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IgG 4 Related disease

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https://www.readbyqxmd.com/read/28098193/non-pathogenic-tissue-resident-cd8-t-cells-uniquely-accumulate-in-the-brains-of-lupus-prone-mice
#1
Peter A Morawski, Chen-Feng Qi, Silvia Bolland
Severe lupus often includes psychiatric and neurological sequelae, although the cellular contributors to CNS disease remain poorly defined. Using intravascular staining to discriminate tissue-localized from blood-borne cells, we find substantial accumulation of CD8(+) T cells relative to other lymphocytes in brain tissue, which correlates with lupus disease and limited neuropathology. This is in contrast to all other affected organs, where infiltrating CD4(+) cells are predominant. Brain-infiltrating CD8(+) T cells represent an activated subset of those found in the periphery, having a resident-memory phenotype (CD69(+)CD122(-)PD1(+)CD44(+)CD62L(-)) and expressing adhesion molecules (VLA-4(+)LFA-1(+)) complementary to activated brain endothelium...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28072956/-clinical-and-immunological-analysis-of-the-patient-with-autoimmunity-due-to-germline-stat3-gain-of-function-mutation
#2
Y Ding, Y Zhang, Y P Wang, H Y Zhao, X M Chen, X H Xue, X M Bai, Y F An, Z Y Zhang, X M Tang, X D Zhao
Objective: To investigate the clinical and immunological laboratory features and gene mutation in a female patient who carried a germline gain-of-function mutation in STAT3. Method: A patient with lymphadenopathy and pancytopenia, visited the Department of Rheumatology and Immunology of Children's Hospital of Chongqing Medical University in May 2016. The clinical and laboratory characteristics, results of immunophenotyping and exome sequencing were analyzed retrospectively and related literature was reviewed...
January 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28067962/concurrent-multiple-myeloma-and-mast-cell-neoplasia-in-a-13-year-old-castrated-male-maine-coon-cat
#3
Jonathan M Bagwell, Heather R Herd, Melanie A Breshears, Steven Hodges, Theresa E Rizzi
A 13-year-old, castrated male Maine Coon cat was presented to Oklahoma State University Boren Veterinary Medical Teaching Hospital for yearly echocardiographic examination monitoring hypertrophic cardiomyopathy (HCM) diagnosed in 2003. Physical examination revealed a heart murmur and premature beats, likely related to HCM, but was otherwise unremarkable. A biochemistry profile revealed a hyperglobulinemia (6.3 g/dL). Cytologic examination of fine-needle aspirates from liver and spleen revealed increased numbers of plasma cells and mast cells, confirmed with subsequent histologic examination...
January 9, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28062188/a-comprehensive-analysis-and-immunobiology-of-autoimmune-neurological-syndromes-during-the-zika-virus-outbreak-in-c%C3%A3%C2%BAcuta-colombia
#4
Juan-Manuel Anaya, Yhojan Rodríguez, Diana M Monsalve, Daniel Vega, Ernesto Ojeda, Diana González-Bravo, Mónica Rodríguez-Jiménez, Carlos A Pinto-Díaz, Pablo Chaparro, María L Gunturiz, Aftab A Ansari, M Eric Gershwin, Nicolás Molano-González, Carolina Ramírez-Santana, Yeny Acosta-Ampudia
We have focused on the epidemiology and immunobiology of Zika virus (ZIKV) infection and factors associated with the development of Guillain-Barré syndrome (GBS) and other neurological syndromes in Cúcuta, the capital of North Santander department, Colombia. Data of patients with ZIKV disease reported to the national population-based surveillance system were used to calculate the basic reproduction number (R0) and the attack rates (ARs) as well as to develop epidemiological maps. Patients with neurological syndromes were contacted and their diagnoses were confirmed...
January 3, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28042126/b-cell-depletion-therapy-normalizes-circulating-follicular-th-cells-in-primary-sj%C3%A3-gren-syndrome
#5
Gwenny M Verstappen, Frans G M Kroese, Petra M Meiners, Odilia B Corneth, Minke G Huitema, Erlin A Haacke, Bert van der Vegt, Suzanne Arends, Arjan Vissink, Hendrika Bootsma, Wayel H Abdulahad
OBJECTIVE: To assess the effect of B cell depletion therapy on effector CD4+ T cell homeostasis and its relation to objective measures of disease activity in patients with primary Sjögren syndrome (pSS). METHODS: Twenty-four patients with pSS treated with rituximab (RTX) and 24 healthy controls (HC) were included. Frequencies of circulating effector CD4+ T cell subsets were examined by flow cytometry at baseline and 16, 24, 36, and 48 weeks after the first RTX infusion...
January 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28035551/agy-a-novel-egg-yolk-derived-anti-gliadin-antibody-is-safe-for-patients-with-celiac-disease
#6
Dory A Sample, Hoon H Sunwoo, Hien Q Huynh, Heather L Rylance, Cheri L Robert, Bi-Wen Xu, Sung H Kang, Naiyana Gujral, Levinus A Dieleman
BACKGROUND: Celiac disease (CD) is a gluten-triggered autoimmune disorder of the small intestine. A lifelong gluten-free diet (GFD) is the only approved treatment; however, strict adherence is difficult and many suffer from inadvertent gluten exposure. Oral egg yolk anti-gliadin antibody (AGY) is a novel treatment to neutralize gluten and may improve the efficacy of the GFD. AIMS: To determine the safety, tolerability, and potential efficacy of AGY in patients with CD...
December 29, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28028974/myocardial-ischaemia-coronary-atherosclerosis-and-pulmonary-pressure-elevation-in-antiphospholipid-syndrome-patients
#7
Agnieszka Padjas, Wojciech Płazak, Magdalena Celińska-Lowenhoff, Adam Mazurek, Carlo Perricone, Piotr Podolec, Jacek Musiał
BACKGROUND: Thrombotic events in antiphospholipid syndrome (APS) involve venous and arterial circulation with the possible involvement of coronary or pulmonary microcirculation. OBJECTIVES: To evaluate the influence of antiphospholipid antibodies (aPL) and on myocardial ischaemia assessed by single-photon emission computerized tomography (SPECT), coronary atherosclerosis assessed by multidetector computerized tomography (MDCT) and pulmonary pressure assessed by transthoracic echocardiography (TTE) in patients with primary antiphospholipid syndrome (PAPS)...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28017203/pregnancy-in-neuromyelitis-optica-spectrum-disorder-a-multicenter-study-from-south-china
#8
Yanlu Huang, Yuge Wang, Yifan Zhou, Qiao Huang, Xiaobo Sun, Chen Chen, Ling Fang, Youming Long, Hui Yang, Honghao Wang, Caixia Li, Zhengqi Lu, Xueqiang Hu, Allan G Kermode, Wei Qiu
OBJECTIVE: This study aimed to assess the effect of pregnancy on the course of neuromyelitis optica spectrum disorder (NMOSD), and the effect of this disease on pregnancy outcomes. METHODS: Consecutive patients with NMOSD were recruited between September 2015 and April 2016 at an outpatient clinic from four referral institutes in South China. Demographic, clinical, and pregnancy data were retrieved by questionnaires to analyze the association between NMOSD and pregnancy, as well as the potential risk factors for relapse...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28011413/a-systematic-review-and-meta-analysis-of-seroprevalence-of-varicella-zoster-virus-a-nationwide-population-based-study
#9
REVIEW
Omolbanin Amjadi, Alireza Rafiei, Mohammadreza Haghshenas, Reza Alizadeh Navaei, Reza Valadan, Zahra Hosseini-Khah, Akbar Hedayatizadeh Omran, Mohsen Arabi, Reza Jafari Shakib, Tahoora Mousavi, G Hossein Ashrafi
Varicella zoster virus (VZV) causes chicken pox as a primary infection following which it becomes latent in neurons. It may then reactivate to cause shingles (herpes zoster). Severity of lesions and VZV pathogenicity are depended on the host's immune response and variant in VZV Dr Athina Myrto ChioniIdentification of VZV seroprevalance rate in general population may lead to develop new health strategic managements such as vaccination. Therefore, we aimed to provide a systematic review of the seroprevalence of VZV infection among Iranian population and estimate age- and gender- specific prevalence of VZV...
December 6, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28000632/an-unusual-cause-of-dysphagia-isolated-igg-4-related-esophageal-disease
#10
Ritambhra Nada, Surinder Singh Rana, Ravi Sharma, Lovneet Dhalaria, Harpreet Singh, Bhagwant R Mittal, Rajesh Gupta, Deepak K Bhasin
No abstract text is available yet for this article.
November 2016: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/27981470/immunoglobulin-g-igg-based-imaging-probe-accumulates-in-m1-macrophage-infiltrated-atherosclerotic-plaques-independent-of-igg-target-molecule-expression
#11
Yoichi Shimizu, Hiroko Hanzawa, Yan Zhao, Sagiri Fukura, Ken-Ichi Nishijima, Takeshi Sakamoto, Songji Zhao, Nagara Tamaki, Mikako Ogawa, Yuji Kuge
PURPOSE: Vulnerable plaques are key factors for ischemic diseases. Thus, their precise detection is necessary for the diagnosis of such diseases. Immunoglobulin G (IgG)-based imaging probes have been developed for imaging biomolecules related to plaque formation for the diagnosis of atherosclerosis. However, IgG accumulates nonspecifically in atherosclerotic regions, and its accumulation mechanisms have not yet been clarified in detail. Therefore, we explored IgG accumulation mechanisms in atherosclerotic lesions and examined images of radiolabeled IgG for the diagnosis of atherosclerosis...
December 15, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27976801/serologic-antibodies-in-relation-to-outcome-in-post-operative-crohn-s-disease
#12
Amy L Hamilton, Michael A Kamm, Peter De Cruz, Emily K Wright, Fabiyola Selvaraj, Fred Princen, Alexandra Gorelik, Danny Liew, Ian C Lawrance, Jane M Andrews, Peter A Bampton, Miles P Sparrow, Timothy H Florin, Peter R Gibson, Henry Debinski, Richard B Gearry, Finlay A Macrae, Rupert W Leong, Ian Kronborg, Graham Radford-Smith, Warwick Selby, Sally J Bell, Steven J Brown, William R Connell
BACKGROUND: Disease recurs frequently after Crohn's disease resection. The role of serological antimicrobial antibodies in predicting recurrence or as a marker of recurrence has not been well defined. METHODS: 169 patients (523 samples) were prospectively studied, with testing peri-operatively, and 6, 12 and 18 months post-operatively. Colonoscopy was performed at 18 months post-operatively. Serologic antibody presence (pANCA, ASCA IgA/IgG, anti-OmpC, anti-CBir1, anti-A4-Fla2, anti-Fla-X) and titre were tested...
December 15, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27973402/the-influence-of-urbanization-modes-on-the-spatial-circulation-of-flaviviruses-within-ouagadougou-burkina-faso
#13
Florence Fournet, Stéphane Rican, Zoé Vaillant, Anna Roudot, Aude Meunier-Nikiema, Daouda Kassié, Roch K Dabiré, Gérard Salem
Dengue is an emerging infectious disease of global significance. Although this virus has been reported for a long time, its significance within the burden of diseases in West Africa is not obvious, especially in Burkina Faso. Our objective was to evaluate flavivirus presence in Ouagadougou (Burkina Faso) and the link between anti-flavivirus antibody seroprevalence and urbanization modes. A population-based cross-sectional survey was conducted and 3015 children were enrolled from Ouagadougou districts with different types and degrees of urbanization (with/without equipment and high/low building density)...
December 10, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27966020/application-of-western-blot-analysis-for-the-diagnosis-of-encephalitozoon-cuniculi-infection-in-rabbits-example-of-a-quantitative-approach
#14
Guillaume Desoubeaux, Ana Pantin, Roman Peschke, Anja Joachim, Carolyn Cray
Diagnosis of Encephalitozoon cuniculi infection in rabbits remains a major veterinary issue. ELISA or immunofluorescence assays are the current reference standards of serological tests. However, these conventional techniques suffer from a lack of accuracy for distinguishing active from past infections, as a positive serostatus is common in clinically normal rabbits. In this study, we assessed the diagnostic performance of Western blot (WB) to detect both anti-E. cuniculi immunoglobulin G (IgG) and immunoglobulin M (IgM) in comparison with ELISA and to address the intensity of the immune response through a quantitative approach...
December 13, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27933180/serum-levels-of-immunoglobulins-and-severity-of-community-acquired-pneumonia
#15
Mari C de la Torre, Pere Torán, Mateu Serra-Prat, Elisabet Palomera, Estel Güell, Ester Vendrell, Joan Carles Yébenes, Antoni Torres, Jordi Almirall
INSTRUCTION: There is evidence of a relationship between severity of infection and inflammatory response of the immune system. The objective is to assess serum levels of immunoglobulins and to establish its relationship with severity of community-acquired pneumonia (CAP) and clinical outcome. METHODS: This was an observational and cross-sectional study in which 3 groups of patients diagnosed with CAP were compared: patients treated in the outpatient setting (n=54), patients requiring in-patient care (hospital ward) (n=173), and patients requiring admission to the intensive care unit (ICU) (n=191)...
2016: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/27893674/relapsing-remitting-lesions-in-a-woman-with-progressive-hemifacial-atrophy-and-chronic-hepatitis-b-virus-infection-a-case-report
#16
Ying Zhang, Mingqin Zhu, Xiaozhen Li, Jing Miao, Chenchen Duan, Li Cui, Xuefan Yu
INTRODUCTION: Progressive hemifacial atrophy (PHA) is a rare disorder characterized by unilateral facial atrophy affecting the skin, subcutaneous tissue, and fat, muscle, and osteocartilagenous structures creating a sunken hemiface appearance.Etiopathogenesis of PHA is poorly understood; no definitive treatment is currently available. CLINICAL FINDINGS: We report a 41-year-old woman with PHA who showed an uncharacteristic "relapsing-remitting" evolution of brain lesions and was seropositive for hepatitis B virus (HBV)...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27891673/igg4-related-disease-experience-of-100-consecutive-cases-from-a-specialist-centre
#17
Adrian C Bateman, Emma L Culver
AIMS: To describe the features of 100 consecutive cases referred to a single UK institution, in which a diagnosis of IgG4-related disease (IgG4-RD) was under consideration. METHODS AND RESULTS: The histological features were reviewed by a single histopathologist and cases categorised using the 2012 Boston criteria: Category 1 - histologically highly suggestive of IgG4-RD; 2 - probable histopathological features of IgG4-RD; 3 - insufficient histopathological features of IgG4-RD...
November 28, 2016: Histopathology
https://www.readbyqxmd.com/read/27866757/differential-diagnosis-of-igg4-related-sialadenitis-primary-sj%C3%A3-gren-syndrome-and-chronic-obstructive-submandibular-sialadenitis
#18
X Hong, W Li, X-Y Xie, Z-Y Zhang, Y Chen, Y Gao, X Peng, J-Z Su, Y-Y Zhang, Z Wang, Z-G Cai, L Zhang, Y-Y Liu, J He, L-M Ren, Z-G Li, G-Y Yu
Our aim was to differentiate IgG4-related sialadenitis, primary Sjögren syndrome, and chronic obstructive submandibular sialadenitis by analysing clinical, radiographic, and pathological features. Fifty-five patients, 50, and 50 were enrolled, respectively and their baseline characteristics and serological, sialographic, and pathological findings compared. The male:female ratio for IgG4-related sialadenitis was 1:1.2 for primary Sjögren syndrome 1:15.7, and for chronic obstructive submandibular sialadenitis1:0...
November 17, 2016: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/27852547/prevalence-of-igg-4-associated-cholangiopathy-based-on-serum-igg-4-levels-in-patients-with-primary-sclerosing-cholangitis-and-its-relationship-with-inflammatory-bowel-disease
#19
Seyed Alireza Taghavi, Shaghayegh Kaedi Majd, Mahnoosh Sianati, Masood Sepehrimanesh
BACKGROUND/AIMS: Autoimmune cholangiopathy is part of a fibro-inflammatory immunoglobulin G-4 (IgG-4)-related systemic disease that causes biliary tract strictures. Its clinical presentation is quite similar to that of more common diseases such as primary sclerosing cholangitis (PSC) and pancreatobilliary malignancies. The aims of the present study were to evaluate the prevalence of IgG-4-associated cholangiopathy (IAC) in patients diagnosed with PSC and its relationship with inflammatory bowel disease (IBD)...
November 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/27851820/impact-of-helicobacter-pylori-immunoglobulin-g-levels-and-atrophic-gastritis-status-on-risk-of-metabolic-syndrome
#20
Atsushi Takeoka, Jun Tayama, Hironori Yamasaki, Masakazu Kobayashi, Sayaka Ogawa, Tatsuo Saigo, Masaki Hayashida, Susumu Shirabe
BACKGROUND: Helicobacter pylori (HP) infection is implicated in gastric and extra-gastric diseases. While gastritis-related chronic inflammation represents a known trigger of metabolic disturbances, whether metabolic syndrome (MetS) is affected by gastritis status remains unclear. We aimed to clarify the effect of HP-related gastritis on the risk of MetS. MATERIALS AND METHODS: We retrospectively enrolled patients undergoing screening for MetS between 2014 and 2015...
2016: PloS One
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