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https://www.readbyqxmd.com/read/28805485/transcriptional-activity-of-transposable-elements-may-contribute-to-gene-expression-changes-in-the-syncytium-formed-by-cyst-nematode-in-arabidopsis-roots
#1
Sarbottam Piya, Morgan Bennett, Aditi Rambani, Tarek Hewezi
Transposable elements (TEs) are mobile genetic materials that constitute a large fraction of plant genomes. Recent experimental evidences indicate that TEs can play key regulatory roles in controlling the expression of adjacent genes during plant development and stress responses. Nevertheless, information about the transcriptional activity of TEs and their impact on proximal genes during plant-nematode interaction remains largely unknown. Here, we identify of differentially expressed TEs and report their possible influence on the expression of nearby genes during the susceptible interaction between the beet cyst nematode Heterodera schachtii and Arabidopsis thaliana...
August 14, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28805196/-the-evaluation-of-color-vision-and-its-diagnostic-value-in-predicting-the-risk-of-diabetic-retinopathy-in-patients-with-glucose-metabolism-disorders
#2
Katarzyna Jończyk-Skórka, Jan Kowalski
AIM: The aim of the study was to evaluate color vision and its diagnostic value in predicting the risk of diabetic retinopathy in patients with glucose metabolism disorders. MATERIALS AND METHODS: The study involved 197 people, 92 women and 105 men aged 63.21 ± 8.74 years. In order to assess glucose metabolism disorders, patients were divided into three groups. The first group (DM) consisted of 60 people (16 women and 44 men aged 61.92 ± 8.46 years). These were people with type 2 diabetes...
July 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28804229/fabrication-of-x-ray-microcalorimeter-focal-planes-composed-of-two-distinct-pixel-types
#3
E J Wassell, J S Adams, S R Bandler, G L Betancourt-Martinez, M P Chiao, M P Chang, J A Chervenak, A M Datesman, M E Eckart, A J Ewin, F M Finkbeiner, J Y Ha, R Kelley, C A Kilbourne, A R Miniussi, K Sakai, F Porter, J E Sadleir, S J Smith, N A Wakeham, W Yoon
We are developing superconducting transition-edge sensor (TES) microcalorimeter focal planes for versatility in meeting specifications of X-ray imaging spectrometers including high count-rate, high energy resolution, and large field-of-view. In particular, a focal plane composed of two sub-arrays: one of fine-pitch, high count-rate devices and the other of slower, larger pixels with similar energy resolution, offers promise for the next generation of astrophysics instruments, such as the X-ray Integral Field Unit (X-IFU) instrument on the European Space Agency's Athena mission...
June 2017: IEEE Transactions on Applied Superconductivity: a Publication of the IEEE Superconductivity Committee
https://www.readbyqxmd.com/read/28796917/single-base-methylome-analysis-reveals-dynamic-epigenomic-differences-associated-with-water-deficit-in-apple
#4
Jidi Xu, Shasha Zhou, Xiaoqing Gong, Yi Song, Steve van Nocker, Fengwang Ma, Qingmei Guan
Cytosine methylation is an essential feature of epigenetic regulation and is involved in various biological processes. Although cytosine methylation has been analyzed at the genomic scale for several plant species, there is a general lack of understanding of the dynamics of global and genic DNA methylation in plants growing in environments challenged with biotic and abiotic stresses. In this study, we mapped cytosine methylation at single-base resolution in the genome of commercial apple (Malus x domestica), and analyzed changes in methylation patterns associated with water deficit in representative drought-sensitive and drought-tolerant cultivars...
August 10, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28772357/tissue-partition-and-risk-assessments-of-trace-elements-in-indo-pacific-finless-porpoises-neophocaena-phocaenoides-from-the-pearl-river-estuary-coast-china
#5
Xiyang Zhang, Wenzhi Lin, Ri-Qing Yu, Xian Sun, Yulong Ding, Hailiang Chen, Xi Chen, Yuping Wu
Throughout the last few decades, an increased number of stranded marine mammals, particularly the Indo-Pacific Finless Porpoises (Neophocaena phocaenoides), were observed in the Pearl River Estuary (PRE). As long-lived, apex predators vulnerable to bioaccumulation of contaminants, the tissue residue levels and health risk of trace elements (TEs) in N. phocaenoides from the PRE have been little studied. Eleven typical TEs distributed in skin, liver and kidney tissues were investigated from 25 specimens stranded along the PRE from 2007 to 2015 in the present study...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28765607/suppression-of-transposable-elements-in-leukemic-stem-cells
#6
Anthony R Colombo, Asif Zubair, Devi Thiagarajan, Sergey Nuzhdin, Timothy J Triche, Giridharan Ramsingh
Genomic transposable elements (TEs) comprise nearly half of the human genome. The expression of TEs is considered potentially hazardous, as it can lead to insertional mutagenesis and genomic instability. However, recent studies have revealed that TEs are involved in immune-mediated cell clearance. Hypomethylating agents can increase the expression of TEs in cancer cells, inducing 'viral mimicry', causing interferon signalling and cancer cell killing. To investigate the role of TEs in the pathogenesis of acute myeloid leukaemia (AML), we studied TE expression in several cell fractions of AML while tracking its development (pre-leukemic haematopoietic stem cells, leukemic stem cells [LSCs], and leukemic blasts)...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28765213/krab-zinc-finger-proteins
#7
REVIEW
Gabriela Ecco, Michael Imbeault, Didier Trono
Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of transcriptional regulators in higher vertebrates. Characterized by an N-terminal KRAB domain and a C-terminal array of DNA-binding zinc fingers, they participate, together with their co-factor KAP1 (also known as TRIM28), in repression of sequences derived from transposable elements (TEs). Until recently, KRAB-ZFP/KAP1-mediated repression of TEs was thought to lead to irreversible silencing, and the evolutionary selection of KRAB-ZFPs was considered to be just the host component of an arms race against TEs...
August 1, 2017: Development
https://www.readbyqxmd.com/read/28764696/healthcare-quality-improvement-and-work-engagement-concluding-results-from-a-national-longitudinal-cross-sectional-study-of-the-productive-ward-releasing-time-to-care-programme
#8
Mark White, Tony Butterworth, John Sg Wells
BACKGROUND: Concerns about patient safety and reducing harm have led to a particular focus on initiatives that improve healthcare quality. However Quality Improvement (QI) initiatives have in the past typically faltered because they fail to fully engage healthcare professionals, resulting in apathy and resistance amongst this group of key stakeholders. Productive Ward: Releasing Time to Care (PW) is a ward-based QI programme created to help ward-based teams redesign and streamline the way that they work; leaving more time to care for patients...
August 1, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28756683/factors-influencing-clinical-consistency-and-variability-in-voice-prosthesis-management
#9
Kelli L Hancock, Elizabeth C Ward, Robyn A Burnett, Peta K Graciet, Priscilla J Lenne, Julia C F MaClean, Felicity J Megee
PURPOSE: Anecdotally it is recognised that management of tracheoesophageal speech (TES) post-laryngectomy varies between speech language pathology (SLP) services and clinicians. This study reviewed patterns of practice for TES management to examine patterns of practice and explore factors influencing variability. METHOD: A national survey was completed by SLP's from clinical services which manage TES. This online survey examined demographic and caseload information, initial voice prosthesis (VP) placement and procedures, VP cleaning and care recommendations, humidification management, equipment and service provision, and service delivery options at each site...
July 31, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28752607/reproducibility-of-heart-rate-recovery-in-patients-with-intermittent-claudication
#10
Rafael Yokoyama Fecchio, Marcel Chehuen, Tiago Peçanha, Gabriel Grizzo Cucato, Luiz Augusto Riani Costa, Anthony Scott Leicht, Raphael Mendes Ritti-Dias, Nelson Wolosker, Cláudia Lúcia de Moraes Forjaz
BACKGROUND: Postexercise heart rate recovery (HRR) is a non-invasive tool for cardiac autonomic function assessment. Reproducibility of HRR has been established in healthy subjects; however, no study has evaluated this reproducibility in clinical populations who may present autonomic dysfunction. Patients with peripheral artery disease and intermittent claudication (IC) often present altered cardiac autonomic function and HRR could be an interesting tool for evaluating autonomic responses to interventions in this population...
July 28, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28747878/transcranial-electric-stimulation-can-impair-gains-during-working-memory-training-and-affects-the-resting-state-connectivity
#11
Annie Möller, Federico Nemmi, Kim Karlsson, Torkel Klingberg
Transcranial electric stimulation (tES) is a promising technique that has been shown to improve working memory (WM) performance and enhance the effect of cognitive training. However, experimental set up and electrode placement are not always determined based on neurofunctional knowledge about WM, leading to inconsistent results. Additional research on the effects of tES grounded on neurofunctional evidence is therefore necessary. Sixty young, healthy, volunteers, assigned to six different groups, participated in 5 days of stimulation or sham treatment...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28743695/ectopic-application-of-the-repressive-histone-modification-h3k9me2-establishes-post-zygotic-reproductive-isolation-in-arabidopsis-thaliana
#12
Hua Jiang, Jordi Moreno-Romero, Juan Santos-González, Geert De Jaeger, Kris Gevaert, Eveline Van De Slijke, Claudia Köhler
Hybrid seed lethality as a consequence of interspecies or interploidy hybridizations is a major mechanism of reproductive isolation in plants. This mechanism is manifested in the endosperm, a dosage-sensitive tissue supporting embryo growth. Deregulated expression of imprinted genes such as ADMETOS (ADM) underpin the interploidy hybridization barrier in Arabidopsis thaliana; however, the mechanisms of their action remained unknown. In this study, we show that ADM interacts with the AT hook domain protein AHL10 and the SET domain-containing SU(VAR)3-9 homolog SUVH9 and ectopically recruits the heterochromatic mark H3K9me2 to AT-rich transposable elements (TEs), causing deregulated expression of neighboring genes...
July 25, 2017: Genes & Development
https://www.readbyqxmd.com/read/28742942/regulation-of-transposable-elements-interplay-between-te-encoded-regulatory-sequences-and-host-specific-trans-acting-factors-in-drosophila-melanogaster
#13
Ana Marija Jakšić, Robert Kofler, Christian Schlötterer
Transposable elements (TEs) are mobile genetic elements that can move around the genome and their expression is one precondition for this mobility. Because the insertion of TEs in new genomic positions is largely deleterious, the molecular mechanisms for transcriptional suppression have been extensively studied. In contrast, very little is known about their primary transcriptional regulation. Here, we characterize the expression dynamics of TE families in Drosophila melanogaster across a broad temperature range (13-29°C)...
July 25, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28740794/tissue-expanders-and-proton-beam-radiotherapy-what-you-need-to-know
#14
Ashley L Howarth, Joshua R Niska, Kenneth Brooks, Aman Anand, Martin Bues, Carlos E Vargas, Raman C Mahabir
Proton beam radiotherapy (PBR) has gained acceptance for the treatment of breast cancer because of unique beam characteristics that allow superior dose distributions with optimal dose to the target and limited collateral damage to adjacent normal tissue, especially to the heart and lungs. To determine the compatibility of breast tissue expanders (TEs) with PBR, we evaluated the structural and dosimetric properties of 2 ex vivo models: 1 model with internal struts and another model without an internal structure...
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28740261/sustained-efficacy-of-closed-loop-electrical-stimulation-for-long-term-treatment-of-absence-epilepsy-in-rats
#15
Gábor Kozák, Antal Berényi
Closed-loop brain stimulation is a promising alternative to treat drug-resistant epilepsies. In contrast to optogenetic interventions, transcranial electrical stimulation (TES) does not require cellular modification of neurons to be effective, and it is less invasive compared to deep brain stimulation. Furthermore, on-demand TES of targeted brain regions allows the potential for normal function of these networks during interictal periods, a possibility that is eliminated by resective surgical treatment approaches...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28735765/incidental-durotomy-during-total-en-bloc-spondylectomy
#16
Noriaki Yokogawa, Hideki Murakami, Satoru Demura, Satoshi Kato, Katsuhito Yoshioka, Hiroyuki Tsuchiya
BACKGROUND CONTEXT: The incidence of incidental durotomy (ID) during total en bloc spondylectomy (TES) tends to be higher than that during other spinal surgeries because of the peculiarities of TES, including its highly invasive nature, epidural tumor extension, and use in patients who often have complicated medical backgrounds. However, there have been no detailed reports on ID associated with TES. PURPOSE: The study aimed to investigate ID during TES in detail...
July 20, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28732137/prevalence-of-sacroiliitis-in-inflammatory-bowel-disease-using-a-standardized-ct-scoring-system
#17
Jonathan Chan, Ismail Sari, David Salonen, Mark S Silverberg, Nigil Haroon, Robert D Inman
OBJECTIVES: There is an increasing emphasis on early identification and treatment of ankylosing spondylitis (AS) of which the hallmark is sacroiliitis. Patients with inflammatory bowel disease (IBD) are at increased risk of AS and often receive CT scans of their abdomen affording clinicians the opportunity to determine the presence of sacroiliitis. Previous studies using CT have relied only on radiologist's gestalt or a non-validated adaptation of the mNY criteria. Our aim is to assess the prevalence of sacroiliitis in IBD using a validated screening tool and to determine how frequently these patients are referred for rheumatologic evaluation...
July 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28731616/inversion-recovery-ultrashort-echo-time-imaging-of-ultrashort-t2-tissue-components-in-ovine-brain-at-3%C3%A2-t-a-sequential-d2-o-exchange-study
#18
Shu-Juan Fan, Yajun Ma, Eric Y Chang, Graeme M Bydder, Jiang Du
Inversion recovery ultrashort echo time (IR-UTE) imaging holds the potential to directly characterize MR signals from ultrashort T2 tissue components (STCs), such as collagen in cartilage and myelin in brain. The application of IR-UTE for myelin imaging has been challenging because of the high water content in brain and the possibility that the ultrashort T2 * signals are contaminated by water protons, including those associated with myelin sheaths. This study investigated such a possibility in an ovine brain D2 O exchange model and explored the potential of IR-UTE imaging for the quantification of ultrashort T2 * signals in both white and gray matter at 3 T...
July 21, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28721360/technical-data-for-concentrated-solar-power-plants-in-operation-under-construction-and-in-project
#19
Ugo Pelay, Lingai Luo, Yilin Fan, Driss Stitou, Mark Rood
This article presents technical data for concentrated solar power (CSP) plants in operation, under construction and in project all over the world in the form of tables. These tables provide information about plants (e.g., name of the CSP plant, country of construction, owner of the plant, aim of the plant) and their technical characteristics (e.g., CSP technology, solar power, area of the plant, presence and type of hybridization system, electricity cost, presence and type of TES, power cycle fluid, heat transfer fluid, operating temperature, operating pressure, type of turbine, type and duration of storage, etc...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28716680/three-dimensional-adiabatic-inversion-recovery-prepared-ultrashort-echo-time-cones-3d-ir-ute-cones-imaging-of-cortical-bone-in-the-hip
#20
Amin Nazaran, Michael Carl, Yajun Ma, Saeed Jerban, Yanchun Zhu, Xing Lu, Jiang Du, Eric Y Chang
PURPOSE: We present three-dimensional adiabatic inversion recovery prepared ultrashort echo time Cones (3D IR-UTE-Cones) imaging of cortical bone in the hip of healthy volunteers using a clinical 3T scanner. METHODS: A 3D IR-UTE-Cones sequence, based on a short pulse excitation followed by a 3D Cones trajectory, with a nominal TE of 32μs, was employed for high contrast morphological imaging of cortical bone in the hip of heathy volunteers. Signals from soft tissues such as muscle and marrow fat were suppressed via adiabatic inversion and signal nulling...
July 14, 2017: Magnetic Resonance Imaging
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