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https://www.readbyqxmd.com/read/29897996/anti-tumor-activity-of-phenoxybenzamine-and-its-inhibition-of-histone-deacetylases
#1
Mario A Inchiosa
The principal finding from this study was the recognition that the α-adrenergic antagonist, phenoxybenzamine, possesses histone deacetylase inhibitory activity. Phenoxybenzamine is approved by the United States Food and Drug Administration for the treatment of hypertensive crises associated with tumors of the adrenal medulla, pheochromocytomas. It has several "off label" indications relative to its capacity to relax vascular smooth muscle and smooth muscle of the urogenital tract. The drug also has a long history of apparent efficacy in ameliorating, and perhaps reversing, the severe symptoms of neuropathic pain syndromes...
2018: PloS One
https://www.readbyqxmd.com/read/29845695/rare-urogenital-anomaly-variant-with-a-separated-didelphic-uterus-and-ipsilateral-renal-agenesis-without-hemivagina-a-case-report
#2
Norikazu Watanabe, Hideki Igarashi, Jun Matsukawa, Koki Matsuo, Satoru Nagase
The combination of a didelphic uterus, obstructed hemivagina, and ipsilateral renal anomaly was first reported in 1950 and later defined as OHVIRA syndrome (Smith & Laufer 2007). OHVIRA syndrome is considered a developmental anomaly of the Müllerian and Wolffian ducts. Although uterine anomalies occur in 2-3% of women, OHVIRA syndrome is rare and accounts for only 0.16-10% of uterine anomalies (Lin et al. 2002, Adair et al. 2011). The typical symptoms are dysmenorrhea after menarche. Herein, we describe the case of a patient with a rare variant of OHVIRA syndrome...
May 29, 2018: Congenital Anomalies
https://www.readbyqxmd.com/read/29779483/a-review-on-pharmacological-and-clinical-aspects-of-linum-usitatissimum-l
#3
Ramin Ansari, Mohammad Mehdi Zarshenas, Amir Hossein Dadbakhsh
INTRODUCTION AND BACKGROUND: Linum usitatissimum L., known as common Flax or linseed, from the family Linnaceae, has long been cultivated in different nations due to its applications in medicine and industry. The present study aims to collect nearly all available information about chemical constituents of Flax, as well as pharmacological properties and confirmed clinical usages of it. METHODS: We searched through databases such as Scopus and PubMed for relevant literatures using the keywords: (Linum usitatissimum), (pharmacology) and (phytochemical) from the beginning to 13 Aug 2017...
May 20, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29742999/mycoplasma-genitalium-infections-in-cuba-surveillance-of-urogenital-syndromes-2014-2015
#4
Brian A Mondeja, Nadia M Rodríguez, Orestes Blanco, Carmen Fernández, Jørgen S Jensen
Mycoplasma genitalium is an emerging sexually transmitted pathogen implicated in urethritis in men and several inflammatory reproductive tract syndromes in women. The prevalence of M. genitalium infections in Cuban patients with urogenital syndromes is unknown. The aim of this study was to analyse the prevalence of M. genitalium infection in sexually-active Cuban men and women with urogenital syndromes as a part of aetiological surveillance of urogenital syndromes in Cuba. Samples from men and women with urogenital syndromes submitted to the Mycoplasma Reference Laboratory for mycoplasma diagnosis from 1 January 2014 to 1 June 2015 were analysed by polymerase chain reaction (PCR) for detection of M...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29734845/the-prevalence-and-determinants-of-genitourinary-syndrome-of-menopause-in-chinese-mid-life-women-a-single-center-study
#5
M Tao, L Geng, Y Zheng, Y Zhou, C Li
OBJECTIVE: This study aimed to explore the prevalence and determinants of genitourinary syndrome of menopause (GSM) in Chinese mid-life women. METHODS: A cross-sectional single-center study was performed among 40-65-year-old women who participated in physical examinations at Shanghai Jiao Tong University Affiliated Sixth People's Hospital from December 2015 to December 2016. The participating women were questioned about their genitourinary symptoms, and the relationships between these symptoms and the women's demographic characteristics were evaluated...
May 8, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29692510/management-of-female-congenital-short-patulous-urethra-with-urethral-tapering-and-pubovaginal-sling-a-report-of-two-cases
#6
Sumit Gahlawat, Hemant Goel, Nikhil Khattar
Congenital short patulous urethra is a rare entity and may be associated with developmental anomalies of mullerian ducts or urogenital sinus. We report the management of two cases of congenital short patulous urethra with stress urinary incontinence (SUI). Both the patients presented with SUI; one was diagnosed with Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome and the other had uterus didelphys with longitudinally septated vagina. Both patients were successfully managed by excisional tapering of the urethra and pubovaginal sling placement...
April 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29680080/no-358-intravaginal-laser-for-genitourinary-syndrome-of-menopause-and-stress-urinary-incontinence
#7
Jens-Erik Walter, Annick Larochelle
OBJECTIVE: This technical bulletin reviews the evidence relating to risks and benefits of using intravaginal laser technology in the management of genitourinary syndrome of menopause and stress urinary incontinence. INTENDED USERS: Gynaecologists, urogynaecologists, urologists, and other health care professionals who assess, counsel, and provide care for women with genitourinary syndrome of menopause and stress urinary incontinence. TARGET POPULATION: Adult women with genitourinary syndrome of menopause and stress urinary incontinence seeking complementary or alternative treatment options to topical estrogen, non-hormonal vaginal moisturizers, physiotherapy, intravaginal devices, and surgery...
April 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29672306/effects-of-bladder-training-and-pelvic-floor-muscle-training-in-female-patients-with-overactive-bladder-syndrome-a-randomized-controlled-trial
#8
Raheela Mohsin Rizvi, Novera Ghayoor Chughtai, Naheed Kapadia
OBJECTIVE: The purpose of our study was to see the efficacy of 3 different modes of treatment for overactive bladder (OAB) in symptoms reduction and quality of life improvement. METHODS: We conducted a 12-week single-blinded randomized controlled trial of women aged 22-65 years with clinical diagnosis of OAB. Arm A (n = 47) received bladder training, arm B (n = 50) received pelvic floor muscle training (PFMT), and arm C (n = 50) received PFMT with biofeedback. Bladder diary was used to assess the difference in urinary frequency, urgency, and leak accidents before and after treatment...
2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29669767/haematometrocolpos-and-acute-pelvic-pain-associated-with-cyclic-uterine-bleeding-ohvira-syndrome
#9
Mayank Aranke, Kim Long Nguyen, Richard D Wagner, Robert P Kauffman
Obstructed hemivagina and ipsilateral renal agenesis syndrome is a complex urogenital malformation usually presenting with obstructed menses and pelvic pain during female adolescence. The diagnosis can be established preoperatively with relative certainty by MRI or ultrasonography, and outcomes are usually satisfactory following surgical resection of the septal portion of the obstructed hemivagina. Such cases are best managed in referral centres with expertise in anatomical disorders of the female genital tract...
April 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29575616/autosomal-dominant-robinow-syndrome-associated-with-a-novel-dvl3-splice-mutation
#10
Magdalena Danyel, Fanny Kortüm, Katarina Dathe, Kerstin Kutsche, Denise Horn
Robinow syndrome is a clinically and genetically heterogeneous disorder characterized by mesomelic limb shortening, distinctive facial features, and variable oral, cardiac, vertebral, and urogenital malformations. We identified the novel de novo splice acceptor mutation c.1715-2A > C in DVL3 in a 15-year-old female patient with typical features of Robinow syndrome. By studying DVL3 transcripts in this patient, we confirmed expression of both wild-type and mutant alleles. Mutant DVL3 mRNAs were found to harbor a deletion of four nucleotides at the beginning of exon 15 and encode a protein product with a distinct -1 reading-frame C-terminus...
April 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29574432/primary-male-factor-infertility-due-to-asthenospermia-in-maturity-onset-diabetes-of-the-young-type-5-mody-5-uncommon-presentation-of-an-uncommon-disease
#11
Partha Pratim Chakraborty, Shinjan Patra, Sugata Narayan Biswas, Himanshu Barman
Mutations in hepatocyte nuclear factor-1β gene result in a multisystemic syndrome where a monogenic form of diabetes (maturity-onset diabetes of young type 5; MODY 5) and renal anomalies, usually bilateral multiple cysts are the most characteristic findings. Many of them have pancreatic structural abnormalities as well. A plethora of extrapancreatic manifestations like altered liver function tests, hypomagnesaemia, hyperuricaemia with/without gout and urogenital malformations, particularly in females are also components of the syndrome...
March 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29573596/lemierre-s-syndrome-following-perianal-abscess-a-case-report
#12
Qusai Aljarrah, Yara Khazaleh, Mooath Al-Jarrah, Jordan W Oldbury, Ahmad K Abou-Foul
INTRODUCTION: Lemierre's syndrome (LS) is a rare and life-threatening condition characterized by suppurative thrombophlebitis of the internal jugular vein (IJV), and a history of head and neck (H&N) sepsis. LS is usually caused by Fusobacterium necrophorum, which is part of the normal flora in the oro-pharynx, and the digestive and urogenital tracts. We here report the first case of LS following perianal sepsis. PRESENTATION OF CASE: A 60-year-old man with a painful left neck swelling, dysphagia and worsening sepsis was referred from a peripheral unit where he had an incision and drainage of a perianal abscess a week earlier...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29572885/health-problems-associated-with-irritable-bowel-syndrome-analysis-of-a-primary-care-registry
#13
E Clevers, B Vaes, S Henrard, G Goderis, J Tack, H Törnblom, M Simrén, L Van Oudenhove
BACKGROUND: Associations between irritable bowel syndrome and other health problems have been described, but comprehensive reports are missing, especially in primary care. AIMS: To investigate which health problems are associated with irritable bowel syndrome, how they cluster together and when they are typically diagnosed relative to irritable bowel syndrome. METHODS: We used Intego, a general practice registry in Flanders, Belgium. Patients with an irritable bowel syndrome diagnosis (n = 13 701) were matched with controls without gastrointestinal diagnosis and controls with organic gastrointestinal disease...
May 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29551555/genitoplasty-in-newborn-females-with-adrenogenital-syndrome-focus-on-the-reconstruction-technique-and-its-outcomes
#14
Marjan Waterloos, Tom Claeys, Maxime Sempels, Erik Van Laecke, Piet Hoebeke, Anne-Françoise Spinoit
The adrenogenital syndrome is an autosomal recessive disorder in which an enzyme defect in the steroid pathway leads to excessive prenatal exposure of androgens. In the female fetus, masculinization of the external genitalia is observed. Surgery aims for functional and aesthetical reconstruction. Many techniques have been described. A video of our modified pull-through reconstruction technique is hereby presented. A retrospective descriptive database was created with patients who underwent genitoplasty for a CAH-associated genital condition...
April 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29549674/a-case-of-masson-s-tumor-of-the-penis-presenting-as-chronic-pelvic-pain-syndrome
#15
Krasimir Yanev, Aleksander Krastanov, Marincho Georgiev, Andrian Tonev, Alexander Timev, Angel Elenkov
The intravascular papillary endothelial hyperplasia (IPEH) or Masson's tumor is an unusual and rare benign disease.It is histologically characterized by papillary and anastomosing channel-like structures lined by proliferating e n dothelium. Radiologically, it is usually presented as a heterogenic solid mass with contrast enhancement, withareas resembling necrosis and thrombosis. These signs can easily be attributed to malignancy. The urogenital tractis extremely rarely affected with only 8 cases described in the kidneys and one of the penis...
March 17, 2018: Urology Journal
https://www.readbyqxmd.com/read/29539909/re-combined-therapy-with-adipose-derived-mesenchymal-stem-cells-and-ciprofloxacin-against-acute-urogenital-organ-damage-in-rat-sepsis-syndrome-induced-by-intrapelvic-injection-of-cecal-bacteria
#16
https://www.readbyqxmd.com/read/29502244/a-rare-case-of-hydrometrocolpos-from-persistent-urogenital-sinus-in-patient-affected-by-adrenogenital-syndrome
#17
REVIEW
Igino Simonetti, Piero Trovato, Francesco Verde, Luca Tarotto, Roberto Della Casa, Maria Concetta Lonardo, Gianfranco Vallone, Maria Grazia Caprio
Persistent urogenital sinus (PUGS) is a congenital pathological condition characterized by an abnormal communication between the urethra and vagina, which has an estimated incidence of 0.6/10,000 female births. It could be the only known malformation or part of a syndrome. PUGS is commonly shown by a pelvic mass, related to a distended bladder, hydrometrocolpos which is due to an obstruction leading to the dilation of the vagina and uterus (i.e., imperforate hymen, transverse vaginal septum or atresia, and PUGS) or both...
March 3, 2018: Journal of Ultrasound
https://www.readbyqxmd.com/read/29478043/prenatal-diagnosis-of-hydro-metro-colpos-a-series-of-20-cases
#18
Michael R Mallmann, Heiko Reutter, Birte Mack-Detlefsen, Ingo Gottschalk, Annegret Geipel, Christoph Berg, Thomas M Boemers, Ulrich Gembruch
BACKGROUND: Hydrocolpos and hydrometrocolpos are rare malformations caused by accumulation of secretion due to congenital obstruction of the vagina. Hydro(metro)colpos may be isolated or can be combined with other malformations as part of a syndromic disorder. We report on a series of 20 cases with hydro(metro)colpos diagnosed prenatally, delineate the differential diagnoses, and illustrate the spectrum of associated malformations. SUBJECTS AND METHODS: This was a retrospective study involving 20 fetuses with hydro(metro)colpos at two large tertiary referral centers in Germany over an 18-year period (2000-2017)...
February 23, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29468003/obstructed-hemivagina-and-ipsilateral-renal-anomaly-ohvira-syndrome
#19
Aziza Al Ghafri, Alaeddin Fida, Abdulaziz Al-Gharras
Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome is a rare congenital abnormality of the female urogenital tract. We reported OHVIRA syndrome in a 15-year-old girl, who was referred to King Faisal Specialist Hospital and Research Centre, due to hematocolpos and an imperforate hymen. The patient was diagnosed as having an absent right kidney since childhood. She presented with progressive development of lower abdominal discomfort and an abdominopelvic mass. She had no history of urinary complaints...
January 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29456211/risk-factors-associated-with-acute-kidney-injury-in-newborns
#20
Emad E Ghobrial, Salma Z Elhouchi, Sarah S Eltatawy, Lilian O Beshara
Acute kidney injury (AKI) in the newborn is a common problem in the neonatal intensive care unit with many underlying factors such as asphyxia, respiratory distress syndrome (RDS), and urogenital anomalies. The aim of this study is to highlight possible risk factors and profile of neonates developing AKI in the Neonatal Intensive Care Unit (NICU) of Cairo University Pediatric Hospital. The study was carried out on 90 neonates (30 patients and 60 controls), among neonates admitted to NICU. The study was done over two months, from January 2015 to March 2015...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
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