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https://www.readbyqxmd.com/read/27729962/the-effects-of-oral-ibuprofen-on-medicinal-closure-of-patent-ductus-arteriosus-in-full-term-neonates-in-the-second-postnatal-week
#1
Mohammad Reza Alipour, Mansooreh Mozaffari Shamsi, Seyedeh Mahdieh Namayandeh, Zohreh Pezeshkpour, Fatemeh Rezaeipour, Mohammadtaghi Sarebanhassanabadi
BACKGROUND: The arterial ductus is a major communicative pathway which is naturally patent in the fetus, connecting the body of the major pulmonary artery to the descending aorta. Although usually closing on its own, the patent ductus arteriosus (PDA) may remain open in the second postnatal week due to a lack of prompt diagnosis in the initial days of life or an absence of prompt treatment. OBJECTIVES: To prevent the untoward sequelae of patency of the ductus arteriosus, and to avoid invasive surgery at higher ages, the researchers in the present study embarked on determining the effects of oral ibuprofen during the second postnatal week on newborns with patent ductus arteriosus...
August 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/27647342/patent-ductus-arteriosus-banding-for-circular-shunting-after-pulmonary-valvuloplasty
#2
Carles Bautista-Rodriguez, Javier Rodriguez-Fanjul, Julio Moreno Hernando, Javier Mayol, Jose Maria Caffarena-Calvar
We report two cases of newborns with critical pulmonary stenosis having intact ventricular septum, who underwent pulmonary valve balloon valvuloplasty followed by banding of a patent ductus arteriosus. Transcatheter pulmonary valvuloplasty was performed one week after delivery. Following the procedure, both developed "circular shunting" as a consequence of left-to-right ductal flow and pulmonary regurgitation. This in turn caused increased blood flow into a dysfunctional right ventricle and low systemic cardiac output syndrome...
September 19, 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27624140/major-determinants-of-survival-and-length-of-stay-in-the-neonatal-intensive-care-unit-of-newborns-from-women-with-premature-preterm-rupture-of-membranes
#3
Meryem Kurek Eken, Abdülhamit Tüten, Enis Özkaya, Güner Karatekin, Ateş Karateke
OBJECTIVE: To assess the predictors of outcome in terms of length of stay in the neonatal intensive care unit (NICU) and survival of neonates from women with preterm premature rupture of membranes (PPROM). METHODS: A population-based retrospective study including three hundred thirty-one singleton pregnant women with PPROM at 24-34 gestational weeks between January 2013 and December 2015 was conducted. Gestational age at delivery, birth weight, route of delivery, newborn gender, maternal age,oligohydramnios, premature retinopathy (ROP), necrotising enterocolitis (NEC), sepsis, fetal growth retardation (FGR), intracranial hemorrhagia (ICH), bronchopulmonary dysplasia (BPD), respiratory distress syndrome (RDS), primary pulmonary hypertension (PPH), congenital cardiac disease (CCD), patent ductus arteriosus (PDA), use of cortisol (betamethasone) and maternal complications including gestational diabetes, preeclampsia, and chorioamnionitis were used to predict neonatal outcomes in terms of length of stay in the NICU and survival...
September 14, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27595870/iatrogenic-skin-disorders-and-related-factors-in-newborn-infants
#4
Zsanett Renáta Csoma, Angéla Meszes, Rita Ábrahám, Lajos Kemény, Gyula Tálosi, Péter Doró
BACKGROUND/OBJECTIVES: Recent technological advances and diagnostic and therapeutic innovations have resulted in an impressive improvement in the survival of newborn infants requiring intensive care. Consequently, with the use of modern invasive diagnostic and therapeutic procedures, the incidence of iatrogenic events has also increased. The aim of this study was to assess various iatrogenic complications in neonates requiring intensive care and determine possible contributing factors to the injuries...
September 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27456581/congenital-acute-megakaryoblastic-leukaemia-in-down-s-syndrome
#5
E Lobato-Mendizabal, A Marín-Lopez, G López-de-la-Cruz, M Presno-Bernal, G J Ruiz-Argüelles
The case of a newborn with Down's syndrome and congenital leukaemia is reported. The malignant white blood cells displayed the CD41 antigen (glycoprotein Ilb/IIIa) identified by monoclonal antibodies HP1-ld and FMC24 and the CD9/p24 antigen identified by monoclonal antibody FMC27. The number of cells in S-phase was 14%, as assessed by the incorporation of 5-bromo 2-deoxyuridine. No other chromosomal abnormalities were identified in addition to 47 XY + 21. The patient died 15 days after the diagnosis, due to Pneumocystis Carinii pneumonia...
1990: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27446597/usefulness-of-ultrasound-examination-in-the-evaluation-of-a-neonate-s-body-fluid-status
#6
Joanna Kieliszczyk, Wojciech Baranowski, Wojciech Kosiak
UNLABELLED: Appropriate hydration is a very important prognostic factor for the patient's health. Ultrasonographic assessment of hydration status is rarely used in pediatric medicine and it is not used at all in neonates due to the fact that no reference values have been established for this age group. The aim of the paper was to establish reference values for neonates. MATERIAL AND METHODS: The study included 50 neonates from two hospitals in the Lower Silesia region of Poland; 25 of them were healthy patients (full-term newborns with no perinatal complications) and 25 were sick patients (newborns with heart defects such as ostium secundum atrial septal defect, ventricular septal defect, permanent foramen ovale and patent ductus arteriosus as well as newborns with neonatal jaundice or pneumonia that occurred during the first days of life)...
June 2016: Journal of Ultrasonography
https://www.readbyqxmd.com/read/27409588/incidence-of-congenital-heart-disease-the-9-year-experience-of-the-guangdong-registry-of-congenital-heart-disease-china
#7
Yanji Qu, Xiaoqing Liu, Jian Zhuang, Guanchun Chen, Jinzhuang Mai, Xiaoling Guo, Yanqiu Ou, Jimei Chen, Wei Gong, Xiangmin Gao, Yong Wu, Zhiqiang Nie
There are 16.5 million newborns in China annually. However, the incidence of congenital heart disease (CHD) has not been evaluated. In 2004, we launched an active province-wide hospital-based CHD registry in the Guangdong Province of southern China. In this study, we examined the incidence of CHD and its subtypes from 2004 to 2012 and compared our findings to the literature. Our results indicate there is an increasing trend of CHD incidence. The increase in incidence occurred mainly for single lesion and the most common subtypes (e...
2016: PloS One
https://www.readbyqxmd.com/read/27405904/morbidity-and-mortality-of-preterm-infants-less-than-26-weeks-of-gestational-age
#8
Maria I Durães, Filipa Flor-DE-Lima, Gustavo Rocha, Henrique Soares, Hercília Guimarães
BACKGROUND: Extreme preterm infants have a high risk of morbidity and mortality. Newborns delivered between 23+0 and 25+6 weeks, are considered to be in the "gray zone" and have uncertain prognosis. For these children medical decision-making becomes complex and controversial. The present study intends to evaluate the neonatal morbidity and mortality of preterm infants born between 23 weeks and 25+6 weeks of gestational age. METHODS: A retrospective study was conducted including all inborn preterm infants, with a gestational age between 23+0 and 25+6 weeks, admitted to a level IIIC NICU, between 1st January, 1996 and 31th December, 2014...
July 13, 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/27403365/ibuprofen-for-ductus-arteriosus-months-after-birth
#9
Odile Frauenfelder, Ingrid M van Beynum, Irwin K M Reiss, Sinno H P Simons
Ibuprofen is a well-known agent used to treat patent ductus arteriosus in preterm neonates in the first days of life. In the current case report we illustrate the potential use of ibuprofen in two preterm neonates 60 and 88 days after birth, respectively. To our knowledge, this is the first report on the effects of ibuprofen on patent ductus arteriosus in preterm newborns after months of life. These cases suggest that the ductus arteriosus does not become refractory for ibuprofen after the first days of life...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27403229/oxidative-stress-related-diseases-in-newborns
#10
REVIEW
Yasemin Ozsurekci, Kubra Aykac
We review oxidative stress-related newborn disease and the mechanism of oxidative damage. In addition, we outline diagnostic and therapeutic strategies and future directions. Many reports have defined oxidative stress as an imbalance between an enhanced reactive oxygen/nitrogen species and the lack of protective ability of antioxidants. From that point of view, free radical-induced damage caused by oxidative stress seems to be a probable contributing factor to the pathogenesis of many newborn diseases, such as respiratory distress syndrome, bronchopulmonary dysplasia, periventricular leukomalacia, necrotizing enterocolitis, patent ductus arteriosus, and retinopathy of prematurity...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27365794/stent-implantation-of-patent-ductus-arteriosus-in-a-newborn-baby
#11
Prabhat Kumar, R Datta, R Nair, G Sridhar
No abstract text is available yet for this article.
April 2011: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/27356085/microarray-gene-expression-analysis-in-ovine-ductus-arteriosus-during-fetal-development-and-birth-transition
#12
Ravi Goyal, Dipali Goyal, Lawrence D Longo, Ronald I Clyman
BACKGROUND: Patent ductus arteriosus (PDA) in the newborn is the most common congenital heart anomaly and is significantly more common in preterm infants. Contemporary pharmacological treatment is effective in only 70-80% of the cases. Moreover, indomethacin or ibuprofen, which are used to close a PDA may be accompanied by serious side effects in premature infants. To explore the novel molecular pathways, which may be involved in the maturation and closure of the ductus arteriosus (DA), we used fetal and neonatal sheep to test the hypothesis that maturational development of DA is associated with significant alterations in specific mRNA expression...
October 2016: Pediatric Research
https://www.readbyqxmd.com/read/27319277/does-ibuprofen-treatment-in-patent-ductus-arteriosus-alter-oxygen-free-radicals-in-premature-infants
#13
Melek Akar, Tulin G Yildirim, Gonca Sandal, Senol Bozdag, Omer Erdeve, Nahide Altug, Nurdan Uras, Serife S Oguz, Ugur Dilmen
: Introduction Ibuprofen is used widely to close patent ductus arteriosus in preterm infants. The anti-inflammatory activity of ibuprofen may also be partly due to its ability to scavenge reactive oxygen species and reactive nitrogen species. We evaluated the interaction between oxidative status and the medical treatment of patent ductus arteriosus with two forms of ibuprofen. Materials and methods This study enrolled newborns of gestational age ⩽32 weeks, birth weight ⩽1500 g, and postnatal age 48-96 hours, who received either intravenous or oral ibuprofen to treat patent ductus arteriosus...
June 20, 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/27197949/principles-of-clinical-management-of-patent-ductus-arteriosus-in-extremely-preterm-neonates
#14
Zhen Han Tan, Vijay R Baral
The clinical management of a patent ductus arteriosus (PDA) in preterm newborns is a controversial topic, and despite nearly three decades of research, varying opinions remain. This dilemma stems from uncertain causal linkage between PDA and neonatal comorbidities, as well as the lack of clear evidence showing that benefits of treatment outweigh risks. There has been a general shift in the management of PDA in preterm newborns from early and aggressive closure to a more conservative approach of watchful waiting and spontaneous closure...
2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27148674/heparin-for-the-prevention-of-intraventricular-haemorrhage-in-preterm-infants
#15
REVIEW
Matteo Bruschettini, Olga Romantsik, Simona Zappettini, Rita Banzi, Luca Antonio Ramenghi, Maria Grazia Calevo
BACKGROUND: Preterm birth remains the major risk factor for the development of intraventricular haemorrhage, an injury that occurs in 25% of very low birth weight infants. Intraventricular haemorrhage is thought to be venous in origin and intrinsic thromboses in the germinal matrix are likely to play a triggering role. Heparin activates antithrombin and promotes the inactivation of thrombin and other target proteinases. The administration of anticoagulants such as heparin may offset the increased risk of developing intraventricular haemorrhage and may also reduce the risk of developing parenchymal venous infarct, a condition known to complicate intraventricular haemorrhage...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27122701/long-term-outcomes-of-native-coarctation-of-the-aorta-after-balloon-angioplasty-or-surgical-aortoplasty-in-newborns-and-young-infants-less-than-3-months-of-age
#16
Hsin-Hui Chiu, Jou-Kou Wang, Yih-Shang Chen, Ing-Sh Chiu, Chung-I Chang, Ming-Tai Lin, Chun-Wei Lu, Shuenn-Nan Chiu, Chun-An Chen, Mei-Hwan Wu
BACKGROUND: Balloon angioplasty of native coarctation of the aorta, though effective, is frequently associated with early restenosis, repeated interventions and aneurysm formation, especially in very young patients. However, available long-term data are limited. METHODS: From Jan. 1986 to Dec. 2007, eighty-eight patients with simple aortic coarctation, isolated or associated with patent ductus arteriosus or ventricular septal defect, and survived angioplasty (n = 17) or surgery (n = 71) within 3 months of age in National Taiwan University Hospital were enrolled...
March 2013: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27112943/myocardial-performance-index-tei-index-in-term-and-preterm-neonates-during-the-neonatal-period
#17
Renata Bokiniec, Paweł Własienko, Maria Katarzyna Borszewska-Kornacka, Dariusz Madajczak, Joanna Szymkiewicz-Dangel
BACKGROUND: The myocardial performance index (MPI) is a noninvasive method to measure global systolic and diastolic myocardial function. In both term and premature neonates, changes in the systolic and diastolic function of the left ventricle (LV) and right ventricle (RV) reflect the degree of neonatal myocardial immaturity and the co-existence of foetal circulation. AIM: To assess MPI (or Tei indices) of both ventricles in term and preterm newborns, and to observe MPI trends throughout the neonatal period...
2016: Kardiologia Polska
https://www.readbyqxmd.com/read/26955892/the-association-of-platelets-with-failed-patent-ductus-arteriosus-closure-after-a-primary-course-of-indomethacin-or-ibuprofen-a-systematic-review-and-meta-analysis
#18
Souvik Mitra, Anthony K Chan, Bosco A Paes
OBJECTIVE: To conduct a meta-analysis of the association of platelet counts and pharmacotherapeutic failure in preterms with a patent ductus arteriosus (PDA). METHODS: MEDLINE, Embase, Science Citation Index, abstracts and conference proceedings were searched, and principal authors contacted. Included studies reported indomethacin or ibuprofen use for PDA closure, compared a group which failed treatment versus a group which did not and reported the association between platelet counts and indomethacin or ibuprofen failure...
April 14, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26955624/analysis-and-comparison-of-the-effects-of-n-bipap-and-bubble-cpap-in-treatment-of-preterm-newborns-with-the-weight-of-below-1500-grams-affiliated-with-respiratory-distress-syndrome-a-randomised-clinical-trial
#19
Alireza Sadeghnia, Behzad Barekateyn, Zohre Badiei, Seyyed Mohsen Hosseini
BACKGROUND: Nowadays, establishment of nCPAP and surfactant administration is considered to be the first level of intervention for newborns engaged in the process of Respiratory Distress Syndrome (RDS). In order to decrease the side effects of the nCPAP management placed in noninvasive-non-cycled respiratory support. Noninvasive-cycled respiratory support mechanism have been developed such as N-BiPAP. Therefore, we compared N-BiPAP with Bubble-CPAP in a clinical trial. MATERIALS AND METHODS: This research was done as an on newborns weighing less than 1500 grams affiliated with RDS...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/26946966/comparison-of-two-dose-regimens-of-ibuprofen-for-the-closure-of-patent-ductus-arteriosus-in-preterm-newborns
#20
Laura Vargas Dornelles, Andréa Lúcia Corso, Rita de Cássia Silveira, Renato Soibelmann Procianoy
OBJECTIVE: To compare the efficacy of intravenous ibuprofen at high (20-10-10mg/kg/dose) and low doses (10-5-5mg/kg/dose) the closure of patent ductus arteriosus in preterm newborns. METHODS: A cohort study with historical control of newborns that received high- and low-dose intravenous ibuprofen, from 2010 to 2013 in a neonatal intensive care unit, for closure of the patent ductus arteriosus, documented by echocardiography. Secondary outcomes included the number of ibuprofen cycles, incidence of bronchopulmonary dysplasia, necrotizing enterocolitis, changes in renal function, and death...
May 2016: Jornal de Pediatria
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