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https://www.readbyqxmd.com/read/29161804/importance-of-biological-ultrafine-particles-in-indoor-dust-as-a-pathogenesis-of-chronic-inflammatory-lung-diseases
#1
Young-Koo Jee, Jinho Yang, Yoon-Keun Kim, You-Young Kim, Tae Soo Kang
The role of infectious agents in the etiology of inflammatory diseases once believed to be non-infectious is increasingly being recognized. Many bacterial components in the indoor dust can evoke inflammatory lung diseases. Bacteria secrete nanometer-sized vesicles into the extracellular milieu, so-called extracellular vesicles (EVs). which are pathophysiologically related to inflammatory diseases. Microbiota compositions in the indoor dust revealed the presence of both gram-negative and gram-positive bacteria...
November 17, 2017: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/29161764/mechanism-of-doxorubicin-cardiotoxicity-evaluated-by-integrating-multiple-molecular-effects-into-a-biophysical-model
#2
M Fernandez-Chas, M J Curtis, S A Niederer
BACKGROUND AND PURPOSE: Doxorubicin (DOX) is an effective cancer therapeutic agent but causes therapy-limiting cardiotoxicity. The effects of DOX and its metabolite doxorubicinol (DOXL) on individual channels have been well characterised in isolation. However, it is unknown how the action and interaction of affected channels combine to generate the phenotypic cardiotoxic outcome. We sought to develop an in silico model that links drug effects on channels to action potential duration (APD) and intracellular Ca(2+) concentration in order to address this gap in knowledge...
November 21, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29161661/chlorogenic-acid-prevents-diabetic-nephropathy-by-inhibiting-oxidative-stress-and-inflammation-through-modulation-of-the-nrf2-ho-1-and-nf-%C3%A4-b-pathways
#3
Liping Bao, Jushuang Li, Dongqing Zha, Lian Zhang, Ping Gao, Tao Yao, Xiaoyan Wu
Oxidative and inflammatory damage have been suggested to play important roles in the pathogenesis of diabetic nephropathy (DN). Chlorogenic acid (CGA) is one of the most abundant polyphenols and has known immunoprotective, antioxidant and anti-inflammatory properties. In the present study, animal experiments were designed to examine the protective effects of CGA in DN, and cellular experiments were designed to explore the underlying mechanisms. CGA significantly attenuated diabetic renal damage based on histological pathology and molecular biological methods...
November 18, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29161442/origin-and-evolution-of-the-bartonella-gene-transfer-agent
#4
Daniel Tamarit, Minna-Maria Neuvonen, Philipp Engel, Lionel Guy, Siv G E Andersson
Gene transfer agents (GTAs) are domesticated bacteriophages that have evolved into molecular machines for the transfer of bacterial DNA. Despite their widespread nature and their biological implications, the mechanisms and selective forces that drive the emergence of GTAs are still poorly understood. Two GTAs have been identified in the Alphaproteobacteria: the RcGTA, which is widely distributed in a broad range of species; and the BaGTA, which has a restricted host range that includes vector-borne intracellular bacteria of the genus Bartonella...
November 17, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29161330/fasciola-spp-mapping-of-the-mf6-epitope-and-antigenic-analysis-of-the-mf6p-hdm-family-of-heme-binding-proteins
#5
Victoria Martínez-Sernández, María J Perteguer, Mercedes Mezo, Marta González-Warleta, Teresa Gárate, M Adela Valero, Florencio M Ubeira
MF6p/FhHDM-1 is a small cationic heme-binding protein which is recognized by the monoclonal antibody (mAb) MF6, and abundantly present in parenchymal cells and secreted antigens of Fasciola hepatica. Orthologs of this protein (MF6p/HDMs) also exist in other causal agents of important foodborne trematodiasis, such as Clonorchis sinensis, Opisthorchis viverrini and Paragonimus westermani. Considering that MF6p/FhHDM-1 is relevant for heme homeostasis in Fasciola and was reported to have immunomodulatory properties, this protein is expected to be a useful target for vaccination...
2017: PloS One
https://www.readbyqxmd.com/read/29161285/hpv-genotypes-co-infections-associated-with-cervical-carcinoma-special-focus-on-phylogenetically-related-and-non-vaccine-targeted-genotypes
#6
Rashmirani Senapati, Bhagyalaxmi Nayak, Shantanu Kumar Kar, Bhagirathi Dwibedi
HPV is the major causative agent for cervical cancer. Study on the risk of cervical cancer associated with different hr-HPV genotypes would be useful for disease management and new vaccine strategy. With limited reports available, the present study aimed to investigate the pattern of HPV genotypes coinfections and risk of cervical carcinoma associated with them in Indian population. 15 HPV genotypes were detected by E6/E7 multiplex nested type-specific PCR in the HPV-positive cervical samples of 172 cervical cancer cases and 174 subjects with normal cytology...
2017: PloS One
https://www.readbyqxmd.com/read/29161173/a-relational-ethics-framework-for-advancing-practice-with-children-with-complex-health-care-needs-and-their-parents
#7
Franco A Carnevale, Gail Teachman, Aline Bogossian
Children with complex health care needs are an emerging population that commonly requires long-term supportive services. A growing body of evidence has highlighted that these children and their families experience significant challenges. Many of these challenges involve ethical concerns that have been under-recognized. In this article, we (a) outline ethical concerns that arise in clinical practice with children with complex health care needs and their families (e.g.: exclusion of children's voices in discussions and decisions that affect them; difficulties in defining their best interests; clashes across the array of social roles that parents manage; limited recognition of the ethical significance of parents' and other family members' interests) and (b) propose a relational ethics framework for addressing these concerns...
November 21, 2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29161007/polymer-based-technologies-for-sensing-applications
#8
Wildemar Stefanio Pereira Carvalho, Menglian Wei, Nduka Ikpo, Yongfeng Gao, Michael J Serpe
Reports in the literature on the development of new chemical sensing technologies have been growing steadily in number for years. For example, a Web of Science topic search using the term "Chemical Sensing" revealed that over 8,000 papers were published in 2015-2017, with over 40,000 citations to those papers. In this review, we focus on highlighting recent examples of chemical sensing related to human health (e.g., disease diagnosis, health monitoring, and water/food safety), and for environmental monitoring...
November 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29160099/safety-of-intradiaphragmatic-delivery-of-adeno-associated-virus-mediated-alpha-glucosidase-raav1-cmv-hgaa-gene-therapy-in-children-affected-by-pompe-disease
#9
Manuela Corti, Cristina Liberati, Barbara K Smith, Lee Ann Lawson, Ibrahim S Tuna, Thomas J Conlon, Kirsten E Erger, Saleem Islam, Roland Herzog, David D Fuller, Shelley Collins, Barry J Byrne
We conducted a first in human trial of diaphragmatic gene therapy (AAV1-CMV-GAA) to treat respiratory and neural dysfunction in early-onset Pompe disease. The primary objective of this study was to assess the safety of rAAV1-CMV-hGAA vector delivered to the diaphragm muscle of Pompe disease subjects with ventilatory insufficiency. Safety was assessed by measurement of change in serum chemistries and hematology, urinalysis, and immune response to GAA and AAV as well as change in level of health. Our data demonstrate that the AAV treatment was safe and there were no adverse events related to the study agent...
November 21, 2017: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/29159766/incidence-of-immune-related-adverse-events-and-its-association-with-treatment-outcomes-the-md-anderson-cancer-center-experience
#10
Takeo Fujii, Rivka R Colen, Mehmet Asim Bilen, Kenneth R Hess, Joud Hajjar, Maria E Suarez-Almazor, Anas Alshawa, David S Hong, Apostolia Tsimberidou, Filip Janku, Jing Gong, Bettzy Stephen, Vivek Subbiah, Sarina A Piha-Paul, Siqing Fu, Padmanee Sharma, Tito Mendoza, Anisha Patel, Selvi Thirumurthi, Ajay Sheshadri, Funda Meric-Bernstam, Aung Naing
Background Immunotherapy is emerging as the cornerstone for treatment of patients with advanced cancer, but significant toxicity (immune-related adverse events [irAEs]) associated with unbridled T cell activity remains a concern. Patients and methods A retrospective review of the electronic medical records of 290 patients with advanced cancer treated on an immunotherapy-based clinical trial in the Department of Investigational Cancer Therapeutics at The University of Texas MD Anderson Cancer Center between February 2010 and September 2015 was performed...
November 21, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29159721/design-synthesis-in-silico-and-in-vitro-antimicrobial-screenings-of-novel-1-2-4-triazoles-carrying-1-2-3-triazole-scaffold-with-lipophilic-side-chain-tether
#11
Mohamed Reda Aouad, Mariem Mohammed Mayaba, Arshi Naqvi, Sanaa K Bardaweel, Fawzia Faleh Al-Blewi, Mouslim Messali, Nadjet Rezki
BACKGROUND: 1,2,4-Triazoles and 1,2,3-triazoles have gained significant importance in medicinal chemistry. RESULTS: This study describes a green, efficient and quick solvent free click synthesis of new 1,2,3-triazole-4,5-diesters carrying a lipophilic side chain via 1,3-dipolar cycloaddition of diethylacetylene dicarboxylate with different surfactant azides. Further structural modifications of the resulting 1,2,3-triazole diesters to their corresponding 1,2,4-triazole-3-thiones via multi-step synthesis has been also investigated...
November 21, 2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/29159705/isopropyl-quinoxaline-7-carboxylate-1-4-di-n-oxide-derivatives-induce-regulated-necrosis-like-cell-death-on-leishmania-leishmania-mexicana
#12
Karla Fabiola Chacón-Vargas, Sergio Andrade-Ochoa, Benjamín Nogueda-Torres, Dulce Carolina Juárez-Ramírez, Edgar E Lara-Ramírez, Ricardo Mondragón-Flores, Antonio Monge, Gildardo Rivera, Luvia Enid Sánchez-Torres
Leishmaniasis is a neglected tropical disease caused by the parasite of the genus Leishmania. About 13 million people are infected worldwide, and it is estimated that 350 million are at risk of infection. Clinical manifestations depend on the parasite species and factors related to the host such as the immune system, nutrition, housing, and financial resources. Available treatments have severe side effects; therefore, research currently focuses on finding more active and less toxic compounds. Quinoxalines have been described as promising alternatives...
November 20, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29159476/the-impact-of-skeletal-muscle-on-the-pharmacokinetics-and-toxicity-of-5-fluorouracil-in-colorectal-cancer
#13
Grant R Williams, Allison M Deal, Shlomit Strulov Shachar, Christine M Walko, Jai N Patel, Bert O'Neil, Howard L McLeod, Marc S Weinberg, Seul Ki Choi, Hyman B Muss, Hanna K Sanoff
PURPOSE: Great heterogeneity exists in the ability of adults with cancer to tolerate chemotherapy. Variability in body composition may affect rates of metabolism of cytotoxic agents and contribute to the variable chemotherapy toxicity observed. The objective of this exploratory study was to examine the association of low skeletal muscle, commonly known as sarcopenia, on the pharmacokinetics (PKs) of 5-fluorouracil (5FU) in patients receiving FOLFOX for colorectal cancer. METHODS: We performed a secondary analysis of a completed multicenter trial that investigated PK-guided 5FU dosing in patients receiving mFOLFOX6 +/- bevacizumab for colorectal cancer...
November 20, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29159146/lactobacillus-plantarum-induces-apoptosis-in-oral-cancer-kb-cells-through-upregulation-of-pten-and-downregulation-of-mapk-signalling-pathways
#14
Abbas Asoudeh-Fard, Abolfazl Barzegari, Alireza Dehnad, Sepideh Bastani, Asal Golchin, Yadollah Omidi
Introduction: The oral tumor is the sixth most prevalent type of cancer worldwide and the second leading cause of cancer-related mortality. Although chemotherapy and immunotherapy are the main strategies for the treatment of oral cancer, an emergence of inevitable resistance to these treatment modalities is the major drawback that causes recurrence of the disease. Nowadays, probiotics have been suggested as adjunctive and complementary treatment modalities for improving the impacts of chemotherapy and immunotherapy agents...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/29158817/extracellular-vesicles-in-cardiovascular-theranostics
#15
REVIEW
Yihua Bei, Saumya Das, Rodosthenis S Rodosthenous, Paul Holvoet, Maarten Vanhaverbeke, Marta Chagas Monteiro, Valter Vinicius Silva Monteiro, Jana Radosinska, Monika Bartekova, Felix Jansen, Qian Li, Johnson Rajasingh, Junjie Xiao
Extracellular vesicles (EVs) are small bilayer lipid membrane vesicles that can be released by most cell types and detected in most body fluids. EVs exert key functions for intercellular communication via transferring their bioactive cargos to recipient cells or activating signaling pathways in target cells. Increasing evidence has shown the important regulatory effects of EVs in cardiovascular diseases (CVDs). EVs secreted by cardiomyocytes, endothelial cells, fibroblasts, and stem cells play essential roles in pathophysiological processes such as cardiac hypertrophy, cardiomyocyte survival and apoptosis, cardiac fibrosis, and angiogenesis in relation to CVDs...
2017: Theranostics
https://www.readbyqxmd.com/read/29158812/enhanced-radiotherapy-using-bismuth-sulfide-nanoagents-combined-with-photo-thermal-treatment
#16
Xiaju Cheng, Yuan Yong, Yiheng Dai, Xin Song, Gang Yang, Yue Pan, Cuicui Ge
Nanotechniques that can improve the effectiveness of radiotherapy (RT) by integrating it with multimodal imaging are highly desirable. Results In this study, we fabricated Bi2S3 nanorods that have attractive features such as their ability to function as contrast agents for X-ray computed tomography (CT) and photoacoustic (PA) imaging as well as good biocompatibility. Both in vitro and in vivo studies confirmed that the Bi2S3 nanoagents could potentiate the lethal effects of radiation via amplifying the local radiation dose and enhancing the anti-tumor efficacy of RT by augmenting the photo-thermal effect...
2017: Theranostics
https://www.readbyqxmd.com/read/29158714/synthesis-and-anticancer-activity-of-new-quinazoline-derivatives
#17
Hatem A Abuelizz, Mohamed Marzouk, Hazem Ghabbour, Rashad Al-Salahi
In this study, a new series of quinazoline derivatives (3-26) was synthesized and characterized via physicochemical and spectral means. Treatment of 2-amino-5-methylbenzoic acid with butyl isothiocyanate resulted in the new 2-thioxoquinazolin-4-one (3). Alkylation and hydrazinolysis of the inherent thioxo group in (1-3) afforded the corresponding thioethers (4-23) and hydrazine derivatives (24 and 25), then 24 was further transformed into tricyclic derivative 26 via cyclocondensation reaction. Compounds 1 and 2, which were previously synthesized, were found to exhibit anticancer activity...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29158366/therapeutic-anticoagulation-in-patients-with-primary-brain-tumors-or-secondary-brain-metastasis
#18
REVIEW
Richard J Lin, David L Green, Gunjan L Shah
Patients with primary or metastatic brain tumors are at increased risk of developing venous thromboses. However, the potential benefit of therapeutic anticoagulation in these patients must be weighed against the deadly complication of intracranial hemorrhage. In this review, we summarize available evidence and recent studies of intracranial bleeding risks in primary and metastatic tumors and the impact of therapeutic anticoagulation. We find that for the majority of primary and treated metastatic brain tumors, the risk of spontaneous bleeding is acceptable and not further increased by careful therapeutic anticoagulation with low molecular weight heparin or direct oral anticoagulants, although thrombocytopenia (platelet count less than 50,000/μL) and other coagulopathies are relative contraindications...
November 20, 2017: Oncologist
https://www.readbyqxmd.com/read/29158279/kkl-35-exhibits-potent-antibiotic-activity-against-legionella-species-independently-of-trans-translation-inhibition
#19
Romain Brunel, Ghislaine Descours, Isabelle Durieux, Patricia Doublet, Sophie Jarraud, Xavier Charpentier
Trans-translation is a ribosome rescue system that is ubiquitous in bacteria. Small molecules defining a new family of oxadiazole compounds that inhibit trans-translation have been found to have broad-spectrum antibiotic activity. We sought to determine the activity of KKL-35, a potent member of the oxadiazole family, against the human pathogen Legionella pneumophila and other related species that can also cause Legionnaires disease (LD). Consistent with the essential nature of trans-translation in L. pneumophila, KKL-35 inhibits growth of all tested strains at sub-micromolar concentrations...
November 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29158194/recent-advances-in-bacteriophage-based-methods-for-bacteria-detection
#20
REVIEW
Łukasz Richter, Marta Janczuk-Richter, Joanna Niedziółka-Jönsson, Jan Paczesny, Robert Hołyst
Fast and reliable bacteria detection is crucial for lowering the socioeconomic burden related to bacterial infections (e.g., in healthcare, industry or security). Bacteriophages (i.e., viruses with bacterial hosts) pose advantages such as great specificity, robustness, toughness and cheap preparation, making them popular biorecognition elements in biosensors and other assays for bacteria detection. There are several possible designs of bacteriophage-based biosensors. Here, we focus on developments based on whole virions as recognition agents...
November 17, 2017: Drug Discovery Today
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