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Osteoarthritis non pharmacological

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https://www.readbyqxmd.com/read/28339432/bipolar-versus-unipolar-intraarticular-pulsed-radiofrequency-thermocoagulation-in-chronic-knee-pain-treatment-a-prospective-randomized-trial
#1
Ersel Gulec, Hayri Ozbek, Sinan Pektas, Geylan Isik
BACKGROUND: Chronic knee pain is a major widespread problem causing significant impairment of daily function. Pulsed radiofrequency has been shown to reduce severe chronic joint pain as a non-pharmacological and less invasive treatment method. OBJECTIVE: We aimed to compare the effectiveness of unipolar and bipolar intraarticular pulsed radiofrequency methods in chronic knee pain control. STUDY DESIGN: Prospective, randomized, double-blind study...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28267751/cost-effectiveness-of-adjunct-non-pharmacological-interventions-for-osteoarthritis-of-the-knee
#2
Beth Woods, Andrea Manca, Helen Weatherly, Pedro Saramago, Eleftherios Sideris, Christina Giannopoulou, Stephen Rice, Mark Corbett, Andrew Vickers, Matthew Bowes, Hugh MacPherson, Mark Sculpher
BACKGROUND: There is limited information on the costs and benefits of alternative adjunct non-pharmacological treatments for knee osteoarthritis and little guidance on which should be prioritised for commissioning within the NHS. This study estimates the costs and benefits of acupuncture, braces, heat treatment, insoles, interferential therapy, laser/light therapy, manual therapy, neuromuscular electrical stimulation, pulsed electrical stimulation, pulsed electromagnetic fields, static magnets and transcutaneous electrical nerve Stimulation (TENS), based on all relevant data, to facilitate a more complete assessment of value...
2017: PloS One
https://www.readbyqxmd.com/read/28258536/move-it-or-lose-it-is-it-reasonable-for-older-adults-with-osteoarthritis-to-continue-to-use-paracetamol-in-order-to-maintain-physical-activity
#3
REVIEW
Kayla Lee, Julie Cooke, Gabrielle Cooper, Alison Shield
Osteoarthritis is a common progressive disease in older adults, and those affected often have impaired physical function, co-existing disease states, and reduced quality of life. In patients with osteoarthritis, pain is reported as a primary cause of mobility limitation, and guidelines recommend a mix of pharmacologic and non-pharmacologic strategies for pain management. The benefits of exercise in the management of osteoarthritis are well established; however, pain appears to be the biggest barrier to patients engaging in, and adhering to, physical activity programs...
March 4, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28251070/knee-osteoarthritis-therapeutic-alternatives-in-primary-care
#4
Allison L Evaniew, Nathan Evaniew
AIM: To discusses pharmacological and non-pharmacological therapeutic alternatives for managing knee osteoarthritis in primary care by primary health care nurse practitioners. METHODS: A case example is presented, the evidence-based guideline recommendations of the Osteoarthritis Research Society International and the American Academy of Orthopaedic Surgeons are reviewed, and a plan of care is developed. RESULTS: Osteoarthritis is the most common form of arthritis seen in primary care, and it is a major public health issue because the aging population and widespread obesity have drastically increased incidence...
February 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28183342/rheumatology-around-the-world-perspectives-from-australia-and-new-zealand
#5
EDITORIAL
Fiona M F McQueen
Rheumatology continues to be an exciting and vibrant specialty for specialists practising in New Zealand and Australia. Clinicians follow treat-to-target regimens to manage peripheral and axial inflammatory arthritides using conventional and biological agents, which have revolutionised management of rheumatic disease over the past two decades. However, optimal clinical practice has significant pharmacoeconomic implications which impact on health funding at a national level, and the advent of biosimilars is keenly awaited...
February 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28141914/exercise-for-hand-osteoarthritis
#6
REVIEW
Nina Østerås, Ingvild Kjeken, Geir Smedslund, Rikke H Moe, Barbara Slatkowsky-Christensen, Till Uhlig, Kåre Birger Hagen
BACKGROUND: Hand osteoarthritis (OA) is a prevalent joint disease that may lead to pain, stiffness and problems in performing hand-related activities of daily living. Currently, no cure for OA is known, and non-pharmacological modalities are recommended as first-line care. A positive effect of exercise in hip and knee OA has been documented, but the effect of exercise on hand OA remains uncertain. OBJECTIVES: To assess the benefits and harms of exercise compared with other interventions, including placebo or no intervention, in people with hand OA...
January 31, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28100423/osteoarthritis-year-in-review-2016-clinical
#7
REVIEW
N E Lane, K Shidara, B L Wise
Both epidemiologic and clinical research continues to be performed in osteoarthritis (OA). While epidemiologic studies identify risk factors for incident and progressive disease, clinical studies explore the role of both non-pharmacologic and pharmacologic treatments, including oral and intra-articular therapies. We performed a systematic review of the literature using PubMed for the time period between April 1, 2015 to February 22, 2016. Selected publications in the areas of both epidemiology and treatment are reviewed in this article...
December 20, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28051248/movardol%C3%A2-n-acetylglucosamine-boswellia-serrata-ginger-supplementation-in-the-management-of-knee-osteoarthritis-preliminary-results-from-a-6-month-registry-study
#8
G Bolognesi, G Belcaro, B Feragalli, U Cornelli, R Cotellese, S Hu, M Dugall
OBJECTIVE: Knee Osteoarthritis (OA) is a chronic disease caused by the deterioration of cartilage in joints, which results in activation of the inflammatory response, pain, and impaired movement. Complementary therapies, particularly supplementation, in the management of moderate/severe knee OA have been gaining attention. This registry study aimed at evaluating the synergistic effect of Movardol®, a supplementation containing active ingredients with recognized anti-inflammatory activities on symptoms and levels of circulating biomarkers of knee OA...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27929434/nutraceutical-supplements-in-the-management-and-prevention-of-osteoarthritis
#9
REVIEW
Paola Castrogiovanni, Francesca Maria Trovato, Carla Loreto, Houda Nsir, Marta Anna Szychlinska, Giuseppe Musumeci
Nutraceuticals are dietary compounds which have a role in the balance of anabolic and catabolic signals in joints. Their regulatory function on homeostasis of cartilage metabolism nutraceuticals is increasingly considered for the management and, above all, the prevention of osteoarthritis (OA). OA is a degenerative disease characterized by cartilage and synovium inflammation that can cause joint stiffness, swelling, pain, and loss of mobility. It is a multifactorial disease and, due to the great percentage of people suffering from it and the general increase in life expectancy, OA is considered as one of the most significant causes of disability in the world...
December 6, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27846245/non-communicable-disease-clinical-practice-guidelines-in-brazil-a-systematic-assessment-of-methodological-quality-and-transparency
#10
Caroline de Godoi Rezende Costa Molino, Nicolina Silvana Romano-Lieber, Eliane Ribeiro, Daniela Oliveira de Melo
BACKGROUND: Annually, non-communicable diseases (NCDs) kill 38 million people worldwide, with low and middle-income countries accounting for three-quarters of these deaths. High-quality clinical practice guidelines (CPGs) are fundamental to improving NCD management. The present study evaluated the methodological rigor and transparency of Brazilian CPGs that recommend pharmacological treatment for the most prevalent NCDs. METHODS: We conducted a systematic search for CPGs of the following NCDs: asthma, atrial fibrillation, benign prostatic hyperplasia, chronic obstructive pulmonary disease, congestive heart failure, coronary artery disease and/or stable angina, dementia, depression, diabetes, gastroesophageal reflux disease, hypercholesterolemia, hypertension, osteoarthritis, and osteoporosis...
2016: PloS One
https://www.readbyqxmd.com/read/27829170/encapsulation-of-nsaids-for-inflammation-management-overview-progress-challenges-and-prospects
#11
REVIEW
Waisudin Badri, Karim Miladi, Qand Agha Nazari, Hélène Greige-Gerges, Hatem Fessi, Abdelhamid Elaissari
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely prescribed drugs. Debilitating diseases such as rheumatoid arthritis and osteoarthritis are commonly managed by NSAIDs. However, NSAIDs pharmacological mechanism is often associated with the presence of gastrointestinal side effects. NSAIDs encapsulation is performed in order to overcome some of the drawbacks linked to their clinical use. To fulfill this purpose, various vectors like polymer-based nanoparticles, liposomes and solid lipid nanoparticles have been proposed...
December 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27761693/curcuma-longa-extract-reduces-inflammatory-and-oxidative-stress-biomarkers-in-osteoarthritis-of-knee-a-four-month-double-blind-randomized-placebo-controlled-trial
#12
Shobhit Srivastava, Anil K Saksena, Sanjay Khattri, Santosh Kumar, Raghubendra Singh Dagur
BACKGROUND AND PURPOSE: Curcuma longa L. (CL), an Indian herb, has been used to treat many disorders because of its wide spectrum of pharmacological activities. It has been shown to exhibit anti-oxidant and anti-inflammatory properties, and is being used as herbal remedy since ancient times. Osteoarthritis of knee (KOA) is a chronic painful disorder in which prolong use of non-steroidal anti-inflammatory drugs (NSAIDs) or steroids may result into many serious side effects; hence, there is a need to develop herbal drugs, having good analgesia without side effects...
December 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27749234/sj%C3%A3-gren-s-syndrome-managed-care-data-from-a-large-united-states-population-highlight-real-world-health-care-burden-and-lack-of-treatment-options
#13
Julie A Birt, YingMeei Tan, Neelufar Mozaffarian
OBJECTIVES: To better understand the real-world characteristics and costs of Sjögren's syndrome (SS). METHODS: Analysing the MarketScan Commercial Claims database from Jan. 1, 2006 to Dec. 31, 2011, we identified 10,414 patients ≥18 years old newly diagnosed with SS. Patient characteristics, drugs (commonly used for SS), resource utilisation, and medical costs were evaluated for 12 months pre- and post-diagnosis. RESULTS: Mean age was 55 years; 90% were female...
October 7, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27686859/relative-efficacy-of-topical-non-steroidal-anti-inflammatory-drugs-and-topical-capsaicin-in-osteoarthritis-protocol-for-an-individual-patient-data-meta-analysis
#14
Monica S M Persson, Yu Fu, Archan Bhattacharya, Siew-Li Goh, Marienke van Middelkoop, Sita M A Bierma-Zeinstra, David Walsh, Michael Doherty, Weiya Zhang
BACKGROUND: Pain is the most troubling issue to patients with osteoarthritis (OA), yet current pharmacological treatments offer only small-to-moderate pain reduction. Current guidelines therefore emphasise the need to identify predictors of treatment response. In line with these recommendations, an individual patient data (IPD) meta-analysis will be conducted. The study aims to investigate the relative treatment effects of topical non-steroidal anti-inflammatory drugs (NSAIDs) and topical capsaicin in OA and to identify patient-level predictors of treatment response...
September 29, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27681448/a-standardized-rescue-exercise-program-for-symptomatic-flare-up-of-knee-osteoarthritis-description-and-safety-considerations
#15
Cecilie Bartholdy, Louise Klokker, Elisabeth Bandak, Henning Bliddal, Marius Henriksen
Study Design Secondary analysis of clinical trial data. Background Knee osteoarthritis (OA) management has changed significantly over recent decades toward nonpharmacological treatments, particularly exercise. However, the optimal exercise program remains to be established. Objective To describe the implementation of standardized rescue exercises for patients with pain exacerbations and to assess whether performing these benefit or further worsen symptoms in patients with exacerbated symptoms of knee OA. Methods The data from 2 randomized controlled studies of exercise in patients with knee OA were used...
November 2016: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/27676827/an-algorithm-to-improve-knee-orthosis-prescription-for-osteoarthritis-patients
#16
Johann Beaudreuil, Jean Marie Coudreuse, Christelle N Guyen, Philippe Deat, Aurore Chabaud, Bruno Pereira, Alain Lorenzo, Frédéric Sailhan, François Rannou, Emmanuel Coudeyre
OBJECTIVE: To develop an algorithm to help orthosis prescription for knee osteoarthritis patients. MATERIAL/PATIENTS AND METHODS: Systematic review of the literature using a qualitative analysis on Pubmed databases, Cochrane Library and Pedro from 1966 to 2015, using the keywords "knee osteoarthritis", "orthosis" with recommendations and highest quality trials. Development of a preliminary version of the algorithm using data from the literature and taking into account experience of different health professionals involved in the management of osteoarthritis patients...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27515563/epigallocatechin-3-o-gallate-up-regulates-microrna-199a-3p-expression-by-down-regulating-the-expression-of-cyclooxygenase-2-in-stimulated-human-osteoarthritis-chondrocytes
#17
Zafar Rasheed, Naila Rasheed, Hani A Al-Shobaili
Osteoarthritis (OA) is a most common form of arthritis worldwide leading to significant disability. MicroRNAs (miRNAs) are non-coding RNAs involved in various aspects of cartilage development, homoeostasis and pathology. Several miRNAs have been identified which have shown to regulate expression of target genes relevant to OA pathogenesis such as matrix metalloproteinase (MMP)-13, cyclooxygenase (COX)-2, etc. Epigallocatechin-3-O-gallate (EGCG), the most abundant and active polyphenol in green tea, has been reported to have anti-arthritic effects, however, the role of EGCG in the regulation of miRNAs has not been investigated in OA...
December 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27492465/cost-utility-modeling-of-early-vs-late-total-knee-replacement-in-osteoarthritis-patients
#18
K Mari, P Dégieux, F Mistretta, F Guillemin, P Richette
Given the dramatic increase in the number of total knee replacement (TKR) surgeries in developed countries, the issue of the best time for surgery needs to be addressed from an economic perspective. OBJECTIVE: To assess, from the perspective of the healthcare payer, the cost-utility of two surgical strategies in which knee replacement is performed at the early or late stage of the disease in patients with knee osteoarthritis (OA). DESIGN: Patient data and evidence from published literature on economic costs and outcomes in OA, including utilities, non-pharmacological, pharmacological and surgical options, combined with population life tables were entered in a Markov model of OA...
August 1, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27489412/non-operative-management-of-osteoarthritis-of-the-knee-joint
#19
REVIEW
Raju Vaishya, Godfrey B Pariyo, Amit Kumar Agarwal, Vipul Vijay
Osteoarthritis is a chronic disorder of synovial joints in which there is progressive softening and disintegration of articular cartilage accompanied by the growth of osteophytes. Treatment designed for osteoarthritis should aim at reducing pain, improve joint mobility, and limit functional impairment. It can be achieved by pharmacological and non-pharmacological means. Non-operative treatment of OA is useful for patients with KL grade 1-3, which are early stages of OA. However, in an advanced stage of OA (KL grade 4), surgical treatment is needed as definitive treatment...
July 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/27326466/an-update-on-the-up-and-coming-therapies-to-treat-osteoarthritis-a-multifaceted-disease
#20
REVIEW
Jorge A Roman-Blas, Emanuele Bizzi, Raquel Largo, Alberto Migliore, Gabriel Herrero-Beaumont
INTRODUCTION: The lack of a complete understanding of the complex processes involved in the etiopathogenesis and subsequent appropriate phenotyping makes it difficult to find therapies that may be efficacious in most patients with osteoarthritis (OA). Consensus recommendations involve mainly non-pharmacological approaches. Analgesics and NSAIDs are considered second choice options due to their poor efficacy/safety ratios. To some extent, OA may be considered an orphan disease. Therefore, there is an urgent need to identify effective and safe new pharmacologic modalities for treating OA...
September 2016: Expert Opinion on Pharmacotherapy
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