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https://www.readbyqxmd.com/read/29332239/which-parameters-are-relevant-in-sagittal-balance-analysis-of-the-cervical-spine-a-literature-review
#1
REVIEW
Fong Poh Ling, T Chevillotte, A Leglise, W Thompson, C Bouthors, Jean-Charles Le Huec
INTRODUCTION: Cervical spine is part of the spine with the most mobility in the sagittal plane. It is important for surgeons to have reliable, simple and reproducible parameters to analyse the cervical. MATERIAL AND METHOD: This study is a systematic review and a critique of current parameters to help improve the study of cervical spinal balance. We conducted a systematic search of PUBMED/MEDLINE for literature published since January 2014. Only studies written in English and containing abstracts were considered for inclusion...
January 13, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29329586/il-33-st2-signaling-contributes-to-radicular-pain-by-modulating-mapk-and-nf-%C3%AE%C2%BAb-activation-and-inflammatory-mediator-expression-in-the-spinal-cord-in-rat-models-of-noncompressive-lumber-disk-herniation
#2
Si-Jian Huang, Jian-Qin Yan, Hui Luo, Lu-Yao Zhou, Jian-Gang Luo
BACKGROUND: Immune and inflammatory responses occurring in the spinal cord play a pivotal role in the progression of radicular pain caused by intervertebral disk herniation. Interleukin-33 (IL-33) orchestrates inflammatory responses in a wide range of inflammatory and autoimmune disorders of the nervous system. Thus, the purpose of this study is to investigate the expression of IL-33 and its receptor ST2 in the dorsal spinal cord and to elucidate whether the inhibition of spinal IL-33 expression significantly attenuates pain-related behaviors in rat models of noncompressive lumbar disc herniation...
January 12, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29325137/review-of-neurosurgery-medical-professional-liability-claims-in-the-united-states
#3
Aladine A Elsamadicy, Amanda R Sergesketter, Michael D Frakes, Shivanand P Lad
BACKGROUND: Due to disparaging costs and rates of malpractice claims in neurosurgery, there has been significant interest in identifying high-risk specialties, types of malpractice claims, and characteristics of claim-prone physicians. OBJECTIVE: To characterize the malpractice claims against neurosurgeons. METHODS: This was a comprehensive analysis of all malpractice liability claims involving a neurosurgeon as the primary defendant, conducted using the Physician Insurers Association of America Data Sharing Project from January 1, 2003 and December 31, 2012...
January 8, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29322267/association-of-decision-making-in-spinal-surgery-with-specialty-and-emotional-involvement-the-indications-in-spinal-surgery-indiana-survey
#4
Nico Sollmann, Carmen Morandell, Lucia Albers, Michael Behr, Alexander Preuss, Andreas Dinkel, Bernhard Meyer, Sandro M Krieg
BACKGROUND: Although recent trials provided level I evidence for the most common degenerative lumbar spinal disorders, treatment still varies widely. Thus, the Indications in Spinal Surgery (INDIANA) survey explores whether decision-making is influenced by specialty or personal emotional involvement of the treating specialist. METHOD: Nationwide, neurosurgeons and orthopedic surgeons specialized in spine surgery were asked to answer an Internet-based questionnaire with typical clinical patient cases of lumbar disc herniation (DH), lumbar spinal stenosis (SS), and lumbar degenerative spondylolisthesis (SL)...
January 10, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29320844/demyelinating-syndrome-in-sle-review-of-different-disease-subtypes-and-report-of-a-case-series
#5
E Chessa, M Piga, A Floris, A Mathieu, A Cauli
Demyelinating syndrome (DS) is a rare manifestation of systemic lupus erythematosus (SLE) (1%) with high clinical heterogeneity and potentially severe prognosis. It can represent a diagnostic and therapeutic challenge for clinicians. A recent study described 5 different patterns of demyelinating disease presentation, characterised by specific clinical, laboratory and brain and spine magnetic resonance imaging abnormalities: 1) neuromyelitis optica; 2) neuromyelitis optica spectrum disorders; 3) DS prevalently involving the brain; 4) DS prevalently involving the brainstem; 5) clinically isolated syndrome...
December 21, 2017: Reumatismo
https://www.readbyqxmd.com/read/29318284/screening-for-adolescent-idiopathic-scoliosis-us-preventive-services-task-force-recommendation-statement
#6
David C Grossman, Susan J Curry, Douglas K Owens, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, Maureen G Phipps, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Adolescent idiopathic scoliosis, a lateral curvature of the spine of unknown cause with a Cobb angle of at least 10°, occurs in children and adolescents aged 10 to 18 years. Idiopathic scoliosis is the most common form and usually worsens during adolescence before skeletal maturity. Severe spinal curvature may be associated with adverse long-term health outcomes (eg, pulmonary disorders, disability, back pain, psychological effects, cosmetic issues, and reduced quality of life)...
January 9, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29317696/unraveling-individual-differences-in-the-hiv-1-transgenic-rat-therapeutic-efficacy-of-methylphenidate
#7
Kristen A McLaurin, Hailong Li, Rosemarie M Booze, Amanda J Fairchild, Charles F Mactutus
Despite the heterogeneity of HIV-1 associated neurocognitive disorders (HAND), assignment of categorical diagnoses based on the level of impairment (e.g., Frascati criteria) obfuscates the well-acknowledged variability observed within the population of HIV-1+ individuals. The present study sought to elucidate the natural heterogeneity in adult HIV-1 transgenic (Tg) rats using three interrelated aims. First, heterogeneity of the HIV-1 transgene was examined using a pretest-posttest design to assess therapeutic efficacy of oral self-administration (OSA) of methylphenidate (MPH; 2...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317530/the-polarity-protein-angiomotin-p130-controls-dendritic-spine-maturation
#8
Michael Wigerius, Dylan Quinn, Antonios Diab, Leanne Clattenburg, Annette Kolar, Jiansong Qi, Stefan R Krueger, James P Fawcett
The actin cytoskeleton is essential for the structural changes in dendritic spines that lead to the formation of new synapses. Although the molecular mechanisms underlying spine formation are well characterized, the events that drive spine maturation during development are largely unknown. In this study, we demonstrate that Angiomotin (AMOT-130) is necessary for spine stabilization. AMOT-130 is enriched in mature dendritic spines and functions to stabilize the actin cytoskeleton by coupling F-actin to postsynaptic protein scaffolds...
January 9, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29315428/cervical-radiculopathy-effectiveness-of-adding-traction-to-physical-therapy-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#9
Paolo Pillastrini, Antonio Romeo, Carla Vanti, Valerio Boldrini, Martina Ruggeri, Andrew Guccione, Lucia Bertozzi
Background: Cervical radiculopathy (CR) is a common cervical spine disorder. Cervical traction (CT) is a frequently recommended treatment for patients with CR. Purpose: The purpose of this study was to conduct a review and meta-analysis of randomized controlled trials (RCTs) on the effect of CT combined with other physical therapy procedures versus physical therapy procedures alone on pain and disability. Data Sources: Data were obtained from COCHRANE Controlled Trials Register, PubMed, CINAHL, Scopus, ISI Web of Science, and PEDro, from their inception to July 2016...
January 5, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29311652/adult-generated-neurons-born-during-chronic-social-stress-are-uniquely-adapted-to-respond-to-subsequent-chronic-social-stress
#10
Zurine De Miguel, Ursula Haditsch, Theo D Palmer, Arantza Azpiroz, Robert M Sapolsky
Chronic stress is a recognized risk factor for psychiatric and psychological disorders and a potent modulator of adult neurogenesis. Numerous studies have shown that during stress, neurogenesis decreases; however, during the recovery from the stress, neurogenesis increases. Despite the increased number of neurons born after stress, it is unknown if the function and morphology of those neurons are altered. Here we asked whether neurons in adult mice, born during the final 5 days of chronic social stress and matured during recovery from chronic social stress, are similar to neurons born with no stress conditions from a quantitative, functional and morphological perspective, and whether those neurons are uniquely adapted to respond to a subsequent stressful challenge...
January 8, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29311593/neogenin-a-regulator-of-adult-hippocampal-neurogenesis-prevents-depressive-like-behavior
#11
Dong Sun, Xiang-Dong Sun, Lu Zhao, Dae-Hoon Lee, Jin-Xia Hu, Fu-Lei Tang, Jin-Xiu Pan, Lin Mei, Xiao-Juan Zhu, Wen-Cheng Xiong
Adult neurogenesis in hippocampal dentate gyrus (DG) is a complex, but precisely controlled process. Dysregulation of this event contributes to multiple neurological disorders, including major depression. Thus, it is of considerable interest to investigate how adult hippocampal neurogenesis is regulated. Here, we present evidence for neogenin, a multifunctional transmembrane receptor, to regulate adult mouse hippocampal neurogenesis. Loss of neogenin in adult neural stem cells (NSCs) or neural progenitor cells (NPCs) impaired NSCs/NPCs proliferation and neurogenesis, whereas increased their astrocytic differentiation...
January 8, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29310658/the-involvement-of-endoplasmic-reticulum-formation-and-protein-synthesis-efficiency-in-vcp-and-atl1-related-neurological-disorders
#12
REVIEW
Yu-Tzu Shih, Yi-Ping Hsueh
The endoplasmic reticulum (ER) is the biggest organelle in cells and is involved in versatile cellular processes. Formation and maintenance of ER morphology are regulated by a series of proteins controlling membrane fusion and curvature. At least six different ER morphology regulators have been demonstrated to be involved in neurological disorders-including Valosin-containing protein (VCP), Atlastin-1 (ATL1), Spastin (SPAST), Reticulon 2 (RTN2), Receptor expression enhancing protein 1 (REEP1) and RAB10-suggesting a critical role of ER formation in neuronal activity and function...
January 8, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29303468/validation-of-patient-reported-outcomes-measurement-information-system-promis-computerized-adaptive-tests-in-cervical-spine-surgery
#13
Barrett S Boody, Surabhi Bhatt, Aditya S Mazmudar, Wellington K Hsu, Nan E Rothrock, Alpesh A Patel
OBJECTIVE The Patient-Reported Outcomes Measurement Information System (PROMIS), which is funded by the National Institutes of Health, is a set of adaptive, responsive assessment tools that measures patient-reported health status. PROMIS measures have not been validated for surgical patients with cervical spine disorders. The objective of this project is to evaluate the validity (e.g., convergent validity, known-groups validity, responsiveness to change) of PROMIS computer adaptive tests (CATs) for pain behavior, pain interference, and physical function in patients undergoing cervical spine surgery...
January 5, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29302913/principles-and-applications-of-the-balanced-steady-state-free-precession-sequence-in-small-animal-low-field-mri
#14
Mario Ricciardi
Magnetic resonance imaging (MRI) in small animal practice is largely based on classic two-dimensional spin-echo, inversion recovery and gradient-echo sequences which are largely limited by low spatial resolution, especially in low-field (LF)-MRI scanners. Nowadays, however, the availability of volumetric sequences can open new perspectives and enhance the diagnostic potential of this imaging modality. Balanced steady-state free precession (bSSFP) is a three-dimensional gradient-echo sequence in which image contrast is given by the ratio of T2 and T1, resulting in low soft-tissue signal, poor cerebral grey/white matter distinction and a bright signal from free fluid and fat...
January 4, 2018: Veterinary Research Communications
https://www.readbyqxmd.com/read/29302265/the-effect-of-low-dose-intravenous-bisphosphonate-treatment-on-osteoporosis-in-children-with-quadriplegic-cerebral-palsy
#15
Soon Jeong Moon, Young Min An, Soon Ki Kim, Young Se Kwon, Ji Eun Lee
Purpose: Quadriplegic children with cerebral palsy are more susceptible to osteoporosis because of various risk factors that interfere with bone metabolism. Pamidronate is effective for pediatric osteoporosis, but there are no guidelines for optimal dosage or duration of treatment in quadriplegic children with osteoporosis. We aimed to evaluate the efficacy of low-dose pamidronate treatment in these patients. Methods: Ten quadriplegic patients on antiepileptic drugs (6 male, 4 female patients; mean age, 10...
December 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29296213/suppression-of-microrna-9-5p-rescues-learning-and-memory-in-chronic-cerebral-hypoperfusion-rats-model
#16
Na Wei, Kai Zheng, Rui Xue, Sheng-Li Ma, Hua-Yan Ren, Hui-Fen Huang, Wei-Wei Wang, Jing-Jing Xu, Kui-Sheng Chen
Chronic cerebral hypoperfusion has been associated with cognitive impairment in dementias, such as Alzheimer's disease (AD) and vascular disease (VaD), the two most common neurodegenerative diseases in aged people. However, the effective therapeutic approaches for both AD and VaD are still missing. MicroRNAs (miRNAs) are small non-coding RNAs that play important roles in the epigenetic regulation in many neurological disorders; the critical roles of miRNAderegulation had been implicated in both AD and VaD. In the current study, we reported that miR-9-5p is elevated in the serum and cerebrospinalfluid of patientswith VaD...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29295823/the-stress-induced-transcription-factor-nr4a1-adjusts-mitochondrial-function-and-synapse-number-in-prefrontal-cortex
#17
Freddy Jeanneteau, Christian Barrère, Mariska Vos, Carlie Jm De Vries, Claude Rouillard, Daniel Levesque, Yann Dromard, Marie-Pierre Moisan, Vanja Duric, Tina C Franklin, Ronald S Duman, David A Lewis, Stephen D Ginsberg, Margarita Arango-Lievano
The energetic costs of behavioral chronic stress are unlikely to be sustainable without neuronal plasticity. Mitochondria have the capacity to handle synaptic activity up to a limit before energetic depletion occurs. Protective mechanisms driven by the induction of neuronal genes likely evolved to buffer the consequences of chronic stress on excitatory neurons in prefrontal cortex (PFC), as this circuitry is vulnerable to excitotoxic insults. Little is known about the genes involved in mitochondrial adaptation to the build up of chronic stress...
January 2, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29288339/cdk5-contributes-to-huntington-s-disease-learning-and-memory-deficits-via-modulation-of-brain-region-specific-substrates
#18
Elena Alvarez-Periel, Mar Puigdellívol, Verónica Brito, Florian Plattner, James A Bibb, Jordi Alberch, Silvia Ginés
Cognitive deficits are a major hallmark of Huntington's disease (HD) with a great impact on the quality of patient's life. Gaining a better understanding of the molecular mechanisms underlying learning and memory impairments in HD is, therefore, of critical importance. Cdk5 is a proline-directed Ser/Thr kinase involved in the regulation of synaptic plasticity and memory processes that has been associated with several neurodegenerative disorders. In this study, we aim to investigate the role of Cdk5 in learning and memory impairments in HD using a novel animal model that expresses mutant huntingtin (mHtt) and has genetically reduced Cdk5 levels...
December 29, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29288142/patient-reported-outcome-measures-utility-for-predicting-spinal-surgery-in-an-integrated-spine-practice
#19
James R Babington, Alicia Edwards, Anna Wright, Taitea Dykstra, Andrew S Friedman, Rajiv K Sethi
BACKGROUND: For the majority of patients, spinal surgery is an elective treatment. The decision as to when and if to pursue surgery is complicated and influenced by a myriad of factors including pain intensity and duration, impact on functional activities, referring physician recommendation and surgeon preference. By understanding the factors that lead a patient to choose surgery we may better understand the decision making process, improve outcomes, and provide more effective care. OBJECTIVE: To investigate the relationship between patient-reported outcome measures (PROMs) at initial physiatry clinic consultation and subsequent decision to pursue surgical treatment...
December 26, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29284890/a-safe-regional-technique-in-a-high-risk-patient-cervical-plexus-blockage
#20
Ayhan Kaydu, Ebru Tarıkçı Kılıç, Erhan Gökçek, Mehmet Salim Akdemir
Regional anesthesia in the form of combined cervical plexus block is gaining popularity as a technique of choice for cervical spine surgeries, especially for urgent ones. An important advantage is that it allows continuous monitoring of patient's neurological status. The success of the block often depends on accurate placement of the local anesthetic. Landmarks for the block are therefore of great importance. In this case, we aimed to present a 74-year-old man with C4-5 odontoid fracture. We planned to perform a unilateral combined cervical plexus block for anterior cervical instrumentation and fusion (ACIF) operation because of his associated high-risk comorbid disorders...
October 2017: Anesthesia, Essays and Researches
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