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https://www.readbyqxmd.com/read/29628163/protecting-children-s-lungs-by-providing-clean-air-during-pregnancy
#1
Benoit Nemery, Patrick de Marie Katoto
No abstract text is available yet for this article.
November 2017: Lancet. Planetary Health
https://www.readbyqxmd.com/read/29608882/diagnostic-ability-of-a-dynamic-multidisciplinary-discussion-in-interstitial-lung-diseases-a-retrospective-observational-study-of-938-cases
#2
Laurens J De Sadeleer, Caressa Meert, Jonas Yserbyt, Hans Slabbynck, Johny A Verschakelen, Eric K Verbeken, Birgit Weynand, Ellen De Langhe, Jan L Lenaerts, Benoit Nemery, Dirk Van Raemdonck, Geert M Verleden, Athol U Wells, Wim A Wuyts
BACKGROUND: The advice of a dynamic multidisciplinary discussion (MDD) is believed to be important in the diagnosis of interstitial lung diseases (ILD). However, to what extent MDD diagnoses differ from the preliminary diagnoses before formal work-up and MDD (preMDD diagnoses), is still insufficiently studied. METHODS: We compared preMDD and MDD diagnoses in patients discussed at the Leuven University Hospitals MDD between January 2005 and December 2015. RESULTS: Of 938 consecutive patients discussed in MDD, 755 (80...
March 30, 2018: Chest
https://www.readbyqxmd.com/read/29574377/atmospheric-nitrate-export-in-streams-along-a-montane-to-urban-gradient
#3
Ilann Bourgeois, Joel Savarino, Julien Némery, Nicolas Caillon, Sarah Albertin, Franck Delbart, Didier Voisin, Jean-Christophe Clément
Nitrogen (N) emissions associated with urbanization exacerbate the atmospheric N influx to remote ecosystems - like mountains -, leading to well-documented detrimental effects on ecosystems (e.g., soil acidification, pollution of freshwaters). Here, the importance and fate of N deposition in a watershed was evaluated along a montane to urban gradient, using a multi-isotopic tracers approach (Δ17 O, δ15 N, δ18 O of nitrate, δ2 H and δ18 O of water). In this setting, the montane streams had higher proportions of atmospheric nitrate compared to urban streams, and exported more atmospheric nitrate on a yearly basis (0...
March 22, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29540230/carbon-load-in-airway-macrophages-as-a-biomarker-of-exposure-to-particulate-air-pollution-a-longitudinal-study-of-an-international-panel
#4
Yang Bai, Hannelore Bové, Tim S Nawrot, Benoit Nemery
BACKGROUND: Carbon load in airway macrophages (AM) has been proposed as an internal marker to assess long-term exposure to combustion-derived pollutant particles. However, it is not known how this biomarker is affected by changes in exposure. We studied the clearance kinetics of black carbon (BC) in AM, obtained by sputum induction, in a one-year panel study. METHODS: AM BC was measured 8 times with 6 weeks intervals in healthy young subjects: 15 long-term residents in Leuven, Belgium (BE, mean annual PM10 20-30 μg/m3 ) and 30 newcomers having arrived recently (< 3 weeks) in Leuven from highly polluted cities (mean annual PM10  > 50 μg/m3 ) in low and middle-income countries (LMIC, n = 15), or from low to moderately polluted cities in high-income countries (HIC, n = 15)...
March 14, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29476353/high-prevalence-of-occupational-exposure-to-solvents-or-silica-in-male-systemic-sclerosis-patients-a-belgian-cohort-analysis
#5
Evelien De Decker, Marie Vanthuyne, Daniel Blockmans, Frederic Houssiau, Jan Lenaerts, Rene Westhovens, Benoit Nemery, Ellen De Langhe
Increasing evidence supports a relation of some occupational exposures to systemic sclerosis pathogenesis. We aimed to evaluate occupational exposure and clinical characteristics in male patients with systemic sclerosis followed in two Belgian academic hospitals. One hundred and three male patients, included in the Belgian Systemic Sclerosis Cohort, were identified. An expert in occupational medicine reviewed the occupational history and allocated the patients to one of the following groups: probable exposure to crystalline silica, probable exposure to solvents, probable exposure to other toxins, or no suspected occupational exposure...
February 23, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29455390/utility-of-multiple-rule-out-ct-screening-of-high-risk-atraumatic-patients-in-an-emergency-department-a-feasibility-study
#6
Mia M Pries-Heje, Rasmus B Hasselbalch, Henriette Raaschou, Bijan Rezanavaz-Gheshlagh, Hanne Heebøll, Shazia Rehman, Mariana Kristensen, Erik Henning Andersen, Lisbet Ravn, Michel C Nèmery, Morten N Lind, Thomas Boel, Peter Sommer Ulriksen, Kasper K Iversen
BACKGROUND: Several large trials have evaluated the effect of CT screening based on specific symptoms, with varying outcomes. Screening of patients with CT based on their prognosis alone has not been examined before. For moderate-to-high risk patients presenting in the emergency department (ED), the potential gain from a CT scan might outweigh the risk of radiation exposure. We hypothesized that an accelerated "multiple rule out" CT screening of moderate-to-high risk patients will detect many clinically unrecognized diagnoses that affect change in treatment...
February 17, 2018: Emergency Radiology
https://www.readbyqxmd.com/read/29450770/how-can-water-quality-be-improved-when-the-urban-waste-water-directive-has-been-fulfilled-a-case-study-of-the-lot-river-france
#7
Josette Garnier, Antsiva Ramarson, Vincent Thieu, Julien Némery, Sylvain Théry, Gilles Billen, Alexandra Coynel
The Lot river, a major tributary of the downstream Garonne river, the largest river on the Northern side of the Pyrenees Mountains, was intensively studied in the 1970s. A pioneering program called "Lot Rivière Claire" provided a diagnosis of water quality at the scale of the whole watershed and proposed an ambitious program to manage nutrient pollution and eutrophication largely caused by urban wastewater releases. Later on, the implementation of European directives from 1991 to 2000 resulted in the nearly complete treatment of point sources of pollution in spite of a doubling of the basin's population...
February 15, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29368146/irritant-induced-asthma-to-hypochlorite-in-mice-due-to-impairment-of-the-airway-barrier
#8
Sofie Van Den Broucke, Lore Pollaris, Greetje Vande Velde, Erik Verbeken, Benoit Nemery, Jeroen Vanoirbeek, Peter Hoet
Inhalation of commonly present irritants, such as chlorine and chlorine derivatives, can cause adverse respiratory effects, including irritant-induced asthma (IIA). We hypothesize that due to airway barrier impairment, exposure to hypochlorite (ClO-) can result in airway hypersensitivity. C57Bl/6 mice received an intra-peritoneal (i.p.) injection of the airway damaging agent naphthalene (NA, 200 mg/kg body weight) or vehicle (mineral oil, MO). In vivo micro-computed tomography (CT) images of the lungs were acquired before and at regular time points after the i...
January 24, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29057902/trpv4-activation-triggers-protective-responses-to-bacterial-lipopolysaccharides-in-airway-epithelial-cells
#9
Yeranddy A Alpizar, Brett Boonen, Alicia Sanchez, Carole Jung, Alejandro López-Requena, Robbe Naert, Brecht Steelant, Katrien Luyts, Cristina Plata, Vanessa De Vooght, Jeroen A J Vanoirbeek, Victor M Meseguer, Thomas Voets, Julio L Alvarez, Peter W Hellings, Peter H M Hoet, Benoit Nemery, Miguel A Valverde, Karel Talavera
Lipopolysaccharides (LPS), the major components of the wall of gram-negative bacteria, trigger powerful defensive responses in the airways via mechanisms thought to rely solely on the Toll-like receptor 4 (TLR4) immune pathway. Here we show that airway epithelial cells display an increase in intracellular Ca2+ concentration within seconds of LPS application. This response occurs in a TLR4-independent manner, via activation of the transient receptor potential vanilloid 4 cation channel (TRPV4). We found that TRPV4 mediates immediate LPS-induced increases in ciliary beat frequency and the production of bactericidal nitric oxide...
October 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28971354/scientists-still-behaving-badly-a-survey-within-industry-and-universities
#10
Simon Godecharle, Steffen Fieuws, Ben Nemery, Kris Dierickx
Little is known about research misconduct within industry and how it compares to universities, even though a lot of biomedical research is performed by-or in collaboration with-commercial entities. Therefore, we sent an e-mail invitation to participate in an anonymous computer-based survey to all university researchers having received a biomedical research grant or scholarship from one of the two national academic research funders of Belgium between 2010 and 2014, and to researchers working in large biomedical companies or spin-offs in Belgium...
October 2, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28913604/differing-perceptions-concerning-research-integrity-between-universities-and-industry-a-qualitative-study
#11
Simon Godecharle, Benoit Nemery, Kris Dierickx
Despite the ever increasing collaboration between industry and universities, the previous empirical studies on research integrity and misconduct excluded participants of biomedical industry. Hence, there is a lack of empirical data on how research managers and biomedical researchers active in industry perceive the issues of research integrity and misconduct, and whether or not their perspectives differ from those of researchers and research managers active in universities. If various standards concerning research integrity and misconduct are upheld between industry and universities, this might undermine research collaborations...
September 14, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28780568/biomass-smoke-exposure-as-an-occupational-risk-cross-sectional-study-of-respiratory-health-of-women-working-as-street-cooks-in-nigeria
#12
Olayemi Fehintola Awopeju, Benoit Nemery, Olusegun Tope Afolabi, Katrien Poels, Jeroen Vanoirbeek, Daniel Osagbemworhue Obaseki, Olufemi Olanisun Adewole, Hervé Anicet Lawin, William Vollmer, Gregory Efosa Erhabor
OBJECTIVE: Little is known about respiratory health of women who are occupationally exposed to biomass smoke outside their homes. This study reports the exposure and respiratory health of street cooks in Ile-Ife, Nigeria. METHODS: We assessed exposure to biomass smoke by questionnaire in 188 street cooks and 197 control women and by personal diffusive samplers to quantify volatile organic compounds (VOCs) in a subsample of the women. Respiratory symptoms were assessed by a standardised questionnaire, and pulmonary function was assessed by spirometry before and after bronchodilation...
October 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28707458/metals-and-health-facts-and-myths
#13
Benoit Nemery
No abstract text is available yet for this article.
January 25, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28704401/il-13-is-a-central-mediator-of-chemical-induced-airway-hyperreactivity-in-mice
#14
Fien C Devos, Lore Pollaris, Jonathan Cremer, Sven Seys, Tomoaki Hoshino, Jan Ceuppens, Karel Talavera, Benoit Nemery, Peter H M Hoet, Jeroen A J Vanoirbeek
BACKGROUND: While the importance of the Th2 cytokine IL-13 as a central mediator of airway hyperreactivity (AHR) has been described in allergic protein-induced asthma, this has never been investigated in chemical-induced asthma. OBJECTIVE: We examined the importance of IL-13 in a mouse model of chemical-induced AHR, using toluene-2,4-diisocyanate (TDI). METHODS: In a first set-up, wild type (WT) and IL-13 knockout (KO) C57Bl/6 mice were dermally treated on days 1 and 8 with 1% TDI or vehicle (acetone/olive oil) on both ears...
2017: PloS One
https://www.readbyqxmd.com/read/28663320/quantifying-asbestos-in-lung-tissue-what-debate
#15
EDITORIAL
Benoit Nemery, Valerie Nuyts, Kristiaan Nackaerts
No abstract text is available yet for this article.
June 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28629359/forced-expiration-measurements-in-mouse-models-of-obstructive-and-restrictive-lung-diseases
#16
Fien C Devos, André Maaske, Annette Robichaud, Lore Pollaris, Sven Seys, Carolina Aznar Lopez, Erik Verbeken, Matthias Tenbusch, Rik Lories, Benoit Nemery, Peter Hm Hoet, Jeroen Aj Vanoirbeek
BACKGROUND: Pulmonary function measurements are important when studying respiratory disease models. Both resistance and compliance have been used to assess lung function in mice. Yet, it is not always clear how these parameters relate to forced expiration (FE)-related parameters, most commonly used in humans. We aimed to characterize FE measurements in four well-established mouse models of lung diseases. METHOD: Detailed respiratory mechanics and FE measurements were assessed concurrently in Balb/c mice, using the forced oscillation and negative pressure-driven forced expiration techniques, respectively...
June 19, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28623424/does-air-pollution-trigger-suicide-a-case-crossover-analysis-of-suicide-deaths-over-the-life-span
#17
Lidia Casas, Bianca Cox, Mariska Bauwelinck, Benoit Nemery, Patrick Deboosere, Tim Steve Nawrot
In addition to underlying health disorders and socio-economic or community factors, air pollution may trigger suicide mortality. This study evaluates the association between short-term variation in air pollution and 10 years of suicide mortality in Belgium. In a bidirectional time-stratified case-crossover design, 20,533 suicide deaths registered between January 1st 2002 and December 31st 2011 were matched by temperature with control days from the same month and year. We used municipality-level air pollution [particulate matter (PM10) and O3 concentrations] data and meteorology data...
November 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28388448/spatial-variation-and-risk-assessment-of-trace-metals-in-water-and-sediment-of-the-mekong-delta
#18
Emilie Strady, Quoc Tuc Dinh, Julien Némery, Thanh Nho Nguyen, Stéphane Guédron, Nhu Sang Nguyen, Hervé Denis, Phuoc Dan Nguyen
The Mekong Delta, is home to 17 million inhabitants and faces numerous challenges relating to climate change, environmental degradation and water issues. In this study, we assess trace metals concentrations (Al, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Mo, Cd, Hg, Pb) in the water, suspended particulate matter and surface sediments of the Tien River, the Northern branch of the Mekong Delta, during both dry and rainy seasons. Metal concentrations in the dissolved and suspended particle phases remain in the low concentration range of the main Asian Tropical River...
July 2017: Chemosphere
https://www.readbyqxmd.com/read/27836956/an-association-of-particulate-air-pollution-and-traffic-exposure-with-mortality-after-lung-transplantation-in-europe
#19
David Ruttens, Stijn E Verleden, Esmée M Bijnens, Ellen Winckelmans, Jens Gottlieb, Gregor Warnecke, Federica Meloni, Monica Morosini, Wim Van Der Bij, Erik A Verschuuren, Urte Sommerwerck, Gerhard Weinreich, Markus Kamler, Antonio Roman, Susana Gomez-Olles, Cristina Berastegui, Christian Benden, Are Martin Holm, Martin Iversen, Hans Henrik Schultz, Bart Luijk, Erik-Jan Oudijk, Johanna M Kwakkel-van Erp, Peter Jaksch, Walter Klepetko, Nikolaus Kneidinger, Claus Neurohr, Paul Corris, Andrew J Fisher, James Lordan, Gerard Meachery, Davide Piloni, Elly Vandermeulen, Hannelore Bellon, Barbara Hoffmann, Danielle Vienneau, Gerard Hoek, Kees de Hoogh, Benoit Nemery, Geert M Verleden, Robin Vos, Tim S Nawrot, Bart M Vanaudenaerde
Air pollution from road traffic is a serious health risk, especially for susceptible individuals. Single-centre studies showed an association with chronic lung allograft dysfunction (CLAD) and survival after lung transplantation, but there are no large studies.13 lung transplant centres in 10 European countries created a cohort of 5707 patients. For each patient, we quantified residential particulate matter with aerodynamic diameter ≤10 µm (PM10) by land use regression models, and the traffic exposure by quantifying total road length within buffer zones around the home addresses of patients and distance to a major road or freeway...
January 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27726086/baseline-seasonal-investigation-of-nutrients-and-trace-metals-in-surface-waters-and-sediments-along-the-saigon-river-basin-impacted-by-the-megacity-of-ho-chi-minh-vietnam
#20
Emilie Strady, Vu Bich Hanh Dang, Julien Némery, Stéphane Guédron, Quoc Tuc Dinh, Hervé Denis, Phuoc Dan Nguyen
The Saigon River, Southern Vietnam, crosses one of the most dynamic developing Megacity in Southeast Asia: Ho Chi Minh City (HCMC). The increased economic, industrial, and domestic developments may affect the environmental quality of water and halieutic resources. In this study, we evaluated the seasonal (dry and wet seasons) biogeochemical state of the Saigon River during two snapshot campaigns conducted along the river basin upstream from HCMC; the Saigon River was characterized by slightly acidic (pH 5.7-7...
February 2017: Environmental Science and Pollution Research International
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