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Yousuke Maeda, Michiko Hanada, Masa-Aki Oikawa
This report describes the descriptive epidemiology of racing fractures that occurred from the 1980s to 2000s on racetracks of the Japan Racing Association (JRA). The incidence of racehorse fractures during flat racing was approximately 1-2%. Fractures occurring during a race are more likely to occur in a forelimb. Fractures mostly occur at the third and fourth corners of oval tracks and on the home stretch. They also occur more frequently at the time of changing the leading limb. Comparison of the incidence of racing fracture between before and after reconstruction of the geometrical configuration of a racetrack revealed that there was an outstanding reduction in the number of serious fractures in the year before and after reconstruction...
2016: Journal of Equine Science
Melissa L Mannion, Fenglong Xie, John Baddley, Lang Chen, Jeffrey R Curtis, Kenneth Saag, Jie Zhang, Timothy Beukelman
BACKGROUND: To investigate the utilization of health care services before and after transfer from pediatric to adult rheumatology care in clinical practice. METHODS: Using US commercial claims data from January 2005 through August 2012, we identified individuals with a JIA diagnosis code from a pediatric rheumatologist followed by any diagnosis code from an adult rheumatologist. Individuals had 6 months observable time before the last pediatric visit and 6 months after the first adult visit...
2016: Pediatric Rheumatology Online Journal
Andrianimaro Florelia Martinetti, Rasoanaivo Mamy Andriantsoa, Rajaonera Tovohery Andriambelo, Rakotoarison Ratsaraharimanana Cathérine Nicole, Raveloson Nasolotsiry Enintsoa
Peutz-Jeghers syndrome (SPJ) is characterized by intestinal hamartomatous polyps in association with mucocutaneous lentiginosis. Patients are exposed to mechanical and bleeding complications. It is a cancer predisposition syndrome. Our study highlights the diagnostic criteria for Peutz-Jeghers syndrome (SPJ), the complications and the therapeutic progresses in patient care. We report the case of a 32-year-old male presenting with a massive melaena. It was hospitalized in the surgical intensive care unit with hypovolemic shock difficult to control...
2016: Pan African Medical Journal
S Abramowicz, S Kim, S Prahalad, A F Chouinard, L B Kaban
The latest change in terminology from juvenile rheumatoid arthritis (JRA) to juvenile idiopathic arthritis (JIA), established by the International League of Associations for Rheumatology (ILAR), has resulted in some confusion for OMFS and other treating clinicians. JIA comprises a group of systemic inflammatory diseases that result in the destruction of hard and soft tissues in a single or multiple joints. In a significant number of patients, one or both temporomandibular joints (TMJ) are also involved. TMJ disease may be accompanied by pain, swelling, and limitation of motion, as well as mandibular retrognathism, open bite, and asymmetry...
July 2016: International Journal of Oral and Maxillofacial Surgery
Mohamed Ahmed Mahmoud Eid, Sobhy M Aly, Shamekh M El-Shamy
OBJECTIVE: To investigate the effects of electromyographic (EMG) biofeedback training on pain, quadriceps strength, and functional ability in juvenile rheumatoid arthritis (JRA). DESIGN: This is a randomized controlled study; 36 children (11 boys and 25 girls) with polyarticular JRA, with ages ranging from 8 to 13 years, were selected and assigned randomly, using computer-generated random numbers, into 2 groups. The control group (n = 18) received the conventional physical therapy program, whereas the study group (n = 18) received the same program as the control group in addition to EMG biofeedback-guided isometric exercises for 3 days a week for 12 weeks...
May 4, 2016: American Journal of Physical Medicine & Rehabilitation
Cláudio Santili, Wilson Lino Júnior, Ellen de Oliveira Goiano, Romero Antunes Barreto Lins, Gilberto Waisberg, Susana Dos Reis Braga, Miguel Akkari
Limping in children is a common complaint at pediatric, pediatric orthopaedic offices and in emergency rooms. There are several causes for this condition, and identifying them is a challenge. The older the patient, the better the anamnesis and more detailed the physical examination will be, enabling an easier medical assessment for searching the source of the disorder. In order to make the approach easier, three age groups can and should be considered. Among infants (1 to 3 years old), diagnosis will most likely be: transitory synovitis, septic arthritis, neurological disorders (mild brain palsy (BP) and muscular dystrophy), congenital hip dislocation (CHD), varus thigh, juvenile rheumatoid arthritis (JRA) and neoplasias (osteoid osteoma, leukemia); in the scholar age group, between 4 and 10 years old, in addition to the diagnoses above, Legg-Calvé-Perthes disease, discoid meniscus, inferior limbs discrepancy and unspecific muscular pain; in adolescents (11 to 15 years old): slipped capital femoral epiphysis, congenital hip dislocation, chondrolysis, overuse syndromes, dissecans osteochondritis, and tarsal coalition...
January 2009: Revista Brasileira de Ortopedia
M A Mohamed, C Goldman, M El-Dib, H Aly
OBJECTIVE: Adverse pregnancy outcomes in mothers with juvenile rheumatoid arthritis (JRA) are not known. The objective of this study was to examine the risk of preterm birth and restricted fetal growth in pregnant mothers diagnosed with JRA, and to examine the impact of race/ethnicity and maternal age on this association. STUDY DESIGN: Hospital discharge records for mothers who gave birth in 2011 and 2012 were examined in the National Inpatient Sample (NIS) database...
April 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
Martina Felix, Mrinal Chayengia, Ritabrata Ghosh, Aditi Sharma, Mohit Prasad
Group cell migration is a highly coordinated process that is involved in a number of physiological events such as morphogenesis, wound healing and tumor metastasis. Unlike single cells, collectively moving cells are physically attached to each other and retain some degree of apical-basal polarity during the migratory phase. Although much is known about direction sensing, how polarity is regulated in multicellular movement remains unclear. Here we report the role of the protein kinase Pak3 in maintaining apical-basal polarity in migrating border cell clusters during Drosophila oogenesis...
November 1, 2015: Development
J F Mendoza Rincón, A K Rodríguez Elias, J M Fragoso, G Vargas Alarcón, K Maldonado Murillo, M L Rivas Jiménez, R E Barbosa Cobos, S Jimenez Morales, G Lugo Zamudio, C Tovilla Zárate, J Ramírez Bello
Rheumatoid arthritis (RA) is a multifactorial disease. A combination of genetic and environmental risk factors contributes to its etiology. Several genes have been reported to be associated with susceptibility to the development of RA. The MHC2TA and FCRL3 genes have been associated previously with RA in Swedish and Japanese populations, respectively. In two recent reports, we show an association between FCRL3 and juvenile rheumatoid arthritis (JRA), and MHC2TA and acute coronary syndrome (ACS) in Mexican population...
February 2016: Rheumatology International
Megan L Krause, Cynthia S Crowson, C John Michet, Thomas Mason, Theresa Wampler Muskardin, Eric L Matteson
OBJECTIVE: To evaluate the incidence and prevalence of juvenile idiopathic arthritis (JIA) in Olmsted County, Minnesota in 1994-2013 and trends in juvenile rheumatoid arthritis (JRA) in 1960-2013. METHODS: Cases of arthritis in 1994-2013 were identified by diagnosis code with medical chart review to confirm diagnosis separately for JIA and JRA. Overall incidence rates with 95% confidence intervals (95% CIs) were age and sex adjusted to the 2010 US white population...
January 2016: Arthritis & Rheumatology
Yasufumi Endo, Shoichi Ito, Yoshiko Ogiyama
Most cases of hemolytic disease of the newborn associated with anti-Jra are mild. However, rare cases of hydrops fetalis and severe anemia have been reported. We treated a neonate with anemia who was born with maternal anti-Jra, which were detected in the umbilical cord plasma. The Jra antigens in the neonate core blood red blood cells (RBCs) exhibited extremely weak reactivity to PEG-IAT, an anti-Jra reagent. However, upon re-examination of Jra antigen using PEG-IAT at 3 months postpartum, positivity was observed...
2015: Biomarker Research
Mithila Handu, Bhagyashree Kaduskar, Ramya Ravindranathan, Amarendranath Soory, Ritika Giri, Vijay Barathi Elango, Harsha Gowda, Girish S Ratnaparkhi
Small ubiquitin-like modifier (SUMO) modification modulates the expression of defense genes in Drosophila, activated by the Toll/nuclear factor-κB and immune-deficient/nuclear factor-κB signaling networks. We have, however, limited understanding of the SUMO-modulated regulation of the immune response and lack information on SUMO targets in the immune system. In this study, we measured the changes to the SUMO proteome in S2 cells in response to a lipopolysaccharide challenge and identified 1619 unique proteins in SUMO-enriched lysates...
October 2015: G3: Genes—Genomes—Genetics
Sigridh Muñoz-Gómez, Burke A Cunha
FAPA syndrome (periodic fever, aphthous stomatititis, pharyngitis and adenitis) is a relatively new entity described in pediatric patients. In adults, reports of FAPA are limited to rare case reports. The differential diagnosis of FAPA in adults includes Behcet's syndrome, familial Mediterranean fever (FMF), Hyper IgD syndrome and juvenile rheumatoid arthritis (JRA), i.e., adult Still's disease. With FAPA syndrome, between episodes patients are completely asymptomatic and serologic inflammatory markers such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and white blood cell (WBC) count are normal...
2013: Journal of Clinical Medicine
V M Dudnyk, V P Popov, Z A Skakyn, G S Gumynska, L L Vinnichuk, O I Marchuk
Provided evaluation of the medical and social inspection of the dcotrors-consultative commission of Vinnytsya regional childrens hospital in children with juvenile rheumatoid arthritis (JRA). Patients with JRA that got position of the child-invalid are given individual program of the rehabilitation that includes medical, professional, sport and physical, social adaptation that gives ability control recommendations for both--physicians and parents.
January 2015: Likars'ka Sprava
Jie-Jen Lee, Chia-Fu Chang, Joen-Rong Sheu, Thanasekaran Jayakumar
Platonin, a photosensitizing dye, is known to possess antioxidant and anti-inflammatory activity. Platonin has been used to treat trauma, ulcers and some acute inflammations and it also reported to improve blood circulation and reduce mortality in endotoxin-induced rat models. Our previous studies established that platonin suppresses the lipopolysaccharides (LPS)-induced inflammatory cytokines, including interleukin-1β (IL-1β-+), IL-6, tumor necrosis factor-α (TNF-α), and inducible nitric oxide synthase (iNOS)...
2014: Current Pharmaceutical Biotechnology
V Y Belizario, J M Erfe, Jra Naig, Plc Chua
OBJECTIVE: To explore risk of school-age children being infected with schistosomiasis in selected villages in the municipality of Calatrava, province of Negros Occidental, Philippines. METHODS: As part of the monitoring and evaluation of the helminth control program in the province of Negros Occidental, parasitological monitoring, through the use microscopy of stool samples processed using Kato-Katz technique, was conducted to describe the baseline and follow-up parasitological status of school-age children in 2010 and 2012, respectively...
May 2015: Asian Pacific Journal of Tropical Medicine
Brock Kitchen, Hugo B Sanchez, Russell A Wagner
Juvenile Rheumatoid Arthritis (JRA) is a progressive disease characterized by pain, swelling, and loss of motion in the joints of adolescents. Total knee arthroplasty (TKA) can be indicated, during the adolescent years, in patients with advanced JRA to alleviate pain and improve function. Because of the relative infrequency of TKA in patients with JRA, evaluation of the type of TKA performed and the results merit review. This case report present two distinct operations performed to obtain full extension. 1...
June 2015: Journal of Orthopaedics
Yan Liu, Daoyong Zhang
The proto-oncogene c-Jun plays crucial roles in tumorigenesis, and its aberrant expression has been implicated in many cancers. Previous studies have shown that the c-Jun gene is positively autoregulated by its product. Notably, it has also been reported that c-Jun proteins are enriched in its gene body region. However, the role of c-Jun proteins in its gene body region has yet to be uncovered. HP1a is an evolutionarily conserved heterochromatin-associated protein, which plays an essential role in heterochromatin-mediated gene silencing...
2015: Epigenetics: Official Journal of the DNA Methylation Society
Hyo-Jeong Kwon, You Lim Kim, Suk Min Lee
[Purpose] The aim of this study was to assess patients' health-related quality of life, compare it with a healthy age-matched population, and examine associations between functional ability and quality of life among juvenile rheumatoid arthritis (JRA) patients. [Subjects and Methods] The study participants were 26 JRA patients and 25 controls. The Childhood Health Assessment Questionnaire and the Pediatric Quality of Life Inventory 4.0 Generic Core Scales were used to evaluate functional ability and health-related quality of life, respectively...
March 2015: Journal of Physical Therapy Science
Jiale Ou, Stephen W K Cheng, Yiu Che Chan
OBJECTIVE: The Zenith pivot branch (p-branch) fenestrated endovascular graft (Cook Medical, Bloomington, Ind) is a new "off-the-shelf" device to treat patients with juxtarenal aortic aneurysms (JRAs). Two options are currently available, which appear to suit >70% of white patients. This study investigates the anatomic applicability of the p-branch fenestrated graft in a cohort of Asian patients with JRA. METHODS: Computed tomography images of 51 consecutive Asian patients with JRA (43 men; mean age, 76...
June 2015: Journal of Vascular Surgery
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