zempachi Ogumi, Hiroki Habazaki
Here, we report remarkable oxygen evolution reaction (OER) catalytic activity of brownmillerite (BM)-type Ca2FeCoO5. The OER activity of this oxide is comparable to or beyond those of the state-of-the-art perovskite (PV)-catalyst Ba0.5Sr0.5Co0.8Fe0.2O3-δ (BSCF) and a precious-metal catalyst RuO2, emphasizing the importance of the characteristic BM structure with multiple coordination environments of transition metal (TM) species. Also, Ca2FeCoO5 is obviously advantageous in terms of expense/laboriousness of the material synthesis...
May 25, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28544449/metagenomic-based-impact-study-of-transgenic-grapevine-rootstock-on-its-associated-virome-and-soil-bacteriome
#16
Jean-Michel Hily, Sandrine Demanèche, Nils Poulicard, Mélanie Tannières, Samia Djennane, Monique Beuve, Emmanuelle Vigne, Gérard Demangeat, Véronique Komar, Claude Gertz, Aurélie Marmonier, Caroline Hemmer, Sophie Vigneron, Armelle Marais, Thierry Candresse, Pascal Simonet, Olivier Lemaire
For some crops, the only possible approach to gain a specific trait requires genome modification. The development of virus-resistant transgenic plants based on the pathogen-derived resistance strategy has been a success story for over three decades. However, potential risks associated with the technology, such as horizontal gene transfer (HGT) of any part of the transgene to an existing gene pool, have been raised. Here, we report no evidence of any undesirable impacts of genetically modified (GM) grapevine rootstock on its biotic environment...
May 25, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28544272/ensemble-variant-interpretation-methods-to-predict-enzyme-activity-and-assign-pathogenicity-in-the-cagi4-naglu-human-n-acetyl-glucosaminidase-and-ube2i-human-sumo-ligase-challenges
#17
Yizhou Yin, Kunal Kundu, Lipika R Pal, John Moult
CAGI (Critical Assessment of Genome Interpretation) conducts community experiments to determine the state of the art in relating genotype to phenotype. Here we report results obtained using newly-developed ensemble methods to address two CAGI4 challenges: enzyme activity for population missense variants found in NAGLU (Human N-acetyl-glucosaminidase) and random missense mutations in Human UBE2I (Human SUMO E2 ligase), assayed in a high throughput competitive yeast complementation procedure. The ensemble methods are effective, ranked 2(nd) for SUMO-ligase and 3(rd) for NAGLU, according to the CAGI independent assessors...
May 24, 2017: Human Mutation
https://www.readbyqxmd.com/read/28544169/recent-progress-of-first-principles-calculations-in-ch3nh3pbi3-perovskite-solar-cells
#18
Sining Yun, Xiao Zhou, Jacky Even, Anders Hagfeldt
Hybrid halide perovskite solar cells (PSCs) exceeding 22% power conversion efficiencies (PCEs) have attracted considerable global attention due to the intrinsic nature of perovskite. Although we all know about that perovskite plays a significant role in the operation of PSCs, the fundamental theories associated with perovskite have not been resolved by the exponential increase in research effort. This raises questions about whether the first-principles calculations are sufficiently addressing the underlying issues in perovskite...
May 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28544022/covalently-modified-graphenes-in-catalysis-electrocatalysis-and-photoresponsive-materials
#19
Sergio Navalon, Jose Raul Herance, Mercedes Alvaro, Hermenegildo García
Ideal graphene is a one-atom thick single layer of carbon atoms having sp2 hybridation in hexagonal arrangement. Due to their large surface area and good dispersability in common solvents, graphenes are suitable platforms to anchor covalently units. The appended unit can introduce additional functionality to graphene. Although the field of covalently modified graphene is still starting compared to the development of other carbon nanoforms, there is alrady many examples describing the use of modified graphenes as recoverable photo-, electro- and catalysts as well as in non-linear optics and to improve mechanical resistance and solubility of graphenes...
May 25, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28543099/evidence-of-altered-mitochondrial-protein-expression-after-chronic-ethanol-consumption-in-the-aged-estrogen-deficient-female-rat-heart
#20
Alexandra M Garvin, J L Miller-Lee, D R Sharda, G M Kanski, J C Hunter, Donna H Korzick
BACKGROUND: Estrogen loss has been implicated to increase the risk of alcoholic cardiomyopathy in post-menopausal women. The purpose of this study was to identify novel mitochondrial protein targets for the treatment of alcoholic cardiomyopathy in aged women using a state-of-the-art proteomics approach. We hypothesized that chronic ethanol (EtOH) ingestion exacerbates maladaptive mitochondrial protein expression in the aged female heart METHODS: Adult (3 mo) and aged (18 mo) F344 ovary-intact or ovariectomized (OVX) rats were randomly assigned an EtOH or control Lieber-DeCarli 'all liquid' diet for 20 wks...
May 19, 2017: Alcoholism, Clinical and Experimental Research
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