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https://www.readbyqxmd.com/read/28730243/a-52-year-old-man-with-gouty-arthritis-and-erosive-lesion-in-the-hip
#1
Vitorino Modesto Dos Santos, Viviane Vieira Passini Soares, Priscilla Souza de Faria, Francisca Germanya Morais Borges Viana, Mayza Lemes Duarte
The case study of peripheral and axial gouty arthritis is described in a 52-year-old man without concomitant clinical evidence of tophaceus gout on physical evaluation on admission. Gout is a metabolic disorder related to excess of uric acid in the extracellular compartment, and deposition of monosodium urate crystals in the joints and other sites. Arthritis and tophi are major manifestations, which more often involve the peripheral joints asymmetrically. Chronic tophaceous gout commonly develops after a decade of recurrent polyarticular gout...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28730225/purkinje-cells-pathology-in-schizophrenia-a-morphometric-approach
#2
Ioannis Asterios Mavroudis, Foivos Petrides, Marina Manani, Fotios Chatzinikolaou, Alin Stelian Ciobică, Manuela Pădurariu, Dimitrios Kazis, Samuel Ndugu Njau, Vasiliki George Costa, Stavros John Baloyannis
OBJECTIVES: Schizophrenia is a brain disorder that affects more than 21 million people worldwide. Ventricle enlargement and reduction in the volume of the temporal lobe overall and in medial temporal structures constitutes the main macroscopic findings, whilst synaptic and spinal changes as well as gliosis in the hippocampal formation, the prefrontal and the entorhinal cortex stand among cardinal microscopic findings in the schizophrenic brains. In recent years, accumulated evidence comes to light about the role of cerebellum in the pathophysiology of schizophrenia...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28729221/sensitivity-to-cocaine-in-adult-mice-is-due-to-interplay-between-genetic-makeup-early-environment-and-later-experience
#3
Matteo Di Segni, Diego Andolina, Alessandra Coassin, Alessandra Accoto, Alessandra Luchetti, Tiziana Pascucci, Carla Luzi, Anna Rita Lizzi, Francesca R D'Amato, Rossella Ventura
Although early aversive postnatal events are known to increase the risk to develop psychiatric disorders later in life, rarely they determine alone the nature and outcome of the psychopathology, indicating that interaction with genetic factors is crucial for expression of psychopathologies in adulthood. Moreover, it has been suggested that early life experiences could have negative consequences or confer adaptive value in different individuals. Here we suggest that resilience or vulnerability to adult cocaine sensitivity depends on a "triple interaction" between genetic makeup x early environment x later experience...
July 17, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28728878/a-mass-spectrometry-based-proteomic-analysis-of-homer2-interacting-proteins-in-the-mouse-brain
#4
Scott P Goulding, Karen K Szumlinski, Candice Contet, Michael J MacCoss, Christine C Wu
In the brain, the Homer protein family modulates excitatory signal transduction and receptor plasticity through interactions with other proteins in dendritic spines. Homer proteins are implicated in a variety of psychiatric disorders such as schizophrenia and addiction. Since Homers serve as scaffolding proteins, identifying their interaction partners is an important first step in understanding their biological function and could help design novel therapeutic strategies. The present study set out to document Homer2-interacting proteins in the mouse brain using a co-immunoprecipitation-based mass spectrometry approach...
July 17, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28725909/skeletal-fluorosis-due-to-fluorocarbon-inhalation-from-an-air-dust-cleaner
#5
Katherine Peicher, Naim M Maalouf
Skeletal fluorosis (SF) is an osteosclerotic metabolic bone disorder caused by excessive ingestion or inhalation of fluoride. SF is extremely rare in developed countries. We report a case of SF due to inhalational abuse from a fluoride-containing air dust cleaner. A 33-year-old man with no past medical history presented with progressively worsening low back pain for 2 years. Physical examination was notable for loss of lumbar lordosis and tenderness over the lumbar spine. Radiographs were notable for uniform generalized osteosclerosis in the long bones, entire spine, rib cage, and pelvic bones, and loss of the normal lumbar curvature...
July 20, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28724954/loss-of-x-linked-protocadherin-19-differentially-affects-the-behavior-of-heterozygous-female-and-hemizygous-male-mice
#6
Shuichi Hayashi, Yoko Inoue, Satoko Hattori, Mari Kaneko, Go Shioi, Tsuyoshi Miyakawa, Masatoshi Takeichi
Mutations in the X-linked gene Protocadherin-19 (Pcdh19) cause female-limited epilepsy and mental retardation in humans. Although Pcdh19 is known to be a homophilic cell-cell adhesion molecule, how its mutations bring about female-specific disorders remains elusive. Here, we report the effects of Pcdh19 knockout in mice on their development and behavior. Pcdh19 was expressed in various brain regions including the cerebral cortex and hippocampus. Although Pcdh19-positive cells were evenly distributed in layer V of wild-type cortices, their distribution became a mosaic in Pcdh19 heterozygous female cortices...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28718273/3d-quantitative-evaluation-of-spine-proprioceptive-perception-motor-control-through-instinctive-self-correction-manoeuvre-in-healthy-young-subjects-posture-an-observational-study
#7
Moreno D'Amico, Edyta Kinel, Piero Roncoletta
BACKGROUND: Conservative treatment in spine deformities and spine related disorders is mainly based on proper individual proprioceptive and motor control training. For these reasons, conservative treatment involves the stimulation of individual capability of perceiving/reducing deformities, blocks and/or improper spine posture by voluntary control. The literature describes that habitually adopted relaxed postures often exacerbate low back pain. Typically, youths can be referred to therapeutic programs aimed at improving the quality of body posture along with fostering the awareness of the importance of correct posture...
July 18, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28717153/proton-pump-inhibitors-and-the-risk-for-fracture-at-specific-sites-data-mining-of-the-fda-adverse-event-reporting-system
#8
Liwei Wang, Mei Li, Yuying Cao, Zhengqi Han, Xueju Wang, Elizabeth J Atkinson, Hongfang Liu, Shreyasee Amin
Proton pump inhibitors (PPIs) are widely used to treat gastric acid-related disorders. Concerns have been raised about potential fracture risk, especially at the hip, spine and wrist. However, fracture risk at other bone sites has not been as well studied. We investigated the association between PPIs and specific fracture sites using an aggregated knowledge-enhanced database, the Food and Drug Administration Adverse Event Reporting System Data Mining Set (AERS-DM). Proportional reporting ratio (PRR) was used to detect statistically significant associations (signals) between PPIs and fractures...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717058/lumbosacral-transitional-vertebrae-cause-spinal-level-misconception-in-surgeries-for-degenerative-lumbar-spine-disorders
#9
Tomowaki Nakagawa, Ko Hashimoto, Takumi Tsubakino, Takeshi Hoshikawa, Takashi Inawashiro, Yasuhisa Tanaka
Human lumbar spine usually consists of five vertebrae; however, some individuals have vertebral anomalies with four or six lumbar vertebrae because of sacralized fifth lumbar vertebra (L5 sacralization) or lumbarized first sacral vertebra (S1 lumbarization), respectively. These vertebral anomalies are called lumbosacral transitional vertebra (LSTV). Although LSTV is an asymptomatic anomaly, it is known to cause misconception in spinal counts and in spinal level at lumbar spinal surgery. The purpose of this study is to evaluate how LSTV affects the diagnosis and surgeries in lumbar spine disorders...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28716964/a-glun2b-selective-nmdar-antagonist-reverses-synapse-loss-and-cognitive-impairment-produced-by-the-hiv-1-protein-tat
#10
Jonathan D Raybuck, Nicholas J Hargus, Stanley A Thayer
HIV-associated neurocognitive disorder (HAND) affects approximately half of HIV-infected patients. Loss of synaptic connections is a hallmark of many neurocognitive disorders, including HAND. The HIV-1 protein transactivator of transcription (Tat) disrupts synaptic connections both in vitro and in vivo and has been linked to impaired neurocognitive function in humans. In vitro studies have shown that ifenprodil, an antagonist selective for GluN2B-containing NMDARs, reverses synapse loss when applied after Tat...
July 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28713243/synaptic-interactome-mining-reveals-p140cap-as-a-new-hub-for-psd-proteins-involved-in-psychiatric-and-neurological-disorders
#11
Annalisa Alfieri, Oksana Sorokina, Annie Adrait, Costanza Angelini, Isabella Russo, Alessandro Morellato, Michela Matteoli, Elisabetta Menna, Elisabetta Boeri Erba, Colin McLean, J Douglas Armstrong, Ugo Ala, Joseph D Buxbaum, Alfredo Brusco, Yohann Couté, Silvia De Rubeis, Emilia Turco, Paola Defilippi
Altered synaptic function has been associated with neurological and psychiatric conditions including intellectual disability, schizophrenia and autism spectrum disorder (ASD). Amongst the recently discovered synaptic proteins is p140Cap, an adaptor that localizes at dendritic spines and regulates their maturation and physiology. We recently showed that p140Cap knockout mice have cognitive deficits, impaired long-term potentiation (LTP) and long-term depression (LTD), and immature, filopodia-like dendritic spines...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28713084/evalution-of-the-effectiveness-of-multimodal-approach-to-the-management-of-cervical-vertigo
#12
Olexandr A Jaroshevskyi, Oleksandr S Payenok, Anna V Logvinenko
INTRODUCTION: Vertigo is one of the most common complaints among patients consulting neurologists and general practitioners - family medicine. A special form of dizziness is cervical vertigo. However, the presence of chronic vertigo and imbalance in this group of patients makes it possible to include the treatment of vestibular rehabilitation in the program. AIM: Evalution of the effectiveness of multimodal approach to the management of cervical vertigo. MATERIAL AND METHODS: 109 patients aged from 18 to 45 with vertigo together with myofascial pain syndrome of neck and shoulder area were examined...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28711376/motor-evoked-potentials-in-patients-with-chronic-whiplash-associated-disorder-grade-ii
#13
Jacques De Reuck
BACKGROUND AND PURPOSE: It is common belief that psychological problems influence the persistence of complains in patients with so-called mild whiplash-associated disorders (WADs). The usefulness of motor evoked potentials (MEPs) is investigated in patients with grade II WAD and remaining complains for more than 6 months. PATIENTS AND METHODS: Twenty consecutive patients, aged between 24 and 58 years, with persistent neck pain for months after a car accident were included...
July 8, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28711207/dual-energy-computed-tomography-applications-for-the-evaluation-of-the-spine
#14
REVIEW
Peter Komlosi, Max Wintermark
Capturing the energy-dependent x-ray attenuation of different tissues, dual-energy computed tomography offers multiple benefits in the imaging of the spine, such as bone and iodinated contrast removal, monosodium urate imaging, and robust reduction of beam-hardening artifacts. The emerging new applications of this technique include bone marrow imaging in acute trauma and myeloinfiltrative disorders, improved bone density determination, and noninvasive assessment of spinal gout.
August 2017: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/28709588/postural-disorders-in-mouth-breathing-children-a-systematic-review
#15
REVIEW
Patricia Dayrell Neiva, Renata Noce Kirkwood, Polyana Leite Mendes, Karl Zabjek, Helena Gonçalves Becker, Sunita Mathur
BACKGROUND: Mouth breathing syndrome can cause sleep disturbances that compromise the performance of children in school. It might also cause postural abnormalities involving the head and cervical spine; however, the association between postural abnormalities and mouth breathing in children is unclear. OBJECTIVE: To assess the methodological quality of studies and determine if there is an association between mouth breathing and postural disorders in children. METHODS: Databases comprised MEDLINE, CINAHL, PEDro, LILACS, EMBASE and Cochrane Central Registrar of Controlled Trials...
July 5, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28704623/process-of-change-in-pain-related-fear-clinical-insights-from-a-single-case-of-persistent-back-pain-managed-with-cognitive-functional-therapy
#16
J P Caneiro, Anne Smith, Martin Rabey, G Lorimer Moseley, Peter O'Sullivan
Study Design Single-case report with repeated measures over 18 months. Background Management of persistent low back pain (PLBP) associated with high pain-related fear is complex. This single-case report aims to provide clinicians with an insight to the process of change in a person with PLBP and high bending-related fear, managed with an individualized behavioral approach - Cognitive Functional Therapy (CFT). Case Description A retired manual worker with PLBP believed that his spine was degenerating, that bending would hurt him and avoidance was the only form of pain control...
July 13, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28704301/congenital-unilateral-absence-of-the-upper-extremity-may-give-rise-to-a-specific-kind-of-thoracolumbar-curve
#17
Z Deniz Olgun, Gokhan Demirkiran, David Polly, Muharrem Yazici
There is an increased incidence of scoliosis in patients with congenital malformations of the upper extremity even in the absence of overt vertebral abnormalities. In this case series, we summarize the curve characteristics of four patients presenting to two spine surgery clinics with unilateral amelia or phocomelia and a progressive scoliotic curve with the apex on the side of deficiency. All patients required orthopedic intervention for their curves. Amelia and phocomelia are severe congenital malformations of the upper limb affecting trunk balance and, conceivably, causing scoliosis with the absence of counterbalancing weight on the affected side...
July 12, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28700967/eosinophilic-granuloma-at-the-cerebellopontine-angle-in-an-adult-a-rare-case-report-and-literature-review
#18
Arash Safarian, Nima Derakhshan, Mousa Taghipour, Amirreza Dehghanian
INTRODUCTION: Langerhans cell histiocytosis (LCH) is a rare immunologic disorder, identified by immature proliferation of histiocytes which may present as systemic or focal lesions. Eosinophilic granuloma (EG) is localized from of LCH mainly involving bones such as skull, femur, spine, ribs, mandible and pelvis. Cerebello-pontine (CP) angle is a rare anatomic location for involvement by EG. PRESENTATION OF CASE: A 32 year old man was being evaluated in our neuro-oncology clinic due to diplopia since 4 months ago...
June 29, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28699327/acute-onset-severe-occipital-neuralgia-associated-with-high-cervical-lesion-in-patients-with-neuromyelitis-optica-spectrum-disorder
#19
Yuichi Hayashi, Akihiro Koumura, Megumi Yamada, Akio Kimura, Toshirou Shibata, Takashi Inuzuka
OBJECTIVE: To address occipital neuralgia in patients with neuromyelitis optica spectrum disorder (NMOSD). BACKGROUND: NMOSD is an inflammatory demyelinating disease that commonly presents with pain; however, headache symptoms have received little attention. METHODS: We presented three cases of NMOSD in which the patients experienced acute-onset, severe, and steroid-responsive occipital neuralgia. All patients provided consent to use their demographic and imaging data retrospectively...
July 2017: Headache
https://www.readbyqxmd.com/read/28694216/an-analysis-of-radiographic-parameters-comparison-between-lumbar-spine-latericumbent-and-full-length-lateral-standing-radiographs
#20
Zhiwei Yang, Fang Xie, Jianxin Zhang, Zhuowen Liang, Zhe Wang, Xueyu Hu, Zhuojing Luo
BACKGROUND CONTEXT: The lumbar spine latericumbent and full-length lateral standing radiographs are most commonly used to assess lumbar disorder. However, there are few literatures regarding the difference and correlation of the sagittal parameters between the two shooting positions. PURPOSE: To investigate the difference of sagittal parameters in spine lateral radiographs between latericumbent and upright positions, identify the correlation and establish a preliminary linear fitting formula...
July 7, 2017: Spine Journal: Official Journal of the North American Spine Society
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