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https://www.readbyqxmd.com/read/28538663/the-cytokine-flt3-ligand-in-normal-and-malignant-hematopoiesis
#1
REVIEW
Panagiotis Tsapogas, Ciaran James Mooney, Geoffrey Brown, Antonius Rolink
The cytokine Fms-like tyrosine kinase 3 ligand (FL) is an important regulator of hematopoiesis. Its receptor, Flt3, is expressed on myeloid, lymphoid and dendritic cell progenitors and is considered an important growth and differentiation factor for several hematopoietic lineages. Activating mutations of Flt3 are frequently found in acute myeloid leukemia (AML) patients and associated with a poor clinical prognosis. In the present review we provide an overview of our current knowledge on the role of FL in the generation of blood cell lineages...
May 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28538456/social-to-moderate-alcohol-consumption-provides-a-protective-effect-for-functional-outcomes-after-fixation-of-orthopaedic-fractures
#2
Hesham Saleh, Adam Driesman, Nina Fisher, Philipp Leucht, Sanjit Konda, Kenneth Egol
OBJECTIVES: To identify the association between social and moderate alcohol consumption and functional outcomes after surgical management of orthopaedic fractures. DESIGN: Prospective cohort study. SETTING: Level 1 trauma center. PATIENTS/PARTICIPANTS: Seven hundred eighty-four patients who were operatively treated for an isolated orthopaedic fracture were prospectively followed. Patients were categorized into groups according to self-reported drinking frequencies based on NIAAA guidelines...
June 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28538453/does-concurrent-tibial-intramedullary-nailing-and-fibular-fixation-increase-rates-of-tibial-nonunion-a-matched-cohort-study
#3
Michael Githens, Justin Haller, Julie Agel, Reza Firoozabadi
OBJECTIVES: To determine if there is a difference in rates of tibial nonunion in patients undergoing tibial intramedullary (IM) nailing and fibular fixation as compared to a matched cohort undergoing tibial IM nailing alone. DESIGN: Retrospective matched cohort study. SETTING: Single Level 1 academic trauma center. PATIENTS: Consecutive patients 18 years and older with a tibia and fibula fracture treated with tibial IM nailing and fibular fixation who were determined radiographically and clinically healed or had a minimum 1-year follow-up were included...
June 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28538288/the-trajectory-of-short-and-long-term-recovery-of-tibial-shaft-fractures-following-intramedullary-nail-fixation
#4
Sebastian J Ko, Peter J O'Brien, Pierre Guy, Henry M Broekhuyse, Piotr A Blachut, Kelly A Lefaivre
OBJECTIVE: To determine the trajectory of recovery following tibial shaft fracture treated with intramedullary nail over the first five years, and to evaluate the magnitude of the changes in functional outcome at various time intervals. DESIGN: Prospective cohort study. SETTING: A level 1 trauma center. PATIENTS/PARTICIPANTS: 132 patients with tibial shaft fracture (OTA 42-A,B,C) were enrolled into the Center's prospectively enrolled orthopaedic trauma database between January 2005 and February 2010...
May 17, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28538286/any-cortical-bridging-predicts-healing-of-supracondylar-femur-fractures-after-treatment-with-locked-plating
#5
Patrick K Strotman, Madhav A Karunakar, Rachel Seymour, William D Lack
OBJECTIVES: To determine the accuracy and reliability of radiographic cortical bridging criteria in predicting the final healing of supracondylar femur fractures after treatment with locked plating. DESIGN: Retrospective review SETTING:: Two level 1 trauma centers PATIENTS/PARTICIPANTS:: We retrospectively reviewed the records at two level 1 trauma centers for patients who presented with supracondylar femur fractures (AO/OTA 33A, C) and were treated with locking plate fixation between 1/1/2004 and 1/1/2011...
May 17, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28537863/severe-pellagra-masked-by-concurrent-plaque-psoriasis-a-case-report-of-a-hidden-diagnosis
#6
Elizabeth A Wang, Jason Kao, Michelle Y Cheng, Chelsea Ma, Soneet Dhillon, Thomas Konia, Emanual Maverakis, Cindy J Chambers
Despite characteristic features, psoriasis can mimic other dermatologic conditions, such as seborrheic dermatitis, lichen simplex chronicus, and certain nutritional deficiencies such as pellagra. We present a patient with a longstanding history of severe plaque psoriasis who presented with disfiguring scaly plaques involving greater than 80% body surface area. The patient's disease was minimally responsive to multiple therapies. Repeat punch biopsies demonstrated parakeratosis, psoriasiform hyperplasia, and dilated blood vessels consistent with psoriasis...
May 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28535104/measuring-the-value-of-new-drugs-validity-and-reliability-of-4-value-assessment-frameworks-in-the-oncology-setting
#7
Tanya G K Bentley, Joshua T Cohen, Elena B Elkin, Julie Huynh, Arnab Mukherjea, Thanh H Neville, Matthew Mei, Ronda Copher, Russell Knoth, Ioana Popescu, Jackie Lee, Jenelle M Zambrano, Michael S Broder
BACKGROUND: Several organizations have developed frameworks to systematically assess the value of new drugs. OBJECTIVE: To evaluate the convergent validity and interrater reliability of 4 value frameworks to understand the extent to which these tools can facilitate value-based treatment decisions in oncology. METHODS: Eight panelists used the American Society of Clinical Oncology (ASCO), European Society for Medical Oncology (ESMO), Institute for Clinical and Economic Review (ICER), and National Comprehensive Cancer Network (NCCN) frameworks to conduct value assessments of 15 drugs for advanced lung and breast cancers and castration-refractory prostate cancer...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28534685/biotin-interference-with-routine-clinical-immunoassays-understand-the-causes-and-mitigate-the-risks
#8
Shanika Samarasinghe, Farah Meah, Vinita Singh, Arshi Basit, Nicholas Emanuele, Mary Ann Emanuele, Alaleh Mazhari, Earle W Holmes
OBJECTIVES: The objectives of this report are to review the mechanisms of biotin interference with streptavidin/biotin-based immunoassays, identify automated immunoassay systems vulnerable to biotin interference, describe how to estimate and minimize the risk of biotin interference in vulnerable assays, and review the literature pertaining to biotin interference in endocrine function tests. METHODS: The data in the manufacturer's "Instructions for Use" for each of the methods utilized by seven immunoassay system were evaluated...
May 23, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28532203/evaluation-in-undergraduate-medical-education-conceptualizing-and-validating-a-novel-questionnaire-for-assessing-the-quality-of-bedside-teaching
#9
Katharina Dreiling, Diego Montano, Herbert Poinstingl, Tjark Müller, Sarah Schiekirka-Schwake, Sven Anders, Nicole von Steinbüchel, Tobias Raupach
BACKGROUND: Evaluation is an integral part of curriculum development in medical education. Given the peculiarities of bedside teaching, specific evaluation tools for this instructional format are needed. Development of these tools should be informed by appropriate frameworks. The purpose of this study was to develop a specific evaluation tool for bedside teaching based on the Stanford Faculty Development Program's clinical teaching framework. METHODS: Based on a literature review yielding 47 evaluation items, an 18-item questionnaire was compiled and subsequently completed by undergraduate medical students at two German universities...
May 22, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28531307/following-instructions-in-patients-with-schizophrenia-the-benefits-of-actions-at-encoding-and-recall
#10
Simon S Y Lui, Tian-Xiao Yang, Chris L Y Ng, Peony T Y Wong, Jessica O Y Wong, Ulrich Ettinger, Eric F C Cheung, Raymond C K Chan
The ability to follow spoken instructions is important to everyday functioning but has seldom been studied in patients with schizophrenia (SZ). Recent evidence suggests that action-based processing may facilitate the ability to follow instructions, which relies largely on working memory. In this study, we tested the hypothesis that SZ patients may also benefit from action-based advantages in following instructions. Forty-eight clinically stable SZ patients and 48 demographic- and IQ-matched controls completed a following spoken instruction span task involving varied encoding and recall conditions...
May 22, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28530310/-drug-therapy-following-bariatric-surgery-examination-of-potential-impact-and-clinical-recommendations
#11
REVIEW
Carmil Azran, Arik Dahan
Bariatric surgery is the most effective solution for morbid obesity, and the number of patients undergoing bariatric surgery is rapidly and constantly growing. The modified gastrointestinal (GI) anatomy of the patient may lead to significant pharmacokinetic alterations in the oral absorption of drugs after surgery. However, due to insufficient available literature and inadequate awareness of the medical team, bariatric surgery patients may be discharged from the hospital with insufficient instructions regarding their medication therapy...
January 2017: Harefuah
https://www.readbyqxmd.com/read/28527600/translation-and-adaptation-of-the-disability-assessment-for-dementia-scale-in-the-spanish-population
#12
Alicia Sánchez-Pérez, Sofia López-Roig, Ana Pampliega Pérez, Paula Peral Gómez, María Ángeles Pastor, Miriam Hurtado-Pomares
BACKGROUND AND OBJECTIVE: Functional assessment is especially relevant in patients with cognitive impairment (CI). The Disability Assessment for Dementia (DAD) scale assesses functional ability and its use is becoming increasingly popular. This study aims to perform the translation and cultural adaptation of the DAD scale in order to create a Spanish version: DAD-E. PATIENTS AND METHOD: A double translation/back-translation process was developed, as well as a pilot study with 14 caregivers of patients with CI, and 3 review meetings to achieve general agreement...
May 17, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28527481/rethinking-anatomy-how-to-overcome-challenges-of-medical-education-s-evolution
#13
REVIEW
Bruno Guimarães, Luís Dourado, Stanislav Tsisar, José Miguel Diniz, Maria Dulce Madeira, Maria Amélia Ferreira
INTRODUCTION: Due to scientific and technological development, Medical Education has been readjusting its focus and strategies. Medical curriculum has been adopting a vertical integration model, in which basic and clinical sciences coexist during medical instruction. This context favours the introduction of new complementary technology-based pedagogical approaches. Thus, even traditional core sciences of medical curriculum, like Anatomy, are refocusing their teaching/learning paradigm...
February 27, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28525796/beneficial-effects-of-training-in-self-distancing-and-perspective-broadening-for-people-with-a-history-of-recurrent-depression
#14
Emma Travers-Hill, Barnaby D Dunn, Laura Hoppitt, Caitlin Hitchcock, Tim Dalgleish
Cognitive training designed to recalibrate maladaptive aspects of cognitive-affective processing associated with the presence of emotional disorder can deliver clinical benefits. This study examined the ability of an integrated training in self-distancing and perspective broadening (SD-PB) with respect to distressing experiences to deliver such benefits in individuals with a history of recurrent depression (≥3 prior episodes), currently in remission. Relative to an overcoming avoidance (OA) control condition, SD-PB: a) reduced distress to upsetting memories and to newly encountered events, both during training when explicitly instructed to apply SD-PB techniques, and after-training in the absence of explicit instructions; b) enhanced capacity to self-distance from and broaden perspectives on participants' experiences; c) reduced residual symptoms of depression...
May 11, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28520996/epidemiology-of-travellers-diarrhea
#15
Robert Steffen
Background: Travellers' diarrhea (TD) continues to be the most frequent health problem in travellers with destinations in lower income parts of the world as compared with where they reside, even if that risk has slightly decreased. Methods: A systematic review was published 18 months ago; now PubMed was searched for more recent publications relating to travel, diarrhea, epidemiology, incidence, risk. Results: A trend to decreasing incidence rates have been noted in this as compared with the last century, but TD remains frequent...
April 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28516967/body-worn-triaxial-accelerometer-coherence-and-reliability-related-to-static-posturography-in-unilateral-vestibular-failure
#16
M Alessandrini, A Micarelli, A Viziano, I Pavone, G Costantini, D Casali, F Paolizzo, G Saggio
Since changes in vestibular function may be one cause of disequilibrium, major advances in measuring postural control and sensory integration in vestibular impairments have been achieved by using posturography. However, in order to overcome problems related to this type of technology, body-worn accelerometers (ACC) have been proposed as a portable, low-cost alternative to posturography for measurements of postural sway in a friendly and ecologic environment. Due to the fact that no study to date has shown the experimental validity of ACC-based measures of body sway with respect to posturography for subjects with vestibular deficits, the aim of the present study was: i) to develop and validate a practical tool that can allow clinicians to measure postural sway derangements in an otoneurological setting by ACC, and ii) to provide reliable, sensitive and accurate automatic analysis of sway that could help in discriminating unilateral vestibular failure (UVF) patients...
June 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28516127/a-pilot-study-for-linking-adolescent-patients-to-an-interactive-tobacco-prevention-program
#17
Karen S Calabro, Salma K Marani, Thuan A Le, Georges E Khalil, Irene M Tami-Maury, Alexander V Prokhorov
CONTEXT: The American Academy of Pediatrics and professional guidelines recommend intervening with adolescents about avoiding tobacco use in the health-care setting. Barriers in the clinical setting limit consistent provision of this critical service. OBJECTIVES: This pilot study compared 2 approaches for referring adolescents to an evidence-based tobacco prevention and cessation program in the outpatient setting. Secondary aims assessed tobacco use, knowledge, and program evaluation...
January 2017: Health Services Research and Managerial Epidemiology
https://www.readbyqxmd.com/read/28516032/a-case-of-respiratory-infection-possibly-caused-by-mycobacterium-triviale-current-problems-on-diagnostic-and-therapeutic-strategies
#18
Asako Okabayashi, Mizue Hasegawa, Akitoshi Sato, Hideki Katsura, Toshiko Kamata, Eitetsu Koh, Yasuo Sekine
Mycobacterium triviale is a subspecies of the Mycobacterium terrae complex, which rarely causes disease in humans. We encountered a case of respiratory infection, possibly caused by M. triviale, which was successfully treated by levofloxacin and clarithromycin. Although DNA-DNA hybridization identified M. triviale in one of three samples, clinical validations convinced us that it was the pathogen. 16s ribosomal RNA sequencing would have been reliable and ideal to perform in this case, although it is not covered by the insurance system in Japan...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28515594/radiofrequency-ablation-of-osteoid-osteoma-in-common-and-technically-challenging-locations-in-pediatric-population
#19
Shaileshkumar Garge, Shyamkumar N Keshava, Vinu Moses, George K Chiramel, Munawwar Ahmed, Suraj Mammen, Vrisha Madhuri
CONTEXT: Percutaneous radiofrequency ablation (RFA) of osteoid osteoma has a high technical and clinical success rate. However, there is limited data on its use in the pediatric population, especially in technically challenging locations. OBJECTIVE: To assess the safety and efficacy of computed tomography (CT)-guided percutaneous RFA of osteoid osteoma in pediatric population. PATIENTS AND METHODS: From June 2009 to May 2014, 30 patients with osteoid osteoma were treated with CT-guided RFA in common (25 cases) and technically challenging (five cases: four near articular surface and one in sacrum) locations...
January 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28514715/impact-of-physician-education-and-availability-of-parameters-regarding-esophageal-pressure-and-transpulmonary-pressure-on-clinical-decisions-involving-ventilator-management
#20
Yasuhiro Norisue, Lonny Ashworth, Takaki Naito, Jun Kataoka, Muneyuki Takeuchi, Sunao Usami, Junko Takada, Shigeki Fujitani
PURPOSE: This study investigated the effects of physician education and the availability of Peso and PL data on physicians' decisions regarding ventilator management during specific simulated clinical conditions. MATERIALS AND METHODS: The study was a prospective, before-after study using a case scenario-based questionnaire and a case simulator device comprising an Avea ventilator and an artificial lung and esophagus, which was connected to a Series 1101 Electronic Breathing Simulator...
April 18, 2017: Journal of Critical Care
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