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https://www.readbyqxmd.com/read/29346216/obesity-and-pancreatic-cancer-overview-of-epidemiology-and-potential-prevention-by-weight-loss
#1
Mu Xu, Xiaoman Jung, O Joe Hines, Guido Eibl, Yijun Chen
Currently, there are no effective preventive strategies for pancreatic cancer. Obesity has been increasingly recognized as a strong but modifiable risk factor of pancreatic cancer. In this article, we aim to review the literature regarding weight loss on prevention of pancreatic cancer. Epidemiological and laboratory studies have shown that obesity is associated with increased incidence of pancreatic cancer and potentially worse cancer outcome. Whereas the underlying pathomechanisms remain unclear, chronic inflammation, insulin resistance, and altered intestinal microbiota are all implicated in the carcinogenic effect of obesity...
February 2018: Pancreas
https://www.readbyqxmd.com/read/29344878/gemcitabine-and-taxane-adjuvant-therapy-with-chemoradiation-in-resected-pancreatic-cancer-a-novel-strategy-for-improved-survival
#2
Zaheer S Kanji, Alicia M Edwards, Margaret T Mandelson, Nadav Sahar, Bruce S Lin, Kasra Badiozamani, Guobin Song, Adnan Alseidi, Thomas R Biehl, Richard A Kozarek, William S Helton, Vincent J Picozzi, Flavio G Rocha
BACKGROUND: Gemcitabine-taxane combination chemotherapy has demonstrated a survival benefit clinically in metastatic pancreatic cancer (PC). The authors present their experience with gemcitabine and docetaxel (gem/tax)-based adjuvant treatment (Rx) after surgery with curative intent. METHODS: Patients with de novo resectable PC from January 2010 to December 2015 were identified from the authors' institutional database and registry. The study included only patients who received gem/tax as their initial Rx administered exclusively at the authors' institution with or without chemoradiation (CRTx)...
January 17, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29344522/intraductal-papillary-mucinous-neoplasms-of-the-pancreas-strategic-considerations
#3
Vicente Morales-Oyarvide, Zhi Ven Fong, Carlos Fernández-Del Castillo, Andrew L Warshaw
Intraductal papillary mucinous neoplasms (IPMN) are cystic neoplasms with the potential for progression to pancreatic cancer. Recognized by the global medical community just over two decades ago, IPMN have gained great epidemiological and clinical relevance thanks to the widespread use of cross-sectional abdominal imaging, which has led to a surge in the number of incidental pancreatic cysts being diagnosed. As our understanding of this disease has improved, we now know that some IPMN have a very elevated risk of cancer and require surgical resection, while others are low-risk lesions and can be followed...
December 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29344445/comparing-postoperative-complications-and-inflammatory-markers-using-total-intravenous-anesthesia-versus-volatile-gas-anesthesia-for-pancreatic-cancer-surgery
#4
Jose M Soliz, Ifeyinwa C Ifeanyi, Mathew H Katz, Jonathan Wilks, Juan P Cata, Thomas McHugh, Jason B Fleming, Lei Feng, Thomas Rahlfs, Morgan Bruno, Vijaya Gottumukkala
Objectives: The objective of this study is to evaluate postoperative complications and inflammatory profiles when using a total intravenous anesthesia (TIVA) or volatile gas-opioid (VO) based anesthesia in patients undergoing pancreatic cancer surgery. Methods: Design, retrospective propensity score matched cohort; Setting, major academic cancer hospital; Patients, all patients who had pancreatic surgery between November 2011 and August 2014 were retrospectively reviewed...
August 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29340918/validation-of-aast-egs-grade-for-acute-pancreatitis
#5
Moustafa Younis, Matthew Hernandez, Mohamed Ray-Zack, Nadeem N Haddad, Asad Choudhry, Pooja Reddy, Martin D Zielinski
BACKGROUND: The AAST recently developed an emergency general surgery (EGS) disease grading system to measure anatomic severity. We aimed to validate this grading system for acute pancreatitis and compare cross sectional imaging-based AAST EGS grade and compare with several clinical prediction models. We hypothesize that increased AAST EGS grade would be associated with important physiological and clinical outcomes and is comparable to other severity grading methods. METHODS: Single institution retrospective review of adult patients admitted with acute pancreatitis during 10/2014-1/2016 was performed...
January 16, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29340813/impact-of-laparoscopy-in-patients-aged-over-70%C3%A2-years-requiring-distal-pancreatectomy-a-french-multicentric-comparative-study
#6
Regis Souche, David Fuks, Julie Perinel, Astrid Herrero, Françoise Guillon, Isabelle Pirlet, Thierry Perniceni, Frederic Borie, Antonio Sa Cunha, Brice Gayet, Jean-Michel Fabre
BACKGROUND: Few data are available concerning short-term results of minimally invasive surgery in patients > 70 years old requiring distal pancreatectomy. The aim of this study was to compare short-term results after laparoscopic (LDP) versus open distal pancreatectomy (ODP) in this subgroup of patients. METHODS: All patients > 70 years who underwent distal pancreatectomy in 3 expert centers between 1995 and 2017 were included and data were retrospectively analyzed...
January 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29340550/modified-heidelberg-technique-for-pancreatic-anastomosis
#7
Orlando Jorge M Torres, Roberto C N da Cunha Costa, Felipe F Macatrão Costa, Romerito Fonseca Neiva, Tarik Soares Suleiman, Yglésio L Moyses S Souza, Shailesh V Shrikhande
BACKGROUND: Pancreatic fistula is a major cause of morbidity and mortality after pancreatoduodenectomy. To prevent this complication, many technical procedures have been described. AIM: To present a novel technique based on slight modifications of the original Heidelberg technique, as new pancreatojejunostomy technique for reconstruction of pancreatic stump after pancreatoduodenectomy and present initial results. METHOD: The technique was used for patients with soft or hard pancreas and with duct size smaller or larger than 3 mm...
October 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/29337177/laparoscopic-versus-open-pancreatectomy-for-pancreatic-ductal-adenocarcinoma-a-systematic-review-and-meta-analysis
#8
REVIEW
Ke Chen, Yu Pan, Bin Zhang, Hendi Maher, Xiu-Jun Cai
BACKGROUND: Laparoscopic pancreatic surgery (LPS) has been widely used in the treatment of benign and low-grade pancreatic diseases. It is necessary to expand the current knowledge on the feasibility and safety of LPS for pancreatic ductal adenocarcinoma (PDAC) by systematic reviewing the published studies and analyzing them by meta-analysis. METHODS: Original articles compared LPS with open pancreatic surgery (OPS) for PDAC, published from January 1994 to August 2017 were searched in medical databases...
January 11, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29336810/does-adjuvant-radiation-provide-any-survival-benefit-after-an-r1-resections-for-pancreatic-cancer
#9
Nicholas R Suss, Mark S Talamonti, Darren S Bryan, Chi-Hsiung Wang, Kristine M Kuchta, Susan J Stocker, David J Bentrem, Kevin K Roggin, David J Winchester, Robert Marsh, Richard A Prinz, Faris M Murad, Marshall S Baker
BACKGROUND: The benefit of adding external beam radiation to adjuvant chemotherapy in patients that have undergone a margin positive resection for early stage, pancreatic ductal adenocarcinoma has not been determined definitively. METHODS: The National Cancer Data Base was queried to evaluate the utility of adjuvant radiation in patients with pathologic stage I-II pancreatic ductal adenocarcinoma who underwent upfront pancreatoduodenectomy with a positive margin (margin positive resection) between 2004 and 2013...
January 11, 2018: Surgery
https://www.readbyqxmd.com/read/29336625/the-clavien-dindo-classification-in-pancreatic-surgery-a-clinical-and-economic-validation
#10
Patrick Téoule, Felix Bartel, Emrullah Birgin, Felix Rückert, Torsten J Wilhelm
BACKGROUND/AIMS: In 2004 P. A. Clavien and D. Dindo published the well-known grading system of postoperative complications. It is established in several surgical disciplines. The aim of this study was to assess its validity in pancreatic surgery. The impact of complication grade on economic resources was investigated as well. METHODS: From a prospective database, we retrospectively evaluated all patients who underwent pancreatic resection between January 2009 and December 2014 at our department...
January 16, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29335228/irreversible-electroporation-for-locally-advanced-pancreatic-cancer-through-a-minimally-invasive-surgery-supported-by-laparoscopic-ultrasound
#11
Ernesto Tartaglia, Massimiliano Fabozzi, Antonia Rizzuto, Anna Settembre, Roberta Abete, Ludovica Guerriero, Pasqualino Favoriti, Diego Cuccurullo, Francesco Corcione
INTRODUCTION: Pancreatic cancer is one of the most lethal cancers worldwide, with 5-years survival rate as low as 6%. The majority of pancreatic cancer patients present locally advanced or metastatic disease at diagnosis. Typically, patients affected by locally advanced pancreatic cancer (LAPC) do not undergo radical surgery but are treated with focal ablative therapies. However, a high rate of morbidity due to the heat sink effect has limited the application of ablative techniques on a routine basis in LAPC patients...
December 28, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29334794/a-look-at-the-progress-of-treating-pancreatic-cancer-over-the-past-20-years
#12
Ruediger Goess, Helmut Friess
Pancreatic cancer is known to be the deadliest of all common cancers. Despite all efforts in pancreatic cancer treatment, the five-year survival rates at diagnosis over the past 20 years have only increased from 5% to 8%. Assuming that pancreatic cancer is going to become the second most frequent cause of cancer related death in the next 20 years, we are all encouraged to treat patients in clinical trials to gain improvements in this devastating disease. Areas covered: This review will provide a summary of pancreatic cancer treatment over the last 20 years, starting with the pivotal study in 1997 which showed the superiority of gemcitabine over 5-FU in advanced pancreatic cancer and is marked as the beginning of a new era in pancreatic cancer treatment...
January 16, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29333081/innate-immunity-recovers-earlier-than-acquired-immunity-during-severe-postoperative-immunosuppression
#13
Gunnar Lachmann, Clarissa von Haefen, Johannes Kurth, Fatima Yuerek, Claudia Spies
Background: Postoperative immune suppression, particularly a loss of cell-mediated immunity, is commonly seen after surgery and is associated with worse outcome, i.e. delayed wound healing, infections, sepsis, multiple-organ failure and cancer recurrence. However, the recovery of immune cells focusing on differences between innate and acquired immunity during severe postoperative immunosuppression is not investigated. Methods: In this retrospective randomized controlled trial (RCT) subgroup analysis, 10 postoperatively immune suppressed patients after esophageal or pancreatic resection were analyzed...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29333072/prevalence-of-incidental-pancreatic-cyst-on-upper-endoscopic-ultrasound
#14
Belén Martínez, Juan F Martínez, José R Aparicio
Background: This study aimed to determine the prevalence of incidental pancreatic cysts in patients undergoing upper endoscopic ultrasound without a known pancreatic abnormality. Methods: This prospective study was conducted in two hospitals in Spain and enrolled consecutive patients referred for upper endoscopic ultrasound for a condition unrelated to the pancreas. Patients with a previous pancreatic anomaly, history of acute or chronic pancreatitis, evidence of acute pancreatitis, previous upper gastrointestinal surgery, or chronic abdominal pain suggestive of pancreatic origin were excluded...
January 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29331883/curative-distal-pancreatectomy-in-patients-with-acinar-cell-carcinoma-of-pancreas-diagnosed-by-endoscopic-aspiration-via-esophago-jejunostomy-a-successful-case-report
#15
Takeomi Hamada, Atsushi Nanashima, Masahide Hiyoshi, Makoto Ikenoue, Naoya Imamura, Koichi Yano, Yoshiro Fujii, Yoshimasa Kubota, Tesshin Ban, Hiroshi Kawakami, Yuichiro Sato
INTRODUCTION: This is a case report on the advances in preoperative endoscopic-guided fine-needle-aspiration (FNA) diagnosis for pancreatic carcinoma to achieve a curative operation even in patients who have a history of total gastrectomy. CASE PRESENTATION: A 65-year-old man, who underwent total gastrectomy for gastric cancer 13 years ago, had discomfort in the left lateral abdomen. A 3-cm hypovascular mass accompanying a large distal pseudocyst in the pancreatic tail was observed on computed tomography...
January 8, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29331400/locally-advanced-pancreas-cancer-staging-and-goals-of-therapy
#16
Nikolaos A Chatzizacharias, Susan Tsai, Michael Griffin, Parag Tolat, Paul Ritch, Ben George, Chad Barnes, Mohammed Aldakkak, Abdul H Khan, William Hall, Beth Erickson, Douglas B Evans, Kathleen K Christians
BACKGROUND: Patients with locally advanced pancreatic cancer have historically been considered inoperable. The purpose of this report was to determine resectability rates for patients with locally advanced pancreatic cancer based on our recently described definitions of type A and type B locally advanced pancreatic cancer. METHODS: An institutional prospective pancreas cancer database was queried for consecutive patients with locally advanced pancreatic cancer treated between January 2009 and June 2017...
January 10, 2018: Surgery
https://www.readbyqxmd.com/read/29331217/the-cost-of-perioperative-complications-following-pancreaticoduodenectomy-a-systematic-review
#17
REVIEW
Jason Wang, Ronald Ma, Leonid Churilov, Paul Eleftheriou, Mehrdad Nikfarjam, Christopher Christophi, Laurence Weinberg
BACKGROUND/OBJECTIVES: Pancreaticoduodenectomy (PD), also known as a Whipple procedure, is commonly performed for a variety of benign and malignant tumours, including of the pancreatic head and surrounding structures. PD is associated with low mortality but high morbidity and costs. Our objective was to describe the financial burden of complications following pancreaticoduodenectomy. METHODS: We searched for articles using the MEDLINE, EMBASE, Cochrane and EconLit databases from the year 2000...
December 19, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29330678/-quality-indicators-with-reference-values-and-threshold-limits-in-general-and-visceral-surgery-for-obesity-and-metabolic-pancreatic-colon-carcinoma-and-rectal-carcinoma-surgery
#18
EDITORIAL
H J Buhr, J Hardt, C Klinger, F Seyfried, A Wiegering, A Dietrich, D K Bartsch, D Lorenz, S Post, C T Germer, T Keck, U Wellner
No abstract text is available yet for this article.
January 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29330039/age-as-a-prognostic-indicator-for-adjuvant-therapy-in-patients-who-underwent-pancreatic-resections-for-cancer
#19
Alicia Eubanks, Julie Pepe, Paula Veldhuis, Sebastian G de la Fuente
PURPOSE: In pancreatic cancer, the greatest increase in survival is attained by surgical resection followed by adjuvant chemotherapy. Although surgical complications and functional status are recognized as independent factors for halting adjuvant therapy in patients that undergo pancreatic resections, other elements may play a role in deciding which patients get treated postoperatively. Here we determined demographic and clinical characteristics of patients receiving adjuvant chemotherapy, with the primary intent to investigate if age alone affects rates of adjuvant therapy...
January 9, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29329156/impact-of-integrated-health-care-delivery-on-racial-and-ethnic-disparities-in-pancreatic-cancer
#20
Jonathan I Chang, Brian Z Huang, Bechien U Wu
OBJECTIVES: The objective of this study was to evaluate whether disparities in pancreatic cancer diagnosis, treatment, and survival are reduced in an integrated health system. METHODS: We conducted a retrospective study (2006-2014) among patients with pancreatic cancer from Kaiser Permanente Southern California. Racial ethnic groups included non-Hispanic whites (NHW), non-Hispanic blacks (NHB), Hispanics, and Asians. We used multivariable and Cox regression analyses to evaluate disparities in diagnosis and treatment utilization (oncology care, surgery, time to surgery, chemotherapy) and overall survival, respectively...
January 12, 2018: Pancreas
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