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https://www.readbyqxmd.com/read/28227990/using-computational-phantoms-to-improve-delivery-of-tumor-treating-fields-ttfields-to-patients
#1
Ze'ev Bomzon, Hadas Sara Hershkovich, Noa Urman, Aafia Chaudhry, Dario Garcia-Carracedo, Anders R Korshoej, Uri Weinberg, Cornelia Wenger, Pedro Miranda, Yoram Wasserman, Eilon D Kirson, Yoram, Ze'ev Bomzon, Hadas Sara Hershkovich, Noa Urman, Aafia Chaudhry, Dario Garcia-Carracedo, Anders R Korshoej, Uri Weinberg, Cornelia Wenger, Pedro Miranda, Yoram Wasserman, Eilon D Kirson, Yoram, Uri Weinberg, Cornelia Wenger, Noa Urman, Hadas Sara Hershkovich, Yoram Wasserman, Anders R Korshoej, Eilon D Kirson, Dario Garcia-Carracedo, Pedro Miranda, Aafia Chaudhry, Zeev Bomzon, Yoram
This paper reviews the state-of-the-art in simulation-based studies of Tumor Treating Fields (TTFields) and highlights major aspects of TTFields in which simulation-based studies could affect clinical outcomes. A major challenge is how to simulate multiple scenarios rapidly for TTFields delivery. Overcoming this challenge will enable a better understanding of how TTFields distribution is correlated with disease progression, leading to better transducer array designs and field optimization procedures, ultimately improving patient outcomes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227979/dispersion-entropy-for-the-analysis-of-resting-state-meg-regularity-in-alzheimer-s-disease
#2
Hamed Azami, Mostafa Rostaghi, Alberto Fernandez, Javier Escudero, Hamed Azami, Mostafa Rostaghi, Alberto Fernandez, Javier Escudero, Alberto Fernandez, Javier Escudero, Mostafa Rostaghi, Hamed Azami
Alzheimer's disease (AD) is a progressive degenerative brain disorder affecting memory, thinking, behaviour and emotion. It is the most common form of dementia and a big social problem in western societies. The analysis of brain activity may help to diagnose this disease. Changes in entropy methods have been reported useful in research studies to characterize AD. We have recently proposed dispersion entropy (DisEn) as a very fast and powerful tool to quantify the irregularity of time series. The aim of this paper is to evaluate the ability of DisEn, in comparison with fuzzy entropy (FuzEn), sample entropy (SampEn), and permutation entropy (PerEn), to discriminate 36 AD patients from 26 elderly control subjects using resting-state magnetoencephalogram (MEG) signals...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227886/development-of-an-open-source-cosimulation-method-of-the-knee
#3
Anne Schmitz, Davide Piovesan, Anne Schmitz, Davide Piovesan, Anne Schmitz, Davide Piovesan
Rigid body dynamics and soft tissue loads are solved simultaneously in a cosimulation framework to couple musculoskeletal dynamics and tissue mechanics. The goal of this work was to implement a validated, open-source cosimulation framework of the knee to determine how this coupling affects computed cartilage loads. The kinematic knee joint of a generic whole body model in the open-source software OpenSim was replaced by a previously developed discrete element knee model that consisted of a six degree of freedom (dof) tibiofemoral joint and one dof patellofemoral joint...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227866/modelling-nutrient-transfer-based-on-3d-imaging-of-the-human-placental-microstructure
#4
S Perazzolo, R M Lewis, B G Sengers, S Perazzolo, R M Lewis, B G Sengers, B G Sengers, R M Lewis, S Perazzolo
Impaired transfer of nutrients from mother to fetus can affect pregnancy outcomes. The placenta has a complex microstructure, including the maternal intervillous space and fetal capillaries. Previous computational models of placental transfer either assumed a simplified idealized local geometry or were based on 2D imaging. In this study, we present a novel 3D computational model to assess the placental transfer of nutrients at the microscale in interaction with the maternal flow environment. A stack of confocal microscopy images of the placental terminal villi was collected and reconstructed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227575/non-invasive-multi-modal-sensing-of-skin-stretch-and-bioimpedance-for-detecting-infiltration-during-intravenous-therapy
#5
Jambu A Jambulingam, Russell McCrory, Leanne West, Omer T Inan, Jambu A Jambulingam, Russell McCrory, Leanne West, Omer T Inan, Leanne West, Omer T Inan, Russell McCrory
Intravenous infiltration is a condition wherein an infused solution leaks inadvertently into soft tissue surrounding a hypodermic needle site. This occurrence affects approximately 6.5% of patients in hospitals worldwide, and can lead to severe tissue damage if not treated immediately. The methods currently used by medical staff to detect an infiltration are subjective and can potentially be prone to error. Infiltration is an even larger concern in pediatric patients, who have smaller veins than adults and have more difficulty in communicating pain or other discomfort associated with the infiltration with medical staff...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227510/feasibility-of-an-ultra-low-power-digital-signal-processor-platform-as-a-basis-for-a-fully-implantable-brain-computer-interface-system
#6
Po T Wang, Keulanna Gandasetiawan, Colin M McCrimmon, Alireza Karimi-Bidhendi, Charles Y Liu, Payam Heydari, Zoran Nenadic, An H Do, Po T Wang, Keulanna Gandasetiawan, Colin M McCrimmon, Alireza Karimi-Bidhendi, Charles Y Liu, Payam Heydari, Zoran Nenadic, An H Do, An H Do, Zoran Nenadic, Colin M McCrimmon, Keulanna Gandasetiawan, Payam Heydari, Alireza Karimi-Bidhendi, Po T Wang, Charles Y Liu
A fully implantable brain-computer interface (BCI) can be a practical tool to restore independence to those affected by spinal cord injury. We envision that such a BCI system will invasively acquire brain signals (e.g. electrocorticogram) and translate them into control commands for external prostheses. The feasibility of such a system was tested by implementing its benchtop analogue, centered around a commercial, ultra-low power (ULP) digital signal processor (DSP, TMS320C5517, Texas Instruments). A suite of signal processing and BCI algorithms, including (de)multiplexing, Fast Fourier Transform, power spectral density, principal component analysis, linear discriminant analysis, Bayes rule, and finite state machine was implemented and tested in the DSP...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227345/wolff-parkinson-white-wpw-syndrome-the-detection-of-delta-wave-in-an-electrocardiogram-ecg
#7
Hassan Adam Mahamat, Sabir Jacquir, Cliff Khalil, Gabriel Laurent, Stephane Binczak, Hassan Adam Mahamat, Sabir Jacquir, Cliff Khalil, Gabriel Laurent, Stephane Binczak, Stephane Binczak, Sabir Jacquir, Gabriel Laurent, Cliff Khalil
The delta wave remains an important indicator to diagnose the WPW syndrome. In this paper, a new method of detection of delta wave in an ECG signal is proposed. Firstly, using the continuous wavelet transform, the P wave, the QRS complex and the T wave are detected, then their durations are computed after determination of the boundary location (onsets and offsets of the P, QRS and T waves). Secondly, the PR duration, the QRS duration and the upstroke of the QRS complex are used to determine the presence or absence of the delta wave...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227283/a-method-to-detect-tortuosity-of-vessel-using-non-imaging-ultrasound-approach-in-carotid-structure
#8
Ravindra B Patil, P Krishnamoorthy, Ravindra B Patil, P Krishnamoorthy, Ravindra B Patil, P Krishnamoorthy
Stroke is a leading cause of functional impairments. The typical screening mechanism is to measure localized Peak Systolic Velocity (PSV) and diagnose impending risk associated with stoke by characterizing the PSV values. However, an accurate measurement of PSV using Doppler ultrasound is affected due to the tortuous nature of carotid artery in elder population group as the angle at which acoustic beam strikes the vessel is over or under estimated resulting in improper measure the blood flow velocity. Hence, the proposed approach estimates the degree of tortuosity of the carotid vessel and includes this as calibration parameter to compute an accurate PSV...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227195/a-new-regression-based-method-for-the-eye-blinks-artifacts-correction-in-the-eeg-signal-without-using-any-eog-channel
#9
Gianluca Di Flumeri, Pietro Arico, Gianluca Borghini, Alfredo Colosimo, Fabio Babiloni, Gianluca Di Flumeri, Pietro Arico, Gianluca Borghini, Alfredo Colosimo, Fabio Babiloni, Gianluca Di Flumeri, Gianluca Borghini, Pietro Arico, Fabio Babiloni, Alfredo Colosimo
Eye blinks artifacts correction in the EEG signal is a best practice in many applications. Nowadays, different approaches can be used to overcome such an issue: the most used methods are based on regression techniques and Independent Component Analysis. It is not clear which is the best performing method, thus the choice of which method to adopt depends on the specific application, on the basis of the method limitations. In fact, on one hand the regression-based methods require at least one EOG channel, and are affected by the mutual contamination between EEG and EOG signals...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226979/quantitative-assessment-of-arm-tremor-in-people-with-neurological-disorders
#10
Jeonghee Kim, Claire Parnell, Thomas Wichmann, Stephen P DeWeerth, Jeonghee Kim, Claire Parnell, Thomas Wichmann, Stephen P DeWeerth, Claire Parnell, Thomas Wichmann, Stephen P DeWeerth, Jeonghee Kim
Abnormal oscillatory movement (i.e. tremor) is usually evaluated with qualitative assessment by clinicians, and quantified with subjective scoring methods. These methods are often inaccurate. We utilized a quantitative and standardized task based on the Fitts' law to assess the performance of arm movement with tremor by controlling a gyration mouse on a computer. The experiment included the center-out tapping (COT) and rectangular track navigation (RTN) tasks. We report the results of a pilot study in which we collected the performance for healthy participants in whom tremor was simulated by imposing oscillatory movements to the arm with a vibration motor...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226961/knee-orthosis-with-variable-stiffness-and-damping-that-simulates-hemiparetic-gait
#11
Christina-Anne Lahiff, Tyagi Ramakrishnan, Seok Hun Kim, Kyle Reed, Christina-Anne Lahiff, Tyagi Ramakrishnan, Seok Hun Kim, Kyle Reed, Christina-Anne Lahiff, Kyle Reed, Tyagi Ramakrishnan, Seok Hun Kim
Individuals with unilateral stroke have neuromuscular weakness or paralysis on one side of the body caused by some muscles disengaging and others overexciting. Hyperextension of the knee joint and complete lack of plantar flexion of the ankle joint are common symptoms of stroke. This paper focuses on the creation and implementation of a small, lightweight, and adjustable orthotic device to be positioned around the knee of an able-bodied person to simulate hemiparetic gait. Force and range of motion data from able-bodied subjects fitted with the orthosis, inducing hemiparetic gait, was collected using the Computer Assisted Rehabilitation ENvironment (CAREN) system...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226950/prediction-of-posture-dependent-tremor-by-the-calculation-of-the-endpoint-compliance
#12
Takuya Murata, Kouhei Sakurada, Toshio Tsuji, Yuichi Kurita, Takuya Murata, Kouhei Sakurada, Toshio Tsuji, Yuichi Kurita, Kouhei Sakurada, Takuya Murata, Toshio Tsuji, Yuichi Kurita
This paper proposes to use the analysis of human mechanical impedance to predict spatial behavior of tremor. Traditional studies have revealed that the variability in force is proportional to the mean level of force generated, which is described as signal dependent noise. The variability in force sometimes generates unintentional and uncontrollable rhythmic muscle movements, called tremor. Tremor appears most commonly on arms and hands due to not only a symptom of a neurological disorder, but also when we tighten our muscles...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226856/evaluation-of-the-electric-field-in-the-brain-during-transcranial-direct-current-stimulation-a-sensitivity-analysis
#13
Laura Santos, Miguel Martinho, Ricardo Salvador, Cornelia Wenger, Sofia R Fernandes, Oscar Ripolles, Giulio Ruffini, Pedro C Miranda, Laura Santos, Miguel Martinho, Ricardo Salvador, Cornelia Wenger, Sofia R Fernandes, Oscar Ripolles, Giulio Ruffini, Pedro C Miranda, Laura Santos, Miguel Martinho, Cornelia Wenger, Ricardo Salvador, Oscar Ripolles, Giulio Ruffini, Sofia R Fernandes, Pedro C Miranda
The use of computational modeling studies accounts currently for the best approach to predict the electric field (E-field) distribution in transcranial direct current stimulation. As with any model, the values attributed to the physical properties, namely the electrical conductivity of the tissues, affect the predicted E-field distribution. A wide range of values for the conductivity of most tissues is reported in the literature. In this work, we used the finite element method to compute the E-field induced in a realistic human head model for two electrode montages targeting the left dorso-lateral prefrontal cortex (DLPFC)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226768/thalamic-gamma-band-desynchronization-in-a-computational-model-of-the-auditory-pathway
#14
Ana E Uriarte, Lars Haab, Narsis Salafzoon, Daniel J Strauss, Ana E Uriarte, Lars Haab, Narsis Salafzoon, Daniel J Strauss, Ana E Uriarte, Lars Haab, Narsis Salafzoon, Daniel J Strauss
Recent studies have focused on modeling the response of the early auditory processing stages to sound stimuli. However, the influence of sound on the higher stages like the auditory thalamus are not well identified. To understand how different sound stimuli affect the response of neurons in these higher stages, it is necessary to model the auditory pathway from the auditory nerve (AN) through the different stages up to the cortex. In this article we present a model of one of the paths through which sound travels from the AN to the cortex...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226757/automatic-detection-and-severity-measurement-of-eczema-using-image-processing
#15
Md Nafiul Alam, Tamanna Tabassum Khan Munia, Kouhyar Tavakolian, Fartash Vasefi, Nick MacKinnon, Reza Fazel-Rezai, Md Nafiul Alam, Tamanna Tabassum Khan Munia, Kouhyar Tavakolian, Fartash Vasefi, Nick MacKinnon, Reza Fazel-Rezai, Fartash Vasefi, Kouhyar Tavakolian, Reza Fazel-Rezai, Tamanna Tabassum Khan Munia, Md Nafiul Alam, Nick MacKinnon
Chronic skin diseases like eczema may lead to severe health and financial consequences for patients if not detected and controlled early. Early measurement of disease severity, combined with a recommendation for skin protection and use of appropriate medication can prevent the disease from worsening. Current diagnosis can be costly and time-consuming. In this paper, an automatic eczema detection and severity measurement model are presented using modern image processing and computer algorithm. The system can successfully detect regions of eczema and classify the identified region as mild or severe based on image color and texture feature...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226740/automated-morphometric-description-of-human-corneal-endothelium-from-in-vivo-specular-and-confocal-microscopy
#16
F Scarpa, A Ruggeri, F Scarpa, A Ruggeri, A Ruggeri, F Scarpa
Corneal images acquired by in-vivo specular and confocal microscopy provide clinical information on the cornea endothelium health state. Indeed, the normal hexagonal shape of endothelial cells is usually affected by age and pathologies. At present, the analysis is based on manual or semi-automatic methods and the segmentation of a large number of endothelial cells is required for a meaningful estimation of the clinical parameters. We propose an automated method that detects the centers of endothelial cells by convolving the original image with customized two-dimensional kernels, derives a structure made by connected vertices from the recognized centers using the Euclidean distance, and fine-tunes the derived structure through a genetic algorithm, which combines information about the typical regularity of endothelial cells shape with the pixels intensity of the actual image...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226715/adaptive-segmentation-and-mask-specific-sobolev-inpainting-of-specular-highlights-for-endoscopic-images
#17
Samar M Alsaleh, Angelica I Aviles, Pilar Sobrevilla, Alicia Casals, James K Hahn, Samar M Alsaleh, Angelica I Aviles, Pilar Sobrevilla, Alicia Casals, James K Hahn, Angelica I Aviles, Samar M Alsaleh, Alicia Casals, Pilar Sobrevilla, James K Hahn
Minimally invasive surgical and diagnostic systems rely on endoscopic images of internal organs to assist medical tasks. Specular highlights are common on those images due to the strong reflectivity of the mucus layer on the organs and the relatively high intensity of the light source. This is a significant source of error that can affect the systems' performance. In this paper, we propose a segmentation method of the specular regions based on an automatic color-adaptive threshold and a gradient-based edge detector...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226630/gaussian-process-dynamical-models-for-multimodal-affect-recognition
#18
Hernan F Garcia, Mauricio A Alvarez, Alvaro A Orozco, Hernan F Garcia, Mauricio A Alvarez, Alvaro A Orozco, Mauricio A Alvarez, Alvaro A Orozco, Hernan F Garcia
Affective computing systems has a great potential in applications for biofeedback systems and cognitive conductual therapies. Here, by analyzing the physiological behavior of a given subject, we can infer the affective state of an emotional process. Since, emotions can be modeled as dynamic manifestations of these signals, a continuous analysis in the valence/arousal space, brings more information of the affective state related to an emotional process. In this paper we propose a method for dynamic affect recognition from multimodal physiological signals...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226527/3d-detection-of-periodic-limb-movements-in-sleep
#19
Heinrich Garn, Bernhard Kohn, Klaus Dittrich, Christoph Wiesmeyr, Gerhard Kloesch, Robert Stepansky, Markus Wimmer, Osman Ipsiroglu, Dieter Grossegger, Manuel Kemethofer, Stefan Seidel, Heinrich Garn, Bernhard Kohn, Klaus Dittrich, Christoph Wiesmeyr, Gerhard Kloesch, Robert Stepansky, Markus Wimmer, Osman Ipsiroglu, Dieter Grossegger, Manuel Kemethofer, Stefan Seidel, Christoph Wiesmeyr, Gerhard Kloesch, Heinrich Garn, Osman Ipsiroglu, Manuel Kemethofer, Robert Stepansky, Dieter Grossegger, Klaus Dittrich, Markus Wimmer, Bernhard Kohn, Stefan Seidel
The standard polysomnographic method for detecting periodic limb movements in sleep (PLMS) includes measuring the electromyography (EMG) signals from electrodes at the left and right tibialis anterior muscles. This procedure has disadvantages as the cabling affects the patients quality of sleep and the electrodes tend to come off during the night, deteriorating data quality. We used contactless monitoring of body movements by a 3D time-of-flight camera mounted above the bed. Changes in the 3D silhouette indicate motion...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226465/in-silico-pre-clinical-trials-for-implantable-cardioverter-defibrillators
#20
Zhihao Jiang, Houssam Abbas, Kuk Jin Jang, Marco Beccani, Jackson Liang, Sanjay Dixit, Rahul Mangharam, Zhihao Jiang, Houssam Abbas, Kuk Jin Jang, Marco Beccani, Jackson Liang, Sanjay Dixit, Rahul Mangharam, Jackson Liang, Marco Beccani, Sanjay Dixit, Rahul Mangharam, Houssam Abbas, Zhihao Jiang, Kuk Jin Jang
Regulatory authorities require that the safety and efficacy of a new high-risk medical device be proven in a Clinical Trial (CT), in which the effects of the device on a group of patients are compared to the effects of the current standard of care. Phase III trials can run for several years, cost millions of dollars, and expose patients to an unproven device. In this paper, we demonstrate how to use a large group of synthetic patients based on computer modeling to improve the planning of a CT so as to increase the chances of a successful trial for implantable cardioverter defibrillators (ICDs)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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