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https://www.readbyqxmd.com/read/27911604/neutrophil-elastase-activity-is-associated-with-exacerbations-and-lung-function-decline-in-bronchiectasis
#1
James D Chalmers, Kelly L Moffitt, Guillermo Suarez-Cuartin, Oriol Sibila, Simon Finch, Elizabeth Furrie, Alison Dicker, Karolina Wrobel, J Stuart Elborn, Brian Walker, S Lorraine Martin, Sara E Marshall, Jeffrey T-J Huang, Thomas C Fardon
RATIONALE: Sputum neutrophil elastase and serum desmosine, a linked marker of endogenous elastin degradation, are possible biomarkers of disease severity and progression in bronchiectasis. This study aimed to determine the association of elastase activity and desmosine with exacerbations and lung function decline in bronchiectasis. METHODS: This was a single-centre prospective cohort study using the TAYBRIDGE registry in Dundee, UK. 433 patients with HRCT-confirmed bronchiectasis provided blood samples for desmosine measurement and 381 provided sputum for baseline elastase activity measurements using an activity based immunosassay and fluorometric substrate assay...
December 2, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27908307/evolution-of-imaging-findings-laboratory-and-functional-parameters-in-rheumatoid-arthritis-patients-after-one-year-of-treatment-with-anti-tnf-%C3%AE-agents
#2
Efstathios E Detorakis, Eleftherios Magkanas, Ismini Lasithiotaki, Prodromos Sidiropoulos, Dimitrios T Boumpas, Nicholas Gourtsoyiannis, Katerina Antoniou, Maria Raissaki
OBJECTIVES: To investigate the efficacy and safety of anti-TNF-α agent treatment compared to non-biologic DMARDs in rheumatoid arthritis patients. METHODS: 82 consecutive patients, 29 males, 53 females, aged 42-79, diagnosed with RA and suitable for anti-TNF-α treatment composed two study groups: 42 with pre-existing rheumatoid arthritis-related interstitial lung disease (RA-ILD) and 40 without RA-ILD. Respective control groups consisted of 44 patients with pre-existing RA-ILD and 44 patients without RA-ILD, treated with non-biologic DMARDs...
October 27, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27886856/a-retrospective-cohort-study-of-outcome-in-systemic-sclerosis-associated-interstitial-lung-disease
#3
Masaki Okamoto, Kiminori Fujimoto, Junko Sadohara, Kiyomi Furuya, Shinjiro Kaieda, Tomoya Miyamura, Eiichi Suematsu, Yasuhiko Kitasato, Tomotaka Kawayama, Hiroaki Ida, Masao Ichiki, Tomoaki Hoshino
BACKGROUND: The relationship between the histological pattern and survival in systemic sclerosis-associated interstitial lung disease (SSc-ILD) is unclear. In patients with SSc-ILD, we investigated whether the clinical data obtained by non-invasive examinations could be used for prognostic evaluation, and attempted to clarify whether complicating acute exacerbation (AE) and the selection of pharmacological therapy were associated with survival. METHODS: Thirty-five patients with SSc-ILD, who had not been diagnosed by surgical lung biopsy were analyzed, retrospectively...
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27880957/integrated-use-of-lung-ultrasound-and-chest-x-ray-in-the-detection-of-interstitial-lung-disease
#4
Luca Vizioli, Federica Ciccarese, Paola Forti, Anna Maria Chiesa, Marco Giovagnoli, Martina Mughetti, Maurizio Zompatori, Marco Zoli
BACKGROUND: Current data have shown that lung ultrasound (LUS) may be useful in the detection of interstitial lung disease (ILD) by the evaluation of B-lines, the sonographic marker of pulmonary interstitial syndrome. Nevertheless, no prospective study has compared LUS to chest X-ray (CXR) for ILD assessment, and there is no general agreement on the specific echographic diagnostic criteria for defining ILD. OBJECTIVES: The aims of this study were (1) to compare the accuracy of LUS and CXR in the detection of ILD using high-resolution CT (HRCT) as the gold standard and (2) to compare the accuracy of different echographic diagnostic criteria for ILD diagnosis...
November 24, 2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27842667/fdg-pet-ct-in-the-prediction-of-pulmonary-function-improvement-in-nonspecific-interstitial-pneumonia-a-pilot-study
#5
V Jacquelin, A Mekinian, P Y Brillet, H Nunes, O Fain, D Valeyre, M Soussan
PURPOSE: Our study aimed to analyse the characteristics of nonspecific interstitial pneumonia (NSIP) using FDG-PET/CT (PET) and to evaluate its ability to predict the therapeutic response. PROCEDURES: Eighteen NSIP patients were included. Maximum standardized uptake value (SUVmax), FDG uptake extent (in percentage of lung volume), high resolution CT scan (HRCT) elementary lesions, and HRCT fibrosis score were recorded. The predictive value of the parameters for lung function improvement was evaluated using logistic regression and Receiver Operating Characteristic (ROC) curve analysis (n=13/18)...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27809901/combined-pulmonary-fibrosis-and-emphysema-a-retrospective-analysis-of-clinical-characteristics-treatment-and-prognosis
#6
Lijuan Zhang, Chunling Zhang, Fushi Dong, Qi Song, Fangzhou Chi, Lu Liu, Yupeng Wang, Chunli Che
BACKGROUND: Combined pulmonary fibrosis and emphysema (CPFE) is increasingly acknowledged as a separate syndrome with distinct clinical, physiological and radiological characteristics. We sought to identify physiologic and radiographic indices that predict mortality in CPFE. METHODS: Data on clinical characteristics, pulmonary function, high-resolution computed tomography (HRCT) and treatment were compared between patients with usual interstitial pneumonia (UIP) plus emphysema (CPFE group) and those with IPF alone (IPF group)...
November 3, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27759640/combined-inhaled-corticosteroid-and-long-acting-%C3%AE-2-adrenergic-agonist-therapy-for-noncystic-fibrosis-bronchiectasis-with-airflow-limitation-an-observational-study
#7
Ping Wei, Jia-Wei Yang, Hai-Wen Lu, Bei Mao, Wen-Lan Yang, Jin-Fu Xu
BACKGROUND AND OBJECTIVE: There is presently no clear evidence on the effect of combined treatment for non-cystic fibrosis (non-CF) bronchiectasis with inhaled corticosteroid (ICS) and long-acting β2-adrenergic agonist (LABA). The objective of this study is to assess the efficacy and safety of salmeterol-fluticasone combined inhaled therapy for non-CF bronchiectasis with airflow limitation. METHODS: An observational study was performed in 120 non-CF bronchiectasis patients diagnosed by high-resolution computed tomography (HRCT) scanning of the chest...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27758987/prognostic-significance-of-surfactant-protein-a-surfactant-protein-d-clara-cell-protein-16-s100-protein-trefoil-factor-3-and-prostatic-secretory-protein-94-in-idiopathic-pulmonary-fibrosis-sarcoidosis-and-chronic-pulmonary-obstructive-disease
#8
Martina Doubková, Michal Karpíšek, Jiri Mazoch, Jana Skřičková, Michael Doubek
BACKGROUND: Identification of serum and bronchoalveolar lavage fluid (BALF) biomarkers may facilitate diagnosis and prognostication in various lung disorders. OBJECTIVE: Serum and BALF levels of surfactant protein A (SP-A), surfactant protein D (SP-D), Clara cell protein 16 (CC16), S100 protein, trefoil factor 3 (TFF3), and prostatic secretory protein 94 (PSP94) were evaluated in 94 consecutive patients (idiopathic pulmonary fibrosis (IPF; n=18), sarcoidosis (n=25), chronic obstructive pulmonary disease (COPD; n=51)), and in 155 healthy controls...
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27709074/correlation-of-delta-high-resolution-computed-tomography-hrct-score-with-delta-clinical-variables-in-early-systemic-sclerosis-ssc-patients
#9
Suparaporn Wangkaew, Juntima Euathrongchit, Pittaporn Wattanawittawas, Nuntana Kasitanon
BACKGROUND: The correlation of changes (delta: Δ) of high-resolution computed tomography (HRCT) score with the Δ of other clinical variables has not been well studied. The purpose of this study was to determine the correlation of Δ HRCT score with Δ percent predicted forced vital capacity (%pFVC), Δ modified Rodnan Skin Score (mRSS), Δ erythrocyte sedimentation rate (ESR), and Δ percent of oxygen saturation at room air (%SpO2) in patients with early systemic sclerosis (SSc). METHODS: We used an inception cohort of early-SSc patients seen at the Rheumatology Clinic, Chiang Mai University, Thailand, between January 2010 and June 2014...
August 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/27692155/clinical-characteristics-in-patients-with-asymmetric-idiopathic-pulmonary-fibrosis
#10
Sean J Callahan, Meng Xia, Susan Murray, Kevin R Flaherty
BACKGROUND: A group of patients with idiopathic pulmonary fibrosis (IPF) presents with disease affecting one lung markedly more than the other. At this time, it is unclear how this population differs from those who present with more symmetric disease. We sought to explain the characteristics of the asymmetric group and how their disease progresses. METHODS: In this retrospective case-control study we accessed an interstitial lung disease (ILD) database and identified 14 asymmetric IPF cases via high-resolution computed tomography (HRCT) scoring of each lung lobe's disease severity...
October 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27692130/factors-associated-with-pulmonary-hypertension-and-long-term-survival-in-bronchiectasis-subjects
#11
Serpil Öcal, Oytun Portakal, Arslan Öcal, Ahmet Uğur Demir, Arzu Topeli, Lütfi Çöplü
BACKGROUND: The development of pulmonary hypertension (PH) and its effect on long-term survival in bronchiectasis subjects has not been explored. The present study aims to analyze the factors associated with PH and its effect on long-term survival in bronchiectasis subjects. METHODS: We prospectively evaluated 23 bronchiectasis subjects without PH and 16 with PH, as well as 20 healthy volunteers. RESULTS: Bronchiectasis subjects with PH were more hypoxemic and had a greater number of involved lobes in high resolution computed tomography (HRCT) than did the bronchiectasis subjects without PH (P < 0...
October 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27635117/a-new-scale-to-assess-the-severity-and-prognosis-of-pulmonary-alveolar-proteinosis
#12
JiuWu Bai, JinFu Xu, WenLan Yang, Beilan Gao, Weijun Cao, Shuo Liang, Huiping Li
Background. Pulmonary Alveolar Proteinosis (PAP) is a syndrome characterized by pulmonary surfactant accumulation. Small proportion of PAP patients experienced spontaneous remission. Objective. The aim of this study was to assess the severity and prognosis of PAP using various indexes. Methods. Characteristics, PaO2, lung function parameters, and HRCT score of 101 patients with PAP were retrospectively analyzed. Many indexes were explored and integrated into a scale. Results. PaO2 was lower among smokers than among never-smokers...
2016: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/27607895/rituximab-therapy-in-primary-sj%C3%A3-gren-s-syndrome-with-interstitial-lung-disease-a-retrospective-cohort-study
#13
Ming-Han Chen, Chun-Ku Chen, Hsiao-Ping Chou, Ming-Huang Chen, Chang-Youh Tsai, Deh-Ming Chang
OBJECTIVES: Interstitial lung disease (ILD) is one of the major systemic manifestations of primary Sjögren's syndrome (pSS). The aim of this study was to evaluate the therapeutic effect of rituximab on pSS patients with ILD. METHODS: Pulmonary function test results, including diffusing capacity for carbon monoxide (DLCO) and DLCO/alveolar volume (Va) ratio, and high-resolution computed tomography (HRCT) findings/scores in ten pSS patients with ILD treated with rituximab were retrospectively investigated...
August 31, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27551950/bronchiectasis-in-yellow-nail-syndrome
#14
Georgia Woodfield, Mitzi Nisbet, Joe Jacob, Wing Mok, Michael R Loebinger, David M Hansell, Athol U Wells, Robert Wilson
BACKGROUND AND OBJECTIVE: Yellow nail syndrome (YNS) is a rare and poorly described disease process. In this case-control study, clinical features and findings on HRCT were compared with idiopathic bronchiectasis (IBx). METHODS: A review of all patients attending an adult bronchiectasis clinic between 2007 and 2013 identified 25 YNS patients. IBx patients were matched in a 2:1 ratio for age, duration of symptoms and gender. RESULTS: Median age of onset was 53 years...
August 23, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27537713/high-resolution-ct-predictors-of-hypersensitivity-pneumonitis
#15
Gilles Rival, Philippe Manzoni, Yves Lacasse, Jean Charles Polio, Virginie Westeel, André Dubiez, Thibaud Soumagne, François Laurent, Jean Charles Dalphin
BACKGROUND: The purpose of this study was to evaluate the use of high-resolution chest computed tomography (HRCT) to distinguish hypersensitivity pneumonitis (HP) from other diffuse parenchymal lung diseases (DPLDs). METHODS: We examined 130 consecutive patients admitted to our hospital with DPLDs proved by HRCT. Patients underwent clinical and paraclinical examinations. Two readers interpreted 111 HRCT scans using predefined criteria. RESULTS: The findings in patients with HP were compared to those with other DPLDs (non-HP) by univariate and multivariate analyses...
2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27484107/impulse-oscillometry-and-spirometry-small-airway-parameters-in-mild-to-moderate-bronchiectasis
#16
Wei-Jie Guan, Jing-Jing Yuan, Yong-Hua Gao, Hui-Min Li, Jin-Ping Zheng, Rong-Chang Chen, Nan-Shan Zhong
BACKGROUND: Both impulse oscillometry and spirometry can reflect small-airway disorders. The objective of this work was to investigate the diagnostic value of impulse oscillometry and spirometry small-airway parameters and their correlation with radiology, disease severity, and sputum bacteriology in mild to moderate bronchiectasis (bronchiectasis severity index <9) and to validate these findings in sensitivity analyses (mild bronchiectasis). METHODS: We recruited 94 subjects with mild to moderate bronchiectasis and 26 healthy subjects...
August 2, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27481079/the-relation-between-the-extent-of-radiological-findings-and-respiratory-functions-in-pneumoconiosis-cases-of-dental-technicians-who-are-working-in-ankara
#17
Dilek Ergün, Recai Ergün, Ender Evcik, Türkan Nadir Öziş, İbrahim Akkurt
INTRODUCTION: In dental technicians, parenchymal changes caused by dust affect pulmonary functions. The evaluation of the relation between radiological scores (chest X-Ray/HRCT) indicating the extent of pulmonary involvement and the severity of functional findings in dental technicians. MATERIALS AND METHODS: 440 dental technicians were evaluated with chest X-Ray, pulmonary function tests (PFTs) and high resolution computed tomography (HRCT). The degree of pulmonary involvement in radiological images was categorized based upon emphysema, the profusion of opacities, ground-glass opacity, honey combing and extent of pleural abnormalities...
December 0: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/27296814/non-cf-bronchiectasis-aetiologic-approach-clinical-radiological-microbiological-and-functional-profile-in-277-patients
#18
Katerina Dimakou, Christina Triantafillidou, Michail Toumbis, Kyriaki Tsikritsaki, Katerina Malagari, Petros Bakakos
BACKGROUND AND OBJECTIVES: Non-Cystic Fibrosis (CF) bronchiectasis is common in Greece but little attention has been paid to the investigation of its aetiology, clinical, radiological, microbiological and lung function profile. METHODS: We prospectively evaluated patients with non-CF bronchiectasis confirmed by high resolution computed tomography (HRCT) of the chest. Aetiology, clinical data, radiology score, microbiological profile and lung function were investigated...
July 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27288033/a-longitudinal-study-characterising-a-large-adult-primary-ciliary-dyskinesia-population
#19
Anand Shah, Amelia Shoemark, Stephanie J MacNeill, Basrull Bhaludin, Andrew Rogers, Diana Bilton, David M Hansell, Robert Wilson, Michael R Loebinger
Primary ciliary dyskinesia (PCD) in adults has not been well described. In this retrospective observational study we aimed to characterise a large adult population and identify features associated with disease progression.We retrospectively analysed 151 adult patients at a single tertiary centre at baseline and longitudinally for a median of 7 years.We found significant variation in age at diagnosis (median 23.5 years; range <1-72 years). Older age at diagnosis was associated with impaired baseline forced expiratory volume in 1 s (FEV1) (r= -0...
August 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27276747/mediastinal-lymphadenopathy-in-patients-with-systemic-sclerosis
#20
Panaya Tumsatan, Jitraporn Wongwiwatchai, Chalida Apinives, Vallop Laopaiboon
BACKGROUND: There are few studies regarding the characteristics of mediastinal lymphadenopathy (MN) in patients with systemic sclerosis (SSc). Understanding its features could help radiologists interpret lung imaging more confidently. OBJECTIVE: To determine the prevalence and characteristics of MLN in patients with SSc and factors associated with MLN. MATERIAL AND METHOD: A retrospective review of medical records and high resolution computed tomography (HRCT) of the lungs of all patients with SSc at Srinagarind Hospital, Khon Kaen University, Thailand between 2009 and 2011 was done...
March 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
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