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https://www.readbyqxmd.com/read/29931160/variation-in-national-readmission-patterns-after-burn-injury
#1
Sarah A Eidelson, Joshua Parreco, Michelle B Mulder, Arjuna Dharmaraja, Joyce I Kaufman, Kenneth G Proctor, Louis R Pizano, Carl I Schulman, Nicholas Namias, Rishi Rattan
Background: A significant proportion of readmissions occur at a different hospital than the index admission, and are thus missed by current quality metrics. No study has examined all-hospital adult 30-day readmission rates, including to different hospitals, following burn injury across the US. The purpose of this study was to evaluate nationwide readmission rates, potential risk factors and ultimately the burden of burn injury readmission, including readmission to a different hospital...
June 19, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29923798/the-lifetime-cost-of-spinal-cord-injury-in-ontario-canada-a-population-based-study-from-the-perspective-of-the-public-health-care-payer
#2
Brian Chun-Fai Chan, Suzanne M Cadarette, Walter P Wodchis, Murray D Krahn, Nicole Mittmann
OBJECTIVE: To determine the publicly funded health care system lifetime cost-of-illness of spinal cord injury (SCI) from the perspective of the Ontario Ministry of Health and Long-term Care. METHODS: Individuals hospitalized for their first SCI between the years 2005 and 2011 were identified and their health care costs were calculated using Ontario administrative health care data. From this information, lifetime costs were estimated using phase-based costing methods...
June 20, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29914425/age-sex-and-the-changing-disability-burden-of-compensated-work-related-musculoskeletal-disorders-in-canada-and-australia
#3
Robert A Macpherson, Tyler J Lane, Alex Collie, Christopher B McLeod
BACKGROUND: The objectives of this study were (1) to identify age and sex trends in the disability burden of compensated work-related musculoskeletal disorders (MSDs) in Canada and Australia; and (2) to demonstrate a means of comparing workers' compensation data internationally. METHODS: All non-fatal, work-related MSD claims with at least one day of compensated time-loss were extracted for workers aged 15-80 during a 10-year period (2004-2013) using workers' compensation data from five Canadian and eight Australian jurisdictions...
June 19, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29914249/a-retrospective-study-examining-the-properties-and-characteristics-of-dementia-patients-in-a-palliative-care-center
#4
Metin Dinçer
Background/aim: The aim of this study is to evaluate why dementia patients (DPs) are admitted to a palliative care center (PCC) and which factors affect the length of stay (LOS) of DPs in the PCC, and to predict the course of the disease. Materials and methods: The files of DPs were scanned retrospectively in the PCC between 2013 and 2016. Data related to age, sex, LOS, symptoms, clinical conditions, comorbidities, and prognosis were recorded. Results: The study included 85 DPs with a mean age of 84.1 ± 6...
June 14, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29913815/distribution-of-concussion-related-symptoms-after-whiplash-injury-in-risk-strata
#5
Helge Kasch, Troels S Jensen
Background/aims The presence and severity of concussion related symptoms after acute whiplash injury are debatable. In this study we examine the distribution and development of the burden of concussion related symptoms in whiplash patients. Methods Consecutively 141 acute whiplash patients and 40 ankle injured controls were recruited from emergency units and were examined after 1 week, 1, 3, 6, 12 months obtaining neck/head VAS score, number-of-non-painful complaints, epidemiological, social, psychological data and neurological examination, active neck mobility, and furthermore muscle tenderness and pain response, strength and duration of neck muscles...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29910685/activation-of-central-alpha-7-nicotinic-acetylcholine-receptor-reverses-suppressed-immune-function-of-t-lymphocytes-and-protects-against-sepsis-lethality
#6
Chao Ren, Xiu-Hua Li, Shi-Bin Wang, Li-Xue Wang, Ning Dong, Yao Wu, Yong-Ming Yao
Sepsis remains the leading cause of high mortality and huge financial burden in intensive care units (ICU), but with scarce effective treatments due to refractory multiple organ dysfunction and persistent immunosuppression. Treatments that aim at modulating immune function and attenuating multiple organ injury will certainly benefit septic cases. Alpha 7 nicotinic acetylcholine receptor (α7nAchR) has been reported with potent immunomodulatory properties in various diseases as the essential mediator of the cholinergic anti-inflammatory pathway (CAP)...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29909774/cardiovascular-magnetic-resonance-assessment-of-acute-cardiovascular-effects-of-voluntary-apnoea-in-elite-divers
#7
L Eichhorn, J Doerner, J A Luetkens, J M Lunkenheimer, R C Dolscheid-Pommerich, F Erdfelder, R Fimmers, J Nadal, B Stoffel-Wagner, H H Schild, A Hoeft, B Zur, C P Naehle
BACKGROUND: Prolonged breath holding results in hypoxemia and hypercapnia. Compensatory mechanisms help maintain adequate oxygen supply to hypoxia sensitive organs, but burden the cardiovascular system. The aim was to investigate human compensatory mechanisms and their effects on the cardiovascular system with regard to cardiac function and morphology, blood flow redistribution, serum biomarkers of the adrenergic system and myocardial injury markers following prolonged apnoea. METHODS: Seventeen elite apnoea divers performed maximal breath-hold during cardiovascular magnetic resonance imaging (CMR)...
June 18, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29907132/association-between-multiple-comorbidities-and-self-rated-health-status-in-middle-aged-and-elderly-chinese-the-china-kadoorie-biobank-study
#8
Xingyue Song, Jing Wu, Canqing Yu, Wenhong Dong, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Zhengming Chen, An Pan, Liming Li
BACKGROUND: Understanding the correlates of self-rated health (SRH) can help public health professionals prioritize health-promotion and disease-prevention interventions. This study aimed to investigate the association between multiple comorbidities and global SRH and age-comparative SRH. METHODS: A total of 512,891 participants aged 30-79 years old were recruited into the China Kadoorie Biobank study from ten regions between 2004 and 2008. Multivariate logistic regression models were used to estimate the odds ratios (ORs) for the associations between comorbidities (including diabetes, hypertension, coronary heart disease, rheumatic heart disease, stroke, tuberculosis, emphysema/bronchitis, asthma, cirrhosis/chronic hepatitis, peptic ulcer, gallbladder disease, kidney disease, fracture, rheumatic arthritis, psychiatric disorders, depressive symptoms, neurasthenia, head injury and cancer) and SRH...
June 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29904225/postgraduate-training-for-trauma-prevention-injury-surveillance-and-research-uganda
#9
Abdulgafoor M Bachani, Nino Paichadze, Jacob A Bentley, Nazarius Mbona Tumwesigye, David Bishai, Lynn Atuyambe, Stephen Wegener, David Guwatudde, Olive C Kobusingye, Adnan A Hyder
Problem: The burden of trauma and injuries in Uganda is substantial and growing. Two important gaps that need addressing are the shortage of trained people and a lack of national data on noncommunicable diseases and their risk factors in Uganda. Approach: We developed and implemented a new track within an existing master of public health programme, aimed at developing graduate-level capacity and promoting research on key national priorities for trauma and injuries...
June 1, 2018: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/29904166/pharmacological-activation-of-epidermal-growth-factor-receptor-signaling-inhibits-colitis-associated-cancer-in-mice
#10
Philip E Dubé, Cambrian Y Liu, Nandini Girish, M Kay Washington, D Brent Polk
Current treatments for inflammatory bowel disease (IBD) target the overactive immune response of the intestinal mucosa. However, epidermal growth factor (EGF), an activating ligand of the EGF receptor (EGFR), has been shown to induce disease remission through direct targeting of intestinal mucosal healing. Despite promising preclinical and clinical results, this EGFR-activating therapy has not progressed, in part due to the potential for carcinogenesis associated with long-term use and the increased risk of colitis-associated cancer (CAC) in IBD...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29903377/morbidity-mortality-and-long-term-consequences-associated-with-diarrhoea-from-cryptosporidium-infection-in-children-younger-than-5-years-a-meta-analyses-study
#11
Ibrahim A Khalil, Christopher Troeger, Puja C Rao, Brigette F Blacker, Alexandria Brown, Thomas G Brewer, Danny V Colombara, Eugenio L De Hostos, Cyril Engmann, Richard L Guerrant, Rashidul Haque, Eric R Houpt, Gagandeep Kang, Poonum S Korpe, Karen L Kotloff, Aldo A M Lima, William A Petri, James A Platts-Mills, David A Shoultz, Mohammed H Forouzanfar, Simon I Hay, Robert C Reiner, Ali H Mokdad
BACKGROUND: The protozoan Cryptosporidium is a leading cause of diarrhoea morbidity and mortality in children younger than 5 years. However, the true global burden of Cryptosporidium infection in children younger than 5 years might have been underestimated in previous quantifications because it only took account of the acute effects of diarrhoea. We aimed to demonstrate whether there is a causal relation between Cryptosporidium and childhood growth and, if so, to quantify the associated additional burden...
July 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29903000/assessing-out-of-pocket-expenditures-for-primary-health-care-how-responsive-is-the-democratic-republic-of-congo-health-system-to-providing-financial-risk-protection
#12
Samia Laokri, Rieza Soelaeman, David R Hotchkiss
BACKGROUND: The goal of universal health coverage is challenging for chronically under-resourced health systems. Although household out-of-pocket payments are the most important source of health financing in low-income countries, relatively little is known about the drivers of primary health care expenditure and the predictability of the burden associated with high fee-for-service payments. This study describes out-of-pocket health expenditure and investigates demand- and supply-side drivers of excessive costs in the Democratic Republic of Congo (DRC), a central African country in the midst of a process of reforming its health financing system towards universal health coverage...
June 15, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29899265/complement-activation-in-liver-transplantation-role-of-donor-macrosteatosis-and-implications-in-delayed-graft-function
#13
REVIEW
Kelley Núñez, Paul Thevenot, Abeer Alfadhli, Ari Cohen
The complement system anchors the innate inflammatory response by triggering both cell-mediated and antibody-mediated immune responses against pathogens. The complement system also plays a critical role in sterile tissue injury by responding to damage-associated molecular patterns. The degree and duration of complement activation may be a critical variable controlling the balance between regenerative and destructive inflammation following sterile injury. Recent studies in kidney transplantation suggest that aberrant complement activation may play a significant role in delayed graft function following transplantation, confirming results obtained from rodent models of renal ischemia/reperfusion (I/R) injury...
June 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29899048/an-ounce-of-prevention-is-better-than-a-pound-of-cure-shouldn-t-we-be-doing-everything-to-reduce-sports-injury-incidence-and-burden
#14
EDITORIAL
Adam Gledhill, Dale Forsdyke
No abstract text is available yet for this article.
June 13, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29898648/toll-like-receptors-signaling-pathways-as-a-potential-therapeutic-target-in-cardiovascular-disease
#15
Seyed Mostafa Parizadeh, Maryam Ghandehari, Motahareh Heydari-Majd, Sima Seifi, Ramin Mardani, Seyed Mohamahdreza Parizadeh, Majid Ghayour-Mobarhan, Gordon A Ferns, Seyed Mahdi Hassanian, Amir Avan
Cardiovascular disease (CVD) is one of the most important causes of morbidity and mortality, and associated with an important economic burden globally. Over the last decade, the prevalence of CVD has been rising globally, and is now associated with millions of death annually in both developed and developing countries. There is good evidence that the immune system is involved in the pathophysiology of CVD. Toll-like receptors (TLRs) and their down-stream signaling pathways play an important role in the immune system...
June 13, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29896932/the-united-states-opioid-epidemic-a-review-of-the-surgeon-s-contribution-and-health-policy-initiatives
#16
REVIEW
Katherine Theisen, Bruce Jacobs, Liam Macleod, Benjamin Davies
Opioid abuse, addiction, and death have reached epidemic proportions in the United States. Communities wear the devastation of the crisis in there pockmarked geography where addiction has increased homelessness and abandoned homes. Rural communities have fractured under the burden while urban centers struggle to contain open market drug dealing. Since 2015 drug overdoses have been the leading cause of injury related death in the United States [1]. Nearly 6% of the US population aged 15-64 reported abusing opioids in 2015; compare this to less than 1% for most other countries [2]...
June 13, 2018: BJU International
https://www.readbyqxmd.com/read/29894670/galectin-3-and-n-acetylglucosamine-promote-myogenesis-and-improve-skeletal-muscle-function-in-the-mdx-model-of-duchenne-muscular-dystrophy
#17
Ann Rancourt, Sébastien S Dufresne, Guillaume St-Pierre, Julie-Christine Lévesque, Haruka Nakamura, Yodai Kikuchi, Masahiko S Satoh, Jérôme Frenette, Sachiko Sato
The muscle membrane, sarcolemma, must be firmly attached to the basal lamina. The failure of proper attachment results in muscle injury, which is the underlying cause of Duchenne muscular dystrophy (DMD), in which mutations in the dystrophin gene disrupts the firm adhesion. In patients with DMD, even moderate contraction causes damage, leading to progressive muscle degeneration. The damaged muscles are repaired through myogenesis. Consequently, myogenesis is highly active in patients with DMD, and the repeated activation of myogenesis leads to the exhaustion of the myogenic stem cells...
June 12, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29894490/biopsychosocial-factors-associated-with-non-recovery-after-a-minor-transport-related-injury-a-systematic-review
#18
Stella Samoborec, Rasa Ruseckaite, Darshini Ayton, Sue Evans
BACKGROUND: Globally, road transport accidents contribute significantly to mortality and burden of disability. Up to 50 million people suffer a transport-related non-fatal injury each year, which often leads to long-term disability. A substantial number of people with minor injuries struggle to recover and little is known about the factors leading to poor or non-recovery. The aim of this paper is to present a systematic review of biopsychosocial factors related to poor or non-recovery after a minor transport-related injury...
2018: PloS One
https://www.readbyqxmd.com/read/29894116/evaluation-of-the-impact-of-ambient-temperatures-on-occupational-injuries-in-spain
#19
Èrica Martínez-Solanas, María López-Ruiz, Gregory A Wellenius, Antonio Gasparrini, Jordi Sunyer, Fernando G Benavides, Xavier Basagaña
BACKGROUND: Extreme cold and heat have been linked to an increased risk of occupational injuries. However, the evidence is still limited to a small number of studies of people with relatively few injuries and with a limited geographic extent, and the corresponding economic effect has not been studied in detail. OBJECTIVES: We assessed the relationship between ambient temperatures and occupational injuries in Spain along with its economic effect. METHODS: The daily number of occupational injuries that caused at least one day of leave and the daily maximum temperature were obtained for each Spanish province for the years 1994-2013...
June 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29893224/measuring-performance-on-the-healthcare-access-and-quality-index-for-195-countries-and-territories-and-selected-subnational-locations-a-systematic-analysis-from-the-global-burden-of-disease-study-2016
#20
(no author information available yet)
BACKGROUND: A key component of achieving universal health coverage is ensuring that all populations have access to quality health care. Examining where gains have occurred or progress has faltered across and within countries is crucial to guiding decisions and strategies for future improvement. We used the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) to assess personal health-care access and quality with the Healthcare Access and Quality (HAQ) Index for 195 countries and territories, as well as subnational locations in seven countries, from 1990 to 2016...
June 2, 2018: Lancet
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