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Inflammation osteoarthritis

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https://www.readbyqxmd.com/read/28713086/intensifying-approach-to-the-therapy-of-patients-with-constellation-of-the-diseases-chronic-obstructive-pulmonary-disease-and-osteoarthritis
#1
Vyacheslav N Zhdan, Maksim М Potyazhenko, Galina S Khaymenova, Nadezhda N Lyulka, Tatyana V Dubrovinskaya, Igor V Ivanitsky
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is one of 21st century. About 210 million people all over the world are suffering with COPD, and annually 3 million people die of it. Under the influence of different factors, such as smoking, air prolusion, evaporation of chemicals, poisoning effect of chemical firings, inflammation processes take place in lungs, and if it is prolonged and take place simultaneously with morphological changes in the lungs, it it provide the de4velopment of the systemic inflammation process...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28711584/biomarkers-reflect-differences-in-osteoarthritis-phenotypes-of-the-lumbar-spine-the-johnston-county-osteoarthritis-project
#2
Adam P Goode, Amanda E Nelson, Virginia B Kraus, Jordan B Renner, Joanne M Jordan
OBJECTIVE: To determine differences in biomarker levels between radiographic phenotypes of facet joint osteoarthritis (FOA) only, spine OA only ((disc space narrowing (DSN) and vertebral osteophytes (OST)) or the combination of FOA and spine OA. DESIGN: A cross-sectional analysis of data from 555 participants in the Johnston County Osteoarthritis Project was performed. Lumbar spine levels were graded by severity (OST and DSN) and presence (FOA) of degeneration. Biomarkers included hyaluronan (HA) and type II collagen (CTX-II)...
July 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28705915/microarray-analysis-of-bone-marrow-lesions-in-osteoarthritis-demonstrates-upregulation-of-genes-implicated-in-osteochondral-turnover-neurogenesis-and-inflammation
#3
Anasuya Kuttapitiya, Lena Assi, Ken Laing, Caroline Hing, Philip Mitchell, Guy Whitley, Abiola Harrison, Franklyn A Howe, Vivian Ejindu, Christine Heron, Nidhi Sofat
OBJECTIVE: Bone marrow lesions (BMLs) are well described in osteoarthritis (OA) using MRI and are associated with pain, but little is known about their pathological characteristics and gene expression. We evaluated BMLs using novel tissue analysis tools to gain a deeper understanding of their cellular and molecular expression. METHODS: We recruited 98 participants, 72 with advanced OA requiring total knee replacement (TKR), 12 with mild OA and 14 non-OA controls...
July 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28705606/regenerative-approaches-for-cartilage-repair-in-the-treatment-of-osteoarthritis
#4
REVIEW
Meihan Li, Rong Xiao, Jing B Li, Qing Zhu
Osteoarthritis (OA) as a debilitating affliction of joints currently affects millions of people and remains an unsolved problem. The disease involves multiple cellular and molecular pathways that converge on the progressive destruction of cartilage. Activation of cartilage regenerative potential and specific targeting pathogenic mediators have been the major focus of research efforts aimed at slowing the progression of cartilage degeneration and preserve joint function. This review will summarize recent key discoveries toward better understanding of the complex mechanisms behind OA development and highlight the latest advances in basic and clinical research in the approach for cartilage regeneration...
July 10, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28704603/relationship-between-knee-pain-and-infra-patellar-fat-pad-morphology-a-within-and-between-person-analysis-from-the-osteoarthritis-initiative
#5
Eva Steidle-Kloc, Adam G Culvenor, Jan Dörrenberg, Wolfgang Wirth, Anja Ruhdorfer, Felix Eckstein
OBJECTIVE: Inflammation is known to be strongly associated with knee pain in osteoarthritis. The infra-patellar fat pad represents a potential source of pro-inflammatory cytokines. Yet, the relationship between infra-patellar fat pad morphology and osteoarthritis symptoms is unclear. METHODS: Here we investigate quantitative imaging parameters of infra-patellar fat pad morphology between: a) painful vs. contralateral pain-free limbs of subjects with unilateral pain; and b) knees of patients with chronic knee pain vs...
July 13, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28696356/rapamycin-maintains-the-chondrocytic-phenotype-and-interferes-with-inflammatory-cytokine-induced-processes
#6
Andrea De Luna-Preitschopf, Hannes Zwickl, Stefan Nehrer, Markus Hengstschläger, Mario Mikula
Osteoarthritis (OA) is hallmarked by a progressive degradation of articular cartilage. Besides risk factors including trauma, obesity or genetic predisposition, inflammation has a major impact on the development of this chronic disease. During the course of inflammation, cytokines such as tumor necrosis factor-alpha(TNF-α) and interleukin (IL)-1β are secreted by activated chondrocytes as well as synovial cells and stimulate the production of other inflammatory cytokines and matrix degrading enzymes. The mTORC1 inhibitor rapamycin is a clinical approved immunosuppressant and several studies also verified its chondroprotective effects in OA...
July 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28695434/the-single-nucleotide-polymorphism-snp-of-tumor-necrosis-factor-%C3%AE-308g-a-gene-is-associated-with-early-onset-primary-knee-osteoarthritis-in-an-egyptian-female-population
#7
Sahar M Abdel Galil, Nillie Ezzeldin, Faten Fawzy, Mohamed El-Boshy
The objective of the present study is to investigate if there is a potential association between the single-nucleotide polymorphisms (SNPs) of the tumor necrosis factor alpha gene (TNF-α -308G/A, rs1800629) and the susceptibility to and severity of early-onset knee osteoarthritis in the Egyptian female population. Genotype distributions and allelic frequencies of TNF-α -308G/A polymorphism were investigated in 210 knee osteoarthritis (OA) patients and 210 age-, sex-, and ethnicity-matched healthy controls (HC)...
July 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28695367/paeonol-inhibits-il-1%C3%AE-induced-inflammation-via-pi3k-akt-nf-%C3%AE%C2%BAb-pathways-in-vivo-and-vitro-studies
#8
Yiting Lou, Chenggui Wang, Qian Tang, Wenhao Zheng, Zhenhua Feng, Xingfang Yu, Xiaoshan Guo, Jianshun Wang
Paeonol, the main active component isolated from the root of Paeonia suffruticosa, has been reported to have anti-inflammatory properties. However, the effects of paeonol on osteoarthritis (OA) remain unclear. The aim of this study was to investigate the anti-inflammatory effects and mechanism of paeonol in IL-1β-induced human OA chondrocytes as well as mice OA models. Human OA chondrocytes were pretreated with different concentrations of paeonol 2 h prior to IL-1β (10 ng/mL) stimulation for 24 h. Nitric oxide (NO) production was determined by Griess method...
July 10, 2017: Inflammation
https://www.readbyqxmd.com/read/28681116/the-relationship-of-platelet-to-lymphocyte-ratio-and-neutrophil-to-monocyte-ratio-to-radiographic-grades-of-knee-osteoarthritis
#9
J Shi, W Zhao, H Ying, J Du, J Chen, S Chen, B Shen
OBJECTIVE: Accumulating data show that platelet to lymphocyte ratio (PLR) and neutrophil to monocyte ratio (NMR) undergo changes during inflammation in various diseases; however, the clinical features remain unclear in knee osteoarthritis (OA) patients. The purpose of our study was to evaluate PLR and NMR in knee OA patients, and assess their relationship to knee OA's radiographic grades. METHODS: A retrospective study on 132 adult knee OA patients and 162 healthy controls (HC) was performed...
July 5, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28676900/serum-levels-of-the-bone-turnover-markers-dickkopf-1-osteoprotegerin-and-tnf-%C3%AE-in-knee-osteoarthritis-patients
#10
Sicong Min, Chao Wang, Wanli Lu, Zhihong Xu, Dongquan Shi, Dongyang Chen, Huajian Teng, Qing Jiang
Knee osteoarthritis (KOA) is a common degenerative joint disease causing pain, stiffness, reduced motion, swelling, crepitus, and disability. Several inflammatory markers and cartilage degradation products can be used as biomarkers in OA. The key factors of bone metabolism in normal joint bone, dickkopf-1 (DKK1) and osteoprotegerin (OPG), interact with Wnt signaling pathway, balancing between bone absorption and bone reconstruction. TNF-α is a key inducer of DKK-1, which belongs to the family of proteins involved in joint remodeling...
July 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28674292/diverse-functions-of-a-disintegrin-and-metalloproteinase-with-thrombospondin-motif-1
#11
Satoshi Hirohata, Junko Inagaki, Takashi Ohtsuki
 A disintegrin and metalloproteinase with thrombospondin motif-1 (ADAMTS1) was initially cloned from a colon cachexia cell line. In the last 20 years, novel matrix metalloproteinase (MMP) genes were found, and in addition to their original members (MMPs and membrane-type MMPs), the current MMP family contains a disintegrin and metalloproteinases (ADAMs) and ADAMTS. ADAM and ADAMTS play essential roles in organogenesis as well as various diseases including osteoarthritis. ADAMTS has 19 members and can be divided into several groups according to their substrates...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28670374/combination-of-circulating-mir-19b-3p-mir-122-5p-and-mir-486-5p-expressions-correlates-with-risk-and-disease-severity-of-knee-osteoarthritis
#12
Ruina Kong, Jie Gao, Yanhui Si, Dongbao Zhao
The aim of this study was to investigate the association of circulating miRNAs profile with the risk of knee osteoarthritis (OA), and evaluate their correlation with clinical characteristics. This study was divided into two parts: exploration stage and validation stage. In exploration stage, 8 knee OA patients and 8 age and gender highly matched health controls (HCs) were recruited, and plasma sample were collected for microarray examination. Differentially expressed miRNAs and enrichment analysis were subsequently performed...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28669703/design-and-development-of-unani-anti-inflammatory-cream
#13
Sana Fatima, Roohi Zaman, Nafis Haider, Shariq Shamsi, Anzar Alam
Inflammation is the symptom of many diseases like rheumatoid arthritis and osteoarthritis. Many side effects are associated with the Non-Steroidal Anti-inflammatory Drugs (NSAIDs) used as conventional treatment for these conditions. In Unani, there are large number of single and compound drugs for inflammatory conditions. One dosage form of Unani system of medicine is named as Zimad in which paste is formed by mixing powder in oil, water, herbal extract. Zimadat is prepared just before application and used in many disease conditions as resolving, styptic, astringent, and antiseptic...
June 29, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28668804/validation-of-a-knowledge-transfer-tool-according-to-the-omeract-filter-does-web-based-real-time-iterative-calibration-enhance-the-evaluation-of-bone-marrow-lesions-in-hip-osteoarthritis
#14
Jacob L Jaremko, Omar Azmat, Robert G W Lambert, Paul Bird, Ida K Haugen, Lennart Jans, Ulrich Weber, Naomi Winn, Veronika Zubler, Walter P Maksymowych
OBJECTIVE: To assess reliability and feasibility of using a Web-based interface and interactive online calibration tool for magnetic resonance imaging (MRI) scoring of bone marrow lesions (BML) in osteoarthritis (OA), applied to the Hip MR Inflammation Scoring System (HIMRISS). METHODS: Seven readers new to HIMRISS (3 radiologists, 4 rheumatologists) scored coronal short-tau inversion recovery MRI from a hip OA observational study obtained pre- and 8-week post-steroid injection (n = 40 × 2 scans × 2 hips = 160 hips)...
July 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28668542/cd56-cd16-natural-killer-cells-expressing-the-inflammatory-protease-granzyme-a-are-enriched-in-synovial-fluid-from-patients-with-osteoarthritis
#15
P Jaime, N García-Guerrero, R Estella, J Pardo, F García-Álvarez, L Martinez-Lostao
OBJECTIVE: Natural killer (NK) cells have been involved in the pathology of different inflammatory and autoimmune disorders. Inflammation is an important regulator of osteoarthritis (OA), but the molecular and cellular mechanisms regulating this process are not well defined. DESIGN: To understand the role of NK cells in OA, we have compared the phenotype (CD56 subsets and perforin and granzyme expression) and cytotoxic function of NK cells in peripheral blood and synovial fluid from patients with OA undergoing total knee arthroplasty...
June 29, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28666239/cryptotanshinone-protects-against-il-1%C3%AE-induced-inflammation-in-human-osteoarthritis-chondrocytes-and-ameliorates-the-progression-of-osteoarthritis-in-mice
#16
Zhenhua Feng, Wenhao Zheng, Xiaobin Li, Jian Lin, Chenglong Xie, Hang Li, Liang Cheng, Aimin Wu, Wenfei Ni
Osteoarthritis (OA) is a common degenerative disease characterized by progressive erosion of articular cartilage, subchondral bone sclerosis and synovitis. Cryptotanshinone (CTS), an active component extracted from the root of Salvia miltiorrhiza Bunge, has been shown to have potent anti-inflammatory effects. However, its effects on OA have not been clearly elucidated. This study aimed to assess the effect of CTS on human OA chondrocytes and mice OA models. Human OA chondrocytes were pretreated with CTS (5, 10 and 20μM) for 2h and subsequently stimulated with IL-1β for 24h...
June 27, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28662306/oxidative-stress-and-chronic-inflammation-in-osteoarthritis-can-nrf2-counteract-these-partners-in-crime
#17
REVIEW
Andrey S Marchev, Petya A Dimitrova, Andrew J Burns, Rumen V Kostov, Albena T Dinkova-Kostova, Milen I Georgiev
Osteoarthritis (OA) is an age-related joint degenerative disease associated with pain, joint deformity, and disability. The disease starts with cartilage damage but then progressively involves subchondral bone, causing an imbalance between osteoclast-driven bone resorption and osteoblast-driven remodeling. Here, we summarize the data for the role of oxidative stress and inflammation in OA pathology and discuss how these two processes are integrated during OA progression, as well as their contribution to abnormalities in cartilage/bone metabolism and integrity...
June 29, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28659793/revisiting-the-role-of-interleukin-1-pathway-in-osteoarthritis-interleukin-1%C3%AE-and-1%C3%AE-and-nlrp3-inflammasome-are-not-involved-in-the-pathological-features-of-the-murine-menisectomy-model-of-osteoarthritis
#18
Sonia Nasi, Hang-Korng Ea, Alexander So, Nathalie Busso
Background: Innate immune response components such as toll-like receptors (TLRs) and NLRP3-inflammasome act in concert to increase IL-1α/β secretion by synovial macrophages. Previous results suggest that IL-1α/β could be an important mediator involved in the pathogenesis of osteoarthritis (OA). Objectives: The aim of our study was to evaluate the role of NLRP3, IL-1β, and IL-1α in the menisectomy (MNX) model of murine OA. Methods: Murine chondrocytes (CHs) and bone marrow-derived machrophages (BMDM) were stimulated with hydroxyapatite (HA) crystals, a form of calcium-containing crystal found in human OA, and IL-1β and IL-6 secretion assayed by ELISA...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28651521/association-study-of-candidate-genes-for-susceptibility-to-kashin-beck-disease-in-a-tibetan-population
#19
Zhengfu Tai, Lulin Huang, Fang Lu, Yi Shi, Shi Ma, Jing Cheng, He Lin, Xin Liu, Yuanfeng Li, Zhenglin Yang
BACKGROUND: Many osteoarthritis (OA) susceptibility genes have been identified in recent years. Given the overlap in the phenotype of joint inflammation between OA and Kashin-Beck disease (KBD), the aim of this study is to explore whether the reported OA susceptibility genes and two genes that may link to OA pathophysiology are associated with KBD in the Tibetan population. METHOD: Fifteen single-nucleotide polymorphisms (SNPs) in 12 candidate genes previously reported as OA susceptibility loci were selected for investigation...
June 26, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28648867/an-initial-investigation-into-endothelial-cc-chemokine-expression-in-the-human-rheumatoid-synovium
#20
Lisa Rump, Derek L Mattey, Oksana Kehoe, Jim Middleton
Rheumatoid arthritis (RA) is a destructive and chronic autoimmune inflammatory disease. Synovial inflammation is a major feature of RA and is associated with leukocyte recruitment. Leukocytes cross the endothelial cells (ECs) into the synovial tissue and fluid and this migration is mediated via a range of chemokines and adhesion molecules on the ECs. As important mediators of leukocyte extravasation, a number of chemokines from each of the chemokine families have been established as expressed in the RA joint...
June 22, 2017: Cytokine
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