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https://www.readbyqxmd.com/read/29456049/six-month-outcomes-after-high-risk-coronary-artery-bypass-graft-surgery-and-preoperative-intra-aortic-balloon-counterpulsation-use-an-inception-cohort-study
#1
Edward Litton, Frances Bass, Anthony Delaney, Graham Hillis, Silvana Marasco, Shay McGuinness, Paul S Myles, Christopher M Reid, Julian A Smith
OBJECTIVE: To inform the design of a pivotal randomized controlled trial of prophylactic intra-aortic balloon counterpulsation (IABC) in patients undergoing coronary artery bypass graft (CABG) at high risk of postoperative low cardiac output syndrome (LCOS). DESIGN: Inception cohort study. SETTING: A total of 13 established cardiac centers in Australia, Canada, New Zealand, and the United Kingdom. PARTICIPANTS: Adult patients were eligible for inclusion if they were listed for CABG surgery and had 2 or more LCOS risk factors (low ejection fraction, severe left main coronary artery disease, redo sternotomy, unstable angina)...
January 5, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29454770/molecular-imaging-of-apoptosis-in-ischemia-reperfusion-injury-with-radiolabeled-duramycin-targeting-phosphatidylethanolamine-effective-target-uptake-and-reduced-nontarget-organ-radiation-burden
#2
Hideki Kawai, Farhan Chaudhry, Aditya Shekhar, Artiom Petrov, Takehiro Nakahara, Takashi Tanimoto, Dongbin Kim, Jiqiu Chen, Djamel Lebeche, Francis G Blankenberg, Koon Y Pak, Frank D Kolodgie, Renu Virmani, Partho Sengupta, Navneet Narula, Roger J Hajjar, Harry W Strauss, Jagat Narula
OBJECTIVES: The purpose of this study was to evaluate the feasibility of imaging apoptosis in experimental ischemia-reperfusion model by technetium-99m (99m Tc)-labeled Duramycin, and compare it to an established tracer,99m Tc-labeled Annexin-V, which has a relative disadvantage of high radiation burden to nontarget organs. BACKGROUND: During apoptosis, the cell membrane phospholipids-phosphatidylserine (PS) and phosphatidylethanolamine (PE) are exposed and can be targeted by Annexin-V and Duramycin, respectively, for in vivo imaging...
February 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29454115/traumatic-spinal-injury-global-epidemiology-and-worldwide-volume
#3
Ramesh Kumar, Jaims Lim, Rania A Mekary, Abbas Rattani, Michael C Dewan, Salman Y Sharif, Enrique Osorio-Fonseca, Kee B Park
BACKGROUND: Traumatic spinal injury (TSI) results from injury to bony, ligamentous and/or neurological structures of the spinal column and can cause significant morbidity and mortality. The global burden of TSI is poorly understood, so we performed a systematic review and meta-analysis to estimate the global volume of TSI. METHODS: We performed a systematic review through PubMed, Embase and Cochrane Databases on TSI studies published from 2000 to 2016. Collected data were used to perform a meta-analysis to estimate the annual incidence of TSI across World Health Organization (WHO) regions and World Bank income groups using random effect models...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29453189/evaluating-the-care4carer-blended-care-intervention-for-partners-of-patients-with-acquired-brain-injury-protocol-for-a-randomized-controlled-trial
#4
Vincent Cm Cox, Vera Pm Schepers, Marjolijn Ketelaar, Caroline M van Heugten, Johanna Ma Visser-Meily
BACKGROUND: Support programs for partners of patients with acquired brain injury are necessary since these partners experience several unfavorable consequences of caregiving, such as a high burden, emotional distress, and poor quality of life. Evidence-based support strategies that can be included in these support programs are psychoeducation, skill building, problem solving, and improving feelings of mastery. A promising approach would seem to be to combine web-based support with face-to-face consultations, creating a blended care intervention...
February 16, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29453113/epidemiological-profile-of-epilepsy-in-low-income-populations
#5
REVIEW
Camilo Espinosa-Jovel, Rafael Toledano, Ángel Aledo-Serrano, Irene García-Morales, Antonio Gil-Nagel
Epilepsy is a global disease with an unequal distribution. About 80% of the affected individuals reside in low and middle income countries. The incidence and prevalence of epilepsy in low income populations is higher than in the rest of the world, this is partly explained by some risk factors such as head trauma, perinatal injury and CNS infections, which are more common in poor regions, especially in rural areas. Epilepsy is considered a treatable condition with high rates of therapeutic response. About three fourths of patients achieve control of the disease with the use of antiepileptic drugs, however, despite this benign prognosis, over 75% of patients from low income populations do not receive treatment at all...
February 8, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29453112/pattern-and-determinants-of-self-reported-enacted-stigma-among-rural-dwellers-living-with-epilepsy-attending-a-tertiary-health-facility-in-enugu-state-nigeria
#6
Birinus A Ezeala-Adikaibe, Justin U Achor, Eddy Aneke, Uchenna Ijoma, Obinna D Onodugo, Casmir Orjioke, Chinwe Onyekonwu, Oluchi Ekenze
PURPOSE: Epilepsy related stigma is a barrier to recovery and has been linked to a broad range of psychosocial consequences and has the potential to influence the provision of care to people with epilepsy. Understanding the determinants of enacted stigma in epilepsy is relevant in the understanding of the burden of epilepsy in Nigeria. METHOD: Using a semi-structured questionnaire, a cross-sectional descriptive study was conducted among rural dwellers receiving treatment for epilepsy in a tertiary referral specialist hospital in Enugu, south east Nigeria...
February 10, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29452802/moving-to-human-trials-for-argon-neuroprotection-in-neurological-injury-a-narrative-review
#7
REVIEW
A J Gardner, D K Menon
Despite the global burden of brain injury, neuroprotective agents remain elusive. There are no clinically effective therapies which reduce mortality or improve long-term cognitive outcome. Ventilation could be an easily modifiable variable in resuscitation; gases are relatively simple to administer. Xenon is the prototypic agent of a new generation of experimental treatments which show promise. However, use is hindered by its prohibitive cost and anaesthetic properties. Argon is an attractive option, being cheaper, easy to transport, non-sedating, and mechanistically distinct from xenon...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29451202/stem-cells-for-spinal-cord-injuries-bearing-translational-potential
#8
REVIEW
Kyriakos Dalamagkas, Magdalini Tsintou, Alexander M Seifalian
Spinal cord injury (SCI) is a highly debilitating neurological disease, which still lacks effective treatment strategies, causing significant financial burden and distress to the affected families. Nevertheless, nanotechnology and regenerative medicine strategies holding promise for the development of novel therapies that would reach from bench to bedside to serve the SCI patients. There has already been significant progress in the field of cell-based therapies, with the clinical application for SCI, currently in phase II of the clinical trial...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29450701/burden-characteristics-and-process-of-care-among-the-pediatric-and-adult-trauma-patients-in-botswana-s-main-hospitals
#9
Michael B Mwandri, Timothy C Hardcastle
BACKGROUND: Botswana is notable among countries with high rates of Road Traffic Collisions (RTC); like many other lower-middle-income countries (LMICs), it lacks trauma systems. The World Health Organization recommends 'Essential Trauma Care' in countries with no formal trauma systems. The proportion of injuries in Emergency Departments and the care process were investigated to gain an overview for enabling the design of a relevant LMICs trauma system. METHOD: Blunt and penetrating trauma patients were included from three major hospitals, examining the proportion of injuries, patient characteristics, the care process and comparing these between pediatrics and adults...
February 15, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29448968/corporate-practices-and-health-a-framework-and-mechanisms
#10
REVIEW
Joana Madureira Lima, Sandro Galea
BACKGROUND: The Global Burden of Disease estimates that approximately a third of deaths worldwide are attributable to behavioural risk factors that, at their core, have the consumption of unhealthful products and exposures produced by profit driven commercial entities. We use Steven Lukes' three-dimensional view of power to guide the study of the practices deployed by commercial interests to foster the consumption of these commodities. Additionally, we propose a framework to systematically study corporations and other commercial interests as a distal, structural, societal factor that causes disease and injury...
February 15, 2018: Globalization and Health
https://www.readbyqxmd.com/read/29447139/global-burden-of-neuropathic-pain
#11
Fiona M Blyth
Global burden of disease studies measure the impact of disability and premature death resulting from specific diseases and injuries. Recently, these studies have highlighted the leading contribution of regional pain conditions (low back pain and neck pain in particular) to the global burden of disability. However, to date, there has not been a systematic approach to measuring the global burden of disease attributable to neuropathic pain (NP) conditions. This article gives a brief overview of the concept of burden of disease, the underlying drivers, and dynamics of disease burden at a population level and proposes an agenda in relation to NP for developing the conceptual and empirical evidence base necessary for estimating the global burden of NP...
March 2018: Pain
https://www.readbyqxmd.com/read/29444686/cumulative-incidence-distribution-and-determinants-of-catastrophic-health-expenditure-in-nepal-results-from-the-living-standards-survey
#12
Mamata Ghimire, Rakesh Ayer, Masahide Kondo
BACKGROUND: Nepal has committed to the global community to achieve universal health coverage by 2030. Nevertheless, Nepal still has a high proportion of out-of-pocket health payment and a limited risk-pooling mechanism. Out-of-pocket payment for the healthcare services could result in catastrophic health expenditure (CHE). Evidence is required to effectively channel the efforts to lower those expenses in order to achieve universal health coverage. However, little is known about CHE and its determinants in a broad national context in Nepal...
February 14, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29444513/comparison-of-three-methods-estimating-baseline-creatinine-for-acute-kidney-injury-in-hospitalized-patients-a-multicentre-survey-in-third-level-urban-hospitals-of-china
#13
Xia-Bing Lang, Yi Yang, Ju-Rong Yang, Jian-Xin Wan, Sheng-Qiang Yu, Jiong Cui, Xiao-Jing Tang, Jianghua Chen
BACKGROUND/AIMS: A lack of baseline serum creatinine (SCr) data leads to underestimation of the burden caused by acute kidney injury (AKI) in developing countries. The goal of this study was to investigate the effects of various baseline SCr analysis methods on the current diagnosis of AKI in hospitalized patients. METHODS: Patients with at least one SCr value during their hospital stay between January 1, 2011 and December 31, 2012 were retrospectively included in the study...
February 8, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29443863/trauma-induced-insurance-instability-variation-in-insurance-coverage-for-patients-who-experience-readmission-after-injury
#14
Charlotte M Rajasingh, Thomas G Weiser, Lisa M Knowlton, Lakshika Tennakoon, David A Spain, Kristan L Staudenmayer
INTRODUCTION: Traumatic injuries result in a significant disruption to patients' lives, including their ability to work, which may place patients at risk of losing insurance coverage. Our objective was to evaluate the impact of injury on insurance status. We hypothesized that trauma patients with ongoing health needs experience changes in coverage. METHODS: We used the Nationwide Readmission Database (2013-2014), a nationally representative sample of readmissions in the United States...
February 13, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29437783/estimating-the-international-burden-of-sport-related-death-a-review-of-data-sources
#15
Kristen L Kucera, Lauren V Fortington, Catherine S Wolff, Stephen W Marshall, Caroline F Finch
INTRODUCTION: Despite detailed recommendations for sports injury data capture provided since the mid-1990s, international data collection efforts for sport-related death remains limited in scope. The purpose of this paper was to review the data sources available for studying sport-related death and describe their key features, coverage, accessibility and strengths and limitations. METHODS: The outcomes of interest for this review was death occurring as a result of participation in organised sport-related activity...
February 1, 2018: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/29434460/relationship-between-comorbidities-and-employment-among-veterans-with-spinal-cord-injury
#16
Lance L Goetz, Lisa Ottomanelli, Scott D Barnett, Bryce Sutton, Eni Njoh
Objective: To determine the relationship between medical and mental health comorbidities in a large cohort of veterans with spinal cord injury (SCI). Methods: Data were collected from interviews and electronic medical records of veterans with SCI (N = 1,047) who received care at 7 geographically diverse SCI centers within the Department of Veterans Affairs across the country (https://clinicaltrials.gov/ct2/show/NCT01141647). Employment, medical, functional, and psychosocial data underwent cross-sectional analysis...
2018: Topics in Spinal Cord Injury Rehabilitation
https://www.readbyqxmd.com/read/29433914/is-it-possible-to-recover-from-traumatic-brain-injury-and-a-glasgow-coma-scale-score-of-3-at-emergency-department-presentation
#17
Farid Sadaka, Amar Jadhav, Melinda Miller, Ammar Saifo, Jacklyn O'Brien, Steven Trottier
INTRODUCTION: A Glasgow Coma Scale (GCS) score of 3 on presentation in patients with traumatic brain injury (TBI) portends a poor prognosis. Consequently, there is often a tendency to treat these patients less aggressively because of low expectations for a good outcome. METHODS AND RESULTS: We performed a retrospective review of patients with TBI and a GCS score of 3. Patients were divided into 2 groups based on Glasgow Outcome Scale (GOS): Group 1 (GOS=1-3) and Group 2 (GOS=4-5)...
January 31, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29433888/trauma-registry-implementation-in-low-and-middle-income-countries-challenges-and-opportunities
#18
REVIEW
Krishna Bommakanti, Isabelle Feldhaus, Girish Motwani, Rochelle A Dicker, Catherine Juillard
BACKGROUND: Trauma registries are an essential part of trauma quality improvement programs aimed at decreasing morbidity and mortality in high-income countries. In low- and middle-income countries (LMICs), where the burden of injury is disproportionately high, hospitals have faced challenges in adapting trauma registry models implemented in high-income countries. We analyze the barriers to trauma registry implementation in LMICs to inform development of sustainable models in resource-constrained settings...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29433877/self-inflicted-gunshot-wounds-readmission-patterns
#19
Charlotte M Rajasingh, Lakshika Tennakoon, Kristan L Staudenmayer
BACKGROUND: Self-inflicted gunshot wounds (SI-GSWs) are often fatal, but roughly 20% of individuals survive. What happens to survivors after the initial hospitalization is unknown. We hypothesized that the SI-GSW survivors are frequently readmitted and that the pattern of readmission is different from that of the survivors of non-GSW self-harm (SH). METHODS: We conducted a retrospective cohort analysis using the 2013 and 2014 Nationwide Readmission Database. Patients with any diagnosis indicating deliberate SH in the first 6 months of the year were included...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29433665/global-disability-adjusted-life-year-estimates-of-long-term-health-burden-and-undernutrition-attributable-to-diarrhoeal-diseases-in-children-younger-than-5-years
#20
Christopher Troeger, Danny V Colombara, Puja C Rao, Ibrahim A Khalil, Alexandria Brown, Thomas G Brewer, Richard L Guerrant, Eric R Houpt, Karen L Kotloff, Kavita Misra, William A Petri, James Platts-Mills, Mark S Riddle, Scott J Swartz, Mohammad H Forouzanfar, Robert C Reiner, Simon I Hay, Ali H Mokdad
BACKGROUND: Diarrhoea is a leading cause of death and illness globally among children younger than 5 years. Mortality and short-term morbidity cause substantial burden of disease but probably underestimate the true effect of diarrhoea on population health. This underestimation is because diarrhoeal diseases can negatively affect early childhood growth, probably through enteric dysfunction and impaired uptake of macronutrients and micronutrients. We attempt to quantify the long-term sequelae associated with childhood growth impairment due to diarrhoea...
March 2018: Lancet Global Health
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