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https://www.readbyqxmd.com/read/29040423/title-therapeutic-strategies-utilising-sdf-1%C3%AE-in-ischaemic-cardiomyopathy
#1
Oliver J Ziff, Daniel I Bromage, Derek M Yellon, Sean M Davidson
Heart failure is rapidly increasing in prevalence and will redraw the global landscape for cardiovascular health. Alleviating and repairing cardiac injury associated with myocardial infarction (MI) is key to improving this burden. Homing signals mobilise and recruit stem cells to the ischaemic myocardium where they exert beneficial paracrine effects. The chemoattractant cytokine SDF-1α and its associated receptor CXCR4 are upregulated after MI and appear to be important in this context. Activation of CXCR4 promotes both cardiomyocyte survival and stem cell migration towards the infarcted myocardium...
October 13, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29036993/-study-on-the-disease-burden-of-chinese-adolescent-in-2015
#2
R B Xu, D Y Jin, Y Song, X J Wang, Y H Dong, Z G Yang, Y J Chen, J Ma
Objective: To discuss the main causes and risk factors of disability and death among current Chinese adolescents. Methods: Subnational data of China from Global Burden of Disease Study 2015 (GBD 2015) was used to rank the causes and risk factors leading to death and disability adjusted life years (DALY) in Chinese adolescents aged between 10 and 19 years old, and thereby to analyze the main cauese and risk factors of death and DALY among Chinese adolescents in different genders. Results: In 2015, among Chinese adolescents aged 10-19 years old, the total DALY was 13 million 490 thousand years, and the total number of deaths was 63 258 cases...
October 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29035611/are-people-who-inject-drugs-frequent-users-of-emergency-department-services-a-cohort-study-2008-2013
#3
Dhanya Nambiar, Tim Spelman, Mark Stoové, Paul Dietze
BACKGROUND: Although people who inject drugs (PWID) have been described as frequent users of emergency services, the majority of research is cross-sectional and involves records from a single emergency department (ED). OBJECTIVES: We describe characteristics of state-wide ED presentations in a cohort of PWID, and compare presentation rates to the general population. We also examine characteristics associated with frequent ED use. METHODS: We used data from a retrospective linkage of public ED presentations from a cohort of 678 PWID between January 2008 and June 2013...
October 16, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29034172/health-and-greenhouse-gas-mitigation-benefits-of-ambitious-expansion-of-cycling-walking-and-transit-in-california
#4
Neil Maizlish, Nicholas J Linesch, James Woodcock
The purpose of this research was to quantify health co-benefits and carbon reductions of preferred scenarios of California regional transportation plans and alternatives with ambitious levels of active transport. The alternatives were designed to examine the efficacy of independent contributions of walking, bicycling, and transit at levels consistent with the U.S. Surgeon General recommendation for physical activity. Using data from travel and health surveys, vital statistics, collision databases, and outputs from regional and statewide travel models, the Integrated Transport and Health Impacts Model estimated the change in the population disease burden, as measured by deaths and disability adjusted life years (DALYs), due to a shift from a 2010 baseline travel pattern to an alternative...
September 2017: Journal of Transport & Health
https://www.readbyqxmd.com/read/29033929/immunity-and-fibrogenesis-the-role-of-th17-il-17-axis-in-hbv-and-hcv-induced-chronic-hepatitis-and-progression-to-cirrhosis
#5
REVIEW
Feliciano Chanana Paquissi
Cirrhosis is a common final pathway for most chronic liver diseases; representing an increasing burden worldwide and is associated with increased morbidity and mortality. Current evidence has shown that, after an initial injury, the immune response has a significant participation in the ongoing damage, and progression from chronic viral hepatitis (CVH) to cirrhosis, driving the activation and maintenance of main fibrogenic pathways. Among immune deregulations, those related to the subtype 17 of T helper lymphocytes (Th17)/interleukin-17 (IL-17) axis have been recognized as key immunopathological and prognostic elements in patients with CVH...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29033615/clinical-economic-and-humanistic-burden-of-needlestick-injuries-in-healthcare-workers
#6
REVIEW
Catherine E Cooke, Jennifer M Stephens
INTRODUCTION: Needlestick injuries (NSIs) from a contaminated needle put healthcare workers (HCWs) at risk of becoming infected with a blood-borne virus and suffering serious short- and long-term medical consequences. Hypodermic injections using disposable syringes and needles are the most frequent cause of NSIs. OBJECTIVE: To perform a systematic literature review on NSI and active safety-engineered devices for hypodermic injection. METHODS: MEDLINE, EMBASE, and COCHRANE databases were searched for studies that evaluated the clinical, economic, or humanistic outcomes of NSI or active safety-engineered devices...
2017: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/29031889/outcomes-important-to-burns-patients-during-scar-management-and-how-they-compare-to-the-concepts-captured-in-burn-specific-patient-reported-outcome-measures
#7
Laura L Jones, Melanie Calvert, Naiem Moiemen, Jonathan J Deeks, Jonathan Bishop, Philip Kinghorn, Jonathan Mathers
BACKGROUND: Pressure garment therapy (PGT) is an established treatment for the prevention and treatment of hypertrophic scarring; however, there is limited evidence for its effectiveness. Burn survivors often experience multiple issues many of which are not adequately captured in current PGT trial measures. To assess the effectiveness of PGT it is important to understand what outcomes matter to patients and to consider whether patient-reported outcome measures (PROMs) can be used to ascertain the effect of treatments on patients' health-related quality of life...
October 11, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29031640/the-application-of-mesenchymal-stem-cells-to-treat-thermal-and-radiation-burns
#8
Kathleen Rodgers, Sachin S Jadhav
Mesenchymal stem cells (MSCs) have been developed for a number of indications due to their regenerative and anti-inflammatory phenotypes and their utility is enhanced by the fact that allogeneic transplant is feasible with this cell type. Animal studies and early human cases indicate this has the potential to be an exciting new therapy for treating chronic non-healing wounds such as diabetic ulcers, burns and cutaneous radiation burns. This review will focus on the use of MSCs to treat thermal and radiation burns...
October 11, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29030619/unwavering-pathobiology-of-volumetric-muscle-loss-injury
#9
Sarah M Greising, Jessica C Rivera, Stephen M Goldman, Alain Watts, Carlos A Aguilar, Benjamin T Corona
Volumetric muscle loss (VML) resulting from extremity trauma presents chronic and persistent functional deficits which ultimately manifest disability. Acellular biological scaffolds, or decellularized extracellular matrices (ECMs), embody an ideal treatment platform due to their current clinical use for soft tissue repair, off-the-shelf availability, and zero autogenous donor tissue burden. ECMs have been reported to promote functional skeletal muscle tissue remodeling in small and large animal models of VML injury, and this conclusion was reached in a recent clinical trial that enrolled 13 patients...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29029604/trauma-burden-in-tanzania-a-one-day-survey-of-all-district-and-regional-public-hospitals
#10
Hendry R Sawe, Juma A Mfinanga, Khalid R Mbaya, Phillip M Koka, Said S Kilindimo, Michael S Runyon, Victor G Mwafongo, Lee A Wallis, Teri A Reynolds
BACKGROUND: Trauma contributes significantly to the burden of disease and mortality throughout the world, but particularly in developing countries. In Tanzania, there is an enormous research gap on trauma; the limited data available reflects realities in cities and areas with moderately- to highly-resourced treatment centers. Our aim was to provide a description of the injury epidemiology across all of Tanzania. Our data will serve as a basis for future larger studies. METHODS: This is a subgroup analysis of a cross-sectional, prospective study of the clinical epidemiology of patients presenting at all public district and regional hospitals in Tanzania...
October 13, 2017: BMC Emergency Medicine
https://www.readbyqxmd.com/read/29027507/development-of-an-mhealth-trauma-registry-in-the-middle-east-using-an-implementation-science-framework
#11
Amber Mehmood, Edward Chan, Katharine Allen, Ammar Al-Kashmiri, Ali Al-Busaidi, Jehan Al-Abri, Mohamed Al-Yazidi, Abdullah Al-Maniri, Adnan A Hyder
BACKGROUND: Trauma registries (TRs) play a vital role in the assessment of trauma care, but are often underutilized in countries with a high burden of injuries. OBJECTIVES: We investigated whether information and communications technology (ICT) such as mobile health (mHealth) could enable the design of a tablet-based application for healthcare professionals. This would be used to inform trauma care and acquire surveillance data for injury control and prevention in Oman...
2017: Global Health Action
https://www.readbyqxmd.com/read/29026520/work-related-musculoskeletal-injuries-sustained-by-australian-osteopaths-qualitative-analysis-of-effects-on-practitioner-health-clinical-practice-and-patient-care
#12
Gopi Anne McLeod, Katerina Annels, Jessica Cohen, Samuel Edwards, Daniel Hodgins, Brett Vaughan
BACKGROUND: There is limited literature that explores the experiences of osteopaths injured while engaging in clinical practice. Evidence from other similar health professions has described the numerous effects of work-related musculoskeletal injuries (WRMI). Work-related musculoskeletal injury refers to trauma to joints, ligaments, muscles and tendons resulting from injury sustained while undertaking work duties. This research aimed to gain a contextualised understanding of the experiences of osteopaths who have sustained a work-related musculoskeletal injury while performing clinical practice...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/29026474/using-growth-mixture-modeling-for-clustering-asian-and-north-african-countries-on-the-road-injury-death-trend-1990-2010
#13
Maryam Salari, Anoshirvan Kazemnejad, Farid Zayeri
OBJECTIVES: The physical injuries and financial implications as a result of road accidents have serious economic, cultural, and social effects. We conducted this study to determine any changes in the trend of road-accident-related deaths in Asian and North African countries from 1990 to 2010. METHODS: The current study was carried out using data from the Global Burden of Disease database. First, the process was assessed using the growth curve divided into six regions...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29025826/patient-characteristics-of-the-accident-and-emergency-department-of-kenyatta-national-hospital-nairobi-kenya-a-cross-sectional-prospective-analysis
#14
Justin Guy Myers, Katherine M Hunold, Karen Ekernas, Ali Wangara, Alice Maingi, Vincent Mutiso, Stephen Dunlop, Ian B K Martin
BACKGROUND: Resource-limited settings are increasingly experiencing a 'triple burden' of disease, composed of trauma, non-communicable diseases (NCDs) and known communicable disease patterns. However, the epidemiology of acute and emergency care is not well characterised and this limits efforts to further develop emergency care capacity. OBJECTIVE: To define the burden of disease by describing the patient population presenting to the Accident and Emergency Department (A&E) at Kenyatta National Hospital (KNH) in Kenya...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29025455/the-burden-of-gunshot-injuries-on-orthopaedic-healthcare-resources-in-south-africa
#15
Case Martin, Gerhard Thiart, Graham McCollum, Stephen Roche, Sithombo Maqungo
BACKGROUND: Injuries inflicted by gunshot wounds (GSWs) are an immense burden on the South African (SA) healthcare system. In 2005, Allard and Burch estimated SA state hospitals treated approximately 127 000 firearm victims annually and concluded that the cost of treating an abdominal GSW was approximately USD1 467 per patient. While the annual number of GSW injuries has decreased over the past decade, an estimated 54 870 firearm-related injuries occurred in SA in 2012. No study has estimated the burden of these GSWs from an orthopaedic perspective...
June 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29025454/an-audit-of-traumatic-brain-injury-tbi-in-a-busy-developing-world-trauma-service-exposes-a-significant-deficit-in-resources-available-to-manage-severe-tbi
#16
Ellen Jerome, Grant L Laing, John L Bruce, Ben Sartorius, Petra Brysiewicz, Damian L Clarke
BACKGROUND: Traumatic brain injury (TBI) affects large numbers of patients, both adults and children, and significant resources are needed to manage it. OBJECTIVE: To determine the burden of TBI and the adequacy of available resources to manage in the Pietermaritzburg Metropolitan Trauma Service (PMTS). METHODS: All patients with a TBI were identified from the hybrid electronic medical registry at Grey's and Edendale hospitals in Pietermaritzburg (PMB), KwaZulu-Natal, South Africa...
June 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29023315/biomarkers-of-drug-induced-kidney-injury
#17
Lynn Redahan, Patrick Murray
PURPOSE OF REVIEW: Drug-induced kidney injury (DIKI) is an important and potentially modifiable cause of acute kidney injury (AKI). The reliance on traditional markers of kidney injury to diagnose DIKI impedes early detection. Biomarkers of DIKI that facilitate early diagnosis and the identification of high-risk patients are essential to ameliorate the clinical burden of this complication. RECENT FINDINGS: Recent progress in this area supports the potential utility of several biomarkers for the diagnosis of DIKI, for the prediction of outcomes and also for monitoring responses to potential nephrotoxic or beneficial therapies...
October 11, 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/29021247/why-we-should-focus-on-the-burden-of-injuries-and-illnesses-not-just-their-incidence
#18
EDITORIAL
Roald Bahr, Benjamin Clarsen, Jan Ekstrand
No abstract text is available yet for this article.
October 11, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29020093/a-shift-from-motorised-travel-to-active-transport-what-are-the-potential-health-gains-for-an-australian-city
#19
Belen Zapata-Diomedi, Luke D Knibbs, Robert S Ware, Kristiann C Heesch, Marko Tainio, James Woodcock, J Lennert Veerman
INTRODUCTION: An alarmingly high proportion of the Australian adult population does not meet national physical activity guidelines (57%). This is concerning because physical inactivity is a risk factor for several chronic diseases. In recent years, an increasing emphasis has been placed on the potential for transport and urban planning to contribute to increased physical activity via greater uptake of active transport (walking, cycling and public transport). In this study, we aimed to estimate the potential health gains and savings in health care costs of an Australian city achieving its stated travel targets for the use of active transport...
2017: PloS One
https://www.readbyqxmd.com/read/29018914/the-effect-of-a-surgery-residency-program-and-enhanced-educational-activities-on-trauma-mortality-in-sub-saharan-africa
#20
Joana Grudziak, Jared Gallaher, Leonard Banza, Bruce Cairns, Carlos Varela, Sven Young, Anthony Charles
INTRODUCTION: To address the need for more surgical providers in low-resource settings, a collaboration to create a surgical residency-training program for local Malawian physicians was established in 2009. This study sought to describe the short-term independent effect of a surgical residency program on trauma mortality at a tertiary trauma center in sub-Saharan Africa. METHODS: We conducted a retrospective analysis of all patients recorded in the trauma surveillance registry of Kamuzu Central Hospital in Lilongwe, Malawi, from 2009 (three residents) through 2014 (11 residents)...
October 10, 2017: World Journal of Surgery
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