Chenxia Xu, Mingshu Wang, Anchun Cheng, Qiao Yang, Juan Huang, Xumin Ou, Di Sun, Yu He, Zhen Wu, Ying Wu, Shaqiu Zhang, Bin Tian, Xinxin Zhao, Mafeng Liu, Dekang Zhu, Renyong Jia, Shun Chen
3D polymerase, also known as RNA-dependent RNA polymerase, is encoded by all known picornaviruses, and their structures are highly conserved. In the process of picornavirus replication, 3D polymerase facilitates the assembly of replication complexes and directly catalyzes the synthesis of viral RNA. The nuclear localization signal carried by picornavirus 3D polymerase, combined with its ability to interact with other viral proteins, viral RNA and cellular proteins, indicate that its noncatalytic role is equally important in viral infections...
2024: Frontiers in Immunology