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JOURNAL ARTICLE
Alexandra B Collins, Rachel S Wightman, E Claire Macon, Yingjie Guan, Abdullah Shihipar, Maxwell Krieger, Rachael Elmaleh, Megan C Smith, Alexis Morales, Adina Badea
BACKGROUND: The North American overdose crisis has continued at unprecedented rates with more than 100,000 overdose deaths estimated to have occurred in the United States in 2022. Regional variations in overdose rates signify differences in local drug supplies. State-level drug supply surveillance systems have been limited in their ability to document and communicate the rapidly changing drug supplies which can hinder harm reduction efforts at the community level. We sought to address by piloting a two-year, community-engaged local drug supply surveillance program in Rhode Island (RI)...
August 2023: International Journal on Drug Policy
#22
JOURNAL ARTICLE
Rachel S Wightman, Jane Metrik, Timmy R Lin, Alexandra B Collins, Francesca L Beaudoin
OBJECTIVES: Cannabinoid hyperemesis syndrome (CHS) is a clinical condition of cyclic vomiting, nausea, and abdominal pain associated with chronic cannabis use. Despite increased recognition of CHS, there are limited details on cannabis use practices and symptoms over time. Understanding what happens in the period surrounding the ED visit, including any changes in symptoms and cannabis use practices following the visit, can help inform the development of patient-centered interventions around cannabis use disorder for patients with CHS...
June 30, 2023: Academic Emergency Medicine
#23
RANDOMIZED CONTROLLED TRIAL
Alexandra B Collins, Janette Baird, Evelyn Nimaja, Yokabed Ashenafi, Melissa A Clark, Francesca L Beaudoin
BACKGROUND: Emergency Departments (EDs) have become critical 'touchpoints' for the identification and early engagement of patients at risk of overdose or who have an opioid use disorder (OUD). Our objectives were to examine patients' ED experiences, identify barriers and facilitators of service uptake in ED settings, and explore patients' experiences with ED staff. METHODS: This qualitative study was part of a randomized controlled trial that evaluated the effectiveness of clinical social workers and certified peer recovery specialists in increasing treatment uptake and reducing opioid overdose rates for people with OUD...
April 18, 2023: BMC Health Services Research
#24
JOURNAL ARTICLE
Tamar Austin, Jennifer Lavalley, Sylvia Parusel, Alexandra B Collins, Michelle Olding, Jade Boyd
BACKGROUND: Harm reduction services that employ or are operated by people who use drugs are an effective means of mitigating overdose risks and other drug-related harms. However, stereotypes portraying people who use criminalized drugs as incapable caregivers persist. This is especially true for women who use drugs, and to a greater extent racialized women, who are characterized as having diverged from traditional ideals of womanhood as a result of drug-user stigma and the intersections of gender- and class-based and racist stereotypes...
April 13, 2023: Harm Reduction Journal
#25
JOURNAL ARTICLE
Taylor Fleming, Alexandra B Collins, Jade Boyd, Ryan McNeil, Kelly R Knight
People who use drugs (PWUD) commonly experience housing instability due to intersecting structural vulnerabilities (e.g., drug prohibition, discriminatory housing policies), and prejudicial or illegal evictions are common. In Vancouver, Canada, evictions have proliferated in the Downtown Eastside, a historically low-income neighbourhood with high rates of drug use and housing instability, resulting in many PWUD being evicted into homelessness. This study characterizes housing trajectories of recently-evicted PWUD through the lens of the institutional circuit of homelessness, and explores how wider contexts of structural vulnerability shape experiences within this...
April 3, 2023: Social Science & Medicine
#26
JOURNAL ARTICLE
Rachel S Wightman, Jeanmarie Perrone, Alexandra B Collins, Sahithi Lakamana, Abeed Sarker
INTRODUCTION: Reddit hosts a large active community of members dedicated to the discussion of cannabinoid hyperemesis syndrome. We sought to describe common themes discussed and the most frequently mentioned triggers and therapies for cannabinoid hyperemesis syndrome exacerbations in the Reddit online community. METHODS: Data collected from six subreddits were filtered using natural language processing to curate posts referencing cannabinoid hyperemesis syndrome...
April 2023: Clinical Toxicology
#27
JOURNAL ARTICLE
Alexandra B Collins, Francesca L Beaudoin, Jane Metrik, Rachel S Wightman
BACKGROUND: Cannabis is the most widely used psychoactive substance in the United States (US), with reported use patterns increasing among adults in recent years. Cannabinoid hyperemesis syndrome (CHS) has been one concern related to increased cannabis use patterns. US emergency departments have reported an increase of CHS cases over the last decade, yet little is known about CHS. This study explores the experiences of people with chronic cannabis use and cyclic vomiting and their perceptions of CHS...
May 1, 2023: Drug and Alcohol Dependence
#28
JOURNAL ARTICLE
Kimberley T Davis, Marcos D Robles, Kerry B Kemp, Philip E Higuera, Teresa Chapman, Kerry L Metlen, Jamie L Peeler, Kyle C Rodman, Travis Woolley, Robert N Addington, Brian J Buma, C Alina Cansler, Michael J Case, Brandon M Collins, Jonathan D Coop, Solomon Z Dobrowski, Nathan S Gill, Collin Haffey, Lucas B Harris, Brian J Harvey, Ryan D Haugo, Matthew D Hurteau, Dominik Kulakowski, Caitlin E Littlefield, Lisa A McCauley, Nicholas Povak, Kristen L Shive, Edward Smith, Jens T Stevens, Camille S Stevens-Rumann, Alan H Taylor, Alan J Tepley, Derek J N Young, Robert A Andrus, Mike A Battaglia, Julia K Berkey, Sebastian U Busby, Amanda R Carlson, Marin E Chambers, Erich Kyle Dodson, Daniel C Donato, William M Downing, Paula J Fornwalt, Joshua S Halofsky, Ashley Hoffman, Andrés Holz, Jose M Iniguez, Meg A Krawchuk, Mark R Kreider, Andrew J Larson, Garrett W Meigs, John Paul Roccaforte, Monica T Rother, Hugh Safford, Michael Schaedel, Jason S Sibold, Megan P Singleton, Monica G Turner, Alexandra K Urza, Kyra D Clark-Wolf, Larissa Yocom, Joseph B Fontaine, John L Campbell
Increasing fire severity and warmer, drier postfire conditions are making forests in the western United States (West) vulnerable to ecological transformation. Yet, the relative importance of and interactions between these drivers of forest change remain unresolved, particularly over upcoming decades. Here, we assess how the interactive impacts of changing climate and wildfire activity influenced conifer regeneration after 334 wildfires, using a dataset of postfire conifer regeneration from 10,230 field plots...
March 14, 2023: Proceedings of the National Academy of Sciences of the United States of America
#29
JOURNAL ARTICLE
Matthias Ginterseder, Weiwei Sun, Wenbi Shcherbakov-Wu, Alexandra R McIsaac, David B Berkinsky, Alexander E K Kaplan, Lili Wang, Chantalle Krajewska, Tara Šverko, Collin F Perkinson, Hendrik Utzat, William A Tisdale, Troy Van Voorhis, Moungi G Bawendi
Lead halide perovskite nanocrystals (LHP NCs) are an emerging materials system with broad potential applications, including as emitters of quantum light. We apply design principles aimed at the structural optimization of surface ligand species for CsPbBr3 NCs, leading us to the study of LHP NCs with dicationic quaternary ammonium bromide ligands. Through the selection of linking groups and aliphatic backbones guided by experiments and computational support, we demonstrate consistently narrow photoluminescence line shapes with a full-width-at-half-maximum below 70 meV...
February 13, 2023: Nano Letters
#30
JOURNAL ARTICLE
Lisa Frueh, Alexandra B Collins, Roxxanne Newman, Nancy P Barnett, Josiah D Rich, Melissa A Clark, Brandon D L Marshall, Alexandria Macmadu
BACKGROUND: The ongoing COVID-19 pandemic has disproportionately affected structurally vulnerable populations including people who use drugs (PWUD). Increased overdose risk behaviors among PWUD during the pandemic have been documented, with research underscoring the role of influencing factors such as isolation and job loss in these behaviors. Here, we use qualitative methods to examine the impact of the COVID-19 pandemic and pandemic-related response measures on drug use behaviors in a sample of PWUD in Rhode Island...
February 4, 2023: Harm Reduction Journal
#31
REVIEW
Charis Wong, Jenna M Gregory, Jing Liao, Kieren Egan, Hanna M Vesterinen, Aimal Ahmad Khan, Maarij Anwar, Caitlin Beagan, Fraser S Brown, John Cafferkey, Alessandra Cardinali, Jane Yi Chiam, Claire Chiang, Victoria Collins, Joyce Dormido, Elizabeth Elliott, Peter Foley, Yu Cheng Foo, Lily Fulton-Humble, Angus B Gane, Stella A Glasmacher, Áine Heffernan, Kiran Jayaprakash, Nimesh Jayasuriya, Amina Kaddouri, Jamie Kiernan, Gavin Langlands, D Leighton, Jiaming Liu, James Lyon, Arpan R Mehta, Alyssa Meng, Vivienne Nguyen, Na Hyun Park, Suzanne Quigley, Yousuf Rashid, Andrea Salzinger, Bethany Shiell, Ankur Singh, Tim Soane, Alexandra Thompson, Olaf Tomala, Fergal M Waldron, Bhuvaneish T Selvaraj, Jeremy Chataway, Robert Swingler, Peter Connick, Suvankar Pal, Siddharthan Chandran, Malcolm Macleod
OBJECTIVES: Motor neuron disease (MND) is an incurable progressive neurodegenerative disease with limited treatment options. There is a pressing need for innovation in identifying therapies to take to clinical trial. Here, we detail a systematic and structured evidence-based approach to inform consensus decision making to select the first two drugs for evaluation in Motor Neuron Disease-Systematic Multi-arm Adaptive Randomised Trial (MND-SMART: NCT04302870), an adaptive platform trial...
February 1, 2023: BMJ Open
#32
Daniel S Green, Franklin Ning, Anna Duemler, Timothy G Myers, Kathryn Trewhitt, Irene Ekwede, Ann McCoy, Nicole Houston, Jung-Min Lee, Stanley Lipkowitz, Alexandra Zimmer, Miroslava Pavelova, Erin N Villanueva, Leslie Smith, Andrew Blakely, Yovanni Casablanca, Steven L Highfill, David F Stroncek, Naoza Collins-Johnson, Sandhya Panch, JoLynn Procter, Chauha Pham, Soumya Korrapati, Steven M Holland, Lindsey B Rosen, Ana T Nunes, Kathryn C Zoon, Christopher B Cole, Christina M Annunziata
No abstract text is available yet for this article.
January 17, 2023: Clinical Cancer Research
#33
JOURNAL ARTICLE
Yasser Selim, Élise Di Lena, Nadia Safa, Sid Rahman, Pepa Kaneva, Liane Feldman, Nawaf Abu-Omar, Zarrukh Baig, Nathan Ginther, Dilip Gill, Zarrukh Baig, Zaini Sarwar, Carlos Verdiales, Mike Moser, Kevin Verhoeff, Valentin Mocanu, Breanna Fang, Jerry Dang, Warren Sun, Noah Switzer, Daniel Birch, Shahzeer Karmali, Julie La, Anood Alqaydi, Xuejiao Wei, Genevieve Digby, Susan Brogly, Shaila Merchant, Kieran Purich, Kevin Verhoeff, Alexander Miles, Janice Y Kung, A M James Shapiro, David L Bigam, Samantha Albacete, Ashlee Matkin, Danielle Dumestre, Lashan Peiris, Rahim Valji, Simon Turner, Kieran Purich, Kevin Verhoeff, Brett Mador, Steffane McLennan, Ali Safar, Atif Jastaniah, Morgan Schellenberg, Natthida Owattanapanich, Areg Grigorian, Lydia Lam, Jeffry Nahmias, Kenji Inaba, Morgan Schellenberg, Panagiotis Liasidis, Kenji Inaba, Demetrios Demetriades, Morgan Schellenberg, Elizabeth R Benjamin, Shaun Cowan, Natthida Owattanapanich, Monica D Wong, Kenji Inaba, Demetrios Demetriades, Morgan Schellenberg, Natthida Owattanapanich, Brent Emigh, Lindsey Karavites, Damon H Clark, Lydia Lam, Kenji Inaba, Morgan Schellenberg, Elizabeth R Benjamin, Natthida Owattanapanich, Kenji Inaba, Demetrios Demetriades, Morgan Schellenberg, Geoffrey A Anderson, Natthida Owattanapanich, Vincent Cheng, Lydia Lam, Kenji Inaba, Lee Myers, Julian Daza, Brian Cuthbertson, Paul Myles, Mark Shulman, Duminda Wijeysundera, Lyndsay T Glass, Patrick B Murphy, Laura Allen, Kathryn Minkhorst, Dillon Bowker, Ephraim S Tang, Kenneth Leslie, Jeffrey E Hawel, Kevin Verhoeff, Odelle Ma, Kieran Purich, Samuel Skinner, Raveena Dhaliwal, Matt Strickland, Garrett Johnson, Jason Park, Ashley Vergis, Lawrence Gillman, Justin Rivard, Keegan Guidolin, Justin Lin, Anudari Zorigtbaatar, Minahil Nadeem, Tarek Ibrahim, Zdenka Neilson, Kyung Young Peter Kim, Luckshi Rajendran, Sami Chadi, Fayez Quereshy, Lyndsay T Glass, Malcolm Davidson, Emily Friedrich, Caitlin Champion, Saba Balvardi, Koorosh Semsar-Kazerooni, Pepa Kaneva, Carmen Mueller, Melina Vassiliou, Mohammed Al Mahroos, Julio Fiore, Kevin Schwartzman, Liane Feldman, Nada Gawad, Kieran Purich, Kevin Verhoeff, Blaire Anderson, Tyler McKechnie, Ryan Daniel, Colin Kruse, Marc Levin, Yung Lee, Aristithes Doumouras, Dennis Hong, Cagla Eskicioglu, Tyler McKechnie, Christopher Povolo, Jay Lee, Yung Lee, Lily Park, Aristithes Doumouras, Dennis Hong, Mohit Bhandari, Cagla Eskicioglu, Kieran Purich, Esther Lee, Kevin Verhoeff, Dasan Sydora, Simon Turner, Matt Strickland, Jessica Henley, Darrell Boone, Stephanie Roberts, Emma Imbert, Duncan McGrouther, Paul Manuel, Christine Li, Mark Dykstra, Haili Wang, Ryan Snelgrove, Samuel Skinner, Kevin Verhoeff, Kieran Purich, Troy Perry, Matthew Strickland, Raveena Dhaliwal, Tori Lenet, Stephanie Skanes, Joseph Tropiano, Daniel McIsaac, Alan Tinmouth, Julie Hallet, Stuart Nicholls, Dean Fergusson, Guillaume Martel, Tori Lenet, Joseph Tropiano, Stephanie Skanes, Victoria Ivankovic, Daniel McIsaac, Alan Tinmouth, Andrea Patey, Dean Fergusson, Guillaume Martel, Jeff Metz, Reza Naqvi, Ruediger Noppens, Jeff Hawel, Ahmad Elnahas, Christopher Schlachta, Nawar Alkhamesi, Hilalion San Ahn, Tori Lenet, Richard Gilbert, Ranjeeta Mallick, Julie Shaw, Daniel McIsaac, Guillaume Martel, Uyen Do, Makena Pook, Tahereh Najafi, Fateme Rajabiyazdi, Charbel El-Kefraoui, Saba Balvardi, Natasha Barone, Hiba Elhaj, Philip Nguyen-Powanda, Lawrence Lee, Gabriele Baldini, Liane Feldman, Julio Fiore, Armin Rouhi, Kieran Purich, Uzair Jogiat, Deng Mapiour, Michael Kim, Brianna Greenberg, Ashlie Nadler, Hala Muaddi, Theres Stukel, Charles De Mestral, Avery Nathens, Stephen Pautler, Bobby Shayegan, Wael Hanna, Christopher Schlachta, Rodney Breau, Laura Hopkins, Timothy Jackson, Paul Karanicolas, Lily Park, Christopher Griffiths, Sam Ali, Victoria Archer, Zacharie Cloutier, Dexter Choi, Tyler McKechnie, Pablo Serrano, Kelly Vogt, J Andrew McClure, Philip Jones, Marko Mrkobrada, Suzanne Flier, Blayne Welk, Luc Dubois, Nori Bradley, Kosar Khwaja, Laura Allen, Lily Tung, Morad Hameed, Karina Spoyalo, Jacinthe Lampron, Carlos Garcia-Ochoa, Atif Jastaniah, Paul Engels, Gaurav Talwar, Zacharie Cloutier, Sam Minor, Brad Moffat, Neil Parry, Kelly Vogt, Shirley Xiaoxuan Deng, Tega Ebeye, Bree T Sharma, Anas Samman, Amna Zulfiqar, Roderick H Purzner, Brittany Greene, Melanie Tsang, Shiva Jayaraman, Patrick Murphy, Laura Allen, Chad G Ball, Morad Hameed, Paul Engels, Rahima Nenshi, Sandy Widder, Sam Minor, Neil Parry, Nori Bradley, Brad Moffat, Kelly Vogt, Mostafa Alhabboubi, Sender Liberman, Evan Wong, Talat Chughtai, Joel Turner, Jessica Lie, Sam Wiseman, Jennifer Li, Nicole Mak, Simon Laplante, Babak Namazi, Parmiss Kiani, Daniel Hashimoto, Adnan Alseidi, Mauricio Pasten, L Michael Brunt, Sujata Gill, Brian Davis, Matthew Bloom, Luise Pernar, Allan Okrainec, Amin Madani, Jessica Lie, Trevor Hamilton, Kylie Nabata, Jenny W Zhang, Darren Zhao, Phil Dawe, Morad Hameed, Jeremy Drung, Laura Allen, Ken Leslie, Jeremy Drung, Thomas Nixon, Kieran Purich, Kevin Verhoeff, Samuel Skinner, Raveena Dhaliwal, Matt Strickland, Alexandra Allard-Coutu, Barbara Heller, Victoria Wright, Wanjae Cho, Michael Wong, Kevin Singh, Sarah Mansouri, Émilie Comeau, Yves Collin, Sonia Cheng Oviedo, Alex Lee, Luckshi Rajendran, Tyler Lamb, Morgann Reid, Anastasia Turner, Kimberly Bertens, Janelle Rekman, Fady Balaa, Jillian Tweedy, Katerina Neumann, Geoff Porter, Michael A D'Elia, Iris Teo, Catherine L Forse, Reilly Musselman, Brent Hopkins, Lily Grozman, Nawaf Alshawan, Shannon Fraser, Simon Bergman, Jean-Sebastien Pelletier, Tsafrir Vanounou, Evan G Wong, Ananya Srivastava, Brodie Nolan, Lyon Qiao, James Jung, Kameela Alibhai, Isabelle Raîche, Heather McDonald, Nada Gawad, Christina Lee, Rona Cheifetz, Philippa Hawley, Jeongyoon Jenny Moon, Zachary Rehany, Mehrshad Bakhshi, Tarek Razek, Jeremy Grushka, Nathalie Boulanger, Larry Watt, Alexandra Vivier, Greg Clark, Paola Fata, Dan Deckelbaum, Kosar Khwaja, Atif Jastaniah, Evan Wong, Nathan How, Kevin Ren, Yuan Qiu, Karyssa Hamann, Karina Spoyalo, Annie Lalande, Andrea MacNeill, Jason Park, Annie Lalande, Stephanie Alexis, Karina Spoyalo, Keiko Patterson, Neha Gadhari, Jiaying Zhao, Andrea MacNeill, Zarrukh Baig, Rubia Ahmed, Ameer Farooq, Ahmer Karimuddin, Christina Schweitzer, Sam Wiseman, Joshua Keogh, Allison Chhor, Housne Begum, Noori Akhtar-Danesh, Christian Finley, Bright Huo, Daria Manos, Zhaolin Xu, Kara Matheson, Samuel Chun, John Fris, Alison Wallace, Daniel French, Yogita S Patel, Jean-Marc Baste, Yaron Shargall, Thomas K Waddell, Kazuhiro Yasufuku, Tiago N Machuca, Feng Xie, Lehana Thabane, Wael C Hanna, Yogita S Patel, Marla K Beauchamp, Joshua Wald, Lawrence Mbuagbaw, Brenda L Key, Sheryl M Green, Wael C Hanna, Uzair Jogiat, Abdollah Behzadi, Laura Donahoe, Awrad Nasralla, Julius Poon, Najib Safieddine, Nazgol Seyednejad, Iran Tavakoli, Simon Turner, Anna L McGuire, Sohat Sharma, Roy A Hilzenrat, Melissa McConechy, Ingrid Frank, Curtis Hughsman, Stephen Yip, James J Choi, John Yee, Uzair Jogiat, Hannah Sasewich, Simon Turner, Vickie Baracos, Dean Eurich, Heather Filafilo, Eric Bedard, Yung Lee, Yasith Samarasinghe, Janhavi Patel, Adree Khondker, Tyler McKechnie, Nadeesha Samarasinghe, Christian Finley, Wael Hanna, Yaron Shargall, John Agzarian, Evan Barber, Melissa Whidden, Francisco Aguirre, Andrew Graham, Gileh-Gol Akhtar-Danesh, Allison Chhor, Housne Begum, Joycelyne Ewusie, Lawrence Mbuagbaw, Shargall Yaron, Adom Bondzi-Simpson, Melanie Keshishi, Yonas Ademe, Ayalew Tizazu, Marci Rose, Sameena Uddin, Michael Ko, Riley Bowker, Jimmy Ddamba, Daniel French, Alison Wallace, Negar Ahmadi, Najib Safieddine, Sayf Gazala, Carmine Simone, Sami A Abdul, Frances Wright, Christian Finley, Patrick J Villeneuve, Sebastian Gilbert, Sudhir Sundaresan, Andrew J E Seely, Donna E Maziak, Pooja Patel, Daria Manos, Alison Wallace, Madelaine Plourde, Lyndsay Harrison, Donna Turner, Jolie Ringash, Douglas Manuel, Biniam Kidane, Vaibhav Gupta, Kathleen Decker, Laura Davis, Gail Darling, Carolyn Compton, Natalie Coburn, Randy Boyes, Michael Pugliese, Alyson Mahar, Amy Hsu, Ge Shi, Andrew Kokavec, Edward Ho, Ryan Waterman, Edward Wang, Kiera Harnden, Richard Malthaner, Rahul Nayak, Mehdi Qiabi, Ge Shi, Richard Malthaner, Rahul Nayak, Mehdi Qiabi, Jacob A Alaichi, Yogita Patel, Forough Farrokhyar, Marko Simunovic, Wael C Hanna, Biniam Kidane, Stephen Gowing, Richard Liu, Sadeesh Srinathan, Larry Tan, Linda Chang Qu, Richard Malthaner, Jacob Alaichi, Peter Malik, Yogita Patel, Wael Hanna, Emily Mackay, Umeed Fahim, Ajmal Hafizi, Ahmad S Ashrafi, Jay Lee, Tyler McKechnie, Nalin Amin, Aristithes Doumouras, Dennis Hong, Cagla Eskicioglu, Kieran Purich, Courtney Streu, Clarence Wong, Dan Schiller, Matthew Castelo, Colin Sue-Chue-Lam, Lawrence Paszat, Adena Scheer, Bettina Hansen, Teruko Kishibe, Nancy Baxter, Antonio Caycedo-Marulanda, Emma Neary, Tarek Ibrahim, Chris Verschoor, Sunil Patel, Shaila Merchant, Sami Chadi, Luis Romagnolo, Antonio Caycedo-Marulanda, Chris Verschoor, Carl Brown, Ahmer Karimuddin, Manoj Raval, Terry Phang, Elena Vikis, George Melich, Sunil Patel, Kelly Brennan, Sunil Patel, Antonio Caycedo-Marulanda, Shaila Merchant, Christopher Booth, Weidong Kong, Chad McClintock, Clare Bankhead, Carl Heneghan, Kelly Brennan, Sunil Patel, Chad McClintock, Shaila Merchant, Antonio Caycedo-Marulanda, Christopher Booth, Clare Bankhead, Carl Heneghan, Kelly Brennan, Lisa Zhang, Jennifer Flemming, Maya Djerboua, Sulaiman Nanji, Antonio Caycedo-Marulanda, Shaila Merchant, Sunil Patel, Richard Garfinkle, Marie Demian, Sarah Sabboobeh, Jeongyoon Moon, Michael Hulme-Moir, A Sender Liberman, Stan Feinberg, Dana M Hayden, Sami A Chadi, Sebastian Demyttenaere, Louise Samuel, Nevart Hotakorzian, Laurence Quintin, Nancy Morin, Gabriela Ghitulescu, Julio Faria, Carol-Ann Vasilevsky, Marylise Boutros, Sahil Sharma, Tyler Mckechnie, Jigish Khamar, Simarpreet Ichhpuniani, Cagla Eskicioglu, Sydney Candy, Sunil Patel, Shaila Merchant, Antonio Caycedo-Marulanda, Clare Bankhead, Carl Heneghan, Tyler McKechnie, Shaylan Govind, Jay Lee, Yung Lee, Dennis Hong, Cagla Eskicioglu, Tyler McKechnie, Justin Lu, Jigish Khamar, Yung Lee, Nalin Amin, Dennis Hong, Cagla Eskicioglu, Tyler McKechnie, Luisa Cardenas, Daniel Schep, Aristithes Doumouras, Dennis Hong, Raimond Wong, Oren Levine, Cagla Eskicioglu, Lawrence Lee, Carmen Mueller, Barry Stein, Patrick Charlebois, Sender Liberman, Gerald Fried, Liane Feldman, Stephan Robitaille, Anna Wang, Sender Liberman, Patrick Charlebois, Barry Stein, Julio F Fiore, Liane Feldman, Lawrence Lee, Stephan Robitaille, Anna Wang, Sender Liberman, Patrick Charlebois, Barry Stein, Julio F Fiore, Liane Feldman, Lawrence Lee, Hamid Sadri, Alan Barkun, Sydney Selznick, Jordan Levy, Ruxandra Bogdan, Jeffrey Hawel, Ahmad Elnahas, Nawar A Alkhamesi, Christopher M Schlachta, Vanessa Wiseman, Antonio Caycedo-Marulanda, Natasha Iaboni, David Hurlbut, Martin Kaufmann, Kevin Yi Mi Ren, Amoon Jamzad, Parvin Mousavi, Gabor Fichtinger, Christopher J B Nicol, John F Rudan, Vanessa Wiseman, Kelly Brennan, Antonio Caycedo-Marulanda, Shaila Merchant, Chad McClintock, Sunil V Patel, Vanessa Wiseman, Chad McClintock, Clare Bankhead, Shaila Merchant, Antonio Caycedo-Marulanda, Chris Booth, Carl Heneghan, Kelly Brennan, Lisa Zhang, Bright Huo, Alexandra Donaldson, Jennifer Flemming, Sulaiman Nanji, Antonio Caycedo-Marulanda, Shaila Merchant, Susan Brogly, Sunil Patel, Laura Baker, Tori Lenet, Lily Park, Sanjay Murthy, Reilly Musselman, Simarpreet Ichhpuniani, Tyler McKechnie, Jay Lee, Jeremy Biro, Yung Lee, Lily Park, Aristithes Doumouras, Dennis Hong, Cagla Eskicioglu, Garrett Johnson, Harminder Singh, Ramzi Helewa, Kristin Reynolds, Kathryn Sibley, Malcolm Doupe, Lisa Zhang, Kelly Brennan, Jennifer Flemming, Sulaiman Nanji, Shaila Merchant, Maya Djerboua, Antonio Caycedo-Marulanda, Sunil Patel, James Holden, Garrett Johnson, David Hochman, Ramzi Helewa, Jeongyoon Jenny Moon, Richard Garfinkle, Sophie Dell'Aniello, Phyllis Zelkowitz, Carol-Ann Vasilevsky, Paul Brassard, Marylise Boutros, Jeongyoon Jenny Moon, Amine Zoughlami, Wusiman Abibula, Alex Amar, Gabriela Ghitulescu, Carol-Ann Vasilevsky, Paul Brassard, Marylise Boutros, Jeongyoon Jenny Moon, Théa Araji, Allison Pang, Carol-Ann Vasilevsky, Marylise Boutros, Jeongyoon Jenny Moon, Alexa Ehlebracht, Julio Faria, Gabriela Ghitulescu, Nancy Morin, Allison Pang, Carol-Ann Vasilevsky, Marylise Boutros, Tiffany Paradis, Stephan Robitaille, Mahalia Oliver, Patrick Charlebois, Barry Stein, Sender Liberman, Liane S Feldman, Lawrence Lee, Zubair Bayat, Erin Kennedy, Charles Victor, Anand Govindarajan, Sunil Patel, Lisa Zhang, Kelly Brennan, Maya Djerboua, Sulaiman Nanji, Shaila J Merchant, Antonio Caycedo-Marulanda, Jennifer Flemming, Michael Fares Maalouf, Stephan Robitaille, Ruxandra Penta, Makena Pook, Julio Flavio Fiore, Liane Feldman, Lawrence Lee, Alon Wachtel, Nathalie Wong-Chong, Daniel Marinescu, Sahir Bhatnagar, Nancy Morin, Gabriela Ghitulescu, Carol-Ann Vasilevsky, Julio Faria, Marylise Boutros, Victoria Baronas, Arif Arif, Gale Ladua, Eric Bhang, Carl Brown, Fergal Donellan, Heather Stuart, Jonathan Loree, Vanessa Wiseman, Sunil Patel, Lisa Zhang, Peter Hugh MacDonald, Shaila Merchant, Kathleen Wattie Barnett, Antonio Caycedo-Marulanda, Jessica Lie, Carl Brown, Ahmer Karimuddin, Heather Stuart, Amandeep Ghuman, Terry Phang, Manoj Raval, Hyea Min Yoon, Roy Hajjar, Gabriela Fragoso, Manon Oliero, Annie Calvé, Hervé Vennin Rendos, Emmanuel Gonzalez, Nicholas J B Brereton, Thibault Cuisiniere, Claire Gerkins, Souad Djediai, Borhane Annabi, Khoudia Diop, Bertrand Routy, Patrick Laplante, Jean-François Cailhier, Nassima Taleb, Hefzi Alratrout, François Dagbert, Rasmy Loungnarath, Herawaty Sebajang, Frank Schwenter, Ramses Wassef, Richard Ratelle, Eric Debroux, Carole Richard, Manuela M Santos, Alexa Ehlebracht, Doulia Hamad, Hatim Alsulaim, Olivia Monton, Daniel Marinescu, Allison Pang, Carol-Ann Vasilevsky, Marylise Boutros, Natasha Caminsky, Daniel Marinescu, Mohammed Alqahtani, Allison Pang, Gabriela Ghitulescu, Carol-Ann Vasilevsky, Marylise Boutros, Natasha Caminsky, Daniel Marinescu, Richard Garfinkle, Marylise Boutros, Richard Gilbert, Terry Zwiep, Joshua Greenberg, Tori Lenet, Reilly Musselman, Lara Williams, Isabelle Raiche, Daniel McIsaac, Kednapa Thavorn, Dean Fergusson, Husein Moloo, Geneviève Morin, Janyssa Charbonneau, Xavier Paré, Jonathan Frigault, François Letarte, Rebecca C Auer, Michael Ott, Paul Karanicolas, Muriel Brackstone, Shady Ashmalla, Joel Weaver, Vicky Tagalakis, Marylise Boutros, Peter Stotland, Antonio Caycedo-Marulanda, Husein Moloo, Shiva Jayaraman, Sunil Patel, Gregoire LeGal, Silvana Spadafora, Steven Maclellan, Daniel Trottier, Derek Jonker, Timothy Asmis, Ranjeeta Mallick, Timothy Ramsay, Marc Carrier, Terry Phang, Delaram Shojaei, Ali Motamedi, Anu Ghuman, Ahmer Karimuddin, Manoj Raval, Carl Brown, Delaram Shojaei, Jessica Hopkins, Haili Wang, Don Buie, Jessica Hopkins, Haili Wang, Don Buie, Yosef Levin, Nasra Al Busaidi, Fateme Rajabiyazdi, Marie Demian, Marylise Boutros, Armaghan Alam, Ameer Farooq, Carl Brown, Terry Phang, Amandeep Ghuman, Ahmer Karimuddin, Manoj Raval, Farhad Udwadia, Natasha Caminsky, Daniel Marinescu, Mohammed Alqahtani, Allison Pang, Carol-Ann Vasilevsky, Marylise Boutros, Sarah Mansouri, Sonia Cheng Oviedo, Nathalie McFadden, Philip Lagace, Richard Spence, Greg Hirsch, Katerina Neumann, Philip Lagace, Katerina Neumann, Richard Spence, Charbel El-Kefraoui, Garrett Johnson, Harminder Singh, Ramzi Helewa, Marguerite Mainprize, Ayse Yilbas, Fernando Spencer Netto, Joel Katz, Megan Melland-Smith, Bree Sharma, Usman Khan, Markus Selzner, Kevin Verhoeff, Valentin Mocanu, Jerry Dang, Hillary Wilson, Noah Switzer, Daniel Birch, Shahzeer Karmali, Kevin Verhoeff, Valentin Mocanu, Uzair Jogiat, Hayley Forbes, Noah Switzer, Daniel Birch, Shahzeer Karmali, Khadija Nasser, Kevin Verhoeff, Valentin Mocanu, Janice Kung, Kieran Purich, Noah Switzer, Daniel Birch, Shahzeer Karmali, Olivier Mailloux, Nicolas Tassé, André Tchernof, Mélanie Nadeau, Philip Dawe, Andrew Beckett, Laurent Biertho, Kieran Purich, Andrea Lin, Kevin Verhoeff, Valentin Mocanu, Janice Y Kung, Daniel W Birch, Shahzeer Karmali, Noah J Switzer, Marta Whyte, Melinda Fowler-Woods, Amanda Fowler-Woods, Geraldine Shingoose, Andrew Hatala, Felicia Daeninck, Ashley Vergis, Krista Hardy, Kathleen Clouston, Ting Li, Estifanos Debru, Mirza Shaharyar Ahmad, Warren Sun, Jerry Dang, Noah Switzer, Daniel Birch, Shahzeer Karmali, Christopher De Gara, Warren Sun, Jennifer Halasz, Jerry Dang, Noah Switzer, Aliyah Kanji, Daniel Birch, Renuca Modi, Shahzeer Karmali, Hilalion San Ahn, Jeffrey Gu, Amer Jarrar, Nicole Kolozsvari, Yung Lee, Yasith Samarasinghe, Lucy Chen, Akithma Hapugall, Arshia Javidan, Tyler McKechnie, Aristithes Doumouras, Dennis Hong, Eileen Roach, Simon Laplante, Shannon Stogryn, Azusa Maeda, Timothy Jackson, Allan Okrainec, Alexandra Chow, Daniel Birch, Shahzeer Karmali, Aliyah Kanji, Noah Switzer, Jessica Trac, Michael Balas, Denise Gee, Matthew Hutter, Ozanan Meireles, James Jung, Wenjing He, Ashley Vergis, Krista Hardy, Karim Ramji, Vanessa Boudreau, Dennis Hong, Mehran Anvari, Pouya Iranmanesh, Karen Barlow, Tyler Cookson, Rafik Bolis, Harsha Shanthanna, Jonah Shiroky, Ekaterina Kouzmina, Shaidah Deghan, Boris Zevin, Cypriana Koziak, Zacharie Cloutier, Tyler Cookson, Karen Barlow, Vanessa Boudreau, Mehran Anvari, Intekhab Hossain, Jane Brodie, Erin O'Brien, Katherine Tedman-Aucoin, Diana Lawlor, Raleen Murphy, Laurie Twells, David Pace, James Ellsmere, Bradley Evans, Valentin Mocanu, Terry Zhang, Edward Deehan, Dina Kao, Naomi Hotte, Daniel Birch, Shahzeer Karmali, Kalutota Samarasinghe, Jens Walter, Karen Madsen, Nader Hanna, Erin Williams, Weidong Kong, Adam Fundytus, Christopher Booth, Sunil Patel, Antonio Caycedo-Marulanda, Wiley Chung, Sulaiman Nanji, Shaila Merchant, Matthew Castelo, Bettina Hansen, Lawrence Paszat, Nancy Baxter, Adena Scheer, Makena Pook, Tahereh Najafi Ghezeljeh, Maxime Lapointe-Gagner, Philip Nguyen-Powanda, Hiba Elhaj, Fateme Rajabiyazdi, Lawrence Lee, Liane S Feldman, Julio Fiore, Jesse Zuckerman, Rinku Sutradhar, Barbara Haas, Matthew Guttman, Antoine Eskander, Natalie Coburn, Tyler Chesney, Bourke Tillman, Victoria Zuk, Alyson Mahar, Amy Hsu, Wing Chan, Julie Hallet, Woo Jin Choi, Keegan Guidolin, Filomena Servidio-Italiano, Fayez Quereshy, Gonzalo Sapisochin, Akie Watanabe, Eitan Prisman, Elliot Mitmaker, Ross Walker, Jonn Wu, Anne Nguyen, Sam Wiseman, Bianka Saravana-Bawan, Dennis Hong, Michael Gupta, Jesse Pasternak, David Cyr, Omar Vergara-Fernandez, Amanpreet Brar, James Conner, Richard Kirsch, Mantaj Brar, Erin Kennedy, Anand Govindarajan, Robert Gryfe, Helen MacRae, Zane Cohen, Robin McLeod, Carol Swallow, Muriel Brackstone, Farhad Ghasemi, Victoria Ivankovic, Megan Delisle, Dawn Stacey, Jad Abou-Khalil, Fady Balaa, Kimberly Bertens, Brittney Dingley, Guillaume Martel, Kristen McAlpine, Carolyn Nessim, Shaheer Tadros, Marc Carrier, Rebecca Auer, Ananya Gopika Nair, David Lim, Dhruvin Hirpara, Antoine Eskander, Natalie Coburn, Rinku Sutradhar, Wing Chan, Julie Hallet, Cecily Stockley, Felicia Pickard, Alexander Mathieson, Michael Hogan, Melanie Seal, Deanna Ng, Belkacem Acidi, Wendy Johnston, Dario Callegaro, Savtaj Brar, Rebecca Gladdy, Peter Chung, Charles Catton, Korosh Khalili, Charles Honore, Carol Swallow, Shelly Luu, Ning Fu, Karineh Kazazian, Karina Pacholczyk, Deanna Ng, Jossie Swett-Cosentino, Paul Savage, Yukiko Shibahara, Sangeetha Kalimuthu, Osvaldo Espin-Garcia, James Conner, Jonathan Yeung, Gail Darling, Carol Swallow, Léamarie Meloche-Dumas, Frédéric Mercier, Victoria Barabash, Calvin Law, Natalie Coburn, Simron Singh, Sten Myrehaug, Wing Chan, Julie Hallet, Michael A D'Elia, Rebecca C Auer, Ashley Eom, Narry Muhn, Barbara Heller, Peter Lovrics, Katelynn Tang, Shawn Khan, Deanna Ng, Daniel Koerber, Eisar Al-Sukhni, David Cyr, Karineh Kazazian, Carol Swallow, Erika Schmitz, Sameer Apte, Carolyn Nessim, Ko Ta Chen, Judy Ban, Leo Chen, Elaine McKevitt, Rebecca Warburton, Jin-Si Pao, Carol Dingee, Urve Kuusk, Amy Bazzarelli, Jieun Newman-Bremang, Nicole Look Hong, Anna Gagliardi, Bryanna Nyhof, Kevin Verhoeff, Braulio Marfil-Garza, Gurpal Sandha, David Cooper, Khaled Dajani, David Bigam, Blaire Anderson, Tatsuya Kin, Anna Lam, Doug O'Gorman, Peter Senior, Camillo Ricordi, A M James Shapiro, Nic Jette, Michael Moser, Zuhaib Mir, Henry Lam, Jennifer Flemming, Diederick Jalink, Sulaiman Nanji, Sean Bennett, Christopher Griffiths, Betty Zhang, Kasia Tywonek, Brandon Meyers, Pablo Serrano, Luckshi Rajendran, Tori Lenet, Risa Shorr, Jad Abou-Khalil, Kimberly Bertens, Fady Balaa, Guillaume Martel, Jesse Zuckerman, Shiva Jayaraman, Alice Wei, Alyson Mahar, Yosuf Kaliwal, Guillaume Martel, Natalie Coburn, Julie Hallet, Woo Jin Choi, Phil Williams, Marco Claasen, Tommy Ivanics, Marina Englesakis, Steven Gallinger, Bettina Hansen, Gonzalo Sapisochin, Woo Jin Choi, Tommy Ivanics, Marco Claasen, Steven Gallinger, Bettina Hansen, Gonzalo Sapisochin, Richard Gilbert, Tori Lenet, Jad Abou-Khalil, Fady Balaa, Guillaume Martel, Alexandre Brind'Amour, Kimberly Bertens, Tori Lenet, Fady Balaa, Kimberly Bertens, Guillaume Martel, Jad Abou-Khalil, Nawal Amhis, Yves Collin, Marco Claasen, Tommy Ivanics, Christian Toso, Rene Adam, Jan Ijzermans, Gonzalo Sapisochin, Wojtek Polak, Sarah Mansouri, Maxime Léveillé, Christine Lawson, Yves Collin, Lee-Hwa Tai, Adriana Workewych, Brittany Greene, Shiva Jayaraman, Melanie Tsang, Alex Lee, Ahmed Al-Arnawoot, Luckshi Rajendran, Tyler Lamb, Anastasia Turner, Morgann Reid, Janelle Rekman, Richard Mimeault, Jad Abou-Khalil, Kimberly Bertens, Guillaume Martel, Fady Balaa, Evelyn Waugh, Chris Zhang, Madeline Lemke, Juan Glinka, Ken Leslie, Anton Skaro, Ephraim Tang, Alice Zhu, Brittany Greene, Melanie Tsang, Shiva Jayaraman, Helia Nabavian, Lev Bubis, Shiva Jayaraman, Melanie E Tsang, Jorge Roldan, Olivia Ganescu, Tsafrir Vanounou, Jean-Sébastien Pelletier, Andrew Lagrotteria, Brittany Greene, Melanie Tsang, Shiva Jayaraman, Jorge Roldan, Olivia Ganescu, Jean-Sébastien Pelletier, Tsafrir Vanounou, Luckshi Rajendran, Woo Jin Choi, Hala Muaddi, Tommy Ivanics, Marco P A W Classen, Gonzalo Sapisochin
No abstract text is available yet for this article.
2022: Canadian Journal of Surgery. Journal Canadien de Chirurgie
#34
JOURNAL ARTICLE
Alexandria Macmadu, Annajane Yolken, Lisa Frueh, Jai'el R Toussaint, Roxxanne Newman, Brendan P Jacka, Alexandra B Collins, Brandon D L Marshall
BACKGROUND: Narrow or non-existent Good Samaritan Law protections and harsh drug selling statutes in the USA have been shown to deter bystanders from seeking medical assistance for overdoses. Additionally, little is known about the actions that police take when responding to overdose events. The objectives of this study were to assess the prevalence and correlates of naloxone administration by police, as well as to examine overdose events where arrests were made and those in which the person who overdosed was described as combative...
October 18, 2022: Harm Reduction Journal
#35
MULTICENTER STUDY
Richard D Carvajal, Marcus O Butler, Alexander N Shoushtari, Jessica C Hassel, Alexandra Ikeguchi, Leonel Hernandez-Aya, Paul Nathan, Omid Hamid, Josep M Piulats, Matthew Rioth, Douglas B Johnson, Jason J Luke, Enrique Espinosa, Serge Leyvraz, Laura Collins, Howard M Goodall, Koustubh Ranade, Chris Holland, Shaad E Abdullah, Joseph J Sacco, Takami Sato
In patients with previously treated metastatic uveal melanoma, the historical 1 year overall survival rate is 37% with a median overall survival of 7.8 months. We conducted a multicenter, single-arm, open-label phase 2 study of tebentafusp, a soluble T cell receptor bispecific (gp100×CD3), in 127 patients with treatment-refractory metastatic uveal melanoma (NCT02570308). The primary endpoint was the estimation of objective response rate based on RECIST (Response Evaluation Criteria in Solid Tumours) v1...
November 2022: Nature Medicine
#36
JOURNAL ARTICLE
Daniel S Green, Franklin Ning, Anna Duemler, Timothy G Myers, Kathryn Trewitt, Irene Ekwede, Ann McCoy, Nicole Houston, Jung-Min Lee, Stanley Lipkowitz, Alexandra Zimmer, Miroslava Pavelova, Erin N Villanueva, Leslie Smith, Andrew Blakely, Yovanni Casablanca, Steven L Highfill, David F Stroncek, Naoza Collins-Johnson, Sandhya Panch, JoLynn Procter, Chauha Pham, Steven M Holland, Lindsey B Rosen, Ana T Nunes, Kathryn C Zoon, Christopher B Cole, Christina M Annunziata
PURPOSE: Ovarian cancer is the most lethal gynecologic cancer and intrinsically resistant to checkpoint immunotherapies. We sought to augment innate immunity, building on previous work with interferons and monocytes. EXPERIMENTAL DESIGN: Preclinical experiments were designed to define the mechanisms of cancer cell death mediated by the combination of interferons alpha and gamma with monocytes. We translated these preclinical findings into a phase I trial of autologous IFN-activated monocytes administered intraperitoneally to platinum-resistant or -refractory ovarian cancer patients...
September 13, 2022: Clinical Cancer Research
#37
JOURNAL ARTICLE
Zhe Wang, Andrew Emmerich, Nicolas J Pillon, Tim Moore, Daiane Hemerich, Marilyn C Cornelis, Eugenia Mazzaferro, Siacia Broos, Tarunveer S Ahluwalia, Traci M Bartz, Amy R Bentley, Lawrence F Bielak, Mike Chong, Audrey Y Chu, Diane Berry, Rajkumar Dorajoo, Nicole D Dueker, Elisa Kasbohm, Bjarke Feenstra, Mary F Feitosa, Christian Gieger, Mariaelisa Graff, Leanne M Hall, Toomas Haller, Fernando P Hartwig, David A Hillis, Ville Huikari, Nancy Heard-Costa, Christina Holzapfel, Anne U Jackson, Åsa Johansson, Anja Moltke Jørgensen, Marika A Kaakinen, Robert Karlsson, Kathleen F Kerr, Boram Kim, Chantal M Koolhaas, Zoltan Kutalik, Vasiliki Lagou, Penelope A Lind, Mattias Lorentzon, Leo-Pekka Lyytikäinen, Massimo Mangino, Christoph Metzendorf, Kristine R Monroe, Alexander Pacolet, Louis Pérusse, Rene Pool, Rebecca C Richmond, Natalia V Rivera, Sebastien Robiou-du-Pont, Katharina E Schraut, Christina-Alexandra Schulz, Heather M Stringham, Toshiko Tanaka, Alexander Teumer, Constance Turman, Peter J van der Most, Mathias Vanmunster, Frank J A van Rooij, Jana V van Vliet-Ostaptchouk, Xiaoshuai Zhang, Jing-Hua Zhao, Wei Zhao, Zhanna Balkhiyarova, Marie N Balslev-Harder, Sebastian E Baumeister, John Beilby, John Blangero, Dorret I Boomsma, Soren Brage, Peter S Braund, Jennifer A Brody, Marcel Bruinenberg, Ulf Ekelund, Ching-Ti Liu, John W Cole, Francis S Collins, L Adrienne Cupples, Tõnu Esko, Stefan Enroth, Jessica D Faul, Lindsay Fernandez-Rhodes, Alison E Fohner, Oscar H Franco, Tessel E Galesloot, Scott D Gordon, Niels Grarup, Catharina A Hartman, Gerardo Heiss, Jennie Hui, Thomas Illig, Russell Jago, Alan James, Peter K Joshi, Taeyeong Jung, Mika Kähönen, Tuomas O Kilpeläinen, Woon-Puay Koh, Ivana Kolcic, Peter P Kraft, Johanna Kuusisto, Lenore J Launer, Aihua Li, Allan Linneberg, Jian'an Luan, Pedro Marques Vidal, Sarah E Medland, Yuri Milaneschi, Arden Moscati, Bill Musk, Christopher P Nelson, Ilja M Nolte, Nancy L Pedersen, Annette Peters, Patricia A Peyser, Christine Power, Olli T Raitakari, Mägi Reedik, Alex P Reiner, Paul M Ridker, Igor Rudan, Kathy Ryan, Mark A Sarzynski, Laura J Scott, Robert A Scott, Stephen Sidney, Kristin Siggeirsdottir, Albert V Smith, Jennifer A Smith, Emily Sonestedt, Marin Strøm, E Shyong Tai, Koon K Teo, Barbara Thorand, Anke Tönjes, Angelo Tremblay, Andre G Uitterlinden, Jagadish Vangipurapu, Natasja van Schoor, Uwe Völker, Gonneke Willemsen, Kayleen Williams, Quenna Wong, Huichun Xu, Kristin L Young, Jian Min Yuan, M Carola Zillikens, Alan B Zonderman, Adam Ameur, Stefania Bandinelli, Joshua C Bis, Michael Boehnke, Claude Bouchard, Daniel I Chasman, George Davey Smith, Eco J C de Geus, Louise Deldicque, Marcus Dörr, Michele K Evans, Luigi Ferrucci, Myriam Fornage, Caroline Fox, Theodore Garland, Vilmundur Gudnason, Ulf Gyllensten, Torben Hansen, Caroline Hayward, Bernardo L Horta, Elina Hyppönen, Marjo-Riitta Jarvelin, W Craig Johnson, Sharon L R Kardia, Lambertus A Kiemeney, Markku Laakso, Claudia Langenberg, Terho Lehtimäki, Loic Le Marchand, Patrik K E Magnusson, Nicholas G Martin, Mads Melbye, Andres Metspalu, David Meyre, Kari E North, Claes Ohlsson, Albertine J Oldehinkel, Marju Orho-Melander, Guillaume Pare, Taesung Park, Oluf Pedersen, Brenda W J H Penninx, Tune H Pers, Ozren Polasek, Inga Prokopenko, Charles N Rotimi, Nilesh J Samani, Xueling Sim, Harold Snieder, Thorkild I A Sørensen, Tim D Spector, Nicholas J Timpson, Rob M van Dam, Nathalie van der Velde, Cornelia M van Duijn, Peter Vollenweider, Henry Völzke, Trudy Voortman, Gérard Waeber, Nicholas J Wareham, David R Weir, Heinz-Erich Wichmann, James F Wilson, Andrea L Hevener, Anna Krook, Juleen R Zierath, Martine A I Thomis, Ruth J F Loos, Marcel den Hoed
Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training...
September 2022: Nature Genetics
#38
JOURNAL ARTICLE
Ricky Tirtakusuma, Katarzyna Szoltysek, Paul Milne, Vasily V Grinev, Anetta Ptasinska, Paulynn S Chin, Claus Meyer, Sirintra Nakjang, Jayne Y Hehir-Kwa, Daniel Williamson, Pierre Cauchy, Peter Keane, Salam A Assi, Minoo Ashtiani, Sophie G Kellaway, Maria R Imperato, Fotini Vogiatzi, Elizabeth K Schweighart, Shan Lin, Mark Wunderlich, Janine Stutterheim, Alexander Komkov, Elena Zerkalenkova, Paul Evans, Hesta McNeill, Alex Elder, Natalia Martinez-Soria, Sarah E Fordham, Yuzhe Shi, Lisa J Russell, Deepali Pal, Alex Smith, Zoya Kingsbury, Jennifer Becq, Cornelia Eckert, Oskar A Haas, Peter Carey, Simon Bailey, Roderick Skinner, Natalia Miakova, Matthew Collin, Venetia Bigley, Muzlifah Haniffa, Rolf Marschalek, Christine J Harrison, Catherine A Cargo, Denis Schewe, Yulia Olshanskaya, Michael J Thirman, Peter N Cockerill, James C Mulloy, Helen J Blair, Josef Vormoor, James M Allan, Constanze Bonifer, Olaf Heidenreich, Simon Bomken
The fusion gene MLL/AF4 defines a high-risk subtype of pro-B acute lymphoblastic leukemia. Relapse can be associated with a lineage switch from acute lymphoblastic to acute myeloid leukemia, resulting in poor clinical outcomes caused by resistance to chemotherapies and immunotherapies. In this study, the myeloid relapses shared oncogene fusion breakpoints with their matched lymphoid presentations and originated from various differentiation stages from immature progenitors through to committed B-cell precursors...
October 27, 2022: Blood
#39
JOURNAL ARTICLE
Alexandria Macmadu, Lisa Frueh, Alexandra B Collins, Roxxanne Newman, Nancy P Barnett, Josiah D Rich, Melissa A Clark, Brandon D L Marshall
BACKGROUND: Scant research has examined the influence of overdoses occurring in social networks (i.e., knowing someone who has overdosed) on individual overdose risk. We sought to characterize drug use behaviors of individuals following the overdose of someone in their social network. METHODS: We conducted semi-structured interviews with 25 people who use drugs and knew someone who overdosed in the prior 90 days. All interviews were conducted in person in Rhode Island from July to October 2021...
September 2022: International Journal on Drug Policy
#40
JOURNAL ARTICLE
Alexandra B Collins, Ryan McNeil, Sandra Czechaczek, Jade Boyd
Through rapid ethnography undertaken in Vancouver, Canada's Downtown Eastside - one of Canada's overdose epicenters - this article examines how gendered expectations of labor shape overdose risk for structurally vulnerable women and gender diverse people who use drugs. Drawing on two participant narratives, we explore how structural, symbolic, and everyday violence frame the lives of women and gender diverse people who use drugs in ways that drive their overdose risk as they balance self-care with caretaking, paid work, and basic survival...
2022: Critical Public Health
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