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https://www.readbyqxmd.com/read/28230394/the-onset-and-time-course-of-semantic-priming-during-rapid-recognition-of-visual-words
#1
Renske S Hoedemaker, Peter C Gordon
In 2 experiments, we assessed the effects of response latency and task-induced goals on the onset and time course of semantic priming during rapid processing of visual words as revealed by ocular response tasks. In Experiment 1 (ocular lexical decision task), participants performed a lexical decision task using eye movement responses on a sequence of 4 words. In Experiment 2, the same words were encoded for an episodic recognition memory task that did not require a metalinguistic judgment. For both tasks, survival analyses showed that the earliest observable effect (divergence point [DP]) of semantic priming on target-word reading times occurred at approximately 260 ms, and ex-Gaussian distribution fits revealed that the magnitude of the priming effect increased as a function of response time...
February 23, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28230156/drebrin-mediated-microtubule-actomyosin-coupling-steers-cerebellar-granule-neuron-nucleokinesis-and-migration-pathway-selection
#2
Niraj Trivedi, Daniel R Stabley, Blake Cain, Danielle Howell, Christophe Laumonnerie, Joseph S Ramahi, Jamshid Temirov, Ryan A Kerekes, Phillip R Gordon-Weeks, David J Solecki
Neuronal migration from a germinal zone to a final laminar position is essential for the morphogenesis of neuronal circuits. While it is hypothesized that microtubule-actomyosin crosstalk is required for a neuron's 'two-stroke' nucleokinesis cycle, the molecular mechanisms controlling such crosstalk are not defined. By using the drebrin microtubule-actin crosslinking protein as an entry point into the cerebellar granule neuron system in combination with super-resolution microscopy, we investigate how these cytoskeletal systems interface during migration...
February 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28224738/rct-evidence-should-not-drive-everything-we-do-clinically-trials-and-errors
#3
Gordon C S Smith
No abstract text is available yet for this article.
March 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28223498/attenuated-pfspz-vaccine-induces-strain-transcending-t-cells-and-durable-protection-against-heterologous-controlled-human-malaria-infection
#4
Kirsten E Lyke, Andrew S Ishizuka, Andrea A Berry, Sumana Chakravarty, Adam DeZure, Mary E Enama, Eric R James, Peter F Billingsley, Anusha Gunasekera, Anita Manoj, Minglin Li, Adam J Ruben, Tao Li, Abraham G Eappen, Richard E Stafford, Natasha Kc, Tooba Murshedkar, Floreliz H Mendoza, Ingelise J Gordon, Kathryn L Zephir, LaSonji A Holman, Sarah H Plummer, Cynthia S Hendel, Laura Novik, Pamela J M Costner, Jamie G Saunders, Nina M Berkowitz, Barbara J Flynn, Martha C Nason, Lindsay S Garver, Matthew B Laurens, Christopher V Plowe, Thomas L Richie, Barney S Graham, Mario Roederer, B Kim Lee Sim, Julie E Ledgerwood, Stephen L Hoffman, Robert A Seder
A live-attenuated malaria vaccine, Plasmodium falciparum sporozoite vaccine (PfSPZ Vaccine), confers sterile protection against controlled human malaria infection (CHMI) with Plasmodium falciparum (Pf) parasites homologous to the vaccine strain up to 14 mo after final vaccination. No injectable malaria vaccine has demonstrated long-term protection against CHMI using Pf parasites heterologous to the vaccine strain. Here, we conducted an open-label trial with PfSPZ Vaccine at a dose of 9.0 × 10(5) PfSPZ administered i...
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28223321/a-non-canonical-function-of-ezh2-preserves-immune-homeostasis
#5
Ajithkumar Vasanthakumar, Dakang Xu, Aaron Tl Lun, Andrew J Kueh, Klaas Pjm van Gisbergen, Nadia Iannarella, Xiaofang Li, Liang Yu, Die Wang, Bryan Rg Williams, Stanley Cw Lee, Ian J Majewski, Dale I Godfrey, Gordon K Smyth, Warren S Alexander, Marco J Herold, Axel Kallies, Stephen L Nutt, Rhys S Allan
Enhancer of zeste 2 (Ezh2) mainly methylates lysine 27 of histone-H3 (H3K27me3) as part of the polycomb repressive complex 2 (PRC2) together with Suz12 and Eed. However, Ezh2 can also modify non-histone substrates, although it is unclear whether this mechanism has a role during development. Here, we present evidence for a chromatin-independent role of Ezh2 during T-cell development and immune homeostasis. T-cell-specific depletion of Ezh2 induces a pronounced expansion of natural killer T (NKT) cells, although Ezh2-deficient T cells maintain normal levels of H3K27me3...
February 21, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28221351/imaging-quantum-stereodynamics-through-fraunhofer-scattering-of-no-radicals-with-rare-gas-atoms
#6
Jolijn Onvlee, Sean D S Gordon, Sjoerd N Vogels, Thomas Auth, Tijs Karman, Bethan Nichols, Ad van der Avoird, Gerrit C Groenenboom, Mark Brouard, Sebastiaan Y T van de Meerakker
Stereodynamics describes how the vector properties of molecules, such as the directions in which they move and the axes about which they rotate, affect the probabilities (or cross-sections) of specific processes or transitions that occur on collision. The main aspects of stereodynamics in inelastic atom-molecule collisions can often be understood from classical considerations, in which the particles are represented by billiard-ball-like hard objects. In a quantum picture, however, the collision is described in terms of matter waves, which can also scatter into the region of the geometrical shadow of the object and reveal detailed information on the pure quantum-mechanical contribution to the stereodynamics...
March 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28217388/neurosurgery-concepts-key-perspectives-on-imaging-characteristics-of-spinal-metastases-surgery-for-low-back-pain-anesthesia-for-disc-surgery-and-laminectomy-versus-laminectomy-and-fusion-for-lumbar-spondylolisthesis
#7
Carlito Lagman, Lawrance K Chung, Luke Macyszyn, Winward Choy, Zachary A Smith, Nader S Dahdaleh, Angela M Bohnen, Jin M Cho, Chaim B Colen, Edward Duckworth, Anand V Germanwala, Peter Kan, Alexander A Khalessi, Chae-Yong Kim, Sandi Lam, Gordon Li, Michael Lim, Jonathan H Sherman, Vincent Y Wang, Gabriel Zada, Isaac Yang
No abstract text is available yet for this article.
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28216433/lifelong-memory-responses-perpetuate-humoral-th2-immunity-and-anaphylaxis-in-food-allergy
#8
Rodrigo Jiménez-Saiz, Derek K Chu, Talveer S Mandur, Tina D Walker, Melissa E Gordon, Roopali Chaudhary, Joshua Koenig, Sarah Saliba, Heather J Galipeau, Adam Utley, Irah L King, Kelvin Lee, Rachel Ettinger, Susan Waserman, Roland Kolbeck, Manel Jordana
BACKGROUND: A number of food allergies (e.g. fish, shellfish, nuts) are lifelong, without any disease-transforming therapies and unclear in their underlying immunology. Clinical manifestations of food allergy are largely mediated by IgE. Although persistent IgE titres have conventionally been attributed to long-lived IgE(+) plasma cells (PCs), this has not been directly and comprehensively tested. OBJECTIVE: To evaluate mechanisms underlying persistent IgE and allergic responses to food allergens...
February 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28215889/effects-of-a-combination-butaphosphan-and-cyanocobalamin-product-and-insulin-on-ketosis-resolution-and-milk-production
#9
J L Gordon, T F Duffield, T H Herdt, D F Kelton, L Neuder, S J LeBlanc
The objective of this study was to determine the effects of butaphosphan-cyanocobalamin (B+C), glargine insulin, and propylene glycol on resolution of ketosis and average daily milk yield after treatment. Cows from 16 herds in Ontario, Canada, and 1 herd in Michigan were tested at weekly intervals between 3 and 16 DIM. Ketosis was defined as blood β-hydroxybutyrate (BHB) ≥1.2 mmol/L. All ketotic cows were given a baseline treatment of 3 d of 300 g of propylene glycol orally. Animals were then randomly assigned to treatment with 3 doses of either 25 mL of B+C or 25 mL of saline placebo and 1 dose of either 2 mL (200 IU) of glargine insulin or 2 mL of saline placebo in a 2 × 2 factorial arrangement...
February 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28213647/increased-and-decreased-pelvic-incidence-sagittal-facet-joint-orientations-are-associated-with-lumbar-spine-osteoarthritis-in-a-large-cadaveric-collection
#10
Douglas S Weinberg, Raymond W Liu, Katherine K Xie, William Z Morris, Jeremy J Gebhart, Zachary L Gordon
PURPOSE: Degenerative joint disease of the lumbar spine is a pervasive problem in healthcare; however, its aetiology and risk factors remain poorly defined. There have been recent attempts to correlate the anatomic parameters of facet angle and pelvic incidence with spine osteoarthritis, although data remains limited. The purpose of this experiment was to determine how age, gender, race, facet angle, tropism, and pelvic incidence correlate to facet joint osteoarthritis in the lumbar spine...
February 17, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28213342/virtual-visits-for-acute-nonurgent-care-a-claims-analysis-of-episode-level-utilization
#11
Aliza S Gordon, Wallace C Adamson, Andrea R DeVries
BACKGROUND: Expansion of virtual health care-real-time video consultation with a physician via the Internet-will continue as use of mobile devices and patient demand for immediate, convenient access to care grow. OBJECTIVE: The objective of the study is to analyze the care provided and the cost of virtual visits over a 3-week episode compared with in-person visits to retail health clinics (RHC), urgent care centers (UCC), emergency departments (ED), or primary care physicians (PCP) for acute, nonurgent conditions...
February 17, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28211686/multipole-moments-in-the-effective-fragment-potential-method
#12
Colleen Bertoni, Lyudmila V Slipchenko, Alston J Misquitta, Mark S Gordon
In the effective fragment potential (EFP) method the Coulomb potential is represented using a set of multipole moments generated by the distributed multipole analysis (DMA) method. Misquitta, Stone, and Fazeli recently developed a basis space-iterated stockholder atom (BS-ISA) method to generate multipole moments. This study assesses the accuracy of the EFP interaction energies using sets of multipole moments generated from the BS-ISA method, and from several versions of the DMA method (such as analytic and numeric grid-based), with varying basis sets...
February 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28198722/triad-viii-nationwide-multicenter-evaluation-to-determine-whether-patient-video-testimonials-can-safely-help-ensure-appropriate-critical-versus-end-of-life-care
#13
Ferdinando L Mirarchi, Timothy E Cooney, Arvind Venkat, David Wang, Thaddeus M Pope, Abra L Fant, Stanley A Terman, Kevin M Klauer, Monica Williams-Murphy, Michael A Gisondi, Brian Clemency, Ankur A Doshi, Mari Siegel, Mary S Kraemer, Kate Aberger, Stephanie Harman, Neera Ahuja, Jestin N Carlson, Melody L Milliron, Kristopher K Hart, Chelsey D Gilbertson, Jason W Wilson, Larissa Mueller, Lori Brown, Bradley D Gordon
OBJECTIVE: End-of-life interventions should be predicated on consensus understanding of patient wishes. Written documents are not always understood; adding a video testimonial/message (VM) might improve clarity. Goals of this study were to (1) determine baseline rates of consensus in assigning code status and resuscitation decisions in critically ill scenarios and (2) determine whether adding a VM increases consensus. METHODS: We randomly assigned 2 web-based survey links to 1366 faculty and resident physicians at institutions with graduate medical education programs in emergency medicine, family practice, and internal medicine...
February 14, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28197614/characterization-of-the-temperature-and-humidity-dependent-phase-diagram-of-amorphous-nanoscale-organic-aerosols
#14
Nicholas E Rothfuss, Markus D Petters
Atmospheric aerosols can exist in amorphous semi-solid or glassy phase states. These states are determined by the temperature (T) and relative humidity (RH). New measurements of viscosity for amorphous semi-solid nanometer size sucrose particles as a function of T and RH are reported. Viscosity is measured by inducing coagulation between two particles and probing the thermodynamic states that induce the particle to relax into a sphere. It is shown that the glass transition temperature can be obtained by extrapolation to 10(12) Pa s from the measured temperature-dependent viscosity in the 10(6) to 10(7) Pa s range...
February 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28195959/treatment-charges-for-traumatic-brain-injury-among-older-adults-at-a-trauma-center
#15
Jennifer S Albrecht, Julia F Slejko, Deborah M Stein, Gordon S Smith
OBJECTIVE: To provide charge estimates of treatment for traumatic brain injury (TBI), including both hospital and physician charges, among adults 65 years and older treated at a trauma center. METHODS: We identified older adults treated for TBI during 2008-2012 (n = 1843) at Maryland's Primary Adult Resource Center and obtained hospital and physician charges separately. Analyses were stratified by sex and all charges were inflated to 2012 dollars. Total TBI charges were modeled as a function of covariates using a generalized linear model...
February 10, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28194006/genome-wide-association-study-identifies-sestd1-as-a-novel-risk-gene-for-lithium-responsive-bipolar-disorder
#16
J Song, S E Bergen, A Di Florio, R Karlsson, A Charney, D M Ruderfer, E A Stahl, K D Chambert, J L Moran, K Gordon-Smith, L Forty, E K Green, I Jones, L Jones, E M Scolnick, P Sklar, J W Smoller, P Lichtenstein, C Hultman, N Craddock, M Landén
No abstract text is available yet for this article.
February 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28191503/differences-in-gut-metabolites-and-microbial-composition-and-functions-between-egyptian-and-u-s-children-are-consistent-with-their-diets
#17
V Shankar, M Gouda, J Moncivaiz, A Gordon, N V Reo, L Hussein, O Paliy
Previous studies indicated that populations consuming a Mediterranean diet rich in fiber, vegetables, and fruits have a significantly lower risk of cardiovascular and metabolic diseases than populations of industrialized societies consuming diets enriched in processed carbohydrates, animal proteins, and fats. To explore the potential contributions of gut microbiota to the observed diet-related metabolic effects, we conducted an integrative analysis of distal gut microbiota composition and functions and intestinal metabolites in Egyptian and U...
January 2017: MSystems
https://www.readbyqxmd.com/read/28188460/gender-differences-in-hiv-risk-behaviors-among-persons-involved-in-the-u-s-criminal-justice-system-and-living-with-hiv-or-at-risk-for-hiv-a-seek-test-treat-and-retain-harmonization-consortium
#18
Kelsey B Loeliger, Mary L Biggs, Rebekah Young, David W Seal, Curt G Beckwith, Irene Kuo, Michael S Gordon, Frederick L Altice, Lawrence J Ouellet, William E Cunningham, Jeremy D Young, Sandra A Springer
The U.S. female criminal justice (CJ) population is rapidly growing, yet large-scale studies exploring gender-specific HIV risk behaviors in the CJ population are lacking. This analysis uses baseline data on adults with a CJ history from eight U.S. studies in an NIH-funded "Seek, Test, Treat, Retain" harmonization consortium. Data were collected using a standardized HIV risk behavior assessment tool and pooled across studies to describe participants' characteristics and risk behaviors. Multilevel mixed-effects logistic regression models were used to test for gender-based behavior differences...
February 10, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28187954/heart-rate-variability-in-insomnia-patients-a-critical-review-of-the-literature
#19
REVIEW
Kirsty L Dodds, Christopher B Miller, Simon D Kyle, Nathaniel S Marshall, Christopher J Gordon
Heart rate variability (HRV) is an objective marker that provides insight into autonomic nervous system dynamics. There is conflicting evidence regarding the presence of HRV impairment in insomnia patients. Web-based databases were used to systematically search the literature for all studies that compared the HRV of insomnia patients to controls or reported the HRV of insomnia patients before and after an intervention. 22 relevant papers were identified. Study characteristics were summarised, HRV measures were extracted and a risk of bias assessment for each study was performed...
June 28, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28182959/predictors-of-depression-in-outpatients-with-heart-failure-an-observational-study
#20
Lucinda J Graven, Geraldine Martorella, Glenna Gordon, Joan S Grant Keltner, Melinda K Higgins
BACKGROUND: Depression is a common comorbidity of heart failure. Little is known about the influence of heart failure symptomatology and coping resources, such as social support and social problem-solving, on depression. OBJECTIVE: To examine whether individual and clinical characteristics, heart failure symptomatology, and the subcomponents of social support and social problem-solving increase the likelihood of depression in outpatients with heart failure. METHODS: A secondary data analysis of a cross sectional study with 201 outpatients with heart failure was conducted...
February 1, 2017: International Journal of Nursing Studies
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