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https://www.readbyqxmd.com/read/28425156/universal-versus-selective-ultrasonography-to-screen-for-large-for-gestational-age-infants-and-associated-morbidity
#1
Ulla Sovio, Alexandros A Moraitis, Hilary S Wong, Gordon C S Smith
OBJECTIVE: To compare the diagnostic effectiveness of selective versus universal ultrasonography as a screening test for large for gestational age (LGA) infants, and to determine whether previously described ultrasonic markers of excessive fetal growth could identify which suspected LGA fetuses were at increased risk of neonatal morbidity. METHODS: We analysed data from a prospective cohort study of nulliparous women, the Pregnancy Outcome Prediction study. All women had clinically indicated scans as per routine care...
April 20, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28423341/glutathione-primes-t-cell-metabolism-for-inflammation
#2
Tak W Mak, Melanie Grusdat, Gordon S Duncan, Catherine Dostert, Yannic Nonnenmacher, Maureen Cox, Carole Binsfeld, Zhenyue Hao, Anne Brüstle, Momoe Itsumi, Christian Jäger, Ying Chen, Olaf Pinkenburg, Bärbel Camara, Markus Ollert, Carsten Bindslev-Jensen, Vasilis Vasiliou, Chiara Gorrini, Philipp A Lang, Michael Lohoff, Isaac S Harris, Karsten Hiller, Dirk Brenner
Activated T cells produce reactive oxygen species (ROS), which trigger the antioxidative glutathione (GSH) response necessary to buffer rising ROS and prevent cellular damage. We report that GSH is essential for T cell effector functions through its regulation of metabolic activity. Conditional gene targeting of the catalytic subunit of glutamate cysteine ligase (Gclc) blocked GSH production specifically in murine T cells. Gclc-deficient T cells initially underwent normal activation but could not meet their increased energy and biosynthetic requirements...
April 18, 2017: Immunity
https://www.readbyqxmd.com/read/28422278/decipher-test-impacts-decision-making-among-patients-considering-adjuvant-and-salvage-treatment-after-radical-prostatectomy-interim-results-from-the-multicenter-prospective-pro-impact-study
#3
John L Gore, Marguerite du Plessis, María Santiago-Jiménez, Kasra Yousefi, Darby J S Thompson, Lawrence Karsh, Brian R Lane, Michael Franks, David Y T Chen, Mark Bandyk, Fernando J Bianco, Gordon Brown, William Clark, Adam S Kibel, Hyung L Kim, William Lowrance, Murugesan Manoharan, Paul Maroni, Scott Perrapato, Paul Sieber, Edouard J Trabulsi, Robert Waterhouse, Elai Davicioni, Yair Lotan, Daniel W Lin
BACKGROUND: Patients with prostate cancer and their providers face uncertainty as they consider adjuvant radiotherapy (ART) or salvage radiotherapy (SRT) after undergoing radical prostatectomy. The authors prospectively evaluated the impact of the Decipher test, which predicts metastasis risk after radical prostatectomy, on decision making for ART and SRT. METHODS: A total of 150 patients who were considering ART and 115 who were considering SRT were enrolled. Providers submitted a management recommendation before processing the Decipher test and again at the time of receipt of the test results...
April 19, 2017: Cancer
https://www.readbyqxmd.com/read/28421992/reply-to-comment-on-clinical-efficacy-of-oral-alendronate-in-ankylosing-spondylitis-a-randomised-placebo-controlled-trial
#4
Ashok K Bhalla, Ashley S Bhalla, Laura C Coates, Jon C Packham, Paul Creamer, Sara Hailwood, Kuntal Chakravarty, Diarmuid Mulherin, Gordon Taylor, Derek L Mattey
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April 18, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28420054/the-prevalence-and-determinants-of-anti-dfs70-autoantibodies-in-an-international-inception-cohort-of-systemic-lupus-erythematosus-patients
#5
M Y Choi, A E Clarke, Y St Pierre, J G Hanly, M B Urowitz, J Romero-Diaz, C Gordon, S-C Bae, S Bernatsky, D J Wallace, J T Merrill, D A Isenberg, A Rahman, E M Ginzler, M Petri, I N Bruce, M A Dooley, P Fortin, D D Gladman, J Sanchez-Guerrero, K Steinsson, R Ramsey-Goldman, M A Khamashta, C Aranow, G S Alarcón, S Manzi, O Nived, A A Zoma, R F van Vollenhoven, M Ramos-Casals, G Ruiz-Irastorza, S S Lim, K C Kalunian, M Inanc, D L Kamen, C A Peschken, S Jacobsen, A Askanase, J Buyon, M Mahler, M J Fritzler
Autoantibodies to dense fine speckles 70 (DFS70) are purported to rule out the diagnosis of SLE when they occur in the absence of other SLE-related autoantibodies. This study is the first to report the prevalence of anti-DFS70 in an early, multinational inception SLE cohort and examine demographic, clinical, and autoantibody associations. Patients were enrolled in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort within 15 months of diagnosis. The association between anti-DFS70 and multiple parameters in 1137 patients was assessed using univariate and multivariate logistic regression...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28419644/diffusion-weighted-imaging-of-hyperpolarized-13-c-urea-in-mouse-liver
#6
Irene Marco-Rius, Jeremy W Gordon, Aras N Mattis, Robert Bok, Romelyn Delos Santos, Subramanian Sukumar, Peder E Z Larson, Daniel B Vigneron, Michael A Ohliger
PURPOSE: To compare the apparent diffusion coefficient (ADC) of hyperpolarized (HP) [(13) C,(15) N]urea to the ADC of endogenous water in healthy and fibrotic mouse liver. MATERIALS AND METHODS: ADC measurements for water and [(13) C]urea were made in agarose phantoms at 14.1T. Next, the ADC of water and injected HP [(13) C,(15) N]urea were measured in eight CD1 mouse livers before and after induction of liver fibrosis using CCl4 . Liver fibrosis was quantified pathologically using the modified Brunt fibrosis score and compared to the measured ADC of water and urea...
April 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28419267/a-national-survey-assessing-the-number-of-records-allowed-open-in-electronic-health-records-at-hospitals-and-ambulatory-sites
#7
Jason S Adelman, Matthew A Berger, Amisha Rai, William L Galanter, Bruce L Lambert, Gordon D Schiff, David K Vawdrey, Robert A Green, Hojjat Salmasian, Ross Koppel, Clyde B Schechter, Jo R Applebaum, William N Southern
To reduce the risk of wrong-patient errors, safety experts recommend limiting the number of patient records providers can open at once in electronic health records (EHRs). However, it is unknown whether health care organizations follow this recommendation or what rationales drive their decisions. To address this gap, we conducted an electronic survey via 2 national listservs. Among 167 inpatient and outpatient study facilities using EHR systems designed to open multiple records at once, 44.3% were configured to allow ≥3 records open at once (unrestricted), 38...
April 17, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28418267/btk-c481s-mediated-resistance-to-ibrutinib-in-chronic-lymphocytic-leukemia
#8
Jennifer A Woyach, Amy S Ruppert, Daphne Guinn, Amy Lehman, James S Blachly, Arletta Lozanski, Nyla A Heerema, Weiqiang Zhao, Joshua Coleman, Daniel Jones, Lynne Abruzzo, Amber Gordon, Rose Mantel, Lisa L Smith, Samantha McWhorter, Melanie Davis, Tzyy-Jye Doong, Fan Ny, Margaret Lucas, Weihong Chase, Jeffrey A Jones, Joseph M Flynn, Kami Maddocks, Kerry Rogers, Samantha Jaglowski, Leslie A Andritsos, Farrukh T Awan, Kristie A Blum, Michael R Grever, Gerard Lozanski, Amy J Johnson, John C Byrd
Purpose Therapeutic targeting of Bruton tyrosine kinase (BTK) with ibrutinib in chronic lymphocytic leukemia has led to a paradigm shift in therapy, and relapse has been uncommon with current follow-up. Acquired mutations in BTK and PLCG2 can cause relapse, but data regarding the prevalence and natural history of these mutations are limited. Patients and Methods Patients accrued to four sequential studies of ibrutinib were included in these analyses. Deep sequencing for BTK and PLCG2 was performed retrospectively on patients who experienced relapse and prospectively on a screening population...
February 13, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28414618/understanding-spanish-language-response-in-a-national-health-communication-survey-implications-for-health-communication-research
#9
A Susana Ramírez, Gordon Willis, Lila Finney Rutten
Spanish-speaking Latinos account for 13% of the U.S. population yet are chronically under-represented in national surveys; additionally, the response quality suffers from low literacy rates and translation challenges. These are the same issues that health communicators face when understanding how best to communicate important health information to Latinos. The Health Information National Trends Survey (HINTS) offers a unique opportunity to understand the health communication landscape and information needs of the U...
April 17, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28414227/quantifying-the-role-of-orbital-contraction-in-chemical-bonding
#10
Daniel S Levine, Martin Head-Gordon
This work reports an approach to variationally quantify orbital contraction in chemical bonds by an extension of an energy decomposition analysis (EDA). The orbital contraction energy is defined as the energy lowering due to optimization of the isolated fragments (that combine to form the bond) with a specially constructed virtual set of contraction/expansion functions. This set contains one function per occupied orbital, obtained as the linear response to scaling the nuclear charges. EDA results for a variety of single bonds show substantial changes in the importance of orbital contraction; it plays a critical role for bonds to H but only a very minor role in the bonds between heavier elements...
April 18, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28412293/glecaprevir-and-pibrentasvir-yield-high-response-rates-in-patients-with-hcv-genotype-1-6-without-cirrhosis
#11
Paul Y Kwo, Fred Poordad, Armen Asatryan, Stanley Wang, David L Wyles, Tarek Hassanein, Franco Felizarta, Mark S Sulkowski, Edward Gane, Benedict Maliakkal, J Scott Overcash, Stuart C Gordon, Andrew J Muir, Humberto Aguilar, Kosh Agarwal, Gregory J Dore, Chih-Wei Lin, Ran Liu, Sandra S Lovell, Teresa I Ng, Jens Kort, Federico J Mensa
BACKGROUND: and Aims Hepatitis C virus (HCV) therapy that is highly efficacious, pangenotypic, with a high barrier to resistance and short treatment duration is desirable. The efficacy and safety of 8- and 12-week treatments with glecaprevir (ABT-493; NS3/4A protease inhibitor) and pibrentasvir (ABT-530; NS5A inhibitor) was evaluated in non-cirrhotic patients with chronic HCV genotype 1-6 infection. METHODS: SURVEYOR-I and SURVEYOR-II were phase 2, open-label, multicenter, dose-ranging trials including patients with chronic HCV genotype 1-6 infection who were either previously untreated or treated with pegylated interferon plus ribavirin...
April 12, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28411194/systematic-characterization-of-a-to-i-rna-editing-hotspots-in-micrornas-across-human-cancers
#12
Yumeng Wang, Xiaoyan Xu, Shuangxing Yu, Kang Jin Kang, Zhicheng Zhou, Leng Han, Yiu Huen Tsang, Jun Li, Hu Chen, Lingegowda S Mangala, Yuan Yuan, A Karina Eterovic, Yiling Lu, Anil K Sood, Kenneth L Scott, Gordon B Mills, Han Liang
RNA editing, a widespread posttranscriptional mechanism, has emerged as a new player in cancer biology. Recent studies have reported key roles for individual miRNA editing events, but a comprehensive picture of miRNA editing in human cancers remains largely unexplored. Here we systematically characterized the miRNA editing profiles of 8,595 samples across 20 cancer types from miRNA sequencing data of The Cancer Genome Atlas and identified 19 adenosine-to-inosine (A-to-I) RNA editing hotspots. We independently validated 15 of them by perturbation experiments in several cancer cell lines...
April 14, 2017: Genome Research
https://www.readbyqxmd.com/read/28409969/first-benchmark-of-relativistic-photoionization-theories-against-3d-ab-initio-simulation
#13
B Hafizi, D F Gordon, J P Palastro
Photoelectron spectra and ionization rates encompassing relativistic intensities and hydrogenlike ions with relativistic binding energies are obtained using a quasiclassical S-matrix approach. These results, along with those based on the imaginary time method, are compared with three-dimensional, ½-period ab initio simulations for a wide range of ionization potentials and electric field amplitudes. Significant differences between the three results are demonstrated. Time-dependent simulations indicate that the peak ionization current can occur before the peak of the electric field...
March 31, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28406723/aspirin-use-and-colorectal-cancer-survival-according-to-tumor-cd274-programmed-cell-death-1-ligand-1-expression-status
#14
Tsuyoshi Hamada, Yin Cao, Zhi Rong Qian, Yohei Masugi, Jonathan A Nowak, Juhong Yang, Mingyang Song, Kosuke Mima, Keisuke Kosumi, Li Liu, Yan Shi, Annacarolina da Silva, Mancang Gu, Wanwan Li, NaNa Keum, Xuehong Zhang, Kana Wu, Jeffrey A Meyerhardt, Edward L Giovannucci, Marios Giannakis, Scott J Rodig, Gordon J Freeman, Daniel Nevo, Molin Wang, Andrew T Chan, Charles S Fuchs, Reiko Nishihara, Shuji Ogino
Purpose Blockade of the programmed cell death 1 (PDCD1, PD-1) immune checkpoint pathway can improve clinical outcomes in various malignancies. Evidence suggests that aspirin (a widely used nonsteroidal anti-inflammatory drug) not only prolongs colorectal cancer survival, but can also activate T cell-mediated antitumor immunity and synergize with immunotherapy through inhibition of prostaglandin E2 production. We hypothesized that the survival benefit associated with aspirin might be stronger in colorectal carcinoma with a lower CD274 (PDCD1 ligand 1, PD-L1) expression level that resulted in lower signaling of the immune checkpoint pathway...
April 13, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28406302/relativistic-ab-initio-accurate-minimal-basis-sets-quantitative-lumos-and-oriented-quasi-atomic-orbitals-for-the-elements-li-xe
#15
George Schoendorff, Aaron C West, Michael W Schmidt, Klaus Ruedenberg, Angela K Wilson, Mark S Gordon
Valence virtual orbitals (VVOs) are a quantitative and basis set independent method for extracting chemically meaningful lowest unoccupied molecular orbitals (LUMOs). The VVOs are formed based on a singular value decomposition (SVD) with respect to pre-computed and internally stored ab initio accurate minimal basis sets (AAMBS) for the atoms. The occupied molecular orbitals and VVOs together form a minimal basis set that can be transformed into orthogonal oriented quasi-atomic orbitals (OQUAOs) that provide a quantitative description of the bonding in a molecular environment...
April 13, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28405880/steap4-expression-in-human-islets-is-associated-with-differences-in-body-mass-index-sex-hba1c-and-inflammation
#16
Hannah M Gordon, Neil Majithia, Patrick E MacDonald, Jocelyn E Manning Fox, Poonam R Sharma, Frances L Byrne, Kyle L Hoehn, Carmella Evans-Molina, Linda Langman, Kenneth L Brayman, Craig S Nunemaker
OBJECTIVE: STEAP4 (six-transmembrane epithelial antigen of the prostate 4) is a metalloreductase that has been shown previously to protect cells from inflammatory damage. Genetic variants in STEAP4 have been associated with numerous metabolic disorders related to obesity, including putative defects in the acute insulin response to glucose in type 2 diabetes. PURPOSE: We examined whether obesity and/or type 2 diabetes altered STEAP4 expression in human pancreatic islets...
April 12, 2017: Endocrine
https://www.readbyqxmd.com/read/28404899/balb-c-mice-immunized-with-a-combination-of-virus-like-particles-incorporating-kaposi-sarcoma-associated-herpesvirus-kshv-envelope-glycoproteins-gpk8-1-gb-and-gh-gl-induced-comparable-serum-neutralizing-antibody-activity-to-uv-inactivated-kshv
#17
Anne K Barasa, Peng Ye, Meredith Phelps, Ganapathiram T Arivudainambi, Timelia Tison, Javier Gordon Ogembo
Infection with Kaposi sarcoma-associated herpesvirus (KSHV) is estimated to account for over 44,000 new cases of Kaposi sarcoma annually, with 84% occurring in Africa, where the virus is endemic. To date, there is no prophylactic vaccine against KSHV. KSHV gpK8.1, gB, and gH/gL glycoproteins, implicated in the virus entry into host cells, are attractive vaccine targets for eliciting potent neutralizing antibodies (nAbs) against virus infection. We incorporated gpK8.1, gB, or gH/gL on the surface of virus-like particles (VLPs) and characterized these VLPs for their composition, size, and functionality...
February 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28403617/publications-of-mark-s-gordon
#18
Mark S Gordon
No abstract text is available yet for this article.
April 13, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28403616/preface-mark-s-gordon
#19
Theresa L Windus, Kim K Baldridge, Michael W Schmidt, Christine M Aikens
No abstract text is available yet for this article.
April 13, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28403615/students-and-co-workers-of-mark-s-gordon
#20
Mark S Gordon
No abstract text is available yet for this article.
April 13, 2017: Journal of Physical Chemistry. A
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