Hongchen Gu, Hanqing Yu, Ling Qin, Hanjie Yu, Yaxiang Song, Guangqi Chen, Dake Zhao, Shu Wang, Wen Xue, Ling Wang, Zisheng Ai, Bei Xu, Ai Peng
As a prominent feature of gout, monosodium urate (MSU) crystal deposition induces gout flares, but its impact on immune inflammation in gout remission remains unclear. Using single-cell RNA sequencing (scRNA-seq), we characterize the transcription profiling of peripheral blood mononuclear cells (PBMCs) among intercritical remission gout, advanced remission gout, and normal controls. We find systemic inflammation in gout remission with MSU crystal deposition at the intercritical and advanced stages, evidenced by activated inflammatory pathways, strengthened inflammatory cell-cell interactions, and elevated arachidonic acid metabolic activity...
September 26, 2023: Cell Reports