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G C I von Meijenfeldt, S C van Beek, F Bastos Gonçalves, H J M Verhagen, C J Zeebregts, A C Vahl, W Wisselink, M J van der Laan, R Balm
OBJECTIVE: The decision whether or not to proceed with surgical intervention of a patient with a ruptured abdominal aortic aneurysm (rAAA) is very difficult in daily practice. The primary objective of the present study was to develop and to externally validate a new prediction model: the Dutch Aneurysm Score (DAS). METHODS: With a prospective cohort of 10 hospitals (n = 508) the DAS was developed using a multivariate logistic regression model. Two retrospective cohorts with rAAA patients from two hospitals (n = 373) were used for external validation...
December 1, 2016: European Journal of Vascular and Endovascular Surgery
Zoran Zorić, Joško Markić, Sandra Pedisić, Viljemka Bučević-Popović, Ivana Generalić-Mekinić, Katarina Grebenar, Tea Kulišić-Bilušić
The present study compares the gastrointestinal stability of rosmarinic acid in aqueous extracts of thyme, winter savory and lemon balm with the stability of pure rosmarinic acid. The stability of rosmarinic acid was detected after two-phase in vitro digestion process (gastric and duodenal) with human gastrointestinal enzymes. The concentration of rosmarinic acid in undigested and digested samples was detected using HPLC-DAD. Results showed that gastrointestinal stability of pure rosmarinic acid was significantly higher than that of rosmarinic acid from plant extracts after both gastric and intestinal phases of digestion...
March 2016: Food Technology and Biotechnology
Elodie Desuzinges Mandon, Aurélien Traversier, Anne Champagne, Lorraine Benier, Stéphane Audebert, Sébastien Balme, Emmanuel Dejean, Manuel Rosa Calatrava, Anass Jawhari
Influenza A virus displays one of the highest infection rates of all human viruses and therefore represents a severe human health threat associated with an important economical challenge. Influenza matrix protein 2 (M2) is a membrane protein of the viral envelope that forms a proton selective ion channel. Here we report the expression and native isolation of full length active M2 without mutations or fusions. The ability of the influenza virus to efficiently infect MDCK cells was used to express native M2 protein...
November 5, 2016: Protein Expression and Purification
Emmanuelle Ginoux, Diane Kottler, Bruno Anglaret, Brigitte Balme, Claude-Eric Bulabois, François Skowron
No abstract text is available yet for this article.
September 2016: JAAD Case Reports
Mona Sarfaty, Jennifer Kreslake, Gary Ewart, Tee L Guidotti, George D Thurston, John R Balmes, Edward W Maibach
The American Thoracic Society (ATS), in collaboration with George Mason University, surveyed international members of the society to assess perceptions, clinical experiences, and preferred policy responses related to global climate change. A recruitment email was sent by the ATS President in October 2015 to 5,013 international members. Subsequently, four reminder emails were sent to nonrespondents. Responses were received from 489 members in 68 countries; the response rate was 9.8%. Half of respondents reported working in countries in Asia (25%) or Europe (25%), with the remainder in South America (18%), North America (Canada and Mexico) (18%), Australia or New Zealand (9%), and Africa (6%)...
October 2016: Annals of the American Thoracic Society
Craig Steinmaus, Catterina Ferreccio, Johanna Acevedo, John R Balmes, Jane Liaw, Patricia Troncoso, David C Dauphiné, Anthony Nardone, Allan H Smith
BACKGROUND: Arsenic in drinking water has been associated with increases in lung disease, but information on the long-term impacts of early-life exposure or moderate exposure levels are limited. METHODS: We investigated pulmonary disease and lung function in 795 subjects from three socio-demographically similar areas in northern Chile: Antofagasta, which had a well-described period of high arsenic water concentrations (860μg/L) from 1958 to 1970; Iquique, which had long-term arsenic water concentrations near 60μg/L; and Arica, with long-term water concentrations ≤10μg/L...
December 15, 2016: Toxicology and Applied Pharmacology
Kristina Ramanauskiene, Raimondas Raudonis, Daiva Majiene
Lemon balm (Melissa officinalis L.) has many biological effects but especially important is its neuroprotective activity. The aim of the study is to produce different extracts of Melissa officinalis and analyse their chemical composition and biological properties on rat glioblastoma C6 cells. Results revealed that rosmarinic acid (RA) is the predominant compound of lemon balm extracts. RA has cytotoxic effect on glioblastoma cells (LC50 290.5 μM after the incubation of 24 h and LC50 171.3 μM after 48 h)...
2016: Oxidative Medicine and Cellular Longevity
Veena B Antony, Carrie A Redlich, Kent E Pinkerton, John Balmes, Jack R Harkema
The American Thoracic Society (ATS) celebrates the 50th anniversary of The National institute of Environmental Sciences (NIEHS). The NIEHS has had enormous impact through its focus on research, training and translational science on lung health. It has been an advocate for clean air both in the US and across the world. The cutting edge science funded by the NIEHS has lead to major discoveries that have broadened our understanding of the pathogenesis and treatment for lung disease. Importantly the NIEHS has developed and fostered mechanisms that require cross cutting science across the spectrum of areas of inquiry, bringing together environmental and social scientists with clinicians to bring their expertise on specific areas of investigation...
September 26, 2016: American Journal of Respiratory and Critical Care Medicine
K A Clark, S Ikram, R P Evershed
Mummification was practised in ancient Egypt for more than 3000 years, emerging from initial observations of buried bodies preserved by natural desiccation. The use of organic balms (and other funerary practices) was a later introduction necessitated by more humid burial environments, especially tombs. The dark colour of many mummies led to the assumption that petroleum bitumen (or natural asphalt) was ubiquitous in mummification; however, this has been questioned for more than 100 years. We test this by investigating 91 materials comprising balms, tissues and textiles from 39 mummies dating from ca 3200 BC to AD 395...
October 28, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
M de Ridder, C C M Marres, L E Smeele, M W M van den Brekel, M Hauptmann, A J M Balm, M L F van Velthuysen
In head and neck squamous cell carcinoma (HNSCC), the search for better prognostic factors beyond TNM-stage is ongoing. Lymph node ratio (LNR) (positive lymph nodes/total lymph nodes) is gaining interest in view of its potential prognostic significance. All HNSCC patients at the Netherlands Cancer Institute undergoing neck dissection for lymph node metastases in the neck region between 2002 and 2012 (n = 176) were included. Based on a protocol change in specimen processing, the cohort was subdivided in two distinct consecutive periods (pre and post 2007)...
December 2016: Virchows Archiv: An International Journal of Pathology
Sepide Miraj, Rafieian-Kopaei, Sara Kiani
Melissa officinalis is a plant cultivated in some parts of Iran. The leaves of lemon balm, Melissa officinalis L (Lamiaceae), are used in Iranian folk medicine for their digestive, carminative, antispasmodic, sedative, analgesic, tonic, and diuretic properties, as well as for functional gastrointestinal disorders. This review article was aimed not only to introduce Melissa officinalis (its growth condition, its chemical compounds, and its traditional usages) but also to overview its antioxidant properties in detail...
September 11, 2016: Journal of Evidence-based Complementary & Alternative Medicine
Narcisa Mandras, Antonia Nostro, Janira Roana, Daniela Scalas, Giuliana Banche, Valeria Ghisetti, Simonetta Del Re, Giacomo Fucale, Anna Maria Cuffini, Vivian Tullio
BACKGROUND: The management of Candida infections faces many problems, such as a limited number of antifungal drugs, toxicity, resistance of Candida to commonly antifungal drugs, relapse of Candida infections, and the high cost of antifungal drugs. Though azole antifungal agents and derivatives continue to dominate as drugs of choice against Candida infections, there are many available data referring to the anticandidal activity of essential oils. Since we have previous observed a good antimicrobial activity of some essential oils against filamentous fungi, the aim of this study was to extend the research to evaluate the activity of the same oils on Candida albicans, C...
2016: BMC Complementary and Alternative Medicine
R Indrakusuma, H Jalalzadeh, R N Planken, H A Marquering, D A Legemate, M J W Koelemay, R Balm
OBJECTIVES: Biomechanical characteristics, such as wall stress, are important in the pathogenesis of abdominal aortic aneurysms (AAA) and can be visualised and quantified using imaging techniques. This systematic review aims to present an overview of all biomechanical imaging markers that have been studied in relation to AAA growth and rupture. METHODS: This systematic review followed the PRISMA guidelines. A search in Medline, Embase, and the Cochrane Library identified 1503 potentially relevant articles...
October 2016: European Journal of Vascular and Endovascular Surgery
Sabyasachi Das, Yoichi Sutoh, Masayuki Hirano, Qifeng Han, Jianxu Li, Max D Cooper, Brantley R Herrin
BAFF (TNF superfamily [TNFSF] 13B/Blys) and APRIL (TNFSF13) are important regulatory factors for lymphocyte activation and survival in mammals. A BAFF/APRIL-like relative called BAFF- and APRIL-like molecule (BALM) has also been identified in cartilaginous and bony fishes, and we report in this study a BAFF-like gene in lampreys. Our phylogenetic analysis of these genes and a related TNFSF12 gene called TNF-like weak inducer of apoptosis (TWEAK) suggest that, whereas an ancestral homolog of BAFF and APRIL was already present in a common ancestor of jawed and jawless vertebrates, TWEAK evolved early on in the jawed vertebrate lineage...
October 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
Samira Najafi-Soulari, Hajar Shekarchizadeh, Mahdi Kadivar
Calcium alginate hydrogel beads were used to encapsulate lemon balm extract. Chitosan layer was used to investigate the effect of hydrogel coating. To determine the interactions of antioxidant compounds of extract with encapsulation materials and its stability, microstructure of hydrogel beads was thoroughly monitored using scanning electron microscopy and Fourier transform infrared (FTIR). Total polyphenols content and antiradical activity of lemon balm extract were also evaluated before and after encapsulation...
November 2016: Journal of Biomaterials Science. Polymer Edition
Kirk R Smith, Alistair Woodward, Bruno Lemke, Matthias Otto, Cindy J Chang, Anna A Mance, John Balmes, Tord Kjellstrom
No abstract text is available yet for this article.
August 13, 2016: Lancet
Tessa Buckle, Gijs H KleinJan, Thijs Engelen, Nynke S van den Berg, Marco C DeRuiter, Uulke van der Heide, Renato A Valdes Olmos, Andrew Webb, Mark A van Buchem, Alfons J Balm, Fijs W B van Leeuwen
PURPOSE: Even when guided by SPECT/CT planning of nodal resection in the head-and-neck area is challenging due to the many critical anatomical structures present within the surgical field. In this study the potential of a (SPECT/)MRI-based surgical planning method was explored. Hereby MRI increases the identification of SNs within clustered lymph nodes (LNs) and vital structures located adjacent to the SN (such as cranial nerve branches). METHOD AND PATIENTS: SPECT/CT and pathology reports from 100 head-and-neck melanoma and 40 oral cavity cancer patients were retrospectively assessed for SN locations in levels I-V and degree of nodal clustering...
September 2016: Oral Oncology
Almudena Pérez-Sánchez, Enrique Barrajón-Catalán, María Herranz-López, Julián Castillo, Vicente Micol
BACKGROUND: Solar ultraviolet (UV) radiation is one of the main causes of a variety of cutaneous disorders, including photoaging and skin cancer. Its UVB component (280-315nm) leads to oxidative stress and causes inflammation, DNA damage, p53 induction and lipid and protein oxidation. Recently, an increase in the use of plant polyphenols with antioxidant and anti-inflammatory properties has emerged to protect human skin against the deleterious effects of sunlight. OBJECTIVE: This study evaluates the protective effects of lemon balm extract (LBE) (Melissa Officinalis, L) and its main phenolic compound rosmarinic acid (RA) against UVB-induced damage in human keratinocytes...
November 2016: Journal of Dermatological Science
Sébastien Balme, Pierre Eugène Coulon, Mathilde Lepoitevin, Benoît Charlot, Naresh Yandrapalli, Cyril Favard, Delphine Muriaux, Mikhael Bechelany, Jean-Marc Janot
For the past 2 decades, emerging single-nanopore technologies have opened the route to multiple sensing applications. Besides DNA sensing, the identification of proteins and amyloids is a promising field for early diagnosis. However, the influence of the interactions between the nanopore surface and proteins should be taken into account. In this work, we have selected three proteins (avidin, lysozyme, and IgG) that exhibit different affinities with the SiNx surface, and we have also examined lysozyme amyloid...
September 6, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
James Mitchell, Katherine Baguley, Michelle Balm, Annemarei Anna Ranta
No abstract text is available yet for this article.
2016: New Zealand Medical Journal
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