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First trimester screening

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https://www.readbyqxmd.com/read/28212108/the-association-between-pre-pregnancy-obesity-and-screening-results-of-depression-for-all-trimesters-of-pregnancy-postpartum-and-1-year-after-birth-a-cohort-study
#1
Hanieh Salehi-Pourmehr, Sakineh Mohammad-Alizadeh, Nayyer Jafarilar-Agdam, Somayyeh Rafiee, Azizeh Farshbaf-Khalili
OBJECTIVE: To determine the relationship between pre-pregnancy obesity and screening results of gestational and post-delivery depression in women referred to the health centers of Tabriz, Iran. METHODS: In this cohort study, 62 and 245 pregnant women with class 2-3 obesity [body mass index (BMI)≥35 kg/m2] and normal-weight (BMI 18.5-24.9 kg/m2) were enrolled, respectively, in the first trimester of pregnancy from December 2012 to January 2016. For matching of groups, nulliparous and multiparous mothers aged 18-35 years were selected with the ratio of 1:4 in obese and normal BMI groups from the same recruitment center and to controlling the confounder factors, inclusion criteria were considered...
February 17, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28199996/importance-of-timing-first-trimester-placental-growth-factor-and-use-of-serial-first-trimester-placental-growth-factor-measurements-in-screening-for-preeclampsia
#2
Beatrice Mosimann, Sofia Amylidi-Mohr, Katrin Höland, Daniel Surbek, Lorenz Risch, Luigi Raio
OBJECTIVE: The aims of this study were to test whether the performance of first-trimester placental growth factor (PlGF) in screening for preterm preeclampsia (PE) is gestational age dependent and to assess the value of serial first-trimester PlGF measurements in discriminating women at risk for PE. METHODS: PlGF was measured in women with singleton pregnancies at their first antenatal visit at 8+0 to 10+6 and additionally at 11+0 to 14+0 weeks of gestation. The difference in absolute values of serial PlGF measurements was expressed as Δ-PlGF...
February 16, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28186956/uterine-artery-doppler-pulsatility-index-at-11-38-weeks-in-icsi-pregnancies-with-egg-donation
#3
Annalisa Inversetti, Luca Mandia, Massimo Candiani, Irene Cetin, Alessandro Larcher, Valeria Savasi, Enrico Papaleo, Paolo Cavoretto
BACKGROUND: Uterine artery Doppler pulsatility index (UtA-PI) may be different in pregnancies with egg donation (ICSI-ED) as compared to conceptions with autologous intra-cytoplasmatic sperm injection (autologous ICSI) and to spontaneous conceptions (SC). METHODS: One hundred and ninety-four pregnant women with different modes of conception (MC) were prospectively evaluated: 53 ICSI-ED, 36 autologous ICSI and 105 SC. To evaluate the effects of different MC on PI, multivariable linear regression (MLR) models predicting UtA-PI were fitted after adjustment for maternal age, body mass index, race, parity, smoking status and gestational age...
February 10, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28182660/first-trimester-screening-of-circulating-c19mc-micrornas-and-the-evaluation-of-their-potential-to-predict-the-onset-of-preeclampsia-and-iugr
#4
Ilona Hromadnikova, Katerina Kotlabova, Katarina Ivankova, Ladislav Krofta
OBJECTIVES: A nested case control study of a longitudinal cohort comparing pregnant women enrolled at 10 to 13 gestational weeks was carried out to evaluate risk assessment for preeclampsia and IUGR based on circulating placental specific C19MC microRNAs in early pregnancy. METHODS: The expression of placental specific C19MC microRNAs (miR-516b-5p, miR-517-5p, miR-518b, miR-520a-5p, miR-520h, and miR-525-5p) was determined in plasma samples from pregnancies that subsequently developed preeclampsia (n = 21), IUGR (n = 18), and 58 normal pregnancies using real-time PCR and comparative Ct method relative to synthetic Caenorhabditis elegans microRNA (cel-miR-39)...
2017: PloS One
https://www.readbyqxmd.com/read/28171716/reference-intervals-of-thyroid-hormones-during-pregnancy-in-korea-an-iodine-replete-area
#5
Hye Jeong Kim, Yoon Young Cho, Sun Wook Kim, Tae Hyuk Kim, Hye Won Jang, Soo-Youn Lee, Suk-Joo Choi, Cheong-Rae Roh, Jong-Hwa Kim, Jae Hoon Chung, Soo-Young Oh
Background/Aims: Maternal thyroid dysfunction has been associated with adverse pregnancy outcomes. The purpose of our study was to establish trimester-specific reference intervals for thyroid hormones in pregnant women in Korea, where iodine intake is more than adequate and to examine pregnancy and perinatal outcomes in their offspring. Methods: Among 459 healthy pregnant women who were screened, we enrolled 417 subjects who had negative results for thyroid autoantibodies...
February 8, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28169498/re-validation-of-a-first-trimester-screening-model-for-pre-eclampsia-in-an-unselected-population-e-scazzocchio-f-crovetto-s-triunfo-e-gratac%C3%A3-s-and-f-figueras-ultrasound-obstet-gynecol-2017-49-188-193
#6
COMMENT
https://www.readbyqxmd.com/read/28162023/comparison-of-two-risk-assessment-algorithms-for-preeclampsia-in-first-trimester-with-consecutive-intake-of-low-dose-aspirin-in-the-high-risk-group-an-observational-study
#7
Ioana-Claudia Lakovschek, Bence Csapo, Vassiliki Kolovetsiou-Kreiner, Karoline Mayer-Pickel, Philipp Reif, Christina Stern, Daniela Ulrich, Uwe Lang, Barbara Obermayer-Pietsch, Mila Cervar-Zivkovic
We analyzed outcome of women screened for preeclampsia with two different multifactorial risk algorithms (Predictor®Software by PerkinElmer; PERK-group:n = 214 and Viewpoint® by GE Healthcare; VIEW-group:n = 209) in first trimester. Women at high risk for developing preeclampsia were advised to take low-dose acetylsalicylic-acid(LDA). Screening positive rates for early onset preeclampsia differed significantly between the two groups (7.9% vs 26.3%;p = 0.000). According clinical use of screening test criteria LDA was prescribed in 63(29...
February 5, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28161058/endogenous-and-exogenous-mir-520c-3p-modulates-cd44-mediated-extravillous-trophoblast-invasion
#8
Hironori Takahashi, Akihide Ohkuchi, Tomoyuki Kuwata, Rie Usui, Yosuke Baba, Hirotada Suzuki, Tha Thu Chaw Kyi, Shigeki Matsubara, Shigeru Saito, Toshihiro Takizawa
INTRODUCTION: Adequate extravillous trophoblast (EVT) invasion is essential for successful placentation. Although miR-520c-3p plays an important role in CD44-mediated invasion in cancer cells, there is little information on whether miR-520c-3p is involved in the regulatory mechanisms of CD44-mediated EVT invasion. METHODS: We screened first trimester trophoblast cells and trophoblast cell lines for expression of miR-520c-3p using real-time polymerase chain reaction...
February 2017: Placenta
https://www.readbyqxmd.com/read/28143885/does-first-trimester-screening-modify-the-natural-history-of-congenital-heart-disease-%C3%A2-analysis-of-outcome-of-regional-cardiac-screening-at-two-different-time-periods
#9
Hana Jicinska, Pavel Vlasin, Michal Jicinsky, Ilga Grochova, Viktor Tomek, Julia Volaufova, Jan Skovranek, Jan Marek
BACKGROUND: -The study analyzed the impact of first trimester screening on the spectrum of congenital heart defects (CHD) later in pregnancy, and on the outcome of fetuses and children born alive with CHD. METHODS: -The spectrum of CHD, associated comorbidities and outcome of fetuses either diagnosed with CHD in the first trimester (Group I, 127 fetuses), or only in the second trimester screening (Group II, 344 fetuses), were analyzed retrospectively between 2007 and 2013...
January 31, 2017: Circulation
https://www.readbyqxmd.com/read/28134395/ultrasound-examination-of-the-fetal-heart
#10
Katherine C Bishop, Jeffrey A Kuller, Brita K Boyd, Eleanor H Rhee, Stephen Miller, Piers Barker
Congenital heart disease (CHD) occurs in 4-13 per 1000 births in the United States. While many risk factors for CHD have been identified, more than 90% of cases occur in low-risk patients. Guidelines for fetal cardiac screening during the second trimester anatomy ultrasound have been developed by the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) in order to improve antenatal detection rates and to standardize the fetal cardiac screening examination. Patients found to be at increased risk of CHD because of risk factors or an abnormal screening examination should be referred for second trimester fetal echocardiography...
January 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28134236/-phq-2-as-first-screening-instrument-of-prenatal-depression-in-primary-health-care-spain
#11
María de la Fe Rodríguez-Muñoz, Pilar Carolina Castelao Legazpi, María Eugenia Olivares Crespo, Cristina Soto Balbuena, Nuria Izquierdo Méndez, Francisco Javier Ferrer Barrientos, Le Huynh-Nhu
OBJECTIVE: Prenatal depression is a major public health problem that is barely treated. Based on existing literature, depression during this period is associated with negative consequences for the mother and the baby. Therefore it is important to make an adequate screening in this population. The aim of this study was to determine the discriminant validity and cut-off of the Patient Health Questionnaire (PHQ-2) as a screening tool to identify the depression in pregnant women living in Spain...
January 30, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28133835/the-cut-off-value-for-normal-nuchal-translucency-evaluated-by-chromosomal-microarray-analysis
#12
Idit Maya, Shiri Yacobson, Sarit Kahana, Josepha Yeshaya, Tamar Tenne, Ifaat Agmon-Fishman, Lital Cohen-Vig, Mordechai Shohat, Lina Basel-Vanagaite, Reuven Sharony
OBJECTIVES: An association between isolated, increased nuchal translucency thickness and pathogenic chromosomal microarray analysis (CMA) has been reported. A recent meta-analysis reported that most studies used a 3.5 mm cut-off value. Considering nuchal translucency distribution and the commonly accepted 5% false positive rate in maternal serum screening, nuchal translucency cut-off levels should be reconsidered. This study evaluated the unique contribution of CMA to the investigation of foetuses with mildly increased nuchal translucency (NT) thickness of 3...
January 30, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28131535/results-of-a-1-year-quality-improvement-process-to-reduce-door-to-needle-time-in-acute-ischemic-stroke-with-mri-screening
#13
D Sablot, N Gaillard, C Colas, P Smadja, C Gely, A Dutray, J-M Bonnec, S Jurici, G Farouil, A Ferraro-Allou, M Jantac, T Allou, C Pujol, N Olivier, A Laverdure, B Fadat, J Mas, A Dumitrana, Y Garcia, H Touzani, P Perucho, T Moulin, C Richard, C Heroum, S Bouly, C Sagnes-Raffy, D Heve
OBJECTIVE: To determine the effects of a 1-year quality-improvement (QI) process to reduce door-to-needle (DTN) time in a secondary general hospital in which multimodal MRI screening is used before tissue plasminogen activator (tPA) administration in patients with acute ischemic stroke (AIS). METHODS: The QI process was initiated in January 2015. Patients who received intravenous (iv) tPA<4.5h after AIS onset between 26 February 2015 to 25 February 2016 (during implementation of the QI process; the "2015 cohort") were identified (n=130), and their demographic and clinical characteristics and timing metrics compared with those of patients treated by iv tPA in 2014 (the "2014 cohort", n=135)...
January 25, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28126630/automatic-detection-and-measurement-of-nuchal-translucency
#14
Giuseppa Sciortino, Domenico Tegolo, Cesare Valenti
In this paper we propose a new methodology to support the physician both to identify automatically the nuchal region and to obtain a correct thickness measurement of the nuchal translucency. The thickness of the nuchal translucency is one of the main markers for screening of chromosomal defects such as trisomy 13, 18 and 21. Its measurement is performed during ultrasound scanning in the first trimester of pregnancy. The proposed methodology is mainly based on wavelet and multi resolution analysis. The performance of our method was analysed on 382 random frames, representing mid-sagittal sections, uniformly extracted from real clinical ultrasound videos of 12 patients...
January 20, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28126366/testing-for-zika-virus-infection-in-pregnancy-key-concepts-to-deal-with-an-emerging-epidemic
#15
REVIEW
Catherine Eppes, Martha Rac, James Dunn, James Versalovic, Kristy O Murray, Melissa A Suter, Magda Sanz Cortes, Jimmy Espinoza, Maxim D Seferovic, Wesley Lee, Peter Hotez, Joan Mastrobattista, Steven L Clark, Michael A Belfort, Kjersti M Aagaard
Zika virus is an emerging mosquito-borne (Aedes genus) arbovirus of the Flaviviridae family. Following epidemics in Micronesia and French Polynesia during the past decade, more recent Zika virus infection outbreaks were first reported in South America as early as May 2013 and spread to now 50 countries throughout the Americas. Although no other flavivirus has previously been known to cause major fetal malformations following perinatal infection, reports of a causal link between Zika virus and microcephaly, brain and ocular malformations, and fetal loss emerged from hard-hit regions of Brazil by October 2015...
January 23, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28120818/pregnancy-and-menopause-in-patients-with-systemic-lupus-erythematosus-and-or-antiphospholipid-syndrome-practical-guide-from-eular
#16
Roberta Vagelli, Chiara Tani, Marta Mosca
Over the last few decades, in reproductive medicine have allowed an improvement in the management and outcome of pregnancy in connective tissue diseases (CTD), such as Systemic progress Lupus Erythematosus and Antiphospholipid Syndrome; however, pregnancy and other related issues represent a crucial moment for patients and their family and some unmet needs are still present. In routine clinical practise, health professionals involved in the care of SLE and/or APS patients need to consider many aspects of the reproductive life of patients, involving not only pregnancy and family planning but also fertility, contraception, cancer surveillance and menopause...
January 25, 2017: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/28116932/-the-risk-factors-of-mood-changing-during-the-perinatal-period
#17
Emőke Adrienn Hompoth, Annamária Töreki, Veronika Baloghné Fűrész, Gábor Németh
INTRODUCTION: The screening of perinatal depression was introduced in Szeged in April 2011. AIM: Our aim was to assess the extent of perinatal mood changing and to explore the risk factors of it. METHOD: Perinatal nurses gave the Edinburgh Postnatal Depression Scale to the 3849 participants four times. RESULTS: In the first trimester were the highest average scores (3.74) and pathological rate (10.8%) compared to the other measurement occasions...
January 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28114879/prevalence-of-chlamydia-trachomatis-and-neisseria-gonorrhoeae-in-an-urban-public-hospital-pregnancy-termination-clinic
#18
JeeYoon Park, Lindsay Zimmerman, Kelly Stempinski, Rebecca Bridge, Alicia Roston, Ashlesha Patel
This study is a follow-up observational study to assess the prevalence of chlamydia (CT) and gonorrhea (GC) among women who undergo a first-trimester surgical termination in a large public, urban hospital-based termination clinic, and to compare the rates to previously published data. We conducted a retrospective chart review on 4197 patients who underwent CT and GC testing before an elective, first-trimester surgical termination between 1 June 2014 and 31 May 2015. The prevalence rates were calculated and compared by chi square tests to previously published data from 1 January 2006 to 30 June 2006 from the same publicly-funded pregnancy termination clinic...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28108156/smfm-consult-series-42-the-role-of-ultrasound-in-women-who-undergo-cell-free-dna-screening
#19
Mary E Norton, Joseph R Biggio, Jeffrey A Kuller, Sean C Blackwell
The introduction of cell-free DNA (cfDNA) screening for aneuploidy into obstetric practice in 2011 revolutionized the strategies utilized for prenatal testing. The purpose of this document is to review the current data on the role of ultrasound in women who have undergone or are considering cfDNA screening. The following are SMFM recommendations: 1) in women who have already received a negative cfDNA screen, ultrasound at 11-14 weeks of gestation solely for the purpose of NT measurement (CPT code 76813) is not recommended (GRADE 1B); 2) we recommend that diagnostic testing should not be recommended to patients solely for the indication of an isolated soft marker in the setting of a negative cfDNA screen (GRADE 2B); 3) in women with an isolated soft marker without other clinical implications (ie, choroid plexus cyst or echogenic intracardiac focus) and a negative cfDNA screen, we recommend describing the finding as "not clinically significant" or as a "normal variant" (GRADE 2B); 4) in women with an isolated soft marker that has no other clinical implication (ie, choroid plexus cyst or echogenic intracardiac focus) and a negative first or second trimester screening result, we recommend describing the finding as "not clinically significant" or as a "normal variant" (GRADE 2B); 5) we recommend that all women in whom a structural abnormality is identified by ultrasound should be offered diagnostic testing with chromosomal microarray (GRADE 1A); 6) we recommend against routine screening for microdeletions with cfDNA (GRADE 1B)...
January 17, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28102101/thyroid-in-pregnancy-from-physiology-to-screening
#20
Drahomira Springer, Jan Jiskra, Zdenka Limanova, Tomas Zima, Eliska Potlukova
Thyroid hormones are crucial for the growth and maturation of many target tissues, especially the brain and skeleton. During critical periods in the first trimester of pregnancy, maternal thyroxine is essential for fetal development as it supplies thyroid hormone-dependent tissues. The ontogeny of mature thyroid function involves organogenesis, and maturation of the hypothalamus, pituitary and the thyroid gland; and it is almost complete by the 12th-14th gestational week. In case of maternal hypothyroidism, substitution with levothyroxine must be started in early pregnancy...
January 19, 2017: Critical Reviews in Clinical Laboratory Sciences
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