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Osteoarthritis non pharmacological

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https://www.readbyqxmd.com/read/27846245/non-communicable-disease-clinical-practice-guidelines-in-brazil-a-systematic-assessment-of-methodological-quality-and-transparency
#1
Caroline de Godoi Rezende Costa Molino, Nicolina Silvana Romano-Lieber, Eliane Ribeiro, Daniela Oliveira de Melo
BACKGROUND: Annually, non-communicable diseases (NCDs) kill 38 million people worldwide, with low and middle-income countries accounting for three-quarters of these deaths. High-quality clinical practice guidelines (CPGs) are fundamental to improving NCD management. The present study evaluated the methodological rigor and transparency of Brazilian CPGs that recommend pharmacological treatment for the most prevalent NCDs. METHODS: We conducted a systematic search for CPGs of the following NCDs: asthma, atrial fibrillation, benign prostatic hyperplasia, chronic obstructive pulmonary disease, congestive heart failure, coronary artery disease and/or stable angina, dementia, depression, diabetes, gastroesophageal reflux disease, hypercholesterolemia, hypertension, osteoarthritis, and osteoporosis...
2016: PloS One
https://www.readbyqxmd.com/read/27829170/encapsulation-of-nsaids-for-inflammation-management-overview-progress-challenges-and-prospects
#2
REVIEW
Waisudin Badri, Karim Miladi, Qand Agha Nazari, Hélène Greige-Gerges, Hatem Fessi, Abdelhamid Elaissari
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely prescribed drugs. Debilitating diseases such as rheumatoid arthritis and osteoarthritis are commonly managed by NSAIDs. However, NSAIDs pharmacological mechanism is often associated with the presence of gastrointestinal side effects. NSAIDs encapsulation is performed in order to overcome some of the drawbacks linked to their clinical use. To fulfill this purpose, various vectors like polymer-based nanoparticles, liposomes and solid lipid nanoparticles have been proposed...
November 6, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27761693/curcuma-longa-extract-reduces-inflammatory-and-oxidative-stress-biomarkers-in-osteoarthritis-of-knee-a-four-month-double-blind-randomized-placebo-controlled-trial
#3
Shobhit Srivastava, Anil K Saksena, Sanjay Khattri, Santosh Kumar, Raghubendra Singh Dagur
BACKGROUND AND PURPOSE: Curcuma longa L. (CL), an Indian herb, has been used to treat many disorders because of its wide spectrum of pharmacological activities. It has been shown to exhibit anti-oxidant and anti-inflammatory properties, and is being used as herbal remedy since ancient times. Osteoarthritis of knee (KOA) is a chronic painful disorder in which prolong use of non-steroidal anti-inflammatory drugs (NSAIDs) or steroids may result into many serious side effects; hence, there is a need to develop herbal drugs, having good analgesia without side effects...
October 19, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27749234/sj%C3%A3-gren-s-syndrome-managed-care-data-from-a-large-united-states-population-highlight-real-world-health-care-burden-and-lack-of-treatment-options
#4
Julie A Birt, YingMeei Tan, Neelufar Mozaffarian
OBJECTIVES: To better understand the real-world characteristics and costs of Sjögren's syndrome (SS). METHODS: Analysing the MarketScan Commercial Claims database from Jan. 1, 2006 to Dec. 31, 2011, we identified 10,414 patients ≥18 years old newly diagnosed with SS. Patient characteristics, drugs (commonly used for SS), resource utilisation, and medical costs were evaluated for 12 months pre- and post-diagnosis. RESULTS: Mean age was 55 years; 90% were female...
October 7, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27686859/relative-efficacy-of-topical-non-steroidal-anti-inflammatory-drugs-and-topical-capsaicin-in-osteoarthritis-protocol-for-an-individual-patient-data-meta-analysis
#5
Monica S M Persson, Yu Fu, Archan Bhattacharya, Siew-Li Goh, Marienke van Middelkoop, Sita M A Bierma-Zeinstra, David Walsh, Michael Doherty, Weiya Zhang
BACKGROUND: Pain is the most troubling issue to patients with osteoarthritis (OA), yet current pharmacological treatments offer only small-to-moderate pain reduction. Current guidelines therefore emphasise the need to identify predictors of treatment response. In line with these recommendations, an individual patient data (IPD) meta-analysis will be conducted. The study aims to investigate the relative treatment effects of topical non-steroidal anti-inflammatory drugs (NSAIDs) and topical capsaicin in OA and to identify patient-level predictors of treatment response...
September 29, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27681448/a-standardized-rescue-exercise-program-for-symptomatic-flare-up-of-knee-osteoarthritis-description-and-safety-considerations
#6
Cecilie Bartholdy, Louise Klokker, Elisabeth Bandak, Henning Bliddal, Marius Henriksen
Study Design Secondary analysis of clinical trial data. Background Knee osteoarthritis (OA) management has changed significantly over recent decades towards non-pharmacological treatments, particularly exercise. However, the optimal exercise program remains to be established. Objective To describe the implementation of standardized rescue exercises, for patients with pain exacerbations, and assess whether performing these benefited or further worsened symptoms in patients with exacerbation of knee OA symptoms...
September 28, 2016: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/27676827/an-algorithm-to-improve-knee-orthosis-prescription-for-osteoarthritis-patients
#7
Johann Beaudreuil, Jean Marie Coudreuse, Christelle N Guyen, Philippe Deat, Aurore Chabaud, Bruno Pereira, Alain Lorenzo, Frédéric Sailhan, François Rannou, Emmanuel Coudeyre
OBJECTIVE: To develop an algorithm to help orthosis prescription for knee osteoarthritis patients. MATERIAL/PATIENTS AND METHODS: Systematic review of the literature using a qualitative analysis on Pubmed databases, Cochrane Library and Pedro from 1966 to 2015, using the keywords "knee osteoarthritis", "orthosis" with recommendations and highest quality trials. Development of a preliminary version of the algorithm using data from the literature and taking into account experience of different health professionals involved in the management of osteoarthritis patients...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27515563/epigallocatechin-3-o-gallate-up-regulates-microrna-199a-3p-expression-by-down-regulating-the-expression-of-cyclooxygenase-2-in-stimulated-human-osteoarthritis-chondrocytes
#8
Zafar Rasheed, Naila Rasheed, Hani A Al-Shobaili
Osteoarthritis (OA) is a most common form of arthritis worldwide leading to significant disability. MicroRNAs (miRNAs) are non-coding RNAs involved in various aspects of cartilage development, homoeostasis and pathology. Several miRNAs have been identified which have shown to regulate expression of target genes relevant to OA pathogenesis such as matrix metalloproteinase (MMP)-13, cyclooxygenase (COX)-2, etc. Epigallocatechin-3-O-gallate (EGCG), the most abundant and active polyphenol in green tea, has been reported to have anti-arthritic effects, however, the role of EGCG in the regulation of miRNAs has not been investigated in OA...
August 12, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27492465/cost-utility-modeling-of-early-vs-late-total-knee-replacement-in-osteoarthritis-patients
#9
K Mari, P Dégieux, F Mistretta, F Guillemin, P Richette
: Given the dramatic increase in the number of total knee replacement (TKR) surgeries in developed countries, the issue of the best time for surgery needs to be addressed from an economic perspective. OBJECTIVE: To assess, from the perspective of the healthcare payer, the cost-utility of two surgical strategies in which knee replacement is performed at the early or late stage of the disease in patients with knee osteoarthritis (OA). DESIGN: Patient data and evidence from published literature on economic costs and outcomes in OA, including utilities, non-pharmacological, pharmacological and surgical options, combined with population life tables were entered in a Markov model of OA...
August 1, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27489412/non-operative-management-of-osteoarthritis-of-the-knee-joint
#10
REVIEW
Raju Vaishya, Godfrey B Pariyo, Amit Kumar Agarwal, Vipul Vijay
Osteoarthritis is a chronic disorder of synovial joints in which there is progressive softening and disintegration of articular cartilage accompanied by the growth of osteophytes. Treatment designed for osteoarthritis should aim at reducing pain, improve joint mobility, and limit functional impairment. It can be achieved by pharmacological and non-pharmacological means. Non-operative treatment of OA is useful for patients with KL grade 1-3, which are early stages of OA. However, in an advanced stage of OA (KL grade 4), surgical treatment is needed as definitive treatment...
July 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/27326466/an-update-on-the-up-and-coming-therapies-to-treat-osteoarthritis-a-multifaceted-disease
#11
Jorge A Roman-Blas, Emanuele Bizzi, Raquel Largo, Alberto Migliore, Gabriel Herrero-Beaumont
INTRODUCTION: The lack of a complete understanding of the complex processes involved in the etiopathogenesis and subsequent appropriate phenotyping makes it difficult to find therapies that may be efficacious in most patients with osteoarthritis (OA). Consensus recommendations involve mainly non-pharmacological approaches. Analgesics and NSAIDs are considered second choice options due to their poor efficacy/safety ratios. To some extent, OA may be considered an orphan disease. Therefore, there is an urgent need to identify effective and safe new pharmacologic modalities for treating OA...
September 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27267755/the-ple-2-no-self-management-and-exercise-program-for-knee-osteoarthritis-study-protocol-for-a-randomized-controlled-trial
#12
Priscila Marconcin, Margarida Espanha, Flávia Yázigi, Pedro Campos
BACKGROUND: International recommendations suggest exercise and self-management programs, including non-pharmacological treatments, for knee osteoarthritis (KOA) because they can benefit pain relief and improve function and exercise adherence. The implementation of a combined self-management and exercise program termed PLE(2)NO may be a good method for controlling KOA symptoms because it encourages the development of self-efficacy to manage the pathology. This study will assess the effects of a self-management and exercise program in comparison to an educational intervention (control program) on symptoms, physical fitness, health-related quality of life, self-management behaviors, self-efficacy, physical activity level and coping strategies...
2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27262323/incorporating-natural-products-pharmaceutical-drugs-self-care-and-digital-mobile-health-technologies-into-molecular-behavioral-combination-therapies-for-chronic-diseases
#13
REVIEW
Grzegorz Bulaj, Margaret M Ahern, Alexis Kuhn, Zachary S Judkins, Randy C Bowen, Yizhe Chen
Merging pharmaceutical and digital (mobile health, mHealth) ingredients to create new therapies for chronic diseases offers unique opportunities for natural products such as omega-3 polyunsaturated fatty acids (n-3 PUFA), curcumin, resveratrol, theanine, or α-lipoic acid. These compounds, when combined with pharmaceutical drugs, show improved efficacy and safety in preclinical and clinical studies of epilepsy, neuropathic pain, osteoarthritis, depression, schizophrenia, diabetes and cancer. Their additional clinical benefits include reducing levels of TNFα and other inflammatory cytokines...
2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27228651/effect-of-mud-bath-therapy-on-serum-biomarkers-in-patients-with-knee-osteoarthritis-results-from-a-randomized-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Nicola A Pascarelli, Sara Cheleschi, Giovanni Bacaro, Giacomo M Guidelli, Mauro Galeazzi, Antonella Fioravanti
BACKGROUND: Balneotherapy is one of the most commonly used non-pharmacological approaches for osteoarthritis (OA). Recent data indicate that some biomarkers could be useful to predict OA progression and to assess therapeutic response. OBJECTIVES: To evaluate the effects of mud-bath therapy on serum biomarkers in patients with knee OA. METHODS: The study group comprised 103 patients with primary symptomatic bilateral knee OA who were randomly assigned to receive a cycle of mud-bath therapy over a period of 2 weeks or to continue their standard therapy alone...
March 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/27184397/pain-management-among-dominican-patients-with-advanced-osteoarthritis-a-qualitative-study
#15
Amy Yu, Christopher A Devine, Rachel G Kasdin, Mónica Orizondo, Wendy Perdomo, Aileen M Davis, Laura M Bogart, Jeffrey N Katz
BACKGROUND: Advanced osteoarthritis and total joint replacement (TJR) recovery are painful experiences and often prompt opioid use in developed countries. Physicians participating in the philanthropic medical mission Operation Walk Boston (OpWalk) to the Dominican Republic have observed that Dominican patients require substantially less opioid medication following TJR than US patients. We conducted a qualitative study to investigate approaches to pain management and expectations for postoperative recovery in patients with advanced arthritis undergoing TJR in the Dominican Republic...
May 17, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27165430/different-expression-of-%C3%AE-subunits-of-the-kca1-1-channel-by-invasive-and-non-invasive-human-fibroblast-like-synoviocytes
#16
Zoltán Pethő, Mark R Tanner, Rajeev B Tajhya, Redwan Huq, Teresina Laragione, Gyorgy Panyi, Pércio S Gulko, Christine Beeton
BACKGROUND: Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA-FLS) contribute to joint inflammation and damage characteristic of the disease. RA-FLS express KCa1.1 (BK, Slo1, MaxiK, KCNMA1) as their major plasma membrane potassium channel. Blocking KCa1.1 reduces the invasive phenotype of RA-FLS and attenuates disease severity in animal models of RA. This channel has therefore emerged as a promising therapeutic target in RA. However, the pore-forming α subunit of KCa1.1 is widely distributed in the body, and blocking it induces severe side effects, thus limiting its value as a therapeutic target...
2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27159532/distribution-and-drivers-of-average-direct-cost-of-osteoarthritis-in-canada-from-2003-to-2010
#17
Behnam Sharif, Jacek A Kopec, Hubert Wong, Aslam H Anis
OBJECTIVES: To estimate the distribution and drivers of the average direct cost of OA in Canada using a population-based health microsimulation model of osteoarthritis (POHEM-OA) from 2003 to 2010. METHODS: We used a previously published microsimulation model to estimate the distribution of average cost of OA across different cost components and OA stages. OA stages were defined according to the patient flow within the healthcare system. Cost components associated with pharmacological and non-pharmacological treatments, physician visits and hospitalization were included...
May 9, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27134504/the-effects-of-adherence-to-non-steroidal-anti-inflammatory-drugs-and-factors-influencing-drug-adherence-in-patients-with-knee-osteoarthritis
#18
Kwan Kyu Park, Choong Hyeok Choi, Chul-Won Ha, Myung Chul Lee
We aimed to compare the clinical outcomes of knee osteoarthritis patients according to drug adherence; and to find out the factors the affecting those outcomes. We analyzed the drug adherence and clinical outcomes in 1,334 primary knee osteoarthritis patients who took non-steroidal anti-inflammatory drugs (NSAIDs) for 3 weeks. Clinical outcomes of Pain Numeric Rating Scale (NRS), Knee injury and Osteoarthritis Outcome Score (KOOS) and EQ-5D were compared at baseline and 3 weeks' follow-up between the two groups of adherent group and non-adherent group (1,167 vs...
May 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27110291/effectiveness-of-physical-and-occupational-therapy-on-pain-function-and-quality-of-life-in-patients-with-trapeziometacarpal-osteoarthritis-a-systematic-review-and-meta-analysis
#19
Bernhard Aebischer, Simone Elsig, Jan Taeymans
INTRODUCTION: Trapeziometacarpal osteoarthritis is associated with more pain and restrictions than other hand osteoarthritis due to the functional importance of the thumb. While the effectiveness of surgical and pharmacological interventions has been widely examined, there is a lack of specific evidence about conservative non-pharmacological trapeziometacarpal osteoarthritis therapies. The objective of this systematic review was to provide evidence-based knowledge on the effectiveness of physiotherapy and occupational therapy on pain, function and quality of life...
March 2016: Hand Therapy
https://www.readbyqxmd.com/read/27079585/isokinetic-muscle-strengthening-for-knee-osteoarthritis-a-systematic-review-of-randomized-controlled-trials-with-meta-analysis
#20
E Coudeyre, A G Jegu, M Giustanini, J P Marrel, P Edouard, B Pereira
OBJECTIVE: To assess the level of scientific evidence and the place in the rehabilitation framework of isokinetic muscle strengthening (IMS) for knee osteoarthritis (OA). METHODS: A systematic review of the English literature in MEDLINE via PubMed, the Cochrane Library, and PEDro databases for only randomized comparative trials. Data that were sufficiently homogeneous underwent comprehensive meta-analysis. Methodological assessment was done by using the CLEAR scale for non-pharmacologic trials...
June 2016: Annals of Physical and Rehabilitation Medicine
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