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Osteoarthritis non pharmacological

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https://www.readbyqxmd.com/read/29760367/-pharmacological-action-and-clinical-outcome-of-newly-developed-nsaids-patch-loqoa-%C3%A2-tape
#1
Noboru Otsuka, Ikuko Yataba
Topical non-steroidal anti-inflammatory drugs (NSAIDs) patches are indispensable for the treatment of musculoskeletal diseases, while they are considered less effective than oral NSAIDs. LOQOA® tape is a tape-type patch containing esflurbiprofen (SFP) as a major active ingredient with potent cyclooxygenase inhibition and sufficient skin permeability. SFP patch (SFPP) showed higher percutaneous absorption rate, rapid pain relief, and potent anti-inflammatory efficacy comparing with existing NSAIDs patches in rat...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/29730785/may-the-force-be-with-you-why-resistance-training-is-essential-for-subjects-with-type-2-diabetes-mellitus-without-complications
#2
REVIEW
Roberto Codella, Marta Ialacqua, Ileana Terruzzi, Livio Luzi
Physical activity, together with diet and pharmacological therapy, represents one of the three cornerstones in type 2 diabetes mellitus treatment and care. The therapeutic appeal of regular physical activity stems from: (i) its non-pharmacological nature; (ii) its beneficial effects on the metabolic risk factors associated with diabetes complications; (iii) its low costs. Evidence accumulated in the last years suggests that aerobic training-endurance training-constitutes a safe modality of intervention, achievable, and effective in diabetes treatment, whenever it is not limited by comorbidities...
May 5, 2018: Endocrine
https://www.readbyqxmd.com/read/29712778/gdnf-neurturin-and-artemin-activate-and-sensitize-bone-afferent-neurons-and-contribute-to-inflammatory-bone-pain
#3
Sara Nencini, Mitchell Ringuet, Dong-Hyun Kim, Claire Greenhill, Jason J Ivanusic
Pain associated with skeletal pathology or disease is a significant clinical problem, but the mechanisms that generate and/or maintain it remain poorly understood. In this study, we explored roles for GDNF, neurturin and artemin signaling in bone pain using male Sprague-Dawley rats. We have shown that inflammatory bone pain involves activation and sensitization of peptidergic, NGF-sensitive neurons via artemin/GFRα3 signaling pathways, and that sequestering artemin might be useful to prevent inflammatory bone pain derived from activation of NGF-sensitive bone afferent neurons...
April 30, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29685141/sinew-acupuncture-for-knee-osteoarthritis-study-protocol-for-a-randomized-sham-controlled-trial
#4
Kwok Yin Au, Haiyong Chen, Wing Chung Lam, Chiu On Chong, Andrew Lau, Varut Vardhanabhuti, Kin Cheung Mak, Fei Jiang, Wing Yi Lam, Fung Man Wu, Hiu Ngok Chan, Yan Wah Ng, Bacon Fung-Leung Ng, Eric Tat-Chi Ziea, Lixing Lao
BACKGROUND: Sinew acupuncture is a new modality of acupuncture in which needles are inserted into acupoints, ashi points or spasm points of sinew and muscles along the meridian sinew pathway. A previous observational study revealed that sinew acupuncture has immediate analgesic effects on various soft tissue injuries, including knee injuries. However, no rigorous trials have been conducted. This study aims to examine whether sinew acupuncture can safely relieve pain and symptoms of knee osteoarthritis (KOA) and improve patients' functional movement and quality of life...
April 23, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29684219/challenges-and-controversies-of-complex-interventions-in-osteoarthritis-management-recognizing-inappropriate-and-discordant-care
#5
Krysia S Dziedzic, Kelli D Allen
A number of controversies and challenges exist for the management of OA in health care. This paper describes the challenges and gaps in OA care, particularly in relation to population health management, complex interventions and outcomes. It sets this in the context of competing health priorities and multimorbidity, access to high quality conservative care, non-pharmacological therapies, resource limitations and models of care. The overuse of some therapies and neglect of others are discussed, as well as the potential for self-management...
May 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29682329/active-discopathy-a-clinical-reality
#6
REVIEW
Margaux Boisson, Marie-Martine Lefèvre-Colau, François Rannou, Christelle Nguyen
In the late 1980s, the description by Modic and colleagues of elementary discovertebral changes detected on MRI (Modic classification) suggested for the first time a possible correlation between anatomical and clinical features in a subgroup of patients with non-specific chronic low back pain. Degenerative disc disease is frequent and usually asymptomatic, but Modic 1 changes in the vertebral endplates adjacent to a degenerated disc are associated with inflammatory-like chronic low back pain and low-grade local and systemic inflammation, which led to the concept of 'active discopathy'...
2018: RMD Open
https://www.readbyqxmd.com/read/29659609/patients-perceived-needs-of-osteoarthritis-health-information-a-systematic-scoping-review
#7
Louisa Chou, Lisa Ellis, Michelle Papandony, K L Maheeka D Seneviwickrama, Flavia M Cicuttini, Kaye Sullivan, Andrew J Teichtahl, Yuanyuan Wang, Andrew M Briggs, Anita E Wluka
BACKGROUND: Optimal management of osteoarthritis requires active patient participation. Understanding patients' perceived health information needs is important in order to optimize health service delivery and health outcomes in osteoarthritis. We aimed to review the existing literature regarding patients' perceived health information needs for OA. METHODS: A systematic scoping review was performed of publications in MEDLINE, EMBASE, CINAHL and PsycINFO (1990-2016)...
2018: PloS One
https://www.readbyqxmd.com/read/29656142/management-of-foot-ankle-osteoarthritis-by-australian-general-practitioners-an-analysis-of-national-patient-encounter-records
#8
Kade L Paterson, Christopher Harrison, Helena Britt, Rana S Hinman, Kim L Bennell
OBJECTIVE: To document the management of foot/ankle osteoarthritis/arthritis (OA) by general practitioners (GP) in Australia. DESIGN: We analysed data from the Bettering the Evaluation and Care of Health Program April 2010-March 2016 inclusive. Patient and GP encounter characteristics were extracted. Data were classified by the International Classification of Primary Care, Version 2, and summarised using descriptive statistics and 95% confidence intervals (95% CIs) around point estimates...
April 12, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29649270/the-quality-of-reporting-in-randomized-controlled-trials-of-acupuncture-for-knee-osteoarthritis-a-cross-sectional-survey
#9
Pengli Jia, Li Tang, Jiajie Yu, Jiali Liu, Deying Kang, Xin Sun
OBJECTIVE: To assess the reporting quality of acupuncture trials for knee osteoarthritis (KOA), and explore the factors associated with the reporting. METHOD: Three English and four Chinese databases were searched from inception to December 2016 for randomized control trials testing effects of acupuncture for knee osteoarthritis. We used the standard CONSORT (2010 version), CONSORT Extension for Non-Pharmacological Treatments, and STRICTA for measuring the quality of reporting...
2018: PloS One
https://www.readbyqxmd.com/read/29619620/evidence-based-non-pharmacological-therapies-for-fibromyalgia
#10
REVIEW
Mansoor M Aman, R Jason Yong, Alan David Kaye, Richard D Urman
PURPOSE OF REVIEW: Fibromyalgia (FM) is the second most common rheumatologic pain disorder after osteoarthritis with a multisystem presentation. While the treatment of FM in a clinical setting incorporates both pharmacologic and non-pharmacologic modalities, the present investigation reviews evolving literature on cognitive behavioral and complementary medical therapies. The recent medical literature on FM was reviewed between 2012 and 2017 via MEDLINE and the Cochrane Central Registry of Controlled Trials, with an emphasis on randomized controlled trials, meta-analyses, and evidence-based treatment guidelines...
April 4, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29504411/inducible-nitric-oxide-synthase-as-a-target-for-osteoarthritis-treatment
#11
Andreas Leonidou, Panagiotis Lepetsos, Michalis Mintzas, Eustathios Kenanidis, George Macheras, Maria Tzetis, Michael Potoupnis, Eleftherios Tsiridis
Inducible nitric oxide synthase (iNOS) is the enzyme responsible for the production of nitric oxide (NO), a major proinflammatory and destructive mediator in osteoarthritis (OA). Areas covered: This is a comprehensive review of the recent literature on the involvement of iNOS in osteoarthritis and its potential to be used as a target for OA treatment. Evidence from in vitro, in vivo and human studies was systematically collected using medical search engines. Preclinical studies have focused on the effect of direct and indirect iNOS inhibitors in both animal and human tissues...
April 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29453622/cognitive-mediators-of-change-in-physical-functioning-in-response-to-a-multifaceted-intervention-for-managing-osteoarthritis
#12
Shannon Stark Taylor, Eugene Z Oddone, Cynthia J Coffman, Amy S Jeffreys, Hayden B Bosworth, Kelli D Allen
PURPOSE: Although non-pharmacological interventions have been shown to improve physical functioning in individuals with osteoarthritis (OA), the mechanisms by which this occurs are often unclear. This study assessed whether changes in arthritis self-efficacy, perceived pain control, and pain catastrophizing mediated changes in physical functioning following an osteoarthritis intervention involving weight management, physical activity, and cognitive-behavioral pain management. METHOD: Three hundred Veteran patients of 30 primary care providers with knee and/or hip OA were cluster randomized to an OA intervention group or usual care...
April 2018: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29407226/dose-response-effects-of-tai-chi-and-physical-therapy-exercise-interventions-in-symptomatic-knee-osteoarthritis
#13
Augustine C Lee, William F Harvey, Lori Lyn Price, Xingyi Han, Jeffrey B Driban, Maura D Iversen, Sima A Desai, Hans E Knopp, Chenchen Wang
BACKGROUND: Therapeutic exercise is a currently recommended nonpharmacological treatment for knee osteoarthritis (KOA). The optimal treatment dose (frequency or duration) has not been determined. OBJECTIVE: To examine dose-response relationships, minimal effective dose, and baseline factors associated with the timing of response from 2 exercise interventions in KOA. DESIGN: Secondary analysis of a single-blind, randomized trial comparing 12-week Tai Chi and physical therapy exercise programs (Trial Registry #NCT01258985)...
January 31, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29406129/a-decision-making-tool-to-prescribe-knee-orthoses-in-daily-practice-for-patients-with-osteoarthritis
#14
Emmanuel Coudeyre, Christelle Nguyen, Aurore Chabaud, Bruno Pereira, Johann Beaudreuil, Jean-Marie Coudreuse, Philippe Deat, Frédéric Sailhan, Alain Lorenzo, François Rannou
OBJECTIVE: To develop a decision-making tool (DMT) to facilitate the prescription of knee orthoses for patients with osteoarthritis (OA) in daily practice. METHODS: A steering committee gathered a multidisciplinary task force experienced in OA management/clinical research. Two members performed a literature review with qualitative analysis of the highest-quality randomized controlled trials and practice guidelines to confirm evidence concerning knee orthosis for OA...
March 2018: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29379312/intra-articular-ozone-or-hyaluronic-acid-injection-which-one-is-superior-in-patients-with-knee-osteoarthritis-a-6-month-randomized-clinical-trial
#15
Seyed Ahmad Raeissadat, Seyed Mansoor Rayegani, Bijan Forogh, Porya Hassan Abadi, Mahsa Moridnia, Shahram Rahimi Dehgolan
Purpose: Knee osteoarthritis (OA) is a common disease, imposing a great burden through pain and decreased function. There are many therapeutic modalities including non-pharmacologic choices and oral, topical, and intra-articular medications. New studies have shown promising results for ozone application in knee OA. Our aim was to compare the effects of ozone therapy versus hyaluronic acid (HA) intra-articular injection in knee OA patients. Methods: In this randomized clinical trial, a total of 174 patients with more than 3 months of chronic pain or swelling in the knee joints along with consistent imaging findings were enrolled and randomly allocated into two groups of HA and ozone, which were planned to undergo 3 weekly injections of HA (Hyalgan®) and 10 mL of a 30 μg/mL ozone solution, respectively...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29318481/transient-receptor-potential-ankyrin-1-trpa1-mediates-lipopolysaccharide-lps-induced-inflammatory-responses-in-primary-human-osteoarthritic-fibroblast-like-synoviocytes
#16
Songjiang Yin, Peimin Wang, Runlin Xing, Linrui Zhao, Xiaochen Li, Li Zhang, Yancheng Xiao
Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associated cation channel, widely expressed in neuronal and non-neuronal cells. Recently, emerging evidences suggested the crucial role of TRPA1 in the disease progression of osteoarthritis (OA). Therefore, we aimed to investigate whether TRPA1 mediate lipopolysaccharide (LPS)-induced inflammatory responses in primary human OA fibroblast-like synoviocytes (OA-FLS). The expression of TRPA1 in LPS-treated OA-FLS was assessed by polymerase chain reaction (PCR) and western blot (WB), and the functionality of TRPA1 channel by Ca2+ influx measurements...
March 2018: Inflammation
https://www.readbyqxmd.com/read/29289942/patterns-of-routine-primary-care-for-osteoarthritis-in-the-uk-a-cross-sectional-electronic-health-records-study
#17
Holly Jackson, Lauren A Barnett, Kelvin P Jordan, Krysia S Dziedzic, Elizabeth Cottrell, Andrew G Finney, Zoe Paskins, John J Edwards
OBJECTIVE: To determine common patterns of recorded primary care for osteoarthritis (OA), and patient and provider characteristics associated with the quality of recorded care. DESIGN: An observational study nested within a cluster-randomised controlled trial. SETTING: Eight UK general practices who were part of the Management of Osteoarthritis in Consultations study. PARTICIPANTS: Patients recorded as consulting within the eight general practices for clinical OA...
December 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/29229563/osteoarthritis-year-in-review-2017-clinical
#18
REVIEW
A E Nelson
This review is based on a systematic review of the literature relevant to clinical topics in osteoarthritis (OA) performed for the time period February 22, 2016 to April 1, 2017. A PubMed search using the terms "osteoarthritis" and "treatment or epidemiology" returned over 800 papers, of which 57 are reviewed here, with inclusion primarily based on relevance to clinical OA. Epidemiologic studies in this time frame focused on the incidence and prevalence of OA, comorbidities and mortality in relation to OA (particularly obesity and cardiovascular disease), and multiple joint involvement...
March 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29185087/assistive-devices-an-effective-strategy-in-non-pharmacological-treatment-for-hand-osteoarthritis-randomized-clinical-trial
#19
D S Amaral, A L B P Duarte, S S Barros, S V Cavalcanti, A Ranzolin, V M M Leite, A T Dantas, A S C R C Oliveira, P S Santos, J C A Silva, C D L Marques
This study aims to evaluate the use of assistive devices as a strategy in non-pharmacological treatment for hand osteoarthritis (HOA). This is a randomized, prospective, parallel, assessor-blinded clinical trial, in which patients with a diagnosis of HOA were randomly allocated to an intervention group (IG), where they received assistive devices for daily life activities, or to a control group (CG), where they received a guideline leaflet with information on joint protection and disease features. The primary outcomes considered were occupational performance, measured by the Canadian Occupational Performance Measure (COPM), and hand function was evaluated through the Score for the Assessment and Quantification of Chronic Rheumatoid Affections of the Hands (SACRAH)...
March 2018: Rheumatology International
https://www.readbyqxmd.com/read/29132341/can-hybrid-hyaluronic-acid-represent-a-valid-approach-to-treat-rizoarthrosis-a-retrospective-comparative-study
#20
Sara Tenti, Nicola Antonio Pascarelli, Stefano Giannotti, Mauro Galeazzi, Nicola Giordano, Antonella Fioravanti
BACKGROUND: Osteoarthritis (OA) of the trapeziometacarpal joint (TMJ) is a disabling condition with a significant impact on quality of life. The optimal management of hand OA requires a combination of non-pharmacological and pharmacological treatments that include intra-articular (i.a.) therapy. EULAR experts recommend corticosteroid injections in TMJ OA and underline the usefulness of hyaluronic acid (HA). The aim of this study was the assessment of the efficacy and tolerability of i...
November 13, 2017: BMC Musculoskeletal Disorders
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