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https://www.readbyqxmd.com/read/29662676/-toxoplasma-gondii-exposure-and-epilepsy-a-matched-case-control-study-in-a-public-hospital-in-northern-mexico
#1
Cosme Alvarado-Esquivel, Yazmin Del Rosario Rico-Almochantaf, Jesús Hernández-Tinoco, Gerardo Quiñones-Canales, Luis Francisco Sánchez-Anguiano, Jorge Torres-González, Eda Guadalupe Ramírez-Valles, Andrea Minjarez-Veloz
Objectives: This study aimed to determine the association between infection with Toxoplasma gondii and epilepsy in patients attended to in a public hospital in the northern Mexican city of Durango. Methods: We performed an age- and gender-matched case-control study of 99 patients suffering from epilepsy and 99 without epilepsy. Sera of participants were analyzed for anti- T. gondii IgG and IgM antibodies using commercially available enzyme-linked immunoassays. Seropositive samples to T...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29652945/clinical-evaluation-and-validation-of-laboratory-methods-for-the-diagnosis-of-bordetella-pertussis-infection-culture-polymerase-chain-reaction-pcr-and-anti-pertussis-toxin-igg-serology-igg-pt
#2
Adria D Lee, Pamela K Cassiday, Lucia C Pawloski, Kathleen M Tatti, Monte D Martin, Elizabeth C Briere, M Lucia Tondella, Stacey W Martin
INTRODUCTION: The appropriate use of clinically accurate diagnostic tests is essential for the detection of pertussis, a poorly controlled vaccine-preventable disease. The purpose of this study was to estimate the sensitivity and specificity of different diagnostic criteria including culture, multi-target polymerase chain reaction (PCR), anti-pertussis toxin IgG (IgG-PT) serology, and the use of a clinical case definition. An additional objective was to describe the optimal timing of specimen collection for the various tests...
2018: PloS One
https://www.readbyqxmd.com/read/29651290/anti-transforming-growth-factor-%C3%AE-igg-elicits-a-dual-effect-on-calcium-oxalate-crystallization-and-progressive-nephrocalcinosis-related-chronic-kidney-disease
#3
Stefanie Steiger, Julia Felicitas Grill, Qiuyue Ma, Tobias Bäuerle, Jutta Jordan, Michaela Smolle, Claudia Böhland, Maciej Lech, Hans-Joachim Anders
Crystallopathies are a heterogeneous group of diseases caused by intrinsic or environmental microparticles or crystals, promoting tissue inflammation and scarring. Certain proteins interfere with crystal formation and growth, e.g., with intrarenal calcium oxalate (CaOx) crystal formation, a common cause of kidney stone disease or nephrocalcinosis-related chronic kidney disease (CKD). We hypothesized that immunoglobulins can modulate CaOx microcrystal formation and crystal growth and that therefore, biological IgG-based drugs designed to specifically target disease modifying proteins would elicit a dual effect on the outcome of CaOx-related crystallopathies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29595510/safety-and-immunogenicity-of-the-novel-tuberculosis-vaccine-id93-gla-se-in-bcg-vaccinated-healthy-adults-in-south-africa-a-randomised-double-blind-placebo-controlled-phase-1-trial
#4
Adam Penn-Nicholson, Michele Tameris, Erica Smit, Tracey A Day, Munyaradzi Musvosvi, Lakshmi Jayashankar, Julie Vergara, Simbarashe Mabwe, Nicole Bilek, Hendrik Geldenhuys, Angelique Kany-Kany Luabeya, Ruth Ellis, Ann M Ginsberg, Willem A Hanekom, Steven G Reed, Rhea N Coler, Thomas J Scriba, Mark Hatherill
BACKGROUND: A vaccine that prevents pulmonary tuberculosis in adults is needed to halt transmission in endemic regions. This trial aimed to assess the safety and immunogenicity of three administrations at varying doses of antigen and adjuvant of an investigational vaccine (ID93 + GLA-SE) compared with placebo in previously BCG-vaccinated healthy adults in a tuberculosis endemic country. METHODS: In this randomised, double-blind, placebo-controlled phase 1 trial, we enrolled HIV-negative, previously BCG-vaccinated adults (aged 18-50 years), with no evidence of previous or current tuberculosis disease, from among community volunteers in the Worcester region of Western Cape, South Africa...
April 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29590158/significance-of-serological-markers-in-the-disease-course-of-ulcerative-colitis-in-a-prospective-clinical-cohort-of-patients
#5
Gyorgy Kovacs, Nora Sipeki, Boglarka Suga, Tamas Tornai, Kai Fechner, Gary L Norman, Zakera Shums, Peter Antal-Szalmas, Maria Papp
BACKGROUND & AIMS: To determine the prognostic potential of classic and novel serologic antibodies regarding unfavorable disease course in a prospective ulcerative colitis (UC) patient cohort, since few and conflicting data are available in the literature regarding this matter. METHODS: 187 consecutive patients were studied prospectively (median follow-up: 135 months) from a single referral IBD center in Hungary. Sera were tested for different IgA/IgG type autoantibodies (anti-neutrophil cytoplasmic [ANCA], anti-DNA-bound-lactoferrin [anti-LFS], anti-goblet cell [anti-GAB] and anti-pancreatic [PAB: anti-CUZD1 and anti-GP2)]) by indirect immunofluorescence technique and for anti-microbial (anti-Saccharomyces cerevisiae [ASCA] IgG/IgA and anti-OMP Plus™ IgA) antibodies by enzyme-linked immunosorbent assays...
2018: PloS One
https://www.readbyqxmd.com/read/29573404/correlation-of-natural-autoantibodies-and-cardiovascular-disease-related-antibacterial-antibodies-in-pericardial-fluid-of-cardiac-surgery-patients
#6
D Simon, O Gilicze, N Farkas, J Najbauer, P Németh, L Lénárd, T Berki
Our previous studies showed that anti-citrate synthase (a-CS) IgM natural autoantibodies are present in healthy individuals without previous antigen stimulation, but no studies have investigated their presence in the pericardial fluid (PF). Therefore we detected the natural anti-CS IgG/M autoantibody levels in plasma and PF of cardiac surgery patients and investigated their relationship with cardiovascular disease-associated bacterial pathogens. PF and blood samples of 22 coronary artery bypass graft (CABG) and 10 aortic valve replacement (AVR) patients were tested for total Ig levels, natural autoantibodies and infection-related antibodies using ELISA and Luminex methods...
March 24, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29572115/low-galactosylation-of-igg-associates-with-higher-risk-for-future-diagnosis-of-rheumatoid-arthritis-during-10-years-of-follow-up
#7
Ivan Gudelj, Perttu P Salo, Irena Trbojević-Akmačić, Malena Albers, Dragan Primorac, Markus Perola, Gordan Lauc
Antibodies are known to have an important role in the development of rheumatoid arthritis (RA), one of the most prevalent chronic inflammatory diseases which primarily involves the joints. Most RA patients develop autoantibodies against immunoglobulin G (IgG) and changes in IgG glycosylation have been associated with RA. We undertook this study to determine whether altered IgG glycosylation precedes the disease diagnosis. We studied IgG glycosylation in RA in two prospective cohorts (N = 14,749) by measuring 28 IgG glycan traits in 179 subjects who developed RA within 10-years follow-up and 358 matched controls...
March 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29549357/igg4-associated-cholangitis-in-patients-resected-for-presumed-perihilar-cholangiocarcinoma-a-30-year-tertiary-care-experience
#8
Eva Roos, Lowiek M Hubers, Robert J S Coelen, Marieke E Doorenspleet, Niek de Vries, Joanne Verheij, Ulrich Beuers, Thomas M van Gulik
BACKGROUND: Distinguishing perihilar cholangiocarcinoma (PHC) from benign forms of sclerosing cholangitis affecting the hilar bile ducts is challenging, since histological confirmation of PHC is difficult to obtain and accurate non-invasive diagnostic tests are not available. IgG4-associated cholangitis (IAC), an imitator of PHC, may present with clinical and radiographical signs of PHC. IAC can be accurately diagnosed with a novel qPCR test. The aim of this study was to investigate the incidence and long-term activity of IAC in patients resected for PHC in a single tertiary center over a period of 30 years...
March 16, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29535184/the-invasin-d-protein-from-yersinia-pseudotuberculosis-selectively-binds-the-fab-region-of-host-antibodies-and-affects-colonization-of-the-intestine
#9
Pooja Sadana, Rebecca Geyer, Joern Pezoldt, Saskia Helmsing, Jochen Huehn, Michael Hust, Petra Dersch, Andrea Scrima
Yersinia pseudotuberculosis is a Gram-negative bacterium and zoonotic pathogen responsible for a wide range of diseases, ranging from mild diarrhea, enterocolitis, lymphatic adenitis to persistent local inflammation. The Y. pseudotuberculosis invasin D (InvD) molecule belongs to the invasin (InvA)-type autotransporter proteins, but its structure and function remain unknown. In this study, we present the first crystal structure of InvD, analyzed its expression and function in a murine infection model, and identified its target molecule in the host...
March 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29535164/glycosylation-profile-of-immunoglobulin-g-is-cross-sectionally-associated-with-cardiovascular-disease-risk-score-and-subclinical-atherosclerosis-in-two-independent-cohorts
#10
Cristina Menni, Ivan Gudelj, Erin MacDonald-Dunlop, Massimo Mangino, Jonas Zierer, Erim Bešić, Peter Joshi, Irena Trbojević-Akmačić, Phil J Chowienczyk, Timothy D Spector, James F Wilson, Gordan Lauc, Ana M Valdes
<u>Rationale:</u> One measure of protein glycosylation (GlycA) has been reported to predict higher cardiovascular risk by reflecting inflammatory pathways <u>Objective:</u> To assess the role of a comprehensive panel of immunoglobulin (IgG) glycosylation traits on traditional risk factors for cardiovascular disease and on presence of subclinical atherosclerosis in addition to GlycA. <u>Methods and Results:</u> We measured 76 IgG glycosylation traits in 2970 women (age range 40-79 years) from the TwinsUK cohort and correlated it to their estimated 10-year atherosclerotic cardiovascular disease (ASCVD) risk score and their carotid and femoral plaque measured by ultrasound imaging...
March 13, 2018: Circulation Research
https://www.readbyqxmd.com/read/29513843/epidemiological-factors-associated-with-toxoplasma-gondii-infection-in-postpartum-women-treated-in-the-public-healthcare-system-of-goi%C3%A3-nia-state-of-goi%C3%A3-s-brazil
#11
Juliana Boaventura Avelar, Marcos Gontijo da Silva, Hanstter Hallison Alves Rezende, Heloisa Ribeiro Storchilo, Waldemar Naves do Amaral, Isolina Rodrigues Xavier, Mariza Martins Avelino, Ana Maria de Castro
INTRODUCTION: Knowledge of the epidemiological profile and risk factors for Toxoplasma gondii infection among postpartum women is a relevant issue, because this protozoan can be vertically transmitted to the developing fetus, which can cause severe and debilitating disease. The aim of this study was to assess the risk factors associated with T. gondii infection in postpartum women in Goiânia, GO, Brazil. METHODS: This cross-sectional study comprised 229 postpartum women, among whom 204 were chronically infected (IgG+/IgM-), and 25 were seronegative (IgG-/IgM-; control group)...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29497417/the-possible-effect-of-b-cell-epitopes-of-epstein-barr-virus-early-antigen-membrane-antigen-latent-membrane-protein-1-and-2a-on-systemic-lupus-erythematosus
#12
Jianxin Tu, Xiaobing Wang, Guannan Geng, Xiangyang Xue, Xiangyang Lin, Xiaochun Zhu, Li Sun
This study was aimed to evaluate the role of B-cell epitopes of Epstein-Barr virus (EBV) Early antigen protein D (EA), envelope glycoprotein GP340/membrane antigen (MA), latent membrane protein (LMP)-1, and LMP-2A in systemic lupus erythematosus (SLE). B-cell epitopes were predicted by analyzing secondary structure, transmembrane domains, surface properties, and homological comparison. 60 female mice were randomized equally into 12 groups: 1-10 groups were immunized by epitope peptides (EPs) 1-10, respectively, while 11 and 12 groups were PBS and Keyhole limpet hemocyanin (KLH) control groups...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29491333/-cerebral-infarction-related-to-varicella-zoster-virus-vasculopathy
#13
Satoshi Namitome, Seigo Shindo, Kuniyasu Wada, Tadashi Terasaki, Makoto Nakajima, Yukio Ando
A 14-year-old girl developed transient disturbance of consciousness, dysarthria, and clumsiness of the right upper limb 4 months after herpes zoster ophthalmicus. Brain MRI showed acute cerebral infarction in the left middle cerebral artery (MCA) territory. CT angiography demonstrated mild stenosis in the top of the left internal carotid artery and the proximal side of the MCA. Cerebrospinal fluid (CSF) examination showed slightly mononuclear pleocytosis (6/μl). Titer of the anti-varicella zoster virus (VZV) IgG antibodies in CSF was increased, and gadolinium-enhanced brain MRI (T1 -weighted imaging) revealed enhancement of the vessel walls at the stenotic lesions...
February 28, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29477943/the-use-of-emergency-apheresis-in-the-management-of-plasma-cell-disorders
#14
REVIEW
Sevgi Kalayoglu-Besisik
Hyperviscosity syndrome (HVS) develops most commonly in Waldenström's macroglobulinemia (WM) and multiple myeloma (MM). Plasmapheresis is the immediate therapy and very effective at relieving symptoms by removing paraprotein. The most commonly used replacement fluid is 4%-5% human albumin in physiologic saline. FFP may be used in patients with coagulation abnormalities. Plasmapheresis should be continued until acute symptoms abate. Hyperviscosity impairs the circulation in the retina and causes hemorrhages around the small retinal vessels...
February 20, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29470571/prevalence-of-myelin-oligodendrocyte-glycoprotein-and-aquaporin-4-igg-in-patients-in-the-optic-neuritis-treatment-trial
#15
John J Chen, W Oliver Tobin, Masoud Majed, Jiraporn Jitprapaikulsan, James P Fryer, Jacqueline A Leavitt, Eoin P Flanagan, Andrew McKeon, Sean J Pittock
Importance: Autoantibodies to aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) are recently established biomarkers of autoimmune optic neuritis whose frequency and accompanying phenotype, especially for MOG-IgG, are still being characterized. The Optic Neuritis Treatment Trial (ONTT) was a well-known randomized clinical trial in optic neuritis; therefore, knowledge of the serostatus and accompanying phenotype of these patients would be useful to determine the frequency of these antibodies in patients presenting with typical monocular optic neuritis and their outcomes...
February 22, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29460864/serosurvey-of-coxiella-burnetii-in-high-risk-population-in-turkey-endemic-to-crimean-congo-haemorrhagic-fever-virus
#16
Rahşan Erturk, Ömer Poyraz, Turabi Güneş
Background & objectives: Q fever caused by Coxiella burnetii is a zoonotic infection that spreads to human beings from animals. This study was aimed to demographically examine the C. burnetii seroprevalence in the people living in villages where Crimean-Congo haemorrhagic fever virus (CCHFV) is endemic, in terms of various risk factors such as tick bites, tick contact, and occupational groups. Methods: A total of 440 serum samples from those living in rural areas of Sivas and Tokat regions in Turkey were included in the study as a risk group; 387of them were serologically CCHFV positive (as confirmed in our previous research)...
October 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29460701/anti-dsdna-titre-in-female-systemic-lupus-erythematosus-patients-relation-to-disease-manifestations-damage-and-antiphospholipid-antibodies
#17
T A Gheita, N M Abaza, N Hammam, A A A Mohamed, I I El-Gazzar, A H Eissa
Background Attempts are ongoing to unveil unresolved queries about anti-double-stranded deoxyribonucleic acid (anti-dsDNA), their precise pathogenic effects and to what extent blocking them would be a useful therapeutic goal. Objectives The aim of the present study was to determine the anti-dsDNA antibodies titre in systemic lupus erythematosus (SLE) patients and investigate their relation to the disease characteristics, activity, damage and antiphospholipid autoantibodies (aPL). Methods Seventy female SLE patients and 35 age- and sex-matched controls were included...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29439708/possible-relationship-between-fibrosis-of-igg4-related-thymitis-and-the-profibrotic-cytokines-transforming-growth-factor-beta-1-interleukin-1-beta-and-interferon-gamma-a-case-report
#18
Atsuko Masunaga, Fumihiro Ishibashi, Eitetsu Koh, Takashi Oide, Yasuo Sekine, Kenzo Hiroshima
BACKGROUND: IgG4-related disease often forms a mass and the affected lesion is clinically removed because the mass cannot be differentiated from a neoplasm. Affected lesions commonly occur in the pancreas, hepatobiliary tract, kidney, and retroperitoneum. However, the lesion rarely occurs in the thymus. A histological worldwide consensus of IgG4-related disease proposed that pathological diagnosis of IgG4-related disease should meet more than two of three major features: 1) dense lymphoplasmacytic infiltration with greater than 40% IgG4+/IgG+ plasma cells, 2) storiform fibrosis; and 3) obliterative phlebitis...
January 17, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29437186/evaluation-of-igg4-plasma-cell-infiltration-in-patients-with-systemic-plasmacytosis-and-other-plasma-cell-infiltrating-skin-diseases
#19
Shintaro Takeoka, Masahiro Kamata, Carren Sy Hau, Mihoko Tateishi, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yuko Sasajima, Shinichi Watanabe, Yayoi Tada
Systemic plasmacytosis is a rare skin disorder characterized by marked infiltration of plasma cells in the dermis. IgG4-related disease is pathologically characterized by lymphoplasmacytic infiltration rich in IgG4+ plasma cells, storiform fibrosis, and obliterative phlebitis, accompanied by elevated levels of serum IgG4. Reports of cases of systemic plasmacytosis with abundant infiltration of IgG4+ plasma cells has led to discussion about the relationship between systemic plasmacytosis and IgG4-related disease...
February 13, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29434730/clinical-and-pathological-characteristics-of-igg4-related-interstitial-lung-disease
#20
Xiaoting Lv, Feng Gao, Qicai Liu, Sheng Zhang, Zhihua Huang, Yongping Zhu, Haiyang Zong, Quwen Li, Sanyan Li
IgG4-related interstitial lung disease (IgG4-RILD), which is characterized by increased IgG4 levels, IgG4+ plasma cell infiltration and irregular whorled fibrosis, is a recently described lung disorder that belongs to the group of systemic fibroinflammatory IgG4-related diseases (IgG4-RD). The aim of the present study was to improve the current knowledge regarding the specific clinical and histopathological characteristics of IgG4-RILD and to investigate its underlying immune mechanism in vivo . A total of 7 patients newly diagnosed with IgG4-RILD were enrolled in the present study (4 men and 3 women; mean age, 57 years; range, 29-71 years)...
February 2018: Experimental and Therapeutic Medicine
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