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E Sahin, M Eraslan Sahin, M Dolanbay, B Ozcelik, H Akgun, C Saatci
This study compared the antiproliferative effects of metformin and progesterone, via examination of the Bcl-2/Bax-caspase apoptotic pathway in estrogen-induced endometrial hyperplasia (EH) in 40 rats. Two rats died after bilateral oophorectomy, and 1 week after surgery, the remaining 38 were randomly divided into three groups: the first (control, n = 12) received 4 mg/kg 17β estradiol hemihydrate (E); the second (n = 13) received 4 mg/kg 17β estradiol hemihydrate and 50 mg/kg metformin (E + M); and the third (n = 13) received 4 mg/kg 17β estradiol hemihydrate and 1 mg/day medroxiprogesterone acetate (E + MPA)...
November 27, 2017: Gynecological Endocrinology
Jack García Uranga-Romano, Marcelino Hernández-Valencia, Arturo Zárate, María Antonia Basavilvazo-Rodríguez
BACKGROUND: Endometriosis is the presence of functional endometrial tissue in the pelvic peritoneum and it affects several age groups. That is why the impact of endometriosis in quality of life is considerable. The objective of this study was to evaluate the effectiveness of dienogest in patients with pelvic pain associated to endometriosis (PPAE). METHODS: The evaluation of the effectiveness was carried out through a systematic review using the Cochrane methodology...
July 2017: Revista Médica del Instituto Mexicano del Seguro Social
Martha A Sánchez-Rodríguez, Mariano Zacarías-Flores, Lizett Castrejón-Delgado, Ana Karen Ruiz-Rodríguez, Víctor Manuel Mendoza-Núñez
The aim of this study was to determine the effect of oral hormone therapy (HT) on oxidative stress (OS) in postmenopausal women with metabolic syndrome (MetS). A randomized, double blind, placebo-controlled trial was carried out. We formed four groups of 25 women each; healthy (HW) and MetS women (MSW) were assigned to HT (1 mg/day of estradiol valerate plus 5 mg/10 day of medroxiprogesterone) or placebo. We measured plasma lipoperoxides, erythrocyte superoxide dismutase and glutathione peroxidase, total plasma antioxidant status and uric acid, as OS markers...
August 24, 2016: International Journal of Molecular Sciences
M F Martinez, G de Nava, K J Demmers, D Tutt, M Rodriguez Sabarrós, B Smaill, M Corti, J Juengel
Two experiments were designed to investigate the administration of intravaginal progesterone in protocols for oestrus and ovulation synchronization in beef heifers. In Experiment 1, cyclic Black Angus heifers (n = 20) received an Ovsynch protocol and were randomly assigned to receive (CIDR-Ovsynch) or not (Ovsynch) a progesterone device between Days 0 and 7. Treatment with a controlled internal drug release (CIDR) device significantly increased the size of the dominant follicle prior to ovulation (12.8 ± 0...
April 2012: Reproduction in Domestic Animals, Zuchthygiene
Renato M Salgado, Rodolfo R Favaro, Telma M T Zorn
BACKGROUND: We have previously demonstrated that four members of the family of small leucine-rich-proteoglycans (SLRPs) of the extracellular matrix (ECM), named decorin, biglycan, lumican and fibromodulin, are deeply remodeled in mouse uterine tissues along the estrous cycle and early pregnancy. It is known that the combined action of estrogen (E2) and progesterone (P4) orchestrates the estrous cycle and prepares the endometrium for pregnancy, modulating synthesis, deposition and degradation of various molecules...
February 4, 2011: Reproductive Biology and Endocrinology: RB&E
M Gatti, P Zunino, R Ungerfeld
Intravaginal sponges (IS) impregnated with progestagens are widely used for oestrous synchronization in ewes. As progestogens depress the immuno response, the first aim was to determine whether medroxiprogesterone acetate (MAP) content affects the vaginal bacteria number (VBN) in IS-treated anoestrous ewes. The second aim was to compare the effectiveness of different antibiotic treatments to control the VBN increase caused by IS. In both experiments, IS were inserted during 14 days in anoestrous ewes. In the first, 11 ewes received commercial sponges (50 mg MAP), and 10 ewes received placebo sponges...
April 2011: Reproduction in Domestic Animals, Zuchthygiene
J F Aller, O Fernandez, E Sanchez
Synchronization of estrous and fixed-time artificial insemination (FTAI) was conducted during the reproductive season of 2008 (March-April) in a local red deer breeding farm in Argentina. Multiparous suckling hinds (n=38) were artificially inseminated following hormonal treatment (intravaginal sponge containing 100mg of medroxiprogesterone acetate). At the time of sponge removal (day 12) 250 IU of eCG and 500 microg of PGF2alpha were given to each hind. The FTAI was performed at 48-55 h after device removal with cryopreserved semen imported from New Zealand...
October 2009: Animal Reproduction Science
Víctor Ruiz Velasco
The management of the leiomyomata uteri, the most common of the uterine tumors, has changed a lot in the lasa years. The tendency for women to postpone a first pregnancy until later years, when there is a more frequent occurrence of myomata and the fertility desire persist. In that way there is an increasing consideration of the conservative therapy. The epidemiological data are exposed, as the main symptoms and the diagnostic procedures. We refer the nowadays conservative treatments, since the surgical ones (myomectomies, abdominal, laparoscopic and histeroscopio, embolization, uterine artery occlusion); including the myolysis, and termoablative techniques; until the pharmacological therapy (Gn-RH(a)) gestrinone medroxiprogesterone, mifepristone, etc...
2006: Anales de la Real Academia Nacional de Medicina
J P Soler, N Mucci, G G Kaiser, J Aller, J W Hunter, T E Dixon, R H Alberio
Two multiple ovulation and embryo transfer (MOET) programs with fresh, frozen and vitrified red deer embryos were carried out during the reproductive season of 2005 and 2006 in a local breeding farm in Argentina. Multiparous (n=10 and 9, respectively) weaned hinds were used as donors for each year. The estrous synchronization treatment of donors and recipients consisted of inserting an ovine intravaginal sponge containing medroxiprogesterone acetate (MAP) for 12 days. Superovulation was conducted with a total dose of 180 mg of NIH-FSH-P1 (Folltropin-V, Bioniche, Belleville, Ontario, Canada), given i...
December 2007: Animal Reproduction Science
Sebastián Carranza Lira, Ana Luz MacGregor Gooch, Aleida Olivares, Sandra Luz González Legorreta, Nadia Saldívar, Juan Carlos Martínez Chéquer
OBJECTIVE: To evaluate the effect of conjugated equine estrogens (CEE) plus medroxyprogesterone acetate (MPA) and raloxifene on serum levels of complement C3 and C4 fractions in postmenopausal women. PATIENTS AND METHOD: Twenty healthy postmenopausal women were studied. In all weight, height and body mass index (BMI) were documented. FSH and estradiol levels were measured. They were randomly divided into two groups, according to the treatment they received: group I, CEE 0...
October 2005: Ginecología y Obstetricia de México
Miriam Judith Diament, Guillermo Daniel Peluffo, Isabel Stillitani, Leandro Carlos Cerchietti, Alfredo Navigante, Stella Maris Ranuncolo, Slobodanka Mariana Klein
Mice bearing LP07 lung adenocarcinoma present some characteristics similar to those shown in patients with several malignant diseases. LP07 tumor bearers develop paraneoplastic syndromes such as cachexia, leukocytosis, and hypercalcemia, partly due to a systemic inflammatory response. We analyzed some of the mechanisms involved in the effectiveness of the association of the appetite-stimulant medroxiprogesterone acetate (MPA) and the nonselective cyclooxigenase (COX) inhibitor indomethacin (INDO) in LP07 tumor bearing mice...
March 2006: Cancer Investigation
F J Pena, J A Gines, J Duque, V Vieitez, R Martinez-Pérez, L Madejón, I Nuñez Martinez, J M Moran, S Fernández-García
A 6-year-old female Alaska Malamute dog was presented for evaluation of abdominal enlargement referred by a local veterinarian. On the history, the owner complained of chronic abdominal enlargement initiated more than 4 months ago, reduced appetite, occasional vomiting and general dullness. He also complained of greenish mucous intermittent vaginal discharge starting 10 days ago. The bitch was chronically treated with medroxiprogesterone acetate. A laparatomy was performed and fluid in the abdomen was found and aspirated during the surgery...
April 2006: Reproduction in Domestic Animals, Zuchthygiene
Giovanni Mantovani, Clelia Madeddu, Antonio Macciò, Giulia Gramignano, Maria Rita Lusso, Elena Massa, Giorgio Astara, Roberto Serpe
OBJECTIVE: Cancer-related anorexia/cachexia syndrome and oxidative stress play a key role in the progression and outcome of neoplastic disease. PATIENTS AND METHODS: On the basis of our previously published studies and clinical experience, we have developed an innovative approach consisting of diet with high polyphenol content (400 mg), p.o. pharmaconutritional support enriched with n - 3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid) 2 cans (237 mL each) per day, medroxiprogesterone acetate 500 mg/d, antioxidant treatment with alpha-lipoic acid 300 mg/d plus carbocysteine lysine salt 2...
October 2004: Cancer Epidemiology, Biomarkers & Prevention
Guilherme de Medeiros Bastos, Ricardo Heitor Brenner, Fabrício Wollman Willke, Jairo Pereira Neves, João Francisco Coelho de Oliveira, José Francisco Manta Bragança, Sérgio Abreu Machado, Patrícia Marafon Porciúncula, Paulo Bayard Dias Gonçalves
The objective was to develop a program for inducing estrus (followed by insemination) of suckled beef cows under nutritional stress (poor body condition). A total of 123 cows, from 60 to 75 days postpartum, were classified according to their body condition score (BCS; range from 1 to 5, in increments of 0.5) and allocated into two groups. On Day 0 (without regard to stage of the estrous cycle), cows (n = 59) in the hormone induction (HI) treatment group were given an intravaginal device (IVD) containing 250 mg of medroxiprogesterone acetate (MAP) and an i...
September 1, 2004: Theriogenology
Pablo Juan Ross, Juan Florencio Aller, Santiago Saul Callejas, Horacio Butler, Ricardo Horacio Alberio
The objective of Experiment 1 was to compare the effects of estradiol benzoate (EB) given 0 or 24h after the end of a progestagen treatment on ovulation and CL formation in anestrous cows. Twenty cows were treated with an intravaginal sponge containing 250 mg of medroxiprogesterone acetate (MPA). At sponge insertion, each cow received 3 mg EB and 10 mg MPA im. At device removal, cows received 0.7 mg EB either at that time (EB0) or 24h later (EB24). Ultrasound examinations and blood sampling to determine plasma progesterone concentrations were performed to detect ovulation and CL formation...
July 2004: Theriogenology
Arnaldo Porcile, Enrique Gallardo, Patricia Duarte, Sócrates Aedo
BACKGROUND: Tibolone has estrogenic, androgenic and progestational effects and is used in post menopausal women. It apparently has weaker effects on endometrial proliferation and mammary stimulation than conventional hormone replacement therapy. AIM: To compare the metabolic effects of tibolone (5 mg/day) and continuous combined conjugated estrogens/medroxyprogesterone acetate in postmenopausal women. PATIENTS AND METHODS: Postmenopausal women, aged 45 to 60 years old, receiving estradiol valerate and medroxyprogesterone were included in the study...
October 2003: Revista Médica de Chile
Kimitaka Kogure, Teruhisa Sakurai, Yasushi Tsuzuki, Masatoshi Ishizaki, Masaaki Nemoto, Toshio Fukusato, Hiroyuki Kuwano, Masatoshi Makuuchi
Long-term survival after the resection for liver metastasis from breast cancer is rare. We report on a 49-year-old woman who has been alive and well for 12 years following hepatic resection for metastatic breast cancer. Fourteen years before, the patient underwent a radical mastectomy for cancer of the right breast. One year after the operation the patient presented with right upper quadrant pain and a large isolated right lobe liver metastasis was found. Initially, it was too large to be treated by hepatectomy...
May 2003: Hepato-gastroenterology
V O Fuentes, V Sanchez, R Rosiles, P I Fuentes
The objective of this work was to study the effect of the endogenous opiate peptide (EOP) antagonist, naloxone, on the preovulatory LH surge and on the time of onset and duration of oestrus in the ewe with induced oestrus during the non-breeding season. Forty Suffolk X Hampshire ewes 2-3-years-old and 50+/- 4kg were studied, ewes were divided at random in two groups of 20, housed in open paddocks under natural photoperiod (19 degrees latitude N); were fed with hay and commercial pellets, and provided water ad libitum...
March 30, 2001: Animal Reproduction Science
F Rodriguez-Alemán, J M Torres, J L Cuadros, E Ruiz, E Ortega
Serum levels of cholesterol (Chol), triglycerides (TG), low-density lipoprotein cholesterol (LDL) high-density lipoprotein cholesterol (HDL), both apolipoproteins A1 and B (Apo A1, Apo B), follicle-stimulating hormone (FSH) luteinizing hormone (LH), estradiol (E2), progesterone (P), testosterone (T) and steroid hormone binding globulin (SHBG) were measured in postmenopausal women, before and after four different estrogen-progestin replacement therapies. Each woman was her own control to avoid genetic or socioeconomic differences...
May 2000: Endocrine Research
J E Romano, B G Crabo, C J Christians
The effect of sterile service on estrus duration, fertility and prolificacy in artificially inseminated dairy goats during breeding season was studied. Nubian does (n=126) were divided into 2 equal groups: service and control. Estrus was synchronized with intravaginal sponges containing either fluorgestone acetate (FGA; 40 mg) or medroxiprogesterone acetate (MAP; 60 mg) for 12 or 14 d, respectively. Two vasectomized teaser bucks were used to detect estrus at 6-h intervals for 5 d after sponge removal (0600, 1200, 1800 and 2400 h)...
April 1, 2000: Theriogenology
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