Xiangyi Kong, Can Ning, Zengenni Liang, Chenglin Yang, You Wu, Yuanyuan Li, Aoao Wu, Yongkang Wang, Siqi Wang, Hui Fan, Wenguang Xiao, Jing Wu, Zhiliang Sun, Zhihang Yuan
Osteoarthritis (OA) is a degenerative joint disease, Increasingly, mitochondrial autophagy has been found to play an important regulatory role in the prevention and treatment of osteoarthritis. Koumine is a bioactive alkaloid extracted from the plant Gelsemium elegans. In previous research, Koumine was found to have potential in improving the progression of OA in rats. However, the specific mechanism of its action has not been fully explained. Therefore, the aim of this study was to investigate whether Koumine can alleviate OA in rats by influencing mitochondrial autophagy...
February 26, 2024: Biomedicine & Pharmacotherapy