keyword
https://read.qxmd.com/read/38519110/prediction-of-progressive-fibrosing-interstitial-lung-disease-in-patients-with-systemic-sclerosis-insight-from-the-crdc-cohort-study
#21
JOURNAL ARTICLE
Min Hui, Xinwang Duan, Jiaxin Zhou, Mengtao Li, Qian Wang, Jiuliang Zhao, Yong Hou, Dong Xu, Xiaofeng Zeng
BACKGROUND: This study aims to establish a reliable prediction model of progressive fibrosing interstitial lung disease (PF-ILD) in patients with systemic sclerosis (SSc)-ILD, to achieve early risk stratification and to help better in preventing disease progression. METHODS: 304 SSc-ILD patients with no less than three pulmonary function tests within 6-24 months were included. We collected data at baseline and compared differences between SSc patients with and without PF-ILD...
March 22, 2024: RMD Open
https://read.qxmd.com/read/38518506/breakthrough-covid-19-in-people-with-multiple-sclerosis-on-disease-modifying-treatments-is-it-still-a-severe-disease
#22
JOURNAL ARTICLE
Paolo Immovilli, Irene Schiavetti, Alessandro Franceschini, Paola De Mitri, Lorenza Gelati, Eugenia Rota, Donata Guidetti
INTRODUCTION: Disease modifying treatments (DMTs) for multiple sclerosis (MS) are effective in preventing both relapses and disability progression. Highly effective treatments (HETs) are more effective than platform therapy in preventing confirmed disability progression (CDP), when used early. Infections may complicate HETs administration, and their prevention through vaccination is crucial in order to assure the safety of people with MS (pwMS). The aim of the present study is to describe the effect of MS DMTs on COVID-19 vaccination and the risk of breakthrough infection in a cohort of pwMS...
March 8, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38516412/thyroid-hormone-action-in-adult-neurogliogenic-niches-the-known-and-unknown
#23
REVIEW
Victor Valcárcel-Hernández, Steffen Mayerl, Ana Guadaño-Ferraz, Sylvie Remaud
Over the last decades, thyroid hormones (THs) signaling has been established as a key signaling cue for the proper maintenance of brain functions in adult mammals, including humans. One of the most fascinating roles of THs in the mature mammalian brain is their ability to regulate adult neurogliogenic processes. In this respect, THs control the generation of new neuronal and glial progenitors from neural stem cells (NSCs) as well as their final differentiation and maturation programs. In this review, we summarize current knowledge on the cellular organization of adult rodent neurogliogenic niches encompassing well-established niches in the subventricular zone (SVZ) lining the lateral ventricles, the hippocampal subgranular zone (SGZ), and the hypothalamus, but also less characterized niches in the striatum and the cerebral cortex...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38515326/dual-effects-of-tgf-%C3%AE-inhibitor-in-als-inhibit-contracture-and-neurodegeneration
#24
JOURNAL ARTICLE
Do-Yeon Lee, Young Nam Kwon, Kwangkook Lee, Sang Jeong Kim, Jung-Joon Sung
As persistent elevation of transforming growth factor-β (TGF-β) promotes fibrosis of muscles and joints and accelerates disease progression in amyotrophic lateral sclerosis (ALS), we investigated whether inhibition of TGF-β would be effective against both exacerbations. The effects of TGF-β and its inhibitor on myoblasts and fibroblasts were tested in vitro and confirmed in vivo, and the dual action of a TGF-β inhibitor in ameliorating the pathogenic role of TGF-β in ALS mice was identified...
March 21, 2024: Journal of Neurochemistry
https://read.qxmd.com/read/38514374/impact-of-foot-functionality-in-patients-with-systemic-sclerosis-cross-sectional-study
#25
JOURNAL ARTICLE
Esther Chicharro-Luna, Miguel Ángel Gracia-Vesga, Laura Ramos-Petersen, Gabriel Gijón-Nogueron
BACKGROUND: Progressive systemic sclerosis or systemic scleroderma (SS) is a chronic and rare autoimmune disease that mainly affects the skin and various internal organs. Raynaud's phenomenon and digital ulcers are some of the symptoms that affect the foot, causing a decrease in the quality of life of patients. The objective of this study is to determine the functionality of the feet in patients with SS and determine the impact on their daily lives. METHODS: A sample of 165 patients (154 women, 11 men) diagnosed with SS with a mean age of 46...
March 7, 2024: Journal of Tissue Viability
https://read.qxmd.com/read/38512652/neuroprotective-effects-of-rutin-against-cuprizone-induced-multiple-sclerosis-in-mice
#26
JOURNAL ARTICLE
Mariam A Nicola, Abdelraheim H Attaai, Mahmoud H Abdel-Raheem, Anber F Mohammed, Yasmin F Abu-Elhassan
Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease of the central nervous system that injures the myelin sheath, provoking progressive axonal degeneration and functional impairments. No efficient therapy is available at present to combat such insults, and hence, novel safe and effective alternatives for MS therapy are extremely required. Rutin (RUT) is a flavonoid that exhibits antioxidant, anti-inflammatory, and neuroprotective effects in several brain injuries. The present study evaluated the potential beneficial effects of two doses of RUT in a model of pattern-III lesion of MS, in comparison to the conventional standard drug; dimethyl fumarate (DMF)...
March 21, 2024: Inflammopharmacology
https://read.qxmd.com/read/38510000/treatment-gaps-in-the-care-of-amyotrophic-lateral-sclerosis-in-the-philippines-a-scoping-review
#27
REVIEW
Iris D Ditan, Christian Wilson R Turalde
Amyotrophic lateral sclerosis (ALS) is a progressive disease affecting both the upper and lower motor neurons. Much of the management of ALS is supportive with the goal of maximizing patient quality of life. While the Philippines was participative in the "Ice Bucket Challenge" in 2014, it is up for investigation whether substantial changes occurred to improve healthcare for ALS patients. This study aims to evaluate the treatment gaps in the management of ALS in the Philippines through a scoping review. Data on epidemiology, health systems, and pharmacotherapy available regarding ALS in the local setting were synthesized...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38509595/nintedanib-downregulates-the-profibrotic-m2-phenotype-in-cultured-monocyte-derived-macrophages-obtained-from-systemic-sclerosis-patients-affected-by-interstitial-lung-disease
#28
JOURNAL ARTICLE
Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere, Maurizio Cutolo
BACKGROUND: Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by vasculopathy and progressive fibrosis of skin and several internal organs, including lungs. Macrophages are the main cells involved in the immune-inflammatory damage of skin and lungs, and alternatively activated (M2) macrophages seem to have a profibrotic role through the release of profibrotic cytokines (IL10) and growth factors (TGFβ1). Nintedanib is a tyrosine kinase inhibitor targeting several fibrotic mediators and it is approved for the treatment of SSc-related interstitial lung disease (ILD)...
March 20, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38509351/the-interplay-between-rheumatic-diseases-and-pulmonary-health
#29
REVIEW
Yuliya Fedorchenko, Olena Zimba, Roman Yatsyshyn, Bohdana Doskaliuk, Liubomyr Zaiats, Mykhailo Fedorchenko
Patients with rheumatic diseases (RDs) are prone to a number of comorbidities, particularly those affecting the respiratory system due to inflammatory and autoimmune mechanisms. Rheumatoid arthritis (RA), systemic sclerosis (SSc), and inflammatory idiopathic myopathies (IIMs) often present with progressive interstitial lung disease (ILD). The prevalence of ILD varies among patients with RDs, with 11% in RA, 47% in SSc, and 41% in IIMs. Some diagnostic markers, including KL-6, cytokines TNF-α and IL-6, and autoantibodies (anti-CCP), play a crucial role in assessing and predicting the course of pulmonary involvement in RDs...
March 20, 2024: Rheumatology International
https://read.qxmd.com/read/38508720/progressive-multifocal-leucoencephalopathy-isolated-to-the-brainstem-and-cerebellum
#30
JOURNAL ARTICLE
Denison Alves Pedrosa, Luis Filipe de Souza Godoy, André Luiz Guimarães de Queiroz, Carla Renata Aparecida Vieira Stella, Rodrigo B Thomaz
No abstract text is available yet for this article.
March 20, 2024: Practical Neurology
https://read.qxmd.com/read/38507990/differential-diagnosis-between-multiple-sclerosis-and-leukodystrophies-a-scoping-review
#31
REVIEW
Luis Eduardo Ramos Chaer, Jakeline Martins de Mendonça, Maria Cristina Del Negro, Ricardo Titze-de-Almeida, Nícolas Philippe Balduino Nogueira, Priscila Mara Provetti, Pedro Renato de Paula Brandão, Diógenes Diego de Carvalho Bispo, Gabriela Billafan Ferreira, Ingrid Faber, Taina Barreto Cavalcante, Tarso Adoni, Juliana F Mazzeu, Felipe von Glehn
Multiple Sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) characterized by damage to the myelin sheaths of oligodendrocytes. Currently, there is no specific biomarker to identify the disease; however, a diagnostic criterion has been established based on patient's clinical, laboratory, and imaging characteristics, which assists in identifying this condition. The primary method for diagnosing MS is the McDonald criteria, first described in 2001 and revised in the years 2005, 2012, and 2017...
March 16, 2024: Journal of the Neurological Sciences
https://read.qxmd.com/read/38507968/the-association-of-resilience-and-positive-mental-health-in-systemic-sclerosis-a-scleroderma-patient-centered-intervention-network-spin-cohort-cross-sectional-study
#32
JOURNAL ARTICLE
Marieke A Neyer, Richard S Henry, Marie-Eve Carrier, Linda Kwakkenbos, Gabrielle Virgili-Gervais, Robyn K Wojeck, Amanda Wurz, Amy Gietzen, Karen Gottesman, Geneviève Guillot, Amanda Lawrie-Jones, Maureen D Mayes, Luc Mouthon, Warren R Nielson, Michelle Richard, Maureen Sauvé, Daphna Harel, Vanessa L Malcarne, Susan J Bartlett, Andrea Benedetti, Brett D Thombs
OBJECTIVE: A previous study using Scleroderma Patient-centered Intervention Network (SPIN) Cohort data identified five classes of people with systemic sclerosis (also known as scleroderma) based on patient-reported somatic (fatigue, pain, sleep) and mental health (anxiety, depression) symptoms and compared indicators of disease severity between classes. Across four classes ("low", "normal", "high", "very high"), there were progressively worse somatic and mental health outcomes and greater disease severity...
March 11, 2024: Journal of Psychosomatic Research
https://read.qxmd.com/read/38505993/the-complement-system-in-neurodegenerative-diseases
#33
JOURNAL ARTICLE
Jacqui Nimmo, Robert A J Byrne, Nikoleta Daskoulidou, Lewis M Watkins, Sarah M Carpanini, Wioleta M Zelek, B Paul Morgan
Complement is an important component of innate immune defence against pathogens and crucial for efficient immune complex disposal. These core protective activities are dependent in large part on properly regulated complement-mediated inflammation. Dysregulated complement activation, often driven by persistence of activating triggers, is a cause of pathological inflammation in numerous diseases, including neurological diseases. Increasingly, this has become apparent not only in well-recognized neuroinflammatory diseases like multiple sclerosis but also in neurodegenerative and neuropsychiatric diseases where inflammation was previously either ignored or dismissed as a secondary event...
March 20, 2024: Clinical Science (1979-)
https://read.qxmd.com/read/38502584/vascular-aging-and-atherosclerosis-a-perspective-on-aging
#34
JOURNAL ARTICLE
Shudong Ma, Xuena Xie, Rong Yuan, Qiqi Xin, Yu Miao, Sean Xiao Leng, Keji Chen, Weihong Cong
Vascular aging (VA) is recognized as a pivotal factor in the development and progression of atherosclerosis (AS). Although various epidemiological and clinical research has demonstrated an intimate connection between aging and AS, the candidate mechanisms still require thorough examination. This review adopts an aging-centric perspective to deepen the comprehension of the intricate relationship between biological aging, vascular cell senescence, and AS. Various aging-related physiological factors influence the physical system's reactions, including oxygen radicals, inflammation, lipids, angiotensin II, mechanical forces, glucose levels, and insulin resistance...
March 6, 2024: Aging and Disease
https://read.qxmd.com/read/38502287/chronic-traumatic-encephalopathy-neuropathologic-change-in-former-australian-rugby-players
#35
JOURNAL ARTICLE
Claire E Shepherd, Heather McCann, Catriona A McLean, Grant L Iverson, Andrew J Gardner
AIMS: We applied the 2021 consensus criteria for both chronic traumatic encephalopathy neuropathological change and traumatic encephalopathy syndrome in a small case series of six former elite-level Australian rugby code players. METHODS: Neuropathological assessment of these cases was carried out at the Sydney and Victorian Brain Banks. Clinical data were collected via clinical interviews and health questionnaires completed by the participants and/or their next of kin, and neuropsychological testing was conducted with participants who were capable of completing this testing...
April 2024: Neuropathology and Applied Neurobiology
https://read.qxmd.com/read/38500270/the-presence-and-burden-of-cognitive-issues-discordance-between-the-perception-of-neurologists-and-people-living-with-multiple-sclerosis
#36
JOURNAL ARTICLE
Iris-Katharina Penner, Virginia De Las Heras, Eddie Jones, Suzannah Hetherington, Himanshu Karu, Rahul Chetlangia, Sourav Biswas, Patricia Dominguez Castro, Carol Lines
BACKGROUND AND PURPOSE: Cognitive impairment is a common symptom of multiple sclerosis (MS) and occurs in more than 40% of people living with MS (plwMS). No real-world study has assessed the perception of neurologists and plwMS on cognitive issues. METHODS: Using data from the 2011-2019 Adelphi MS Disease Specific Programme database, this real-world, retrospective, cross-sectional multi-cohort study included people aged ≥18 years with relapsing-remitting MS and secondary progressive MS from the United States, UK and the EU...
March 18, 2024: European Journal of Neurology
https://read.qxmd.com/read/38498118/corneal-nerves-and-amyotrophic-lateral-sclerosis-an-in-vivo-corneal-confocal-imaging-study
#37
JOURNAL ARTICLE
Raoul K Khanna, Sophie Catanese, Hélène Blasco, Pierre-Jean Pisella, Philippe Corcia
OBJECTIVES: Amyotrophic lateral sclerosis (ALS) is a severe motor neuron disorder. Diagnosis is challenging due to its clinical heterogeneity and the absence of definitive diagnostic tools, leading to delays averaging between 9.1 and 27 months. In vivo corneal confocal microscopy, assessing the sub-basal nerve plexus of the cornea, has been proposed as a potential biomarker for ALS. We aimed to determine whether the assessment of corneal nerves using in vivo confocal microscopy can serve as an imaging biomarker for ALS...
March 18, 2024: Journal of Neurology
https://read.qxmd.com/read/38496443/molecular-mimicry-as-a-mechanism-of-viral-immune-evasion-and-autoimmunity
#38
Cole Maguire, Chumeng Wang, Akshara Ramasamy, Cara Fonken, Brinkley Morse, Nathan Lopez, Dennis Wylie, Esther Melamed
Mimicry of host protein structures ("molecular mimicry") is a common mechanism employed by viruses to evade the host's immune system. To date, studies have primarily evaluated molecular mimicry in the context of full protein structural mimics. However, recent work has demonstrated that short linear amino acid (AA) molecular mimics can elicit cross-reactive antibodies and T-cells from the host, which may contribute to development and progression of autoimmunity. Despite this, the prevalence of molecular mimics throughout the human virome has not been fully explored...
March 9, 2024: bioRxiv
https://read.qxmd.com/read/38494831/chronic-interstitial-lung-disease-associated-with-systemic-lupus-erythematosus-a-multicentric-study-of-89-cases
#39
JOURNAL ARTICLE
Lou Deneuville, Arthur Mageau, Marie Pierre Debray, Karim Sacre, Nathalie Costedoat-Chalumeau, Eric Hachulla, Yurdagul Uzunhan, Erwan Le Tallec, Jacques Cadranel, Sylvain Marchand Adam, David Montani, Martine Rémi-Jardin, Martine Reynaud-Gaubert, Gregoire Prevot, Guillaume Beltramo, Bruno Crestani, Vincent Cottin, Raphael Borie
BACKGROUND AND OBJECTIVE: Chronic interstitial lung disease (ILD) occurs rarely with systemic lupus erythematosus (SLE) as compared with other connective tissue diseases. This multicentric retrospective study of patients with SLE-ILD from the OrphaLung and French SLE networks during 2005-2020 aimed to describe the characteristics of patients with SLE-ILD and analyse factors associated with prognosis. METHODS: We analysed data for 89 patients with SLE-ILD (82 women, 92...
March 17, 2024: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://read.qxmd.com/read/38494277/paraneoplastic-autoimmune-myelopathies
#40
REVIEW
Mayra Montalvo, Eoin P Flanagan
Paraneoplastic myelopathies are a rare but important category of myelopathy. They usually present with an insidious or subacute progressive neurologic syndrome. Risk factors include tobacco use and family history of cancer. Cerebrospinal fluid analysis usually shows lymphocytic pleocytosis with elevated protein. MRI findings suggest that paraneoplastic myelopathies include longitudinally extensive T2 hyperintensities that are tract-specific and accompanied by enhancement, but spinal MRIs can also be normal...
2024: Handbook of Clinical Neurology
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