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https://www.readbyqxmd.com/read/29057902/trpv4-activation-triggers-protective-responses-to-bacterial-lipopolysaccharides-in-airway-epithelial-cells
#1
Yeranddy A Alpizar, Brett Boonen, Alicia Sanchez, Carole Jung, Alejandro López-Requena, Robbe Naert, Brecht Steelant, Katrien Luyts, Cristina Plata, Vanessa De Vooght, Jeroen A J Vanoirbeek, Victor M Meseguer, Thomas Voets, Julio L Alvarez, Peter W Hellings, Peter H M Hoet, Benoit Nemery, Miguel A Valverde, Karel Talavera
Lipopolysaccharides (LPS), the major components of the wall of gram-negative bacteria, trigger powerful defensive responses in the airways via mechanisms thought to rely solely on the Toll-like receptor 4 (TLR4) immune pathway. Here we show that airway epithelial cells display an increase in intracellular Ca(2+) concentration within seconds of LPS application. This response occurs in a TLR4-independent manner, via activation of the transient receptor potential vanilloid 4 cation channel (TRPV4). We found that TRPV4 mediates immediate LPS-induced increases in ciliary beat frequency and the production of bactericidal nitric oxide...
October 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28971354/scientists-still-behaving-badly-a-survey-within-industry-and-universities
#2
Simon Godecharle, Steffen Fieuws, Ben Nemery, Kris Dierickx
Little is known about research misconduct within industry and how it compares to universities, even though a lot of biomedical research is performed by-or in collaboration with-commercial entities. Therefore, we sent an e-mail invitation to participate in an anonymous computer-based survey to all university researchers having received a biomedical research grant or scholarship from one of the two national academic research funders of Belgium between 2010 and 2014, and to researchers working in large biomedical companies or spin-offs in Belgium...
October 2, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28913604/differing-perceptions-concerning-research-integrity-between-universities-and-industry-a-qualitative-study
#3
Simon Godecharle, Benoit Nemery, Kris Dierickx
Despite the ever increasing collaboration between industry and universities, the previous empirical studies on research integrity and misconduct excluded participants of biomedical industry. Hence, there is a lack of empirical data on how research managers and biomedical researchers active in industry perceive the issues of research integrity and misconduct, and whether or not their perspectives differ from those of researchers and research managers active in universities. If various standards concerning research integrity and misconduct are upheld between industry and universities, this might undermine research collaborations...
September 14, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28780568/biomass-smoke-exposure-as-an-occupational-risk-cross-sectional-study-of-respiratory-health-of-women-working-as-street-cooks-in-nigeria
#4
Olayemi Fehintola Awopeju, Benoit Nemery, Olusegun Tope Afolabi, Katrien Poels, Jeroen Vanoirbeek, Daniel Osagbemworhue Obaseki, Olufemi Olanisun Adewole, Hervé Anicet Lawin, William Vollmer, Gregory Efosa Erhabor
OBJECTIVE: Little is known about respiratory health of women who are occupationally exposed to biomass smoke outside their homes. This study reports the exposure and respiratory health of street cooks in Ile-Ife, Nigeria. METHODS: We assessed exposure to biomass smoke by questionnaire in 188 street cooks and 197 control women and by personal diffusive samplers to quantify volatile organic compounds (VOCs) in a subsample of the women. Respiratory symptoms were assessed by a standardised questionnaire, and pulmonary function was assessed by spirometry before and after bronchodilation...
October 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28707458/metals-and-health-facts-and-myths
#5
Benoit Nemery
No abstract text is available yet for this article.
January 25, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28704401/il-13-is-a-central-mediator-of-chemical-induced-airway-hyperreactivity-in-mice
#6
Fien C Devos, Lore Pollaris, Jonathan Cremer, Sven Seys, Tomoaki Hoshino, Jan Ceuppens, Karel Talavera, Benoit Nemery, Peter H M Hoet, Jeroen A J Vanoirbeek
BACKGROUND: While the importance of the Th2 cytokine IL-13 as a central mediator of airway hyperreactivity (AHR) has been described in allergic protein-induced asthma, this has never been investigated in chemical-induced asthma. OBJECTIVE: We examined the importance of IL-13 in a mouse model of chemical-induced AHR, using toluene-2,4-diisocyanate (TDI). METHODS: In a first set-up, wild type (WT) and IL-13 knockout (KO) C57Bl/6 mice were dermally treated on days 1 and 8 with 1% TDI or vehicle (acetone/olive oil) on both ears...
2017: PloS One
https://www.readbyqxmd.com/read/28663320/quantifying-asbestos-in-lung-tissue-what-debate
#7
EDITORIAL
Benoit Nemery, Valerie Nuyts, Kristiaan Nackaerts
No abstract text is available yet for this article.
June 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28629359/forced-expiration-measurements-in-mouse-models-of-obstructive-and-restrictive-lung-diseases
#8
Fien C Devos, André Maaske, Annette Robichaud, Lore Pollaris, Sven Seys, Carolina Aznar Lopez, Erik Verbeken, Matthias Tenbusch, Rik Lories, Benoit Nemery, Peter Hm Hoet, Jeroen Aj Vanoirbeek
BACKGROUND: Pulmonary function measurements are important when studying respiratory disease models. Both resistance and compliance have been used to assess lung function in mice. Yet, it is not always clear how these parameters relate to forced expiration (FE)-related parameters, most commonly used in humans. We aimed to characterize FE measurements in four well-established mouse models of lung diseases. METHOD: Detailed respiratory mechanics and FE measurements were assessed concurrently in Balb/c mice, using the forced oscillation and negative pressure-driven forced expiration techniques, respectively...
June 19, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28623424/does-air-pollution-trigger-suicide-a-case-crossover-analysis-of-suicide-deaths-over-the-life-span
#9
Lidia Casas, Bianca Cox, Mariska Bauwelinck, Benoit Nemery, Patrick Deboosere, Tim Steve Nawrot
In addition to underlying health disorders and socio-economic or community factors, air pollution may trigger suicide mortality. This study evaluates the association between short-term variation in air pollution and 10 years of suicide mortality in Belgium. In a bidirectional time-stratified case-crossover design, 20,533 suicide deaths registered between January 1st 2002 and December 31st 2011 were matched by temperature with control days from the same month and year. We used municipality-level air pollution [particulate matter (PM10) and O3 concentrations] data and meteorology data...
November 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28388448/spatial-variation-and-risk-assessment-of-trace-metals-in-water-and-sediment-of-the-mekong-delta
#10
Emilie Strady, Quoc Tuc Dinh, Julien Némery, Thanh Nho Nguyen, Stéphane Guédron, Nhu Sang Nguyen, Hervé Denis, Phuoc Dan Nguyen
The Mekong Delta, is home to 17 million inhabitants and faces numerous challenges relating to climate change, environmental degradation and water issues. In this study, we assess trace metals concentrations (Al, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Mo, Cd, Hg, Pb) in the water, suspended particulate matter and surface sediments of the Tien River, the Northern branch of the Mekong Delta, during both dry and rainy seasons. Metal concentrations in the dissolved and suspended particle phases remain in the low concentration range of the main Asian Tropical River...
July 2017: Chemosphere
https://www.readbyqxmd.com/read/27836956/an-association-of-particulate-air-pollution-and-traffic-exposure-with-mortality-after-lung-transplantation-in-europe
#11
David Ruttens, Stijn E Verleden, Esmée M Bijnens, Ellen Winckelmans, Jens Gottlieb, Gregor Warnecke, Federica Meloni, Monica Morosini, Wim Van Der Bij, Erik A Verschuuren, Urte Sommerwerck, Gerhard Weinreich, Markus Kamler, Antonio Roman, Susana Gomez-Olles, Cristina Berastegui, Christian Benden, Are Martin Holm, Martin Iversen, Hans Henrik Schultz, Bart Luijk, Erik-Jan Oudijk, Johanna M Kwakkel-van Erp, Peter Jaksch, Walter Klepetko, Nikolaus Kneidinger, Claus Neurohr, Paul Corris, Andrew J Fisher, James Lordan, Gerard Meachery, Davide Piloni, Elly Vandermeulen, Hannelore Bellon, Barbara Hoffmann, Danielle Vienneau, Gerard Hoek, Kees de Hoogh, Benoit Nemery, Geert M Verleden, Robin Vos, Tim S Nawrot, Bart M Vanaudenaerde
Air pollution from road traffic is a serious health risk, especially for susceptible individuals. Single-centre studies showed an association with chronic lung allograft dysfunction (CLAD) and survival after lung transplantation, but there are no large studies.13 lung transplant centres in 10 European countries created a cohort of 5707 patients. For each patient, we quantified residential particulate matter with aerodynamic diameter ≤10 µm (PM10) by land use regression models, and the traffic exposure by quantifying total road length within buffer zones around the home addresses of patients and distance to a major road or freeway...
January 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27726086/baseline-seasonal-investigation-of-nutrients-and-trace-metals-in-surface-waters-and-sediments-along-the-saigon-river-basin-impacted-by-the-megacity-of-ho-chi-minh-vietnam
#12
Emilie Strady, Vu Bich Hanh Dang, Julien Némery, Stéphane Guédron, Quoc Tuc Dinh, Hervé Denis, Phuoc Dan Nguyen
The Saigon River, Southern Vietnam, crosses one of the most dynamic developing Megacity in Southeast Asia: Ho Chi Minh City (HCMC). The increased economic, industrial, and domestic developments may affect the environmental quality of water and halieutic resources. In this study, we evaluated the seasonal (dry and wet seasons) biogeochemical state of the Saigon River during two snapshot campaigns conducted along the river basin upstream from HCMC; the Saigon River was characterized by slightly acidic (pH 5.7-7...
February 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27562651/assessment-of-personality-related-levels-of-functioning-a-pilot-study-of-clinical-assessment-of-the-dsm-5-level-of-personality-functioning-based-on-a-semi-structured-interview
#13
Birgitte Thylstrup, Sebastian Simonsen, Caroline Nemery, Erik Simonsen, Jane Fjernestad Noll, Mikkel Wanting Myatt, Morten Hesse
BACKGROUND: The personality disorder categories in the Diagnostic and Statistical Manual of Mental Disorders IV have been extensively criticized, and there is a growing consensus that personality pathology should be represented dimensionally rather than categorically. The aim of this pilot study was to test the Clinical Assessment of the Level of Personality Functioning Scale, a semi-structured clinical interview, designed to assess the Level of Personality Functioning Scale of the DSM-5 (Section III) by applying strategies similar to what characterizes assessments in clinical practice...
August 25, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27550908/asbestos-bodies-in-bronchoalveolar-lavage-in-the-21st-century-a-time-trend-analysis-in-a-clinical-population
#14
Valerie Nuyts, Hadewijch Vanhooren, Sarah Begyn, Kristiaan Nackaerts, Benoit Nemery
OBJECTIVES: Asbestos bodies (AB) in bronchoalveolar lavage (BAL) can be detected by light microscopy and their concentration is indicative of past cumulative asbestos exposure. We assessed clinical and exposure characteristics, as well as possible time trends, among patients in whom AB had been quantified in BAL. METHODS: BAL samples obtained from 578 participants between January 1997 and December 2014 were available for analysis. The processing of samples and the microscopic analysis were performed by a single expert and 76% of samples came from a single tertiary care hospital, allowing clinical and exposure data to be extracted from patient files...
January 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27346740/respiratory-medication-sales-and-urban-air-pollution-in-brussels-2005-to-2011
#15
Lidia Casas, Koen Simons, Tim S Nawrot, Olivier Brasseur, Priscilla Declerck, Ronald Buyl, Danny Coomans, Benoit Nemery, An Van Nieuwenhuyse
BACKGROUND: We investigated the associations between daily sales of respiratory medication and air pollutants in the Brussels-Capital Region between 2005 and 2011. METHODS: We used over-dispersed Poisson Generalized Linear Models to regress daily individual reimbursement data of prescribed asthma and COPD medication from the social security database against each subject's residential exposure to outdoor particulate matter (PM10) or NO2 estimated, by interpolation from monitoring stations...
September 2016: Environment International
https://www.readbyqxmd.com/read/27345299/nociceptive-and-sympathetic-innervations-in-the-abaxial-part-of-the-cranial-horn-of-the-equine-medial-meniscus-an-immunohistochemical-approach
#16
Elodie Nemery, Annick Gabriel, Joëlle Piret, Nadine Antoine
In athletic horses, diseases leading to lameness are of great importance due to the loss of performance and the resultant economic concerns. Although stifle lesions are frequent in the hindlimb, due to the large size and complexity of the joint, and although meniscal tears have been identified as the most common soft tissue injuries in this joint, little is known about the mechanism that causes the painful sensation and thus the lameness. The aim of our study was to highlight any peripheral fibres involved in meniscal nociception in five macroscopically sound cranial horns of the equine medial meniscus, which has been one of the most common sites reported for equine meniscal injuries...
December 2016: Journal of Anatomy
https://www.readbyqxmd.com/read/27167124/health-impact-assessment-of-a-predicted-air-quality-change-by-moving-traffic-from-an-urban-ring-road-into-a-tunnel-the-case-of-antwerp-belgium
#17
Daan Van Brusselen, Wouter Arrazola de Oñate, Bino Maiheu, Stijn Vranckx, Wouter Lefebvre, Stijn Janssen, Tim S Nawrot, Ben Nemery, Dirk Avonts
BACKGROUND: The Antwerp ring road has a traffic density of 300,000 vehicles per day and borders the city center. The 'Ringland project' aims to change the current 'open air ring road' into a 'filtered tunneled ring road', putting the entire urban ring road into a tunnel and thus filtering air pollution. We conducted a health impact assessment (HIA) to quantify the possible benefit of a 'filtered tunneled ring road', as compared to the 'open air ring road' scenario, on air quality and its long-term health effects...
2016: PloS One
https://www.readbyqxmd.com/read/27126687/neuro-immune-interactions-in-chemical-induced-airway-hyperreactivity
#18
Fien C Devos, Brett Boonen, Yeranddy A Alpizar, Tania Maes, Valérie Hox, Sven Seys, Lore Pollaris, Adrian Liston, Benoit Nemery, Karel Talavera, Peter H M Hoet, Jeroen A J Vanoirbeek
Asthma may be induced by chemical sensitisers, via mechanisms that are still poorly understood. This type of asthma is characterised by airway hyperreactivity (AHR) and little airway inflammation. Since potent chemical sensitisers, such as toluene-2,4-diisocyanate (TDI), are also sensory irritants, it is suggested that chemical-induced asthma relies on neuro-immune mechanisms.We investigated the involvement of transient receptor potential channels (TRP) A1 and V1, major chemosensors in the airways, and mast cells, known for their ability to communicate with sensory nerves, in chemical-induced AHR...
August 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27088280/microtia-in-cornelia-de-lange-syndrome-a-case-from-democratic-republic-of-the-congo
#19
Tony Kayembe Kitenge, Toni Kasole Lubala, Sebastien Mbuyi-Musanzayi, Leon Kabamba Ngombe, Cyrille Katshiez Nawej, Paul Musa Obadia, Celestin Banza Lubaba Nkulu, Benoit Nemery, Koenraad Devriendt
No abstract text is available yet for this article.
October 2016: Clinical Dysmorphology
https://www.readbyqxmd.com/read/27085497/short-term-health-effects-in-the-general-population-following-a-major-train-accident-with-acrylonitrile-in-belgium
#20
K Simons, T De Smedt, C Stove, P De Paepe, M Bader, B Nemery, C Vleminckx, K De Cremer, I Van Overmeire, S Fierens, B Mertens, T Göen, T Schettgen, H Van Oyen, J Van Loco, A Van Nieuwenhuyse
BACKGROUND: Following a train derailment, several tons of acrylonitrile (ACN) exploded, inflamed and part of the ACN ended up in the sewage system of the village of Wetteren. More than 2000 residents living in the close vicinity of the accident and along the sewage system were evacuated. A human biomonitoring study of the adduct N-2-cyanoethylvaline (CEV) was carried out days 14-21 after the accident. OBJECTIVES: (1) To describe the short-term health effects that were reported by the evacuated residents following the train accident, and (2) to explore the association between the CEV concentrations, extrapolated at the time of the accident, and the self-reported short-term health effects...
July 2016: Environmental Research
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