keyword
https://read.qxmd.com/read/38455098/extracellular-vesicles-derived-from-mesenchymal-stem-cells-mediate-extracellular-matrix-remodeling-in-osteoarthritis-through-the-transport-of-microrna-29a
#21
JOURNAL ARTICLE
Fan Yang, Wan-Qi Xiong, Chen-Zhi Li, Ming-Jian Wu, Xiu-Zhi Zhang, Chun-Xiao Ran, Zhen-Hao Li, Yan Cui, Bao-Yi Liu, De-Wei Zhao
BACKGROUND: Knee osteoarthritis (KOA) is a common orthopedic condition with an uncertain etiology, possibly involving genetics and biomechanics. Factors like changes in chondrocyte microenvironment, oxidative stress, inflammation, and immune responses affect KOA development. Early-stage treatment options primarily target symptom relief. Mesenchymal stem cells (MSCs) show promise for treatment, despite challenges. Recent research highlights microRNAs (miRNAs) within MSC-released extracellular vesicles that can potentially promote cartilage regeneration and hinder KOA progression...
February 26, 2024: World Journal of Stem Cells
https://read.qxmd.com/read/38453635/advances-in-the-study-of-mitophagy-in-osteoarthritis
#22
JOURNAL ARTICLE
Hong Cao, Xuchang Zhou, Bowen Xu, Han Hu, Jianming Guo, Miao Wang, Nan Li, Zou Jun
Osteoarthritis (OA), characterized by cartilage degeneration, synovial inflammation, and subchondral bone remodeling, is among the most common musculoskeletal disorders globally in people over 60 years of age. The initiation and progression of OA involves the abnormal metabolism of chondrocytes as an important pathogenic process. Cartilage degeneration features mitochondrial dysfunction as one of the important causative factors of abnormal chondrocyte metabolism. Therefore, maintaining mitochondrial homeostasis is an important strategy to mitigate OA...
March 15, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38452214/digging-deeper-into-pain-an-ethological-behavior-assay-correlating-well-being-in-mice-with-human-pain-experience
#23
JOURNAL ARTICLE
Luke A Pattison, Alexander Cloake, Sampurna Chakrabarti, Helen Hilton, Rebecca H Rickman, James P Higham, Michelle Y Meng, Luke W Paine, Maya Dannawi, Lanhui Qiu, Anne Ritoux, David C Bulmer, Gerard Callejo, Ewan St John Smith
The pressing need for safer, more efficacious analgesics is felt worldwide. Preclinical tests in animal models of painful conditions represent one of the earliest checkpoints novel therapeutics must negotiate before consideration for human use. Traditionally, the pain status of laboratory animals has been inferred from evoked nociceptive assays that measure their responses to noxious stimuli. The disconnect between how pain is tested in laboratory animals and how it is experienced by humans may in part explain the shortcomings of current pain medications and highlights a need for refinement...
March 5, 2024: Pain
https://read.qxmd.com/read/38451090/nanomedicines-promote-cartilage-regeneration-in-osteoarthritis-by-synergistically-enhancing-chondrogenesis-of-mesenchymal-stem-cells-and-regulating-inflammatory-environment
#24
JOURNAL ARTICLE
Shi-He Cui, Yi Yan, An Lu, Yun Dou, Zhen-Wen Li, Ze-Hang Zhu, Ming-Ze Du, Yue-Feng Zhu, Xin Chen, Xiangyu Wang, Lin-Xia Jiang, Yujie Shi, Xiaoyan Liu, Yuan-Jun Zhu, Dong Jiang, Jian-Cheng Wang
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive erosion of the articular cartilage and inflammation. Mesenchymal stem cells' (MSCs) transplantation in OA treatment is emerging, but its clinical application is still limited by the low efficiency in oriented differentiation. In our study, to improve the therapeutic efficiencies of MSCs in OA treatment by carbonic anhydrase IX (CA9) siRNA (siCA9)-based inflammation regulation and Kartogenin (KGN)-based chondrogenic differentiation, the combination strategy of MSCs and the nanomedicine codelivering KGN and siCA9 (AHK-CaP/siCA9 NPs) was used...
March 7, 2024: ACS Nano
https://read.qxmd.com/read/38447596/inhibition-of-sat1-alleviates-chondrocyte-inflammation-and-ferroptosis-by-repressing-alox15-expression-and-activating-the-nrf2-pathway
#25
JOURNAL ARTICLE
Jingting Xu, Zhaoxuan Ruan, Zhou Guo, Liangcai Hou, Genchun Wang, Zehang Zheng, Xiong Zhang, Haigang Liu, Kai Sun, Fengjing Guo
AIMS: Osteoarthritis (OA) is the most common chronic pathema of human joints. The pathogenesis is complex, involving physiological and mechanical factors. In previous studies, we found that ferroptosis is intimately related to OA, while the role of Sat1 in chondrocyte ferroptosis and OA, as well as the underlying mechanism, remains unclear. METHODS: In this study, interleukin-1β (IL-1β) was used to simulate inflammation and Erastin was used to simulate ferroptosis in vitro...
March 7, 2024: Bone & Joint Research
https://read.qxmd.com/read/38444758/characterizing-hedgehog-pathway-features-in-senescence-associated-osteoarthritis-through-integrative-multi-omics-and-machine-learning-analysis
#26
JOURNAL ARTICLE
Tao Wang, Zhengrui Li, Shijian Zhao, Ying Liu, Wenliang Guo, Raquel Alarcòn Rodrìguez, Yinteng Wu, Ruqiong Wei
Purpose: Osteoarthritis (OA) is a disease of senescence and inflammation. Hedgehog's role in OA mechanisms is unclear. This study combines Bulk RNA-seq and scRNA-seq to identify Hedgehog-associated genes in OA, investigating their impact on the pathogenesis of OA. Materials and methods: Download and merge eight bulk-RNA seq datasets from GEO, also obtain a scRNA-seq dataset for validation and analysis. Analyze Hedgehog pathway activity in OA using bulk-RNA seq datasets. Use ten machine learning algorithms to identify important Hedgehog-associated genes, validate predictive models...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38440290/the-role-of-inflammatory-mediators-and-matrix-metalloproteinases-mmps-in-the-progression-of-osteoarthritis
#27
REVIEW
Anwesha Mukherjee, Bodhisatwa Das
Osteoarthritis (OA) is a chronic musculoskeletal disorder characterized by an imbalance between (synthesis) and catabolism (degradation) in altered homeostasis of articular cartilage mediated primarily by the innate immune system. OA degenerates the joints resulting in synovial hyperplasia, degradation of articular cartilage with damage of the structural and functional integrity of the cartilage extracellular matrix, subchondral sclerosis, osteophyte formation, and is characterized by chronic pain, stiffness, and loss of function...
March 2024: Biomater Biosyst
https://read.qxmd.com/read/38438104/the-effect-of-plasma-cytokines-on-the-expression-of-adiponectin-and-its-receptors-in-the-synovial-membrane-of-joints-and-the-infrapatellar-fat-pad-in-patients-with-rheumatoid-arthritis-and-osteoarthritis
#28
JOURNAL ARTICLE
Michał Czerewaty, Małgorzata Łączna, Kajetan Kiełbowski, Estera Bakinowska, Paweł Dec, Andrzej Modrzejewski, Daniel Kotrych, Piotr Burszewski, Krzysztof Safranow, Andrzej Pawlik
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that leads to joint destruction. Numerous pro-inflammatory mediators, including adipokines, play an important role in the pathogenesis of RA. OBJECTIVE: The aim of the study was to investigate the relationships between selected plasma cytokines and expression of adiponectin and its receptors in the synovium and the infrapatellar fat pad in patients with RA and osteoarthritis (OA). METHODS: Blood, synovium and fat pad samples from 18 patients with RA and 18 with OA were collected during joint replacement surgery...
March 2, 2024: Prostaglandins & Other Lipid Mediators
https://read.qxmd.com/read/38434027/transcriptomics-analyses-of-il-1%C3%AE-stimulated-rat-chondrocytes-in-temporomandibular-joint-condyles-and-effect-of-platelet-rich-plasma
#29
JOURNAL ARTICLE
Shasha Liu, Chaolun Wu, Yuxin Zhang
The biological mechanism of action of platelet-rich plasma (PRP) in the treatment of temporomandibular joint (TMJ) osteoarthritis remains unclear. This study explored the mechanisms underlying interleukin (IL)-1β-induced inflammation and investigated the effect of PRP on TMJ condylar chondrocytes. Primary chondrocytes were isolated from the TMJ condyle of 4-week-old rats, and differentially expressed genes among three treatment groups (phosphate-buffered saline [control], IL-1β, and IL-1β + PRP) were identified using RNA-seq and characterized using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes path-enrichment analyses...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38433252/targeted-knockdown-of-pgam5-in-synovial-macrophages-efficiently-alleviates-osteoarthritis
#30
JOURNAL ARTICLE
Yuhang Liu, Ruihan Hao, Jia Lv, Jie Yuan, Xuelei Wang, Churong Xu, Ding Ma, Zhouyi Duan, Bingjun Zhang, Liming Dai, Yiyun Cheng, Wei Lu, Xiaoling Zhang
Osteoarthritis (OA) is a common degenerative disease worldwide and new therapeutics that target inflammation and the crosstalk between immunocytes and chondrocytes are being developed to prevent and treat OA. These attempts involve repolarizing pro-inflammatory M1 macrophages into the anti-inflammatory M2 phenotype in synovium. In this study, we found that phosphoglycerate mutase 5 (PGAM5) significantly increased in macrophages in OA synovium compared to controls based on histology of human samples and single-cell RNA sequencing results of mice models...
March 4, 2024: Bone Research
https://read.qxmd.com/read/38432573/lovastatin-impairs-cellular-proliferation-and-enhances-hyaluronic-acid-production-in-fibroblast-like-synoviocytes
#31
JOURNAL ARTICLE
Wen-Tien Wu, Chen-Chie Wang, Dai-Hua Lu, Kuan-Jung Lu, Yu-Chia Chang, Kai-Chiang Yang
INTRODUCTION: Statins have demonstrated chondroprotective effects by reducing inflammation and mitigating extracellular matrix degradation. However, statins are also reported to be cytotoxic to several types of cells. Early-onset osteoarthritis (OA) is characterized by synovial inflammation, which adversely affects hyaluronan (HA) production in fibroblast-like synoviocytes (FLSs). Nevertheless, the precise effects of statins on the synovium remain unclear. METHODS: This study investigated the impact of lovastatin on human FLSs, and HA secretion-related genes, signaling pathways, and production were evaluated...
March 1, 2024: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/38429844/inhibition-of-cc-chemokine-receptor-10-ameliorates-osteoarthritis-via-inhibition-of-the-phosphoinositide-3-kinase-akt-mammalian-target-of-rapamycin-pathway
#32
JOURNAL ARTICLE
Yan Luo, Feng Zhou, Xiaojing Wang, Runwei Yang, Yi Li, Xiaochun Wu, Bin Ye
BACKGROUND: Osteoarthritis (OA) is a joint disease characterized by inflammation and progressive cartilage degradation. Chondrocyte apoptosis is the most common pathological feature of OA. Interleukin-1β (IL-1β), a major inflammatory cytokine that promotes cartilage degradation in OA, often stimulates primary human chondrocytes in vitro to establish an in vitro OA model. Moreover, IL-1β is involved in OA pathogenesis by stimulating the phosphoinositide-3-kinase (PI3K)/Akt and mitogen-activated protein kinases pathways...
March 1, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38425744/nir-enhanced-pt-single-atom-g-c-3-n-4-nanozymes-as-sod-cat-mimics-to-rescue-atp-energy-crisis-by-regulating-oxidative-phosphorylation-pathway-for-delaying-osteoarthritis-progression
#33
JOURNAL ARTICLE
Jianhui Xiang, Xin Yang, Manli Tan, Jianfeng Guo, Yuting Ye, Jiejia Deng, Zhangrui Huang, Hanjie Wang, Wei Su, Jianwen Cheng, Li Zheng, Sijia Liu, Jingping Zhong, Jinmin Zhao
Osteoarthritis (OA) progresses due to the excessive generation of reactive oxygen and nitrogen species (ROS/RNS) and abnormal ATP energy metabolism related to the oxidative phosphorylation pathway in the mitochondria. Highly active single-atom nanozymes (SAzymes) can help regulate the redox balance and have shown their potential in the treatment of inflammatory diseases. In this study, we innovatively utilised ligand-mediated strategies to chelate Pt4+ with modified g-C3 N4 by π-π interaction to prepare g-C3 N4 -loaded Pt single-atom (Pt SA/C3 N4 ) nanozymes that serve as superoxide dismutase (SOD)/catalase (CAT) mimics to scavenge ROS/RNS and regulate mitochondrial ATP production, ultimately delaying the progression of OA...
June 2024: Bioactive Materials
https://read.qxmd.com/read/38420347/glucosamine-attenuates-alcohol-induced-acute-liver-injury-via-inhibiting-oxidative-stress-and-inflammation
#34
JOURNAL ARTICLE
Weiwen Lai, Shipeng Zhou, Yan Bai, Qishi Che, Hua Cao, Jiao Guo, Zhengquan Su
Alcohol liver disease (ALD) is a liver disease caused by long-term heavy drinking. Glucosamine (GLC) is an amino monosaccharide that plays a very important role in the synthesis of human and animal cartilage. GLC is commonly used in the treatment of mild to moderate osteoarthritis and has good anti-inflammatory and antioxidant properties. In this study, alcoholic injury models were constructed in mice and human normal hepatocyte L02 cells to explore the protective effect and mechanism of GLC on ALD. Mice were given GLC by gavage for 30 days...
2024: Current research in food science
https://read.qxmd.com/read/38420081/hyperacute-serum-and-knee-osteoarthritis
#35
REVIEW
Ashim Gupta, Adarsh Aratikatla
The knees are the most frequently affected weight-bearing joints in osteoarthritis (OA), impacting millions of people globally. With increasing life spans and obesity rates, the prevalence of knee OA will further mount, leading to a significant increase in the economic burden. The usual treatment modalities utilized to manage knee OA have shortcomings. Over the last decade, the field of regenerative medicine involving the use of biologics, such as autologous peripheral blood-derived orthobiologics, including hyperacute serum (HS), has evolved and shown potential for managing knee OA...
January 2024: Curēus
https://read.qxmd.com/read/38418169/-study-on-the-mechanism-of-cross-linked-hyaluronic-acid-dexamethasone-hydrogelin-post-traumatic-osteoarthritis
#36
JOURNAL ARTICLE
Z W Zhang, J Y Zhao, Y Feng, K Yin, P C Li, X C Wei
Objective: To explore the mechanism of cross-linked hyaluronic acid-dexamethasone hydrogel (cHA-Dex) in inhibiting chondrocyte apoptosis and alleviating early post-traumatic osteoarthritis (PTOA). Methods: To generate PTOA model, anterior cruciate ligament transection (ACLT)was performed on SD rats ( n =70), and the sham surgery group ( n =70) was set as control. The changes in inflammatory indicators such as interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), matrix metalloproteinase-3 (MMP-3), and matrix metalloproteinase-13 (MMP-13) in the joint lavage fluid were measured at different time points (1-14 days, 5 rats at each time point) after surgery...
March 5, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38415250/songorine-modulates-macrophage-polarization-and-metabolic-reprogramming-to-alleviate-inflammation-in-osteoarthritis
#37
JOURNAL ARTICLE
Xi-Xi He, Yuan-Jun Huang, Chun-Long Hu, Qiong-Qian Xu, Qing-Jun Wei
INTRODUCTION: Osteoarthritis (OA) is a prevalent joint disorder characterized by multifaceted pathogenesis, with macrophage dysregulation playing a critical role in perpetuating inflammation and joint degeneration. METHODS: This study focuses on Songorine, derived from Aconitum soongaricum Stapf, aiming to unravel its therapeutic mechanisms in OA. Comprehensive analyses, including PCR, Western blot, and immunofluorescence, were employed to evaluate Songorine's impact on the joint microenvironment and macrophage polarization...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38414449/mir-106a-mimics-the-nuclear-factor-%C3%AE%C2%BAb-signalling-pathway-by-targeting-dr6-in-rats-with-osteoarthritis
#38
JOURNAL ARTICLE
Luping Cui, Yongbin Han, Zhijie Dong
INTRODUCTION: Osteoarthritis (OA) is a common inflammatory joint disease characterised by progressive cartilage destruction. Management of this condition remains a significant challenge, and new therapies are required. We investigated the protective effects of miR-106a mimics in a murine model of OA. MATERIAL AND METHODS: This study was performed using both in vitro and in vivo OA models. Primary chondrocytes were isolated from female rats, with inflammation induced via treatment with lipopolysaccharide (LPS)...
2024: Archives of Medical Science: AMS
https://read.qxmd.com/read/38413171/long-term-effectiveness-of-a-lifestyle-intervention-for-rheumatoid-arthritis-and-osteoarthritis-1-year-follow-up-of-the-plants-for-joints-randomised-clinical-trial
#39
JOURNAL ARTICLE
Carlijn A Wagenaar, Wendy Walrabenstein, Marike van der Leeden, Franktien Turkstra, Martijn Gerritsen, Jos W R Twisk, Maarten Boers, Martin van der Esch, Henriët van Middendorp, Peter J M Weijs, Dirkjan van Schaardenburg
OBJECTIVES: In two randomised controlled trials, the Plants for Joints (PFJ) multidisciplinary lifestyle intervention reduced signs and symptoms of rheumatoid arthritis (RA), or metabolic syndrome-associated hip or knee osteoarthritis (MSOA) compared with usual care. The current study investigated long-term outcomes. METHODS: After completion of two 16-week trials in people with (1) RA or (2) MSOA, control groups switched to the active PFJ intervention. At the end of the intervention, all participants were followed up in a 1-year observational extension study...
February 27, 2024: RMD Open
https://read.qxmd.com/read/38412715/koumine-inhibits-il-1%C3%AE-induced-chondrocyte-inflammation-and-ameliorates-extracellular-matrix-degradation-in-osteoarthritic-cartilage-through-activation-of-pink1-parkin-mediated-mitochondrial-autophagy
#40
JOURNAL ARTICLE
Xiangyi Kong, Can Ning, Zengenni Liang, Chenglin Yang, You Wu, Yuanyuan Li, Aoao Wu, Yongkang Wang, Siqi Wang, Hui Fan, Wenguang Xiao, Jing Wu, Zhiliang Sun, Zhihang Yuan
Osteoarthritis (OA) is a degenerative joint disease, Increasingly, mitochondrial autophagy has been found to play an important regulatory role in the prevention and treatment of osteoarthritis. Koumine is a bioactive alkaloid extracted from the plant Gelsemium elegans. In previous research, Koumine was found to have potential in improving the progression of OA in rats. However, the specific mechanism of its action has not been fully explained. Therefore, the aim of this study was to investigate whether Koumine can alleviate OA in rats by influencing mitochondrial autophagy...
February 26, 2024: Biomedicine & Pharmacotherapy
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