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https://www.readbyqxmd.com/read/29233780/a-novel-series-of-n-acyl-substituted-indole-linked-benzimidazoles-and-naphthoimidazoles-as-potential-anti-inflammatory-anti-biofilm-and-anti-microbial-agents
#1
Rajan Abraham, Prakash Periakaruppan, Karthikeyan Mahendran, Murugappan Ramanathan
A novel N-acyl substituted indole-linked benzimidazoles and naphthoimidazoles were synthesized. Their chemical structures were confirmed using spectroscopic tools including 1H NMR, 13C NMR and CHN-elemental analyses. Anti inflammatory activity for all target compounds was evaluated in-vitro. The synthesized compounds hinder the biofilm formation and control the growth of the pathogen, Staphylococcus epidermis. Anti microbial activity of the compounds was evaluated against both Gram negative and Gram positive bacteria such as Staphylococcus aureus (MTCC 2940), Pseudomonas aeruginosa (MTCC424), Escherchia coli (MTCC 443) and Enterococcus fecalis...
December 9, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29230206/anaerobic-corrosion-of-304-stainless-steel-caused-by-the-pseudomonas-aeruginosa-biofilm
#2
Ru Jia, Dongqing Yang, Dake Xu, Tingyue Gu
Pseudomonas aeruginosa is a ubiquitous bacterium capable of forming problematic biofilms in many environments. They cause biocorrosion of medical implants and industrial equipment and infrastructure. Aerobic corrosion of P. aeruginosa against stainless steels has been reported by some researchers while there is a lack of reports on anaerobic P. aeruginosa corrosion in the literature. In this work, the corrosion by a wild-type P. aeruginosa (strain PAO1) biofilm against 304 stainless steel (304 SS) was investigated under strictly anaerobic condition for up to 14 days...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29225413/outbreak-of-hospital-infection-from-biofilm-embedded-pan-drug-resistant-pseudomonas-aeroginosa-due-to-a-contaminated-bronchoscope
#3
Nader Alipour, Alper Karagoz, Abbas Taner, Nasrin Gaeini, Nastaran Alipour, Hassan Zeytin, Fatih Yildiz, Riza Durmaz
Background: Colistin-resistant Pseudomonas aeruginosa (P. aeruginosa) has been defined as pandrug-resistant (PDR) strain. Outbreaks of PDR P. aeruginosa especially in pulmonary tract infections due to contaminated bronchoscopes have rarely been reported. The emergence of pandrug-resistant strains in both CF (Cystic Fibrosis) and non-CF clinical isolates over recent years remains of a great concern. Hospital wards contaminated with PDR P. aeruginosa infection, must be shot down until their eradication...
2017: Tap Chi y Hoc du Phong, Journal of Preventive Medicine / Hoi y Hoc du Phong Viet Nam
https://www.readbyqxmd.com/read/29216242/the-oxyr-regulated-phnw-gene-encoding-2-aminoethylphosphonate-pyruvate-aminotransferase-helps-protect-pseudomonas-aeruginosa-from-tert-butyl-hydroperoxide
#4
Warunya Panmanee, Nisanart Charoenlap, Sopapan Atichartpongkul, Aekkapol Mahavihakanont, Matthew D Whiteside, Geoff Winsor, Fiona S L Brinkman, Skorn Mongkolsuk, Daniel J Hassett
The LysR member of bacterial transactivators, OxyR, governs transcription of genes involved in the response to H2O2 and organic (alkyl) hydroperoxides (AHP) in the Gram-negative pathogen, Pseudomonas aeruginosa. We have previously shown that organisms lacking OxyR are rapidly killed by <2 or 500 mM H2O2 in planktonic and biofilm bacteria, respectively. In this study, we first employed a bioinformatic approach to elucidate the potential regulatory breadth of OxyR by scanning the entire P. aeruginosa PAO1 genome for canonical OxyR promoter recognition sequences (ATAG-N7-CTAT-N7-ATAG-N7-CTAT)...
2017: PloS One
https://www.readbyqxmd.com/read/29215338/evaluation-of-antimicrobial-durability-and-anti-biofilm-effects-in-urinary-catheters-against-enterococcus-faecalis-clinical-isolates-and-reference-strains
#5
Didem Kart, Ayşe Semra Kustimur, Meral Sağıroğlu, Ayşe Kalkancı
BACKGROUND: Enterococcus faecalis, Escherichia coli, Staphylococcus epidermidis, Pseudomonas aeruginosa and Candida albicans biofilms are major causes of catheter-associated urinary tract infections. Antimicrobial-coated or impregnated urinary catheters are seen as a possible way to prevent these infections. AIMS: To determine the biofilm-forming ability of 89 E. faecalis isolates from urinary tract infections and to compare several urinary catheters for antimicrobial durability and the inhibitory effects on biofilm formation of different laboratory strains and clinical isolates of E...
December 1, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29214017/morphological-bactericidal-fast-acting-effects-of-peracetic-acid-a-high-level-disinfectant-against-staphylococcus-aureus-and-pseudomonas-aeruginosa-biofilms-in-tubing
#6
T Chino, Y Nukui, Y Morishita, K Moriya
Background: The bactericidal effect of disinfectants against biofilms is essential to reduce potential endoscopy-related infections caused by contamination. Here, we investigated the bactericidal effect of a high-level disinfectant, peracetic acid (PAA), against Staphylococcus aureus and Pseudomonas aeruginosa biofilm models in vitro. Methods: S. aureus and P. aeruginosa biofilms were cultured at 35 °C for 7 days with catheter tubes. The following high-level disinfectants (HLDs) were tested: 0...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29213262/the-oxidative-stress-agent-hypochlorite-stimulates-c-di-gmp-synthesis-and-biofilm-formation-in-pseudomonas-aeruginosa
#7
Nikola Strempel, Michael Nusser, Anke Neidig, Gerald Brenner-Weiss, Joerg Overhage
The opportunistic human pathogen Pseudomonas aeruginosa is able to survive under a variety of often harmful environmental conditions due to a multitude of intrinsic and adaptive resistance mechanisms, including biofilm formation as one important survival strategy. Here, we investigated the adaptation of P. aeruginosa PAO1 to hypochlorite (HClO), a phagocyte-derived host defense compound and frequently used disinfectant. In static biofilm assays, we observed a significant enhancement in initial cell attachment in the presence of sublethal HClO concentrations...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29211965/early-detection-of-biofouling-on-water-purification-membranes-by-ambient-ionization-mass-spectrometry-imaging
#8
Swathy Jakka Ravindran, Ramesh Kumar, Amitava Srimany, Ligy Philip, Thalappil Pradeep
By direct analysis of water purification membranes using ambient ionization mass spectrometry, an attempt has been made to understand the molecular signatures of bacterial fouling. Membrane based purification methods are used extensively in water treatment and a major challenge for them is biofouling. The build-up of microbes and their extracellular polymeric matrix clog the membranes and reduce their efficiency. To understand the early stages of bacterial fouling on water purification membranes, we have used Desorption Electrospray Ionization Mass Spectrometry (DESI MS), where ion formation occurs in ambient conditions and the ionization event is surface sensitive...
December 6, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29208541/biological-synthesis-of-silver-nanoparticles-using-%C3%AE-1-3-glucan-binding-protein-and-their-antibacterial-antibiofilm-and-cytotoxic-potential
#9
Mahalingam Anjugam, Baskaralingam Vaseeharan, Arokiadhas Iswarya, Mani Divya, Narayanan Marimuthu Prabhu, Krishnasamy Sankaranarayanan
The present study reports the biological synthesis of silver nanoparticles using crustacean immune molecule β-1, 3 glucan binding protein (β-GBP) purified from the haemolymph of blue swimmer crab Portunus pelagicus. The characterization of synthesized β-GBP based silver nanoparticles (Ppβ-GBP-AgNPs) was made by UV-Vis spectroscopy, XRD, FTIR and TEM analysis. UV-Vis spectra recorded the strong absorbance peak at 420 nm due to its surface plasmon resonance. The XRD analysis revealed the crystalline nature of synthesized nanoparticles with Bragg's reflection peaks at (111), (200), (220), (311) planes...
December 2, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29204285/molecular-characterization-of-acinetobacter-baumannii-isolated-from-iraqi-hospital-environment
#10
I M S Al-Kadmy, A N M Ali, I M A Salman, S S Khazaal
Healthcare-associated items are a common source of acquired infections, and hospital-acquired infections cause significant mortality and morbidity worldwide. Acinetobacter baumannii is the most prevalent infection-causing organism in the hospital environment. Hospital articles and objects are the main sources of infection with the ability to transmit some of the pathogenic microorganisms such as A. baumannii, which is considered a serious problem in therapeutic treatments. In the current study, we isolated A...
January 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29204075/comparative-anticancer-and-antimicrobial-activity-of-aerial-parts-of-acacia-salicina-acacia-laeta-acacia-hamulosa-and-acacia-tortilis-grown-in-saudi-arabia
#11
Mohamed F Alajmi, Perwez Alam, Saleh I Alqasoumi, Nasir Ali Siddiqui, Omer A Basudan, Afzal Hussain, Fohad Mabood Husain, Azmat Ali Khan
The standardized ethanol extract (EE) of aerial parts of four Acacia species [A. salicina (ASEE), A. laeta (ALEE), A. hamulosa (AHEE), and A. tortilis (ATEE)] were examined in order to compare their cytotoxic and antimicrobial activities. All the extracts were standardized by UPLC- PDA method using rutin as standard compound. The extracts ALEE, AHEE and ATEE were found to contain rutin along with several other phytoconstituents while rutin was absent in ASEE. All the extracts showed varying level of antimicrobial activity with zone of inhibition ranged from 11 to 21 mm against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans...
December 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29202722/eradication-of-p-aeruginosa-biofilm-in-endotracheal-tubes-based-on-lock-therapy-results-from-an-in-vitro-study
#12
María Jesús Pérez-Granda, María Consuelo Latorre, Beatriz Alonso, Javier Hortal, Rafael Samaniego, Emilio Bouza, María Guembe
BACKGROUND: Despite the several strategies available for the management of biofilm-associated ventilator-associated pneumonia, data regarding the efficacy of applying antibiotics to the subglottic space (SS) are scarce. We created an in vitro model to assess the efficacy of antibiotic lock therapy (ALT) applied in the SS for eradication of Pseudomonas aeruginosa biofilm in endotracheal tubes (ETTs). METHODS: We applied 2 h of ALT to a P. aeruginosa biofilm in ETTs using a single dose (SD) and a 5-day therapy model (5D)...
December 4, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29201023/a-marine-actinomycete-rescues-caenorhabditis-elegans-from-pseudomonas-aeruginosa-infection-through-restitution-of-lysozyme-7
#13
Siti N Fatin, Tan Boon-Khai, Alexander Chong Shu-Chien, Melati Khairuddean, Amirul Al-Ashraf Abdullah
The resistance of Pseudomonas aeruginosa to conventional antimicrobial treatment is a major scourge in healthcare. Therefore, it is crucial that novel potent anti-infectives are discovered. The aim of the present study is to screen marine actinomycetes for chemical entities capable of overcoming P. aeruginosa infection through mechanisms involving anti-virulence or host immunity activities. A total of 18 actinomycetes isolates were sampled from marine sediment of Songsong Island, Kedah, Malaysia. Upon confirming that the methanolic crude extract of these isolates do not display direct bactericidal activities, they were tested for capacity to rescue Caenorhabditis elegans infected with P...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29199454/effects-of-null-mutation-of-the-heat-shock-gene-htpg-on-the-production-of-virulence-factors-by-pseudomonas-aeruginosa
#14
Anna M Grudniak, Barbara Klecha, Krystyna I Wolska
AIM: Pseudomonas aeruginosa is one of the most clinically important opportunistic pathogen in humans. The aim of the project was to study effects of HtpG on the selected virulence factors responsible for pathogenesis and biofilm formation of P. aeruginosa. METHODOLOGY: By characterizing a htpG null mutant of P. aeruginosa, we have identified the role of HtpG in the production of selected factors. RESULTS: We showed that ΔhtpG mutant affects many physiological processes containing: decreased activity of the LasA protease, reduction of biofilm formation, decreased motility, and diminished amount of rhamnolipids and pyoverdine/pyocyanin...
December 4, 2017: Future Microbiology
https://www.readbyqxmd.com/read/29194975/biofilm-recruitment-under-nanofiltration-conditions-the-influence-of-resident-biofilm-structural-parameters-on-planktonic-cell-invasion
#15
Olivier Habimana, Eoin Casey
It is now generally accepted that biofouling is inevitable in pressure-driven membrane processes for water purification. A large number of published articles describe the development of novel membranes in an effort to address biofouling in such systems. It is reasonable to assume that such membranes, even those with antimicrobial properties, when applied in industrial-scale systems will experience some degree of biofouling. In such a scenario, an understanding of the fate of planktonic cells, such as those entering with the feed water, has important implications with respect to contact killing particularly for membranes with antimicrobial properties...
December 1, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/29194257/clinical-significance-of-biofilm-on-silicone-tubes-removed-from-patients-with-nasolacrimal-duct-stenosis
#16
Sung Hyun Kim, Choul Yong Park, Sang Won Hwang, Minwook Chang
PURPOSE: To determine the relationship between the optical density of biofilms on silicone tubes and surgical outcomes. METHODS: A total of 43 silicone tubes from 33 patients with nasolacrimal duct stenosis were enrolled at 6 months after bicanalicular silicone tube intubation. The removed silicone tubes were divided into 2 segments. One segment of silicone tube was cultured while the other segment was used to measure optical density of biofilm. Each segment was divided into 3 pieces according to average normal human nasolacrimal anatomy...
November 29, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29191704/microfouling-inhibition-of-human-nosocomial-pathogen-pseudomonas-aeruginosa-using-marine-cyanobacteria
#17
Felix LewisOscar, Chari Nithya, Sulaiman Ali Alharbi, Naiyf S Alharbi, Nooruddin Thajuddin
Pseudomonas aeruginosa is a Gram negative, opportunistic biofilm forming pathogenic bacterium which is developing as a serious problem worldwide. The pathogenicity of P. aeruginosa mainly depends upon biofilm and quorum sensing (QS) mechanism. Targeting biofilm and QS regulated factor will automatically reduce the pathogenicity of P. aeruginosa. Therefore it is compulsory to identify naturally derived biofilm and QS inhibitors against P. aeruginosa. In the present study Oscillatoria subuliformis, a marine cyanobacterium was used against the biofilm and QS of P...
November 27, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29184024/identification-of-fitness-determinants-during-energy-limited-growth-arrest-in-pseudomonas-aeruginosa
#18
David W Basta, Megan Bergkessel, Dianne K Newman
Microbial growth arrest can be triggered by diverse factors, one of which is energy limitation due to scarcity of electron donors or acceptors. Genes that govern fitness during energy-limited growth arrest and the extent to which they overlap between different types of energy limitation are poorly defined. In this study, we exploited the fact that Pseudomonas aeruginosa can remain viable over several weeks when limited for organic carbon (pyruvate) as an electron donor or oxygen as an electron acceptor. ATP values were reduced under both types of limitation, yet more severely in the absence of oxygen...
November 28, 2017: MBio
https://www.readbyqxmd.com/read/29182855/bacterial-adhesion-to-ultrafiltration-membranes-role-of-hydrophilicity-natural-organic-matter-and-cell-surface-macromolecules
#19
Sara BinAhmed, Anissa Hasane, Zhaoxing Wang, Aslan Mansurov, Santiago Romero-Vargas Castrillón
Insight into the mechanisms underlying bacterial adhesion is critical to the formulation of membrane biofouling control strategies. Using AFM-based single-cell force spectroscopy, we investigated the interaction between Pseudomonas fluorescens, a biofilm-forming bacterium, and polysulfone (PSF) ultrafiltration (UF) membranes to unravel the mechanisms underlying early-stage membrane biofouling. We show that hydrophilic polydopamine (PDA) coatings decrease bacterial adhesion forces at short bacterium-membrane contact times...
November 28, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29180529/the-abc-of-biofilm-drug-tolerance-the-merr-like-regulator-brlr-is-an-activator-of-abc-transport-systems-with-pa1874-77-contributing-to-the-tolerance-by-pseudomonas-aeruginosa-biofilms-to-tobramycin
#20
Bandita Poudyal, Karin Sauer
A hallmark of biofilms is their tolerance to killing by antimicrobial agents. In P. aeruginosa, biofilm drug tolerance requires the c-di-GMP responsive, MerR transcriptional regulator BrlR. However, the mechanism by which BrlR mediates biofilm drug tolerance has not been elucidated. Here, we demonstrate that BrlR activates the expression of at least 7 ABC transport systems, including PA1874-77, with ChIP and DNA binding assays confirming BrlR binding to the promoter region of PA1874-77. Insertional inactivation of the 7 ABC transport systems rendered P...
November 27, 2017: Antimicrobial Agents and Chemotherapy
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