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https://www.readbyqxmd.com/read/28545138/sumo-4-a-novel-functional-candidate-in-the-human-placental-protein-sumoylation-machinery
#1
Dora Baczyk, Melanie C Audette, Sascha Drewlo, Khrystyna Levytska, John C Kingdom
BACKGROUND: Small ubiquitin-like modifiers (SUMOs) conjugate to proteins post-translationally, thereby affecting target localization, activity and stability. Functional SUMO family members identified in the human placenta include SUMO-1 to SUMO-3, which are elevated in pre-eclampsia. Whether the fourth isoform, SUMO-4, plays a role in placental development and function remains unknown. OBJECTIVES: We tested the hypothesis that SUMO-4 is expressed in the human placenta and demonstrates altered SUMOylation in pre-eclamptic pregnancies...
2017: PloS One
https://www.readbyqxmd.com/read/28393580/second-trimester-cervical-length-and-outcomes-of-induction-of-labor-at-term
#2
Rupsa C Boelig, Anju Suhag, Juliana Guarente, Kelly Orzechowski, Vincenzo Berghella
OBJECTIVE: To evaluate whether second-trimester cervical length (CL) is associated with induction of labor (IOL) outcomes. METHODS: Retrospective cohort study of nulliparous singletons undergoing CL screening at 18 0/7-23 6/7 weeks from 1/1/2012 to 12/31/2013. Women induced at term (≥37 weeks) were included. Primary outcome was vaginal delivery (VD) within 24 h. The effect of CL on outcomes was assessed by incidence across CL quartiles and a receiver operating characteristics (ROC) curve...
April 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28347281/a-structural-equation-analysis-on-the-relationship-between-maternal-health-services-utilization-and-newborn-health-outcomes-a-cross-sectional-study-in-eastern-uganda
#3
Rornald Muhumuza Kananura, Robert Wamala, Elizabeth Ekirapa-Kiracho, Moses Tetui, Suzanne N Kiwanuka, Peter Waiswa, Leonard K Atuhaire
BACKGROUND: Neonatal and maternal health services have a bearing on neonatal mortality. Direct and indirect factors affecting neonatal health outcomes therefore require understanding to enable well-targeted interventions. This study, therefore, assessed the interrelationship between newborn health outcomes and maternal service utilization factors. METHODS: We investigated maternal health utilization factors using health facility delivery and at least four Antenatal Care (ANC) visits; and newborn health outcomes using newborn death and low birth weight (LBW)...
March 27, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28340831/pregnancy-and-delivery-in-the-sequel-of-kidney-transplantation-single-center-study-of-8-years-experience
#4
Y Yuksel, S Tekin, D Yuksel, I Duman, M Sarier, L Yucetin, E Turan, H Celep, T Ugurlu, M M Inal, Y H Asuman, A Demirbas
BACKGROUND: Depending on hyphothalamic, hyphophyseal, and gonadal axis dysfunction, anovulatory irregular cycles occur and the probability of pregnancy decreases in the patients with chronic kidney disease (CKD). Maternal mortality and morbidity rates are increased in CKD patients; the risk of premature delivery is 70% and the risk of preeclampsia is 40% more than normal among those with a creatine level of >2.5 mg/dL. METHODS: If a pregnancy is expected in the sequel of kidney transplantation (KT), a multidisciplinary team approach should be adopted and both the gynecologist and the nephrologist should follow the patient simultaneously...
April 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28236314/non-visualization-of-choroid-plexus-of-the-fourth-ventricle-as-a-first-trimester-predictor-of-posterior-fossa-anomalies-and-chromosomal-defects-a-three-dimensional-ultrasound-study
#5
P Martinez-Ten, T Illescas, B Adiego, M Estevez, C Bermejo, A E Wong, W Sepulveda
OBJECTIVE: To assess non-visualization of the choroid plexus of the fourth ventricle (CP-IVV) as a simple, qualitative, and reproducible first-trimester ultrasound feature of the posterior fossa that predicts brain anomalies and chromosomal defects. METHODS: Three-dimensional (3D) ultrasound datasets of the fetal brain were prospectively obtained from 65 consecutive singleton, normal first-trimester fetuses and retrospectively from 27 fetuses identified as having an abnormal fetal posterior fossa on the first-trimester scan, which were randomly included in the final study group...
February 25, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28119871/why-is-digit-ratio-correlated-to-sports-performance
#6
REVIEW
Tae Beom Kim, Khae Hawn Kim
Second to fourth digit ratio is the ratio of second to fourth digit length. It has been known that digit ratio is sexually dimorphic in humans, such that males tend to have lower digit ratio (longer fourth digits relative to second digits) than females. Digit ratio is thought to be a biomarker of the balance between fetal testosterone (FT) and fetal estrogen (FE) in a relatively narrow developmental window at the end of the first trimester of pregnancy. On the contrary, the relationships between digit ratio and levels of sex steroids in adults are not clear...
December 2016: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/27965957/22q11-deletion-syndrome-and-urogenital-manifestations-a-clinicopathological-case-report
#7
M Vachette, G E Grant, J Bouquet de la Joliniere, M Jotterand, N Ben Ali, A Feki, R Capoccia Brugger
BACKGROUND: Deletion in the chromosomal region 22q11 results from the abnormal development of the third and fourth pharyngeal pouches during embryonic life and presents an expansive phenotype with more than 180 clinical features described that involve every organ and system. HISTORY AND SIGNS: A 23-year-old African woman presented for the first trimester echography, which revealed an isolated anechoic structure suggesting a ureteral dilatation. The suspicion of a malposition of great arteries in the second trimester indicated an amniocentesis leading to a diagnosis of 22q11 deletion...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27876552/long-term-altered-immune-responses-following-fetal-priming-in-a-non-human-primate-model-of-maternal-immune-activation
#8
Destanie R Rose, Milo Careaga, Judy Van de Water, Kim McAllister, Melissa D Bauman, Paul Ashwood
Infection during pregnancy can lead to activation of the maternal immune system and has been associated with an increased risk of having an offspring later diagnosed with a neurodevelopmental disorders (NDD) such as autism spectrum disorder (ASD) or schizophrenia (SZ). Most maternal immune activation (MIA) studies to date have been in rodents and usually involve the use of lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C). However, since NDD are based on behavioral changes, a model of MIA in non-human primates could potentially provide data that helps illuminate complex behavioral and immune outputs in human NDD...
July 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27818641/parental-relationship-with-twins-from-pregnancy-to-3-months-the-relation-among-parenting-stress-infant-temperament-and-well-being
#9
Laura E Prino, Luca Rollè, Cristina Sechi, Luciana Patteri, Anna Ambrosoli, Angela M Caldarera, Eva Gerino, Piera Brustia
Objective: The transition to parenthood, from pregnancy to postpartum period, is a critical process, particularly for couples expecting twins. There is very little literature regarding the links between anxiety, depression, dyadic adjustment, parental stress, and infant temperament spanning from pregnancy to postpartum. This study has two aims: first, to examine whether mothers' and fathers' anxiety, depression, and dyadic adjustment, assessed at the sixth month of pregnancy and 3 months postpartum, are associated with infants' negative affectivity (NA) and parenting stress; second, to examine whether there is any difference between fathers' and mothers' levels of parenting stress and perception of the twins' temperament, as well as to evaluate, separately for mothers and fathers, whether the levels of parenting stress and perception of child temperament differ for each twin...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27766742/intracranial-translucency-assessment-at-first-trimester-nuchal-translucency-ultrasound
#10
Annah Lane, Ling Lee, Donna Traves, Andreas Lee
INTRODUCTION: The antenatal diagnosis of open spina bifida (OSB), a neural tube defect, is predominantly made at the second trimester morphology scan by ultrasound detection of structural abnormalities resulting from the associated Chiari II malformation. Evidence has emerged suggesting that these structural abnormalities can be detected earlier, by examination of the posterior fossa as part of the first trimester nuchal translucency scan. In particular, absence of the intra-cranial translucency (IT) of the fourth ventricle has shown promise as a diagnostic marker of OSB, although the sensitivity and specificity of this finding varies widely in the literature...
April 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/27465578/haematological-malignancies-in-pregnancy-an-overview-with-an-emphasis-on-thrombotic-risks
#11
Netanel A Horowitz, Noa Lavi, Yona Nadir, Benjamin Brenner
With increase of maternal age, the incidence of haematological malignancies during pregnancy is rising and posing diagnostic and treatment challenges. Lymphoma is the fourth most common malignancy diagnosed in pregnancy; Hodgkin lymphoma is more frequent in pregnant women than non-Hodgkin lymphoma (NHL). The proportion of highly aggressive lymphomas in pregnant women is significantly higher than in non-pregnant women of reproductive age. Reproductive organ involvement is observed in almost half of pregnant women with NHL...
September 27, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27439420/cumulative-physiologic-dysfunction-and-pregnancy-characterization-and-association-with-birth-outcomes
#12
Kimberly Schmitt McKee, Christopher Seplaki, Susan Fisher, Susan W Groth, I Diana Fernandez
Objective To characterize cumulative physiologic dysfunction (CPD) in pregnancy as a measure of the biological effects of chronic stress and to examine its associations with gestational age and birth weight. Methods Women ≤28 weeks gestation were enrolled from obstetric clinics in Rochester, NY and followed through their delivery. CPD parameters included total cholesterol, Interleukin 6 (IL-6), high sensitivity-C-reactive protein (hs-CRP), systolic and diastolic blood pressure, body mass index at <14 weeks gestation, glucose tolerance, and urinary albumin collected in the third trimester...
January 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/27417614/preeclampsia-eclampsia-adverse-outcomes-reduction-the-preeclampsia-eclampsia-checklist
#13
Oroma B Nwanodi
Globally, preeclampsia-eclampsia (PE-E) is a major cause of puerperal intensive care unit admission, accounting for up to 10% of maternal deaths. PE-E primary prevention is possible. Antepartum low-dose aspirin prophylaxis, costing USD $10-24 can cut the incidence of PE-E in half. Antepartum low molecular weight heparin combined with low-dose aspirin prophylaxis can cut the incidence of early onset PE-E and fetuses that are small for their gestational age in half. Despite predictive antepartum models for PE-E prophylaxis, said prophylaxis is not routinely provided...
May 13, 2016: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/27398699/placental-weight-in-pregnant-women-with-type-1-diabetes-mellitus-the-association-with-fetal-growth
#14
Supal Mehta, Jane Khoury, Menachem Miodovnik, Tetsuya Kawakita, Shelley Ehrlich, Katherine Bowers
Objective To determine the association between placental weight (PW) and large for gestational age (LGA) in women with type 1 diabetes mellitus (T1DM) and whether glycemic control modifies the association. Study Design In a retrospective analysis of a cohort of women with T1DM, poor glycemic control was defined as glycohemoglobin A1(HbA1)≥ 8.5% (≥2 standard deviations [SD] above mean), and LGA as birth weight > 90th percentile, according to gestation, race, and sex. Multivariable logistic regression was used for analysis...
November 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27343270/female-digit-length-ratio-2d-4d-and-time-to-pregnancy
#15
M P Vélez, T E Arbuckle, P Monnier, W D Fraser
STUDY QUESTION: Is the female 2th- to 4th-finger ratio (2D:4D) associated with fecundity as measured by time-to-pregnancy (TTP)? SUMMARY ANSWER: Our study does not support an association between female 2D:4D and TTP. WHAT IS KNOWN ALREADY: The 2th- to 4th-finger ratio (2D:4D) has been proposed as a potential indicator of greater androgen exposure during fetal development. Women exposed in utero to unbalanced steroid hormones may have impaired fecundity in the adulthood...
September 2016: Human Reproduction
https://www.readbyqxmd.com/read/27330925/brain-tumor-in-an-in-vitro-fertilization-facilitated-pregnancy-fourth-ventricle-anaplastic-ependymoma-in-the-second-trimester
#16
Nurzhan Ryskeldiyev, Gabit Olenbay, Raushan Auezova, Tim Killeen, Nurgul Aldiyarova, Zauresh Akhmetzhanova, Evaldas Cesnulis, Serik Akshulakov
We present a case of fourth ventricle anaplastic ependymoma in a pregnancy which was the first result of three rounds of in vitro fertilization (IVF) and embryo transfer. Whether hormonal treatment can directly or indirectly precipitate brain tumors to develop or become symptomatic is unclear.
June 2016: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/27251871/multilevel-provider-based-sampling-for-recruitment-of-pregnant-women-and-mother-newborn-dyads
#17
Thomas J McLaughlin, Onesky Aupont, Claudia A Kozinetz, David Hubble, Tiffany A Moore-Simas, Deborah Davis, Christina Park, Ruth Brenner, Deidre Sepavich, Marianne Felice, Chantal Caviness, Tim Downs, Beatrice J Selwyn, Michele R Forman
OBJECTIVE: In 2010, the National Children's Study launched 3 alternative recruitment methods to test possible improvements in efficiency compared with traditional household-based recruitment and participant enrollment. In 2012, a fourth method, provider-based sampling (PBS), tested a probability-based sampling of prenatal provider locations supplemented by a second cohort of neonates born at a convenience sample of maternity hospitals. METHODS: From a sampling frame of 472 prenatal care provider locations and 59 maternity hospitals, 49 provider and 7 hospital locations within or just outside 3 counties participated in study recruitment...
June 2016: Pediatrics
https://www.readbyqxmd.com/read/27243597/primary-hyperparathyroidism-in-pregnancy-a-case-series-and-literature-review
#18
REVIEW
Naile Gokkaya, Adem Gungor, Arzu Bilen, Habib Bilen, Darina Gviniashvili, Yusuf Karadeniz
Primary Hyperparathyroidism (PHP) in pregnancy constitutes a serious danger to mother and fetus. The diagnosis of PHP in pregnancy presents a challenge, and PHP commonly goes unidentified and untreated in pregnancy. We present four case reports about patients having PHP, which is very rare condition in pregnancy and their treatment modalities. Three patients, not to be controlled biochemically, denied the parathyroidectomy operation although they are informed about the details of their disease. They are followed up with medical therapy...
October 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27238438/pivotal-periods-for-pregnancy-loss-during-the-first-trimester-of-gestation-in-lactating-dairy-cows
#19
REVIEW
Milo C Wiltbank, Giovanni M Baez, Alvaro Garcia-Guerra, Mateus Z Toledo, Pedro L J Monteiro, Leonardo F Melo, Julian C Ochoa, José E P Santos, Roberto Sartori
Loss of pregnancy can occur at many different stages of gestation and for a variety of causes but clearly produces a negative impact for reproductive and economic performances of dairy herds. This review describes four pivotal periods for pregnancy loss during the first trimester of gestation and discusses possible causes for pregnancy failure during these periods. The first period occurs during the first week after breeding with lack of fertilization and death of the early embryo producing major losses in pregnancy, particularly under specific environmental and hormonal conditions...
July 1, 2016: Theriogenology
https://www.readbyqxmd.com/read/27157177/investigation-of-nutritional-behaviors-in-the-first-and-second-trimesters-in-pregnant-women-referring-to-clinics-in-hamadan-iran-in-2013
#20
Seyedeh Zahra Masoumi, Parisa Parsa, Farideh Kazemi, Ali Reza Soltanian, Gissoo Dadvand, Shabnam Habib
BACKGROUND: Pregnancy is a particular period in women's life that is accompanied by an increase in nutritional needs. Having a normal pregnancy period and successful pregnancy outcomes depends on the intake of sufficient amount of food. The present study aimed to determine nutritional behaviors in pregnant women in the first and second trimesters referring to clinics in Hamadan, Iran. METHODS: This cross-sectional study was conducted on 170 women referred to health and treatment centers of Hamadan in 2013...
September 1, 2016: Global Journal of Health Science
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