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James W Behan, Adam Sutton, Ashley Wysong
Skin cancer is the most common of human cancers and outnumbers all other types of cancer combined in the USA by over threefold. The majority of non-melanoma skin cancers are easily treated with surgery or locally destructive techniques performed under local anesthesia in the cost-effective outpatient setting. However, there is a subset of "high-risk" cases that prove challenging in terms of morbidity, mortality, adjuvant treatment required, as well as overall cost to the health care system. In our opinion, the term "high risk" when applied to skin cancer can mean one of three things: a high-risk tumor with aggressive histologic and/or clinical features with an elevated risk for local recurrence or regional/distant metastasis, a high-risk patient with the ongoing development of multiple skin cancers, and a high-risk patient based on immunosuppression...
December 2016: Current Treatment Options in Oncology
Cameron Trodello, Jon-Paul Pepper, Michael Wong, Ashley Wysong
BACKGROUND: Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer and metastasizes in 2% to 5% of cases. OBJECTIVE: Systematic evaluation of published cases of metastatic cSCC (mSCC) treated with cisplatin or cetuximab from 1989 to 2014. MATERIALS AND METHODS: A literature search was performed to identify cases of mSCC treated with cisplatin or cetuximab. Patient demographics, tumor characteristics, response rates, and disease-free survivals were extracted...
September 9, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Justin J Leitenberger, Howard Rogers, John C Chapman, Ian A Maher, Matthew C Fox, Chris B Harmon, Evans C Bailey, Peter Odland, Ashley Wysong, Tim Johnson, Oliver J Wisco
BACKGROUND: Standardized definitions and methods of surveillance for local recurrence of nonmelanoma skin cancer are critical in determining cure rates attributed to treatment modalities. OBJECTIVE: We sought to offer a standard definition of local recurrence after surgical treatment of nonmelanoma skin cancer and to propose an acceptable surveillance period and tracking methods. METHODS: A literature search was performed for background definitions of local recurrence and tracking methods...
November 2016: Journal of the American Academy of Dermatology
Ashley Wysong, Brent R Taylor, Michael Graves, Vineet Mishra, Ryan Gilbertson, Hubert T Greenway, Leland Housman
BACKGROUND: Venous ulcers are very common with few curative treatment options. OBJECTIVE: To report the closure rate and clinical characteristics of active venous ulcers in a vein clinic using endovenous laser ablation (EVLA) with a 1,320-nm laser. METHODS AND MATERIALS: A prospective database was kept consisting of patients with an active venous ulcer at the time of consultation in a single-practitioner academic vein clinic from March 2007 to May 2014...
August 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Kristi Wysong, Jennan A Phillips, Stephanie Hammond
Chronic exposure to a broad array of antigens after workers inhale aerosolized organic dust particles from mold, animal dander, bird droppings, and chemicals, especially pesticides or herbicides, increases risk for hypersensitivity pneumonitis. Several demographic characteristics of immigrant workers in farming, poultry processing, construction, and landscaping increase this worker population's risk.
June 2016: Workplace Health & Safety
Daniel A Belkin, Ashley Wysong
Radiographic imaging is important for the full evaluation of high-risk cutaneous tumors. The correct modality should be chosen based on tumor subtype and clinical question. Locally advanced tumors may require imaging to evaluate the extent of disease, such as bony involvement, orbital infiltration, or perineural invasion. Tumors at high risk for regional and distant metastasis require imaging to identify local and distant tumor burden.
March 2016: Seminars in Cutaneous Medicine and Surgery
Wiggin W Lee, Wysong Ashley, Jonathan Cotliar, Jae Jung
No abstract text is available yet for this article.
January 2016: Journal of Geriatric Oncology
Adam Sutton, Ashley Crew, Ashley Wysong
No abstract text is available yet for this article.
March 2016: JAMA Dermatology
David S Kountz, Fadia T Shaya, Alan H Gradman, Gary A Puckrein, Michael H Kim, Jennifer Wilbanks, James G Stevenson, David L Larsen, Michael Wysong, Viktor Chirikov, Wayne T Pan, Liuo Xu
A multidimensional approach involving consideration of available resources, individual patient characteristics, patient preferences, and cost of treatment is often required to optimize clinical decision making in the management of atrial fibrillation (AF). In order to bring together varying perspectives on effective tactics and to formulate innovative strategies to improve the management of AF, a think tank consortium of advisors was assembled from across the spectrum of health care stakeholders. Focus groups were conducted and facilitated by a moderator and a notetaker...
November 2015: Journal of Managed Care & Specialty Pharmacy
Jessie R Wilburn, Jeffrey Bourquin, Andrea Wysong, Christopher L Melby
INTRODUCTION: Meals rich in both fructose and fat are commonly consumed by many Americans, especially young men, which can produce a significant postprandial lipemic response. Increasing evidence suggests that aerobic exercise can attenuate the postprandial increase in plasma triacylglycerols (TAGs) in response to a high-fat or a high-fructose meal. However, it is unknown if resistance exercise can dampen the postprandial lipemic response to a meal rich in both fructose and fat. METHODS: Eight apparently healthy men (Mean ± SEM; age = 27 ± 2 years) participated in a crossover study to examine the effects of acute resistance exercise on next-day postprandial lipemia resulting from a high-fructose, high-fat meal...
2015: Nutrition and Metabolic Insights
Jean Anderson, Megan Wysong, Deb Estep, Giulia Besana, Sharon Kibwana, John Varallo, Kai Sun, Enriquito Lu
BACKGROUND: HIV infection increases a woman's risk for cervical cancer, and cervical cancer incidence and mortality rates are higher in countries with high HIV prevalence and limited resources for screening. Visual inspection with acetic acid (VIA) allows screening and treatment of cervical lesions in a single-visit approach (SVA), but data on its performance in HIV-infected women are limited. This study's objective was to examine cervical cancer screening using VIA/SVA in programs serving HIV-infected women...
2015: PloS One
Adria E Navarro, Julia Wysong, Marguerite DeLiema, Elizabeth L Schwartz, Michael B Nichol, Kathleen H Wilber
OBJECTIVE: Preliminary evidence suggests that elder abuse forensic centers improve victim welfare by increasing necessary prosecutions and conservatorships and reducing the recurrence of protective service referrals. Center team members gather information and make decisions designed to protect clients and their assets, yet the collective process of how these case reviews are conducted remains unexamined. The purpose of this study is to present a model describing the interprofessional approach of investigation and response to financial exploitation (FE), a frequent and complex type of abuse of vulnerable adults...
August 2016: Gerontologist
Todd B Sells, Ryan Chau, Jeffrey A Ecsedy, Rachel E Gershman, Kara Hoar, Jessica Huck, David A Janowick, Vivek J Kadambi, Patrick J LeRoy, Matthew Stirling, Stephen G Stroud, Tricia J Vos, Gabriel S Weatherhead, Deborah R Wysong, Mengkun Zhang, Suresh K Balani, Joseph B Bolen, Mark G Manfredi, Christopher F Claiborne
The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, selective, orally bioavailable inhibitors of Aurora A that have advanced into human clinical trials. Alisertib (10) is currently being evaluated in multiple Phase II and III clinical trials in hematological malignancies and solid tumors.
June 11, 2015: ACS Medicinal Chemistry Letters
David T Woodley, Ashley Wysong, Brittany DeClerck, Mei Chen, Wei Li
Significance: The treatment and care of patients with skin wounds are a major healthcare expenditure. Burn wounds, iatrogenic surgical wounds, venous stasis dermatitis ulcers, diabetic lower limb ulcers, pressure ulcers, and skin wounds from peripheral neuropathies are largely treated with only supportive care. Despite a great deal of research into using growth factors as therapeutic agents, to date, the field has been disappointing. The only biologic agent that is Federal Drug Administration (FDA) approved for promoting skin wound healing is recombinant platelet-derived growth factor (PDGF-BB), but its modest efficacy and expense limit its use clinically...
April 1, 2015: Advances in Wound Care
David Kim, Latanya Benjamin, Ashley Wysong, David Hovsepian, Joyce Teng
Venolymphatic malformations (VLMs) are vascular anomalies consisting of both veins and lymph vessels. A 2-week-old newborn presented with large VLMs on the left forehead, temple, preauricular area, and orbit. Patient was at imminent risk for permanent vision loss due to a localized mass effect. Surgical excision or debulking was contraindicated due to its complexity and proximity to the left eye, and the patient failed to respond to the sildenafil treatment and sclerotherapy. Patient was subsequently started on oral sirolimus 0...
July 2015: Dermatologic Therapy
Jose Alejandro Rauh-Hain, Olivia Wysong Foley, Dina Winograd, Carolina Andrade, Rachel Marie Clark, Roberto Javier Vargas, Emily Moss Hinchcliff, Katherine McKinley Esselen, Neil Stuart Horowitz, Marcela Guadalupe del Carmen
OBJECTIVE: The purpose of this study was to compare clinical characteristics and survival between patients with stage I epithelial ovarian cancer and fallopian tube cancer. STUDY DESIGN: We identified women with stage I epithelial ovarian cancer and fallopian tube cancer who underwent treatment from 2000-2010. Correlation between categoric variables was assessed with χ2 test. The Kaplan-Meier survival analysis was used to generate overall survival data. Factors predictive of outcome were compared with the use of the log-rank test and Cox proportional hazards model...
May 2015: American Journal of Obstetrics and Gynecology
Ashley Wysong, Mina S Ally, Christina S Gamba, Manisha Desai, Susan M Swetter, Kristina Seiffert-Sinha, Animesh A Sinha, Marcia L Stefanick, Jean Y Tang
OBJECTIVE: Evidence for the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on non-melanoma skin cancer (NMSC) risk is inconsistent. We prospectively examined whether regular, inconsistent, or no/low-use of NSAIDs is associated with lower NMSC risk among 54,728 postmenopausal Caucasian women in the Women's Health Initiative Observational Study enrolled between 1993 and 1998. METHODS: Logistic regression models were used to assess odds of NMSC after adjusting for skin type, sun exposure history and indication for NSAID use...
December 2014: Preventive Medicine
Ashley Wysong, David Kim, Tim Joseph, Deborah F MacFarlane, Jean Y Tang, Hayes B Gladstone
BACKGROUND: Quantitative data on soft tissue aging of the face are scarce, particularly in men. OBJECTIVE: Magnetic resonance imaging (MRI) was used to quantify and compare facial soft tissue loss in men. MATERIALS AND METHODS: Two thousand thirty-seven MRIs were screened and 30 male subjects were divided into young, middle, and old-aged groups. A blinded radiologist measured temporal, infraorbital, and medial and lateral cheek areas. RESULTS: The mean thickness of the subcutaneous tissue in the temporal area was 12...
July 2014: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Bharathi Lingala, Shufeng Li, Ashley Wysong, Allison K Truong, David Kim, Anne Lynn S Chang
BACKGROUND: Asian-Americans represent the fastest growing minority group in the United States, but are under-represented patients in outpatient dermatology clinics. At the same time, skin cancer rates in individuals of Asian descent are increasing, but skin cancer detection appears to be delayed in Asian-Americans compared to white individuals. Some health-care provider related factors for this phenomenon have been reported in the literature, but the patient-related factors are unclear...
2014: BMC Dermatology
Mina Sarah Ally, Sumaira Aasi, Ashley Wysong, Claudia Teng, Eric Anderson, Irene Bailey-Healy, Anthony Oro, Jinah Kim, Anne Lynn Chang, Jean Yuh Tang
BACKGROUND: Vismodegib is an oral hedgehog-pathway inhibitor approved for advanced basal cell carcinoma (BCC). Although most BCCs are amenable to surgery, excision of large tumors in aesthetically sensitive sites may compromise function or cosmesis. OBJECTIVE: We sought to evaluate the reduction in BCC surgical defect area after 3 to 6 months of neoadjuvant vismodegib. METHODS: This was an open-label, single-arm intervention trial with a primary outcome of change in target-tumor surgical defect area pre- and post-vismodegib (150 mg/d)...
November 2014: Journal of the American Academy of Dermatology
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