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https://www.readbyqxmd.com/read/28636254/pirfenidone-reduces-subchondral-bone-loss-and-fibrosis-after-murine-knee-cartilage-injury
#1
Deva D Chan, Jun Li, Wei Luo, Dan N Predescu, Brian J Cole, Anna Plaas
Pirfenidone is an anti-inflammatory and anti-fibrotic drug that has shown efficacy in lung and kidney fibrosis. Because inflammation and fibrosis have been linked to the progression of osteoarthritis, we investigated the effects of oral Pirfenidone in a mouse model of cartilage injury, which results in chronic inflammation and joint-wide fibrosis in mice that lack hyaluronan synthase 1 (Has1(-/-) ) in comparison to wild-type. Femoral cartilage was surgically injured in wild-type and Has1(-/-) mice, and Pirfenidone was administered in food starting after 3 days...
June 21, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28635964/elastically-driven-intermittent-microscopic-dynamics-in-soft-solids
#2
Mehdi Bouzid, Jader Colombo, Lucas Vieira Barbosa, Emanuela Del Gado
Soft solids with tunable mechanical response are at the core of new material technologies, but a crucial limit for applications is their progressive aging over time, which dramatically affects their functionalities. The generally accepted paradigm is that such aging is gradual and its origin is in slower than exponential microscopic dynamics, akin to the ones in supercooled liquids or glasses. Nevertheless, time- and space-resolved measurements have provided contrasting evidence: dynamics faster than exponential, intermittency and abrupt structural changes...
June 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28634724/darma-software-for-dual-axis-rating-and-media-annotation
#3
Jeffrey M Girard, Aidan G C Wright
Continuous measurement systems provide a means of measuring dynamic behavioral and experiential processes as they play out over time. DARMA is a modernized continuous measurement system that synchronizes media playback and the continuous recording of two-dimensional measurements. These measurements can be observational or self-reported and are provided in real-time through the manipulation of a computer joystick. DARMA also provides tools for reviewing and comparing collected measurements and for customizing various settings...
June 20, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28633817/computational-study-of-state-equation-effect-on-single-acoustic-cavitation-bubble-s-phenomenon
#4
Kaouther Kerboua, Oualid Hamdaoui
Many models have been established to study the evolution of the bubble dynamics and chemical kinetics within a single acoustic cavitation bubble during its oscillation. The content of the bubble is a gas medium that generates the evolution of a chemical mechanism governed by the internal bubble conditions. These gases are described by a state equation, linking the pressure to the volume, temperature and species amounts, and influencing simultaneously the dynamical, the thermal and the mass variation in the cavitation bubble...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28633084/public-health-costs-accounting-of-inorganic-pm2-5-pollution-in-metropolitan-areas-of-the-united-states-using-a-risk-based-source-receptor-model
#5
Jinhyok Heo, Peter J Adams, H Oliver Gao
In order to design effective strategies to reduce the public health burden of ambient fine particulate matter (PM2.5) imposed in an area, it is necessary to identify the emissions sources affecting that location and quantify their contributions. However, it is challenging because PM2.5 travels long distances and most constituents are the result of complex chemical processes. We developed a reduced-form source-receptor model for estimating locations and magnitudes of downwind health costs from a source or, conversely, the upwind sources that contribute to health costs at a receptor location...
June 17, 2017: Environment International
https://www.readbyqxmd.com/read/28632760/the-development-of-acquired-equivalence-from-childhood-to-adulthood-a-cross-sectional-study-of-265-subjects
#6
Gábor Braunitzer, Attila Őze, Gabriella Eördegh, Anna Pihokker, Petra Rózsa, László Kasik, Szabolcs Kéri, Attila Nagy
Acquired equivalence (AE) is a form of feedback-based associative learning where the subject learns that two or more stimuli are equivalent in terms of being mapped onto the same outcomes or responses. While several studies dealt with how various neurological and psychiatric conditions affect performance on AE tasks (typically with small populations), studies dealing with AE in healthy subjects are rare, and no study has ever made an attempt to plot the development of this form of learning from the childhood through adulthood...
2017: PloS One
https://www.readbyqxmd.com/read/28632652/utility-of-cardiac-magnetic-resonance-imaging-in-the-management-of-adult-congenital-heart-disease
#7
Giuseppe Muscogiuri, Aurelio Secinaro, Paolo Ciliberti, Megan Fuqua, Arni Nutting
The increasing number of patients with adult congenital heart disease (ACHD) calls for the development of noninvasive imaging techniques that allow a long-term evaluation of native and postsurgical anatomy and function. Echocardiography remains the imaging modality of choice for congenital heart disease, but it is affected by limited acoustic windows and poor tissue characterization. Cardiac computed tomography and cardiac catheter angiography are 2 valid alternatives for the anatomic and functional assessment of ACHD; however, both use ionizing radiation, and cardiac catheter angiography requires an invasive approach...
July 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28632591/acetabular-retroversion-but-not-increased-acetabular-depth-or-coverage-in-slipped-capital-femoral-epiphysis-a-matched-cohort-study
#8
Tobias Hesper, Sarah D Bixby, Young-Jo Kim, Yi-Meng Yen, Garrett Bowen, Patricia Miller, Michael B Millis, Eduardo N Novais
BACKGROUND: Femoral head overcoverage by a deep and retroverted acetabulum has been postulated as a mechanical factor in slipped capital femoral epiphysis (SCFE). We assessed acetabular depth, coverage, and version in the hips of patients with unilateral SCFE; in the contralateral, uninvolved hips; and in healthy control hips. METHODS: Thirty-six patients affected by unilateral SCFE were matched to 36 controls on the basis of sex and age. The acetabular depth-width ratio (ADR), the lateral center-edge angle (LCEA), the anterior and posterior acetabular sector angle (ASA), and version (10 mm distal to the highest point of the acetabular dome and at the level of the femoral head center) were assessed on computed tomography (CT)...
June 21, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28632586/interrater-and-intrarater-reliability-of-arthroscopic-measurements-of-articular-cartilage-defects-in-the-knee
#9
David C Flanigan, James L Carey, Robert H Brophy, William C Graham, Alex C DiBartola, David Hamilton, Haikady N Nagaraja, Christian Lattermann
BACKGROUND: Cartilage lesions of the knee are difficult to treat. Lesion size is a critical factor in treatment algorithms, and the accurate, reproducible sizing of lesions is important. In this study, we evaluated the interrater and intrarater reliability of, and correlations in relation to, various arthroscopic sizing techniques. METHODS: Five lesions were created in each of 10 cadaveric knees (International Cartilage Repair Society grade 3C). Three orthopaedic surgeons used 4 techniques (visualization and use of a 3-mm probe, a simple metal ruler, and a sliding metallic ruler tool) to estimate lesion size...
June 21, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28632052/motor-unit-firing-frequency-of-lower-limb-muscles-during-an-incremental-slide-board-skating-test
#10
Tatiane Piucco, Rodrigo Bini, Masanori Sakaguchi, Fernando Diefenthaeler, Darren Stefanyshyn
This study investigated how the combination of workload and fatigue affected the frequency components of muscle activation and possible recruitment priority of motor units during skating to exhaustion. Ten male competitive speed skaters performed an incremental maximal test on a slide board. Activation of six muscles from the right leg was recorded throughout the test. A time-frequency analysis was performed to compute overall, high, and low frequency bands from the whole signal at 10, 40, 70, and 90% of total test time...
February 28, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28632021/neuromyelitis-optica-application-of-computer-diagnostics-to-historical-case-reports
#11
Pablo Garcia Reitboeck, Peter Garrard, Timothy Peters
The retrospective diagnosis of illnesses by medical historians can often be difficult and prone to bias, although knowledge of the medical disorders of historical figures is key to the understanding of their behavior and reactions. The recent application of computer diagnostics to historical figures allows an objective differential diagnosis to be accomplished. Taking an example from clinical neurology, we analyzed the earliest reported cases of Devic's disease (neuromyelitis optica) that commonly affects the optic nerve and spinal cord and was previously often confused with multiple sclerosis...
February 10, 2017: Journal of the History of the Neurosciences
https://www.readbyqxmd.com/read/28631959/advance-care-planning-for-patients-with-amyotrophic-lateral-sclerosis
#12
Benjamin H Levi, Zachary Simmons, Courtney Hanna, Allyson Brothers, Erik Lehman, Elana Farace, Megan Bain, Renee Stewart, Michael J Green
PURPOSE: To determine whether an advance care planning (ACP) decision-aid could improve communication about end-of-life treatment wishes between patients with amyotrophic lateral sclerosis (ALS) and their clinicians. METHODS: Forty-four patients with ALS (>21, English-speaking, without dementia) engaged in ACP using an interactive computer based decision-aid. Before participants completed the intervention, and again three months later, their clinicians reviewed three clinical vignettes, and made treatment decisions (n = 18) for patients...
March 5, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28631816/cognitive-rehabilitation-for-adults-with-traumatic-brain-injury-to-improve-occupational-outcomes
#13
REVIEW
K Suresh Kumar, Selvaraj Samuelkamaleshkumar, Anand Viswanathan, Ashish S Macaden
BACKGROUND: Cognitive impairment in people with traumatic brain injury (TBI) could affect multiple facets of their daily functioning. Cognitive rehabilitation brings about clinically significant improvement in certain cognitive skills. However, it is uncertain if these improved cognitive skills lead to betterments in other key aspects of daily living. We evaluated whether cognitive rehabilitation for people with TBI improves return to work, independence in daily activities, community integration and quality of life...
June 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28631689/-objective-tympanophonia-caused-by-myoclonus-of-the-auricular-muscles
#14
N V Boiko
The objective of the present literature review was to systematize the available data on the etiology, pathogenesis, clinical features, diagnostics, and treatment of muscular tympanophonia. The commonest source of muscular tympanophonia is the tremor (myoclonus) of the soft palate or the middle ear; sometimes this condition can be a consequence of myoclonus of the external ear muscles or head muscles. Pharmacotherapy of muscular tympanophonia does not invariably result in the favourable outcome. The author describes a rare observation of objective tympanophonia attributable to myoclonus of the auricular muscle...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28631289/three-dimensional-orientation-of-the-acetabulum
#15
Daisuke Suzuki, Satoshi Nagoya, Hiroyuki Takashima, Kenji Tateda
This study was designed specifically to determine the normal acetabular orientation and femoral head covering, and whether these are affected by age or sex. Computed tomographic images of normal Japanese hip joints were used (males 60, females 60; mean age 48.3 years, range 15-79 years). Male and female age profiles were matched. The reconstructed 3D pelvic images were aligned in the anatomical pelvic coordinate system. The acetabular orientation angles and femoral covering angles were measured in the sagittal, coronal, and horizontal planes...
June 20, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28631190/pedicle-screw-insertion-accuracy-in-terms-of-breach-and-reposition-using-a-new-intraoperative-cone-beam-computed-tomography-imaging-technique-and-evaluation-of-the-factors-associated-with-these-parameters-of-accuracy-a-series-of-695-screws
#16
Virginie Cordemans, Ludovic Kaminski, Xavier Banse, Bernard G Francq, Christine Detrembleur, Olivier Cartiaux
PURPOSE: The goals of this study were to assess the accuracy of pedicle screw insertion using an intraoperative cone beam computed tomography (CBCT) system, and to analyze the factors potentially influencing this accuracy. METHODS: Six hundred and ninety-five pedicle screws were inserted in 118 patients between October 2013 and March 2016. Screw insertion was performed using 2D-fluoroscopy or CBCT-based navigation. Accuracy was assessed in terms of breach and reposition...
June 19, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28631064/analysis-of-case-parent-trios-for-imprinting-effect-using-a-loglinear-model-with-adjustment-for-sex-of-parent-specific-transmission-ratio-distortion
#17
Lam Opal Huang, Claire Infante-Rivard, Aurélie Labbe
Transmission ratio distortion (TRD) is a phenomenon where parental transmission of disease allele to the child does not follow the Mendelian inheritance ratio. TRD occurs in a sex-of-parent-specific or non-sex-of-parent-specific manner. An offset computed from the transmission probability of the minor allele in control-trios can be added to the loglinear model to adjust for TRD. Adjusting the model removes the inflation in the genotype relative risk (RR) estimate and Type 1 error introduced by non-sex-of-parent-specific TRD...
June 19, 2017: Human Genetics
https://www.readbyqxmd.com/read/28630855/qualitative-correlation-between-postoperatively-increased-vertical-dimension-and-mandibular-position-in-skeletal-class-iii-using-partial-least-square-path-modeling
#18
Na-Ri Kim, Soo-Byung Park, Jihyun Lee, Youn-Kyung Choi, Sang Min Shin, Yong-Seok Choi, Yong-Il Kim
BACKGROUND: This study constructed a partial-least-square path-modeling (PLS-PM) model and found the pathway by which the postsurgical vertical dimension (VD) affects the extent of the final mandibular setback on the B point at the posttreatment stage for the skeletal class III surgery-first approach (SFA). METHODS: This study re-analyzed the data from the retrospective study by Lee et al. on 40 patients with skeletal class III bimaxillary SFA. Variables were obtained from cone beam computed tomography (CBCT)-generated cephalograms...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28630670/universal-structure-motifs-in-biominerals-a-lesson-from-nature-for-the-efficient-design-of-bioinspired-functional-materials
#19
REVIEW
Joe Harris, Corinna F Böhm, Stephan E Wolf
Biominerals are typically indispensable structures for their host organism in which they serve varying functions, such as mechanical support and protection, mineral storage, detoxification site, or as a sensor or optical guide. In this perspective article, we highlight the occurrence of both structural diversity and uniformity within these biogenic ceramics. For the first time, we demonstrate that the universality-diversity paradigm, which was initially introduced for proteins by Buehler et al. (Cranford & Buehler 2012 Biomateriomics; Cranford et al...
August 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28630033/trust-and-credibility-in-web-based-health-information-a-review-and-agenda-for-future-research
#20
Laura Sbaffi, Jennifer Rowley
BACKGROUND: Internet sources are becoming increasingly important in seeking health information, such that they may have a significant effect on health care decisions and outcomes. Hence, given the wide range of different sources of Web-based health information (WHI) from different organizations and individuals, it is important to understand how information seekers evaluate and select the sources that they use, and more specifically, how they assess their credibility and trustworthiness...
June 19, 2017: Journal of Medical Internet Research
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