keyword
MENU ▼
Read by QxMD icon Read
search

Understandability

keyword
https://www.readbyqxmd.com/read/28821197/regional-variability-in-percentage-of-breast-cancers-reported-as-positive-for-her2-in-california-implications-of-patient-demographics-on-laboratory-benchmarks
#1
Chieh-Yu Lin, Eugene E Carneal, Daphne Y Lichtensztajn, Scarlett L Gomez, Christina A Clarke, Kristin C Jensen, Allison W Kurian, Kimberly H Allison
Objectives: The expected regional variability in percent human epidermal growth factor receptor 2 (HER2)-positive breast cancers is not currently clear. Methods: Data from the 2006 to 2011 California Cancer Registry were examined by county and health service area. The influence of demographic and pathologic features was used in a multivariable logistic regression model to compare expected with observed HER2-positive percentages by region. Results: There was significant geographic variation by California counties (11...
September 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28821188/panmixia-and-limited-interspecific-introgression-in-coyotes-canis-latrans-from-west-virginia-and-virginia-usa
#2
Justin H Bohling, Lauren L Mastro, Jennifer R Adams, Eric M Gese, Sheldon F Owen, Lisette P Waits
The expansion of coyotes (Canis latrans) into the eastern United States has had major consequences for ecological communities and wildlife managers. Despite this, there has been little investigation of the genetics of coyotes across much of this region, especially outside of the northeast. Understanding patterns of genetic structure and interspecific introgression would provide insights into the colonization history of the species, its response to the modern environment, and interactions with other canids. We examined the genetic characteristics of 121 coyotes from the mid-Atlantic states of West Virginia and Virginia by genotyping 17 polymorphic nuclear DNA microsatellite loci...
September 1, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28821185/phylogeography-and-ecological-niche-modeling-of-the-desert-iguana-dipsosaurus-dorsalis-baird-girard-1852-in-the-baja-california-peninsula
#3
Tania Valdivia-Carrillo, Francisco J García-De León, Ma Carmen Blázquez, Carina Gutiérrez-Flores, Patricia González Zamorano
Understanding the factors that explain the patterns of genetic structure or phylogeographic breaks at an intraspecific level is key to inferring the mechanisms of population differentiation in its early stages. These topics have been well studied in the Baja California region, with vicariance and the dispersal ability of individuals being the prevailing hypothesis for phylogeographic breaks. In this study, we evaluated the phylogeographic patterns in the desert iguana (Dipsosaurus dorsalis), a species with a recent history in the region and spatial variation in life history traits...
September 1, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28821184/repetitive-dna-in-the-catfish-genome-rdna-microsatellites-and-tc1-mariner-transposon-sequences-in-imparfinis-species-siluriformes-heptapteridae
#4
Juceli Gonzalez Gouveia, Ivan Rodrigo Wolf, Laurival Antonio Vilas-Boas, John Seymour Heslop-Harrison, Trude Schwarzacher, Ana Lúcia Dias
Physical mapping of repetitive DNA families in the karyotypes of fish is important to understand the organization and evolution of different orders, families, genera, or species. Fish in the genus Imparfinis show diverse karyotypes with various diploid numbers and ribosomal DNA (rDNA) locations. Here we isolated and characterized Tc1-mariner nucleotide sequences from Imparfinis schubarti, and mapped their locations together with 18S rDNA, 5S rDNA, and microsatellite probes in Imparfinis borodini and I. schubarti chromosomes...
September 1, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28821182/microsatellite-mutation-rate-in-atlantic-sturgeon-acipenser-oxyrinchus
#5
Hanna Panagiotopoulou, James D Austin, Katarzyna Zalewska, Magdalena Gonciarz, Kinga Czarnogórska, Jan Gawor, Piotr Weglenski, Danijela Popovic
Understanding mutation rates can greatly extend the utility of population and conservation genetic analyses. Herein, we present an estimate of genome-wide microsatellite mutation rate in Atlantic sturgeon (Acipenser oxyrinchus) based on parent-offspring transmission patterns. We screened 307 individuals for parentage and mutation-rate analysis applying 43 variable markers. Out of 13228 allele transfers, 11 mutations were detected, producing a mutation rate of 8.3 × 10-4 per locus per generation (95% confidence interval: 1...
September 1, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28821151/flexibility-of-backbone-fibrils-in-%C3%AE-chitin-crystals-with-different-degree-of-acetylation
#6
Zechuan Yu, Denvid Lau
Acetyl groups are backbone outreaches that enhance inter-fibril connection in chitin and chitosan fibril bundle. Removal of acetyl groups affects flexibility of chitosan fibril bundle, thereby affecting mechanical strength of chitosan-based products. Understandings of relationship between degree of acetylation and flexibility of chitin fibril bundle conduce to optimization of synthetic chitin materials. Here, the relationship is examined by performing molecular dynamics simulations. Coiling of chitin and chitosan fibril bundle with different degree of acetylation is observed and flexibility of fibrils is measured...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821093/urea-free-synthesis-of-chitin-based-acrylate-superabsorbent-polymers-under-homogeneous-conditions-effects-of-the-degree-of-deacetylation-and-the-molecular-weight
#7
T G Liu, Y T Wang, B Li, H B Deng, Z L Huang, L W Qian, X Wang
In order to understand the chemical structure of chitin-based acrylate superabsorbent polymers (SAP), chitin was dissolved in NaOH aqueous solution via freezing-thawing cyclic treatment without urea, subsequently, a transparent hydrogel was prepared by copolymerizing the alkali-chitin solution and acrylic acid directly. The effects of the degree of deacetylation (DDA) and the molecular weight (Mw) of chitin on the properties of SAP were investigated in detail. With increasing the DDA and Mw, the yield improved while the water absorbency decreased, yet the effect of DDA is insignificant if the Mw is smaller enough...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821072/understanding-the-mechanisms-of-oxygen-diffusion-through-surface-functionalized-nanocellulose-films
#8
Maria Soledad Peresin, Kari Kammiovirta, Harri Heikkinen, Leena-Sisko Johansson, Jari Vartiainen, Harri Setälä, Monika Österberg, Tekla Tammelin
A concept for direct surface modification on self-standing films of cellulose nanofibrils (CNF) is demonstrated using an aminosilane group in cellulose compatible solvent (dimethyl acetamide, DMA). The chemically modified structure efficiently prevents the oxygen molecules from interacting with the nanocellulose film in the presence of water molecules. Oxygen permeability values lower than 1mLmmm(-2)day(-1)atm(-1) were achieved at extremely high levels of relative humidity (RH95%). The aminosilane reaction is compared to conventional hydrophobization reaction using hexamethyldisilazane...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821017/the-location-of-australian-buruli-ulcer-lesions-implications-for-unravelling-disease-transmission
#9
Arvind Yerramilli, Ee Laine Tay, Andrew J Stewardson, Peter G Kelley, Emma Bishop, Grant A Jenkin, Mike Starr, Janine Trevillyan, Andrew Hughes, N Deborah Friedman, Daniel P O'Brien, Paul D R Johnson
BACKGROUND: Buruli ulcer (BU), caused by Mycobacterium ulcerans, is increasing in incidence in Victoria, Australia. To improve understanding of disease transmission, we aimed to map the location of BU lesions on the human body. METHODS: Using notification data and clinical records review, we conducted a retrospective observational study of patients diagnosed with BU in Victoria from 1998-2015. We created electronic density maps of lesion locations using spatial analysis software and compared lesion distribution by age, gender, presence of multiple lesions and month of infection...
August 18, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28821005/anticonvulsant-effect-of-cannabidiol-in-the-pentylenetetrazole-model-pharmacological-mechanisms-electroencephalographic-profile-and-brain-cytokine-levels
#10
Luciano R Vilela, Isabel V Lima, Érica B Kunsch, Hyorrana Priscila P Pinto, Aline S de Miranda, Érica Leandro M Vieira, Antônio Carlos P de Oliveira, Marcio Flávio D Moraes, Antônio L Teixeira, Fabricio A Moreira
Cannabidiol (CBD), the main nonpsychotomimetic compound from Cannabis sativa, inhibits experimental seizures in animal models and alleviates certain types of intractable epilepsies in patients. Its pharmacological profile, however, is still uncertain. Here we tested the hypothesis that CBD anticonvulsant mechanisms are prevented by cannabinoid (CB1 and CB2) and vanilloid (TRPV1) receptor blockers. We also investigated its effects on electroencephalographic (EEG) activity and hippocampal cytokines in the pentylenetetrazole (PTZ) model...
August 15, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28820957/the-association-between-pregnancy-intention-and-breastfeeding
#11
Shimrit Keddem, Rosemary Frasso, Melissa Dichter, Alexandra Hanlon
BACKGROUND: Although breastfeeding is associated with proven benefits to both mother and child, there are many factors that influence a mother's decision to breastfeed. Pregnancy intentionality at the time of conception is associated with postpartum maternal behavior including breastfeeding. Research aim: We sought to understand how maternal and paternal pregnancy intentions were associated with breastfeeding initiation and duration in a nationally representative sample. METHODS: We used a cross-sectional, retrospective study of the CDC National Survey of Family Growth data to examine the link between pregnancy intentionality and breastfeeding initiation and duration among women ages 15 to 44 years...
August 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28820952/adult-intelligence-the-construct-and-the-criterion-problem
#12
Phillip L Ackerman
Over 100 years have passed since Binet and Simon proposed scales for assessment of intelligence of children to predict academic success and failure. The extension of these assessments to adults largely resulted from efforts of psychologists to provide insights for military selection in World War I. At the time, relatively little thought was given to how adult intelligence might differ from child and adolescent intelligence. Traditional approaches for assessing adult intelligence have largely survived. However, there is little reference to adult intellectual functioning outside of laboratory-based tasks and clinical assessments of pathology...
August 1, 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28820946/proteogenomic-investigation-of-strain-variation-in-clinical-mycobacterium-tuberculosis-isolates
#13
Tiaan Heunis, Anzaan Dippenaar, Robin M Warren, Paul D van Helden, Ruben G van der Merwe, Nicolaas C Gey van Pittius, Arnab Pain, Samantha L Sampson, David L Tabb
Mycobacterium tuberculosis consists of a large number of different strains that display unique virulence characteristics. Whole-genome sequencing has revealed substantial genetic diversity among clinical M. tuberculosis isolates, and elucidating the phenotypic variation encoded by this genetic diversity will be of utmost importance to fully understand M. tuberculosis biology and pathogenicity. In this study we integrated whole-genome sequencing and mass spectrometry (GeLC-MS/MS) to reveal strain-specific characteristics in the proteomes of two clinical M...
August 18, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28820940/polyoxometalate-cationic-cluster-and-%C3%AF-%C3%AE-cyclodextrin-from-primary-interactions-to-supramolecular-hybrid-materials
#14
Mhamad Aly Moussawi, Nathalie Leclerc-Laronze, Sébastien Floquet, Pavel A Abramov, Maxim Nailyevich Sokolov, Stephane Cordier, Anne Ponchel, Eric Monflier, Herve Bricout, David Landy, Mohamed Haouas, Jerome Marrot, Emmanuel Cadot
Herein, we report on a three-component supramolecular hybrid system built from specific recognition processes involving a Dawson type polyoxometalate [P2W18O62](6-,) a cationic electron-rich cluster {[Ta6Br12(H6O)6]@2CD}(2+) and γ-cyclodextrin. Investigations of such a class of materials have been conducted using bottom-up approach by studying the specific interactions between -CD and both types of inorganic units. Their ability to interact has been investigated in the solid state by single-crystal X-ray diffraction and in solution using multinuclear NMR methods (including DOSY, EXSY and COSY), ESI-mass and UV-vis spectroscopies, electrochemistry and ITC experiments...
August 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28820938/multi-scale-simulation-of-receptor-drug-association-kinetics-application-to-neuramidase-inhibitors
#15
Fabian Zeller, Manuel P Luitz, Rainer Bomblies, Martin Zacharias
A detailed understanding of the drug-receptor association process is of fundamental importance for drug design. Due to the long timescales of typical binding kinetics, the atomistic simulation of the ligand traveling from bulk solution into the binding site is still computationally challenging. In this work, we apply a multi-scale approach of combined molecular dynamics (MD) and Brownian dynamics (BD) simulations to investigate association pathway ensembles for the two prominent H1N1 neuraminidase inhibitors oseltamivir and zanamivir...
August 18, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28820934/supramolecular-sensors-for-opiates-and-their-metabolites
#16
Elena G Shcherbakova, Ben Zhang, Samer Gozem, Tsuyoshi Minami, Peter Y Zavalij, Mariia Pushina, Lyle Isaacs, Pavel Anzenbacher
The present work develops a sensing approach for opiates using acyclic cucurbituril (aCBs) sensors comprising four glycouril units terminated on both ends with naphthalene fluorophore walls. The connectivity between the glycourils and the naphthalene rings largely defines the opening size of the cucurbituril cavity and its diameter. The large hydrophobic binding cavity is flexible and is able to adapt to guests of various size and topology. The recognition event between the aCBs and guests results in modification of the fluorescence of the terminal walls, a fluorescence response that can be used to sense the drugs of abuse morphine, heroin and oxycodone as well as their metabolites...
August 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28820933/surface-chemistry-of-la0-99sr0-01nbo4-d-and-its-implication-for-proton-conduction
#17
Cheng Li, Stevin S Pramana, Na Ni, John A Kilner, Stephen J Skinner
Acceptor doped LaNbO4 is a promising electrolyte material for proton conducting fuel cell (PCFC) applications. As charge transfer processes govern device performance, the outermost surface of acceptor doped LaNbO4 will play an important role in determining the overall cell performance. However, the surface composition is poorly characterized, and the understanding of its impact on the proton exchange process is rudimentary. In this work, the surface chemistry of 1 at% Sr doped LaNbO4 (La0.99Sr0.01NbO4-d, denoted as LSNO) proton conductor is characterized using LEIS and SIMS...
August 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28820909/dose-of-physical-activity-physical-functioning-and-disability-risk-in-mobility-limited-older-adults-results-from-the-life-study-randomized-trial
#18
Roger A Fielding, Jack M Guralnik, Abby C King, Marco Pahor, Mary M McDermott, Catrine Tudor-Locke, Todd M Manini, Nancy W Glynn, Anthony P Marsh, Robert S Axtell, Fang-Chi Hsu, W Jack Rejeski
Understanding the minimal dose of physical activity required to achieve improvement in physical functioning and reductions in disability risk is necessary to inform public health recommendations. To examine the effect of physical activity dose on changes in physical functioning and the onset of major mobility disability in The Lifestyle Interventions and Independence for Elders (LIFE) Study. We conducted a multicenter single masked randomized controlled trial that enrolled participants in 2010 and 2011 and followed them for an average of 2...
2017: PloS One
https://www.readbyqxmd.com/read/28820904/parametric-studies-of-metabolic-cooperativity-in-escherichia-coli-colonies-strain-and-geometric-confinement-effects
#19
Joseph R Peterson, John A Cole, Zaida Luthey-Schulten
Characterizing the complex spatial and temporal interactions among cells in a biological system (i.e. bacterial colony, microbiome, tissue, etc.) remains a challenge. Metabolic cooperativity in these systems can arise due to the subtle interplay between microenvironmental conditions and the cells' regulatory machinery, often involving cascades of intra- and extracellular signalling molecules. In the simplest of cases, as demonstrated in a recent study of the model organism Escherichia coli, metabolic cross-feeding can arise in monoclonal colonies of bacteria driven merely by spatial heterogeneity in the availability of growth substrates; namely, acetate, glucose and oxygen...
2017: PloS One
https://www.readbyqxmd.com/read/28820901/using-local-ecological-knowledge-to-monitor-threatened-mekong-megafauna-in-lao-pdr
#20
Thomas N E Gray, Amphone Phommachak, Kongseng Vannachomchan, Francois Guegan
Pressures on freshwater biodiversity in Southeast Asia are accelerating yet the status and conservation needs of many of the region's threatened fish species are unclear. This impacts the ability to implement conservation activities and to understand the effects of infrastructure developments and other hydrological changes. We used Local Ecological Knowledge from fishing communities on the Mekong River in the Siphandone waterscape, Lao PDR to estimate mean and mode last capture dates of eight rare or culturally significant fish species in order to provide conservation monitoring baselines...
2017: PloS One
keyword
keyword
113098
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"