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hepatitis b and pregnancy

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https://www.readbyqxmd.com/read/27898957/supplementation-of-corn-dried-distillers-grains-plus-solubles-to-gestating-beef-cows-fed-low-quality-forage-ii-impacts-on-uterine-blood-flow-circulating-estradiol-17%C3%AE-and-progesterone-and-hepatic-steroid-metabolizing-enzyme-activity
#1
V C Kennedy, B R Mordhorst, J J Gaspers, M L Bauer, K C Swanson, C O Lemley, K A Vonnahme
The objective of this study was to investigate the effects of supplementing dried distillers' grains plus solubles (DDGS) during late gestation on uterine blood flow (BF), circulating steroid hormones and hepatic steroid metabolizing enzymes, and calf and placental weights. Multiparous beef cows were randomly divided into a control group (CON; = 15) consuming a diet containing 90% corn stover and 10% corn silage (DM basis) for ad libitum intake and a treatment group (SUP; = 12) consuming the same diet and DDGS (0...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898721/hepatitis-b-virus-infections-and-associated-factors-among-pregnant-women-attending-antenatal-care-clinic-at-deder-hospital-eastern-ethiopia
#2
Abdi Umare, Berhanu Seyoum, Tesfaye Gobena, Tamirat Haile Mariyam
BACKGROUND: Hepatitis B virus (HBV) infection is a serious public health problem worldwide. Reports have shown that 68,600 people die of HBV infection and more than 300,000 deaths due to liver cancer secondary to hepatitis B every year globally. Women who are infected with HBV can vertically transmit the infection to their infants. This study aims to determine the prevalence of HBV infection and associated factors among pregnant women. METHODS AND FINDINGS: A hospital-based cross-sectional study was conducted among pregnant women who attended antenatal care clinic (ANC) for routine pregnancy check-up between 18 March 2015 and 15 May 2015...
2016: PloS One
https://www.readbyqxmd.com/read/27879486/prospective-interventional-study-of-tenofovir-in-pregnancy-to-prevent-vertical-transmission-of-hepatitis-b-in-highly-viremic-women
#3
Pierre O Sellier, Sarah Maylin, Béatrice Berçot, Dorothée Chopin, Amanda Lopes, Guy Simoneau, John Evans, Véronique Delcey, Jean-Louis Bénifla, François Simon, Jean-François Bergmann
BACKGROUND: The risk of vertical transmission of hepatitis B virus (HBV) increases as maternal HBV DNA increase, despite serovaccination to newborns. METHODS: From 1 July 2012 to 1 January 2016, all pregnant women in Lariboisiere Hospital, Paris, France, with HBV DNA of 5 log10 IU/ml and above were administered tenofovir from week 28 of pregnancy until delivery. HBV DNA was measured at months 1, 2 of tenofovir and at delivery. The newborns were serovaccinated, tested for hepatitis B surface antigen, hepatitis B core antibody (HBcAb)±HBV DNA, and hepatitis B surface antibody (HBsAb) when aged 9 months, and then 24 months...
November 22, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27875320/association-of-chronic-hepatitis-b-virus-infection-with-preterm-birth-our-experience-and-meta-analysis
#4
Ai-Min Cui, Jian-Guo Shao, Hai-Bo Li, Yi Shen, Zhi-Xian Chen, Sheng Zhang, Zhao-Lian Bian, Gang Qin, Xiao-Yan Cheng
OBJECTIVES: To assess the association of chronic hepatitis B virus (HBV) infection with preterm birth (PTB). METHODS: A cohort of 20,498 pregnant women (497 HBV carriers with 20,001 non-HBV controls) with normal alanine aminotransferase (ALT) levels was selected from the Obstetrics & Gynecology Hospital of Nantong University. The clinical parameters and PTB incidence were compared between HBV carriers and non-HBV subjects. For the meta-analysis, we searched the PubMed, Ovid and Cochrane Library databases for studies comparing PTB incidence between individuals with chronic HBV infection and non-HBV subjects...
November 22, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27873053/relationship-between-the-mechanism-of-hepatitis-b-virus-father-infant-transmission-and-pregnancy-outcome
#5
Ying Kong, Yi Liu, Xiaojing Liu, Na Li, Zirong Zhu, Aiyun Zhang, Jianxue Liu, Feng Ye, Shumei Lin
PURPOSE: This study examined the relationship between the mechanism of hepatitis B virus (HBV) father-infant transmission via reproductive cells and pregnancy outcome. METHODS: Abandoned in vitro fertilization (IVF) embryos of fathers with chronic HBV infection were taken as study objects. HBV mRNA in embryos was detected, and successfully transplanted embryos were followed up to determine the relationship between HBV-infected embryos and pregnancy outcome. RESULTS: HBV mRNA signals were detected in one embryo in the group with HBV-positive fathers; the positive rate was 1/18 (5...
November 21, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27866601/assessment-of-state-perinatal-hepatitis-b-prevention-laws
#6
Lindsay A Culp, Lisa Caucci, Nancy E Fenlon, Megan C Lindley, Noele P Nelson, Trudy V Murphy
INTRODUCTION: Identifying pregnant women with hepatitis B virus (HBV) infection for post-exposure prophylaxis of their infants is critical to preventing mother-to-child transmission of HBV infection. HBV infection in infancy results in premature death from chronic liver disease or cancer in 25% of affected infants. Universal screening of pregnant women for HBV infection is the standard of care, and in many states is supported by laws for screening and reporting these infections to public health...
December 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27852658/indications-for-antiviral-therapy-for-chronic-hepatitis-b-in-pregnant-mothers
#7
Eric Raeyoon Yoo, Ryan Babu Perumpail, George Cholankeril, Aijaz Ahmed
The use of antiviral therapy for chronic hepatitis B virus (HBV) infection in the setting of pregnancy needs to be individualised based on limited data. We report a case of a 34-year-old Korean-American woman with a history of pregnancy with emergent caesarean section due to prolonged labour in the setting of HBV e-antigen (HBeAg) positive chronic HBV with a pretreatment baseline HBV DNA level of 110000 000 million copies per mL. Her first delivery was complicated by mother-to-child transmission (MTCT) of HBV infection to her daughter despite standard active and passive immunoprophylaxis...
November 15, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27805270/national-trends-of-hepatitis-b-and-c-during-pregnancy-across-sociodemographic-behavioral-and-clinical-factors-united-states-1998-2011
#8
Jason L Salemi, Kiara K Spooner, Maria C Mejia de Grubb, Anjali Aggarwal, Jennifer L Matas, Hamisu M Salihu
Currently, data examining nationally representative prevalence and trends of HBV or HCV among specific subgroups of pregnant women in the US are unavailable. We conducted a cross-sectional analysis of hospitalizations for liveborn singleton deliveries from 1998 to 2011 using data from the Nationwide Inpatient Sample. After identifying deliveries with HBV, HCV, and HIV infection during pregnancy, survey logistic regression was used to identify risk factors. Temporal trends were analyzed using joinpoint regression...
November 2, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27796133/vertical-transmission-of-hepatitis-b-virus-during-pregnancy-and-delivery-in-denmark
#9
Nina Weis, Susan Cowan, Sofie Hallager, Sandra Dröse, Lena Hagelskjær Kristensen, Karin Grønbæk, Jan Gerstoft, Lone G Madsen, Mette Rye Clausen, Suzanne Lunding, Britta D Tarp, Toke S Barfod, Stine Sloth, Dorte Kinggaard Holm, Jesper Jensen, Henrik Krarup
OBJECTIVE: In Denmark, pregnant women have been screened for hepatitis B virus (HBV) since 2005, and children born to HBV-infected mothers offered hepatitis B immunoglobulin at birth, vaccination against HBV at birth and after 1, 2 and 12 months. The purpose of this study was to determine the risk of vertical HBV transmission in children born to mothers with chronic HBV infection, to investigate the antibody response in the children and to investigate possible maternal predictive risk factors for HBV transmission...
October 31, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27795784/-seroprevalence-of-hbsag-in-pregnant-women-in-central-morocco
#10
Mohammed Sbiti, Hanane Khalki, Imane Benbella, Lhoussaine Louzi
Maternal-fetal transmission of hepatitis B virus (HBV) is a global public health problem leading to the implementation of strengthened prevention measures. Viral replication in HIV-positive mother, assessed based on HBeAg positivity and the rate of viral load, determines the contamination risk which is very important during perinatal period. Mothers with chronic HBV are a real reservoir of vertical transmission of this infection. This is a prospective investigation of 1120 pregnant Moroccan women aiming to study the seroprevalence of HBsAg which was 2...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27763549/maternal-betaine-supplementation-throughout-gestation-and-lactation-modifies-hepatic-cholesterol-metabolic-genes-in-weaning-piglets-via-ampk-lxr-mediated-pathway-and-histone-modification
#11
Demin Cai, Mengjie Yuan, Haoyu Liu, Shifeng Pan, Wenqiang Ma, Jian Hong, Ruqian Zhao
Betaine serves as an animal and human nutrient which has been heavily investigated in glucose and lipid metabolic regulation, yet the underlying mechanisms are still elusive. In this study, feeding sows with betaine-supplemented diets during pregnancy and lactation increased cholesterol content and low-density lipoprotein receptor (LDLR) and scavenger receptor class B type I (SR-BI) gene expression, but decreasing bile acids content and cholesterol-7a-hydroxylase (CYP7a1) expression in the liver of weaning piglets...
October 18, 2016: Nutrients
https://www.readbyqxmd.com/read/27761922/urticarial-exanthema-due-to-hepatitis-b-in-a-pregnant-woman-mimicking-a-polymorphic-eruption-of-pregnancy
#12
B Lozano-Masdemont, L Gómez-Recuero-Muñoz, A Pulido-Pérez, I Molina-López, R Suárez-Fernández
Hepatitis B virus (HBV) infection in pregnant women is very rare in western countries, thus, cutaneous manifestation of HBV infection may be confused with a dermatosis specific of pregnancy. We report a 39-year-old woman who presented in her 20th week of pregnancy with a pruritic rash, which consisted of generalized erythematous plaques, some of them with a purple centre. Serology testing showed acute HBV infection, and a biopsy revealed a superficial and interstitial perivascular inflammatory infiltrate of lymphocytes and eosinophils...
October 20, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27749537/telbivudine-treatment-of-hepatitis-b-virus-infected-pregnant-women-at-different-gestational-stages-for-the-prevention-of-mother-to-child-transmission-outcomes-of-telbivudine-treatment-during-pregnancy
#13
Zhangmin Tan, Yuzhu Yin, Jin Zhou, Lingling Wu, Chengfang Xu, Hongying Hou
This prospective study evaluated the viability of telbivudine for blocking mother-to-child transmission (MTCT) of hepatitis B virus (HBV) infection.Pregnant women positive for the hepatitis B surface antigen began telbivudine treatment before 14 weeks of gestation (i.e., early), between 14 and 28 weeks of gestation (late), or not at all (control). In the late-treatment group, 55 women terminated telbivudine therapy within puerperium. All neonates underwent routine hepatitis B immunoglobulin plus vaccination...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27747531/rituximab-for-rheumatoid-arthritis
#14
Marc D Cohen, Edward Keystone
Rituximab is a chimeric monoclonal antibody directed at the CD20 molecule on the surfaces of some but not all B cells. It depletes almost all peripheral B cells, but other niches of B cells are variably depleted, including synovium. Its mechanism of action in rheumatoid arthritis (RA) is only partially understood. Rituximab was efficacious in clinical trials of patients with RA, including those who are methotrexate naïve, those with an incomplete response to methotrexate, and those with an incomplete response to tumor necrosis factor inhibitors...
December 2015: Rheumatol Ther
https://www.readbyqxmd.com/read/27742003/epidemiology-of-hepatitis-b-virus-infection-and-impact-of-vaccination-on-disease
#15
Noele P Nelson, Philippa J Easterbrook, Brian J McMahon
Integration of hepatitis B vaccination into national immunization programs has resulted in substantial reductions of hepatitis B virus (HBV) transmission in previously high endemic countries. The key strategy for control of the HBV epidemic is birth dose and infant vaccination. Additional measures include use of hepatitis B immunoglobulin (HBIG) and diagnosis of mothers at high risk of transmitting HBV and use of antiviral agents during pregnancy to decrease maternal DNA concentrations to undetectable concentrations...
November 2016: Clinics in Liver Disease
https://www.readbyqxmd.com/read/27741190/gestational-alloimmune-liver-disease-a-devastating-condition-preventable-with-maternal-intravenous-immunoglobulin
#16
Hannah B Anastasio, Maureen Grundy, Meredith L Birsner, Karin J Blakemore
BACKGROUND: Gestational alloimmune liver disease, a form of profound liver failure in the newborn, is the main underlying cause of the entity formerly known as neonatal hemochromatosis. Antepartum maternal intravenous immunoglobulin (IVIG) has been shown to prevent gestational alloimmune liver disease, which otherwise has a recurrence risk above 90% in subsequent pregnancies. CASE: A 30-year-old woman, gravida 3 para 0120, presented early in gestation. Her previous pregnancy had been complicated by fetal growth restriction, oligohydramnios, and ultimately fatal fulminant neonatal liver failure...
November 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27658693/hepatitis-b-viral-load-response-to-two-antiviral-regimens-tenofovir-lamivudine-vs-lamivudine-in-hiv-and-hbv-co-infected-pregnant-women-in-guangxi-china-the-tenofovir-in-pregnancy-tip-study
#17
Liming Wang, Jeffrey Wiener, Marc Bulterys, Xiaoyu Wei, Lili Chen, Wei Liu, Shujia Liang, Colin Shepard, Linhong Wang, Ailing Wang, Fujie Zhang, Athena P Kourtis
BACKGROUND:  There is limited information on HBV-antiviral therapy among HIV/HBV co-infected pregnant women. METHODS:  Phase II randomized controlled trial of a regimen containing tenofovir (TDF) /lamivudine (3TC), versus 3TC, in HIV/HBV co-infected pregnant women in China. The HBV virological response was compared in study arms (Clinical Trials registration: #NCT01125696). RESULTS:  Median decline of HBV DNA was 2.60 log10 copies/ml in the TDF-3TC arm; 2...
September 22, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27643724/hepatic-fat-and-abdominal-adiposity-in-early-pregnancy-together-predict-impaired-glucose-homeostasis-in-mid-pregnancy
#18
L R De Souza, H Berger, R Retnakaran, P A Vlachou, J L Maguire, A B Nathens, P W Connelly, J G Ray
Hepatic fat and abdominal adiposity individually reflect insulin resistance, but their combined effect on glucose homeostasis in mid-pregnancy is unknown. A cohort of 476 pregnant women prospectively underwent sonographic assessment of hepatic fat and visceral (VAT) and total (TAT) adipose tissue at 11-14 weeks' gestation. Logistic regression was used to assess the relation between the presence of maternal hepatic fat and/or the upper quartile (Q) of either VAT or TAT and the odds of developing the composite outcome of impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or gestational diabetes mellitus at 24-28 weeks' gestation, based on a 75 g OGTT...
2016: Nutrition & Diabetes
https://www.readbyqxmd.com/read/27630725/prevalence-of-hepatitis-b-and-c-viral-infection-among-pregnant-women-in-peshawar-pakistan
#19
Irshad Ahmad
BACKGROUND: Viral hepatitis during pregnancy is associated with a high risk of maternal complications. The virus has a high risk of vertical transmission and it has been reported as the leading cause of maternal death. OBJECTIVES: To study the prevalence of hepatitis B (HBV) and hepatitis C (HCV) viral infections among pregnant women in the Peshawar district of Pakistan. MATERIALS AND METHODS: The cross-sectional study took place between July 2013 and April 2014...
June 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27628034/the-leptin-system-and-its-expression-at-different-nutritional-and-pregnant-stages-in-lined-seahorse-hippocampus-erectus
#20
Huixian Zhang, Geng Qin, Yanhong Zhang, Shuisheng Li, Qiang Lin
Leptin is an essential hormone for the regulation of energy metabolism and food intake in vertebrate animals. To better understand the physiological roles of leptin in nutrient regulation in paternal ovoviviparous fish (family Syngnathidae), the present study cloned the full-length of leptin-a and leptin receptor (lepr) genes in lined seahorse (Hippocampus erectus). Results showed that there was a 576-bp intron between two exons in leptin-a gene but no leptin-b gene in seahorse. Although the primary amino acid sequence conservation of seahorse leptin-a was very low, the 3-D structure modeling of seahorse leptin-a revealed strong conservation of tertiary structure with other vertebrates...
October 15, 2016: Biology Open
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