Anja C M de Bruin, Monique I Spronken, Adinda Kok, Miruna E Rosu, Dennis de Meulder, Stefan van Nieuwkoop, Pascal Lexmond, Mathis Funk, Lonneke M Leijten, Theo M Bestebroer, Sander Herfst, Debby van Riel, Ron A M Fouchier, Mathilde Richard
Highly pathogenic avian influenza viruses (HPAIVs) cause severe hemorrhagic disease in terrestrial poultry and are a threat to the poultry industry, wild life, and human health. HPAIVs arise from low pathogenic avian influenza viruses (LPAIVs), which circulate in wild aquatic birds. HPAIV emergence is thought to occur in poultry and not wild aquatic birds, but the reason for this species-restriction is not known. We hypothesized that, due to species-specific tropism and replication, intrahost HPAIV selection is favored in poultry and disfavored in wild aquatic birds...
February 26, 2024: PLoS Pathogens