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Atrial natriuretic factor

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https://www.readbyqxmd.com/read/29773102/-over-expression-of-bdnf-inhibits-angiotensin-ii-induced-apoptosis-of-cardiomyocytes-in-sd-rats
#1
Jingli Cao, Yingfeng Wu, Geming Liu, Zhenlong Li
Objective To investigate the role and molecular mechanism of brain-derived neurotrophic factor (BDNF) against the process of cardiomyocyte hypertrophy and apoptosis. Methods Cardiomyocyte hypertrophy were estabolished by angiotensin II (Ang II) in neonatal cardiomyocytes in vitro and incomplete ligature of abdominal aorta of SD rats in vivo. BDNF over-expressing recombinant vector pcDNA5-BDNF was transfected into cardiomyocytes by liposomes. Immunofluorescence staining was used to detect the effect of BDNF transfection on the surface area of myocardial cells...
March 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29761335/-biomarkers-and-atrial-fibrillation-prediction-of-recurrences-and-thromboembolic-events-after-rhythm-control-management
#2
REVIEW
Jelena Kornej, Katja Schumacher, Daniela Husser, Gerhard Hindricks
Atrial fibrillation (AF) is the most common arrhythmia in clinical praxis and is associated with an increased risk for cardio- and cerebrovascular complications leading to an increased mortality. Catheter ablation represents one of the most important and efficient therapy strategies in AF patients. Nevertheless, the high incidence of arrhythmia recurrences after catheter ablation leads to repeated procedures and higher treatment costs. Recently, several scores had been developed to predict rhythm outcomes after catheter ablation...
May 14, 2018: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/29759295/effect-of-acute-kidney-injury-after-percutaneous-mitral-valve-repair-on-outcome
#3
Maximilian Spieker, Katharina Hellhammer, Stratis Katsianos, Julian Wiora, Tobias Zeus, Patrick Horn, Malte Kelm, Ralf Westenfeld
Limited data exist on the occurrence of acute kidney injury (AKI) associated with percutaneous mitral valve repair (PMVR). The objectives of the present study were (1) to assess the prevalence of AKI after MitraClip (Abbott Vascular, Santa Clara, California) implantation, (2) to analyze the predictive factors of AKI, and (3) to evaluate the prognostic value of AKI after PMVR with a view to optimizing the management of high-risk patients. A total of 206 patients (serum creatinine [SCr] 1.3 ± 0.6 mg/dl, estimated glomerular filtration rate 55 ± 24 ml/min) who underwent PMVR were included...
April 17, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29747050/long-non-coding-rna-chrf-facilitates-cardiac-hypertrophy-through-regulating-akt3-via-mir-93
#4
Yang Wo, Jie Guo, Peihui Li, Hongxia Yang, Jinshan Wo
BACKGROUND: Non-coding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been demonstrated as central mediators in cardiac hypertrophy responses. LncRNA cardiac hypertrophy related factor (CHRF) has been reported to be implicated in cardiac hypertrophy. However, the underlying mechanisms of CHRF have not been thoroughly elucidated. METHODS: Expressions of CHRF and microRNA-93 (miR-93) in heart tissues and cardiomyocytes were detected by RT-qPCR assay...
April 11, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29729262/potential-roles-of-circulating-matrix-metalloproteinase-28-mmp-28-in-patients-with-atrial-fibrillation
#5
Gao Zhan, Ge Wenhua, Hu Jie, Qu Xiang, Chen Lingzhi, Xia Xue, Chen Xing-Xing, Zhu Qianli, Huang Weijian, Zhou Hao
AIMS: Atrial fibrillation is the most common heart disease. Previous research has found that several members of the matrix metalloproteinase (MMP) family are involved. However, the role of the most recently discovered member of the MMP family, MMP-28, has not been fully investigated. The present study aimed to reveal the role of MMP-28 in atrial fibrillation. MAIN METHODS: 254 patients with sinus rhythm, paroxysmal atrial fibrillation, or persistent atrial fibrillation were enrolled in this prospective observational study...
May 2, 2018: Life Sciences
https://www.readbyqxmd.com/read/29728805/large-volume-crystalloid-fluid-is-associated-with-increased-hyaluronan-shedding-and-inflammation-in-a-canine-hemorrhagic-shock-model
#6
Lisa Smart, C J Boyd, M A Claus, E Bosio, G Hosgood, A Raisis
Shedding of the endothelial glycocalyx precedes leukocyte activation and adherence in acute inflammation. Rapid administration of crystalloid or colloid fluids for treating hemorrhagic shock may cause endothelial glycocalyx shedding, thereby increasing inflammation. This study aimed to compare the effect of different fluid treatments in a canine shock model on glycocalyx biomarker, hyaluronan, and inflammatory biomarkers. Greyhound dogs under general anesthesia subject to hemorrhage for 60 min were given 20 mL kg-1 of either fresh whole blood (FWB), hydroxyethyl starch (HES) 130/0...
May 4, 2018: Inflammation
https://www.readbyqxmd.com/read/29721000/association-between-preoperative-high-sensitive-troponin-i-levels-and-cardiovascular-events-after-hip-fracture-surgery-in-the-elderly
#7
Bum Sung Kim, Tae-Hoon Kim, Jeong-Hwan Oh, Chang Hee Kwon, Sung Hea Kim, Hyun-Joong Kim, Heung Kon Hwang, Sang-Man Chung
Objective: Cardiovascular complications contribute to postoperative morbidity and mortality in elderly hip fracture patients. Limited data are available regarding which preoperative risk factors predict cardiovascular course following hip fracture surgery (HFS). We used high sensitive troponin I (hs-TnI) assays and clinical parameters to identify preoperative risk factors associated with major adverse cardiac events (MACE) in elderly hip fracture patients. Method: From August 2014 to November 2016, 575 patients with hip fracture were enrolled in a retrospective, single-center registry...
March 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29682806/biomarkers-for-heart-failure-small-molecules-with-high-clinical-relevance
#8
REVIEW
C Magnussen, S Blankenberg
Heart failure (HF) is a rising epidemic due to the ageing population and progress in all areas of medicine. Thus, research efforts are made to ensure a timely diagnosis, to improve prognosis and treatment of the disease and to facilitate risk prediction at the population level. Because of their noninvasive determination with mostly high sensitivity and accuracy, circulating blood biomarkers are becoming increasingly important for daily clinical practice. Natriuretic peptides, especially B-type natriuretic peptide (BNP), N-terminal pro-B-type natriuretic peptide (Nt-proBNP) and midregional pro-atrial natriuretic peptide (MR-proANP) and cardiac troponins are established blood biomarkers in HF diagnosis and prognosis of HF-related outcomes...
April 22, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29678849/effects-of-adenovirus-mediated-vegf165-gene-therapy-on-myocardial-infarction
#9
Chao Wang, Boya Zhang, Yu Lin, Yang Dong
AIM: To evaluate the role of adenovirus-mediated transduction human VEGF isoform 165 via direct myocardial injection in rats with an occluded circumflex coronary artery, and the possible underlying mechanism. METHODS: Sprague-Dawley rats were induced myocardial infarction (MI) with ligation of the left coronary artery. Rats were randomly divided into 4 groups: 1) the sham group; 2) the MI group; 3) the NS (normal saline) group and 4) the VEGF group. Direct myocardial injection of 0...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29672210/prognostic-utility-of-stress-testing-and-cardiac-biomarkers-in-menopausal-women-at-low-to-intermediate-risk-for-coronary-artery-disease-smart-study-5-year-outcome
#10
Sahar S Abdelmoneim, Caroline A Ball, Francesca Mantovani, Mary E Hagen, Susan Eifert-Rain, Susan Wilansky, Ramon Castello, Patricia A Pellikka, Patricia J M Best, Sharon L Mulvagh
BACKGROUND: In women with low to intermediate risk of coronary artery disease (CAD), prognostic detection strategies have been controversial. We present the follow-up data of the SMART trial in peri/postmenopausal women at low to intermediate risk of CAD. OBJECTIVES: To determine the value of contrast stress echocardiography (CSE), stress electrocardiogram (sECG), and serum biomarkers for prediction of cardiovascular events (CE) in peri/postmenopausal women at low to intermediate risk of CAD...
April 19, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29665154/development-and-validation-of-a-risk-stratification-score-for-new-onset-atrial-fibrillation-in-stemi-patients-undergoing-primary-percutaneous-coronary-intervention
#11
Annamaria Mazzone, Marco Scalese, Umberto Paradossi, Serena Del Turco, Nicoletta Botto, Alberto De Caterina, Giuseppe Trianni, Marcello Ravani, Antonio Rizza, Sabrina Molinaro, Cataldo Palmieri, Sergio Berti, Giuseppina Basta
AIM: New-onset atrial fibrillation (NOAF) is a complication not infrequent in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) and has been associated with worse in-hospital and long-term prognosis. We aimed to develop and validate a risk score based on common clinical risk factors and routine blood biomarkers to assess the early incidence of NOAF post-pPCI, before discharge. METHODS: The risk score for NOAF occurrence during hospitalisation (about 5 days) was developed in a cohort of 1135 consecutive STEMI patients undergoing pPCI while was externally validated in a temporal cohort of 771 STEMI patients...
April 17, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29663995/-risk-factors-of-atrial-fibrillation-in-critical-ill-patients
#12
Jianyu Fu, Hongying Bi, Yunsong Xia, Hui Fang, Xu Liu, Yan Tang, Difen Wang
OBJECTIVE: To observe the clinical features of atrial fibrillation (AF) patients, and to explore the correlation between the routine detection index and the new-onset AF and to find out risk factors for new AF in critically ill patients. METHODS: A prospective observational study was conducted. The patients with AF admitted to intensive care unit (ICU) of the Affiliated Hospital of Guizhou Medical University from March 2016 to June 2017 were enrolled. The patients were divided into new-onset AF group and past-existed AF group according to their past history of AF (including persistent AF, paroxysmal AF or permanent AF)...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29628444/ph-domain-leucine-rich-repeat-protein-phosphatase-2-phlpp2-regulates-g-protein-coupled-receptor-kinase-5-grk5-induced-cardiac-hypertrophy-in-vitro
#13
Szu-Tsen Yeh, Cristina M Zambrano, Walter J Koch, Nicole H Purcell
PH domain leucine-rich repeat protein phosphatase (PHLPP) is a serine/threonine phosphatase that has been shown to regulate cell growth and survival through dephosphorylation of several members of the AGC family of kinases. G-protein coupled receptor kinase 5 (GRK5) is an AGC kinase that regulates phenylephrine (PE) induced cardiac hypertrophy through its non-canonical function of directly targeting proteins to the nucleus to regulate transcription. Here we investigated the possibility that the PHLPP2 isoform can regulate GRK5 induced cardiomyocyte hypertrophy in neonatal rat ventricular myocytes (NRVMs)...
April 8, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29622288/comparison-of-prognostic-usefulness-of-serum-insulin-like-growth-factor-binding-protein-7-in-patients-with-heart-failure-and-preserved-versus-reduced-left-ventricular-ejection-fraction
#14
Camilla Hage, Mette Bjerre, Jan Frystyk, Harvest F Gu, Kerstin Brismar, Erwan Donal, Jean-Claude Daubert, Cecilia Linde, Lars H Lund
We aimed to characterize of the role of insulin-like growth factor-binding protein 7 (IGFBP-7) in heart failure (HF) pathophysiology. IGFBP-7 has been associated with cardiac hypertrophy and diastolic dysfunction in HF. In 86 patients with HF with a preserved ejection fraction (HFpEF) (ejection fraction [EF] ≥45%) and 79 with HF with a reduced ejection fraction (HFrEF), we assessed concentrations of serum IGFBP-7, correlations between serum IGFBP-7 and clinical data, diastolic function, and associations with outcome...
March 14, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29604277/jip3-deficiency-attenuates-cardiac-hypertrophy-by-suppression-of-jnk-pathway
#15
Qinghua Ma, Yuxiu Liu, Lianghua Chen
Pathological cardiac hypertrophy is a leading cause of morbidity and mortality worldwide; however, our understanding of the molecular mechanisms revealing the disease is still unclear. In the present study, we suggested that c-Jun N-terminal kinase (JNK)-interacting protein 3 (JIP3), involved in various cellular processes, played an essential role in regulating pathological cardiac hypertrophy through in vivo and in vitro studies. JIP3 was highly expressed in human hearts with hypertrophic cardiomyopathy (HCM), and in mouse hypertrophic hearts...
March 28, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29584705/particulate-guanylyl-cyclase-a-cgmp-signaling-pathway-in-the-kidney-physiologic-and-therapeutic-indications
#16
REVIEW
Yang Chen, John C Burnett
The particulate guanylyl cyclase A (pGC-A)/cGMP pathway plays important roles in regulating renal physiological function and as well as in counteracting pathophysiological conditions. Naturally occurring peptide pGC-A activators consist of atrial natriuretic peptide (ANP), b-type NP (BNP), and urodilatin (URO). These activators bind and activate pGC-A, generating the second messenger cyclic 3',5' guanosine monophosphate (cGMP). Cyclic GMP binds to downstream pathway effector molecules including protein kinase G (PKG), cGMP-gated ion channels, and phosphodiesterases (PDEs)...
March 27, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29578055/serum-nitric-oxide-level-correlates-with-serum-brain-natriuretic-peptide-and-whole-blood-viscosity-in-hemodialysis-patients
#17
Jong Hwan Jung, Dong Hwan Lee, Young I Cho, Yoon Jung Chae, Yu Jin Jung, Kyung Pyo Kang, Won Kim
BACKGROUND: Nitric oxide (NO) is tonically synthesized by the vascular endothelium and known as a marker of vasodilatation and blood flow. As NO has a critical role in hemodynamics, NO may be associated with other hemodynamics-related factors including atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP) and whole blood viscosity (WBV). It has been reported that serum NO level increased in patients undergoing hemodialysis. However, there are few reports about the relationship between NO and hemodynamic parameters in hemodialysis patients...
March 23, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29569957/protein-tyrosine-phosphatase-1b-inactivation-limits-aging-associated-heart-failure-in-mice
#18
Marie Besnier, David Coquerel, Julie Favre, Anais Dumesnil, Dominique Guerrot, Isabelle Remy-Jouet, Paul Mulder, Zoubir Djerada, Fabienne Tamion, Vincent Richard, Antoine Ouvrard-Pascaud
Background- We previously showed that Protein Tyrosine Phosphatase 1B inactivation (PTP1B-/- ) in mice improved left ventricular (LV) angiogenesis, perfusion, remodeling and function, and limits endothelial dysfunction after myocardial infarction. However, whether PTP1B inactivation slows aging-associated cardiovascular dysfunction remains unknown. Methods and Results- WT and PTP1B-/- mice were allowed to age until 18 months. Compared to old WT in which aging increased the LV mRNA expression of PTP1B, old PTP1B-/- mice had: 1) reduced cardiac hypertrophy with decreased LV mRNA levels of hypertrophic markers, atrial and brain natriuretic peptides; 2) lower LV fibrosis (collagen: WT 16{plus minus}3, PTP1B-/- 5{plus minus}3 %, p<0...
March 23, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29549404/antidromic-neurogenic-activity-and-cutaneous-bacterial-flora
#19
REVIEW
Marc G J Feuilloley
By its size and diversity, the cutaneous microbial flora is the second of the human body and there is a growing body of research showing its key role in cutaneous homeostasis. However, skin is also the first neuroendocrine organ and it is now demonstrated that bacteria can sense a multitude of human hormones and neurotransmitters. Then, besides of the intrinsic effect of their virulence factors on cutaneous neurogenic activity, recent data demonstrate that the virulence, invasion potential, and biofilm formation activity of some of the principal species of the cutaneous bacteria flora are directly controlled by neuropeptides released by sensory nerve endings including substance P and calcitonin gene-related peptide...
May 2018: Seminars in Immunopathology
https://www.readbyqxmd.com/read/29535268/atrial-cardiopathy-and-the-risk-of-ischemic-stroke-in-the-chs-cardiovascular-health-study
#20
Hooman Kamel, Traci M Bartz, Mitchell S V Elkind, Peter M Okin, Evan L Thacker, Kristen K Patton, Phyllis K Stein, Christopher R deFilippi, Rebecca F Gottesman, Susan R Heckbert, Richard A Kronmal, Elsayed Z Soliman, W T Longstreth
BACKGROUND AND PURPOSE: Emerging evidence suggests that an underlying atrial cardiopathy may result in thromboembolism before atrial fibrillation (AF) develops. We examined the association between various markers of atrial cardiopathy and the risk of ischemic stroke. METHODS: The CHS (Cardiovascular Health Study) prospectively enrolled community-dwelling adults ≥65 years of age. For this study, we excluded participants diagnosed with stroke or AF before baseline...
April 2018: Stroke; a Journal of Cerebral Circulation
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