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JOURNAL ARTICLE
Mazvita Muchengeti, Julia Bohlius, Tafadzwa G Dhokotera
PURPOSE OF REVIEW: Historically, conjunctival cancer has been associated with HIV particularly in sub-Saharan Africa. The human papilloma virus (HPV) has been implicated as a potential causative agent without conclusive evidence. This review covers recent evidence of the epidemiology, diagnosis and treatment of conjunctival cancer in people living with HIV (PLWH). RECENT FINDINGS: HIV infection has been attributed to 33% of squamous cell carcinoma of the conjunctiva in sub-Saharan Africa...
February 1, 2021: Current Opinion in Infectious Diseases
#22
JOURNAL ARTICLE
Katayoun Taghavi, Eliane Rohner, Partha Basu, Nicola Low, Anne Rutjes, Julia Bohlius
BACKGROUND: Portable devices that can be used to perform colposcopy may improve cervical cancer screening in low- and middle-income countries (LMIC) where access to colposcopy is limited. The objective of this study was to systematically review the diagnostic test accuracy (DTA) of these devices for the detection of cervical intraepithelial neoplasia grade 2 or higher (CIN2+). METHODS: In accordance with our protocol (Prospero CRD42018104286), we searched Embase, Medline and the Cochrane Controlled Register of Trials up to 9/2019...
November 16, 2020: BMC Women's Health
#23
JOURNAL ARTICLE
Kristina Stojkov, Tobias Silzle, Georg Stussi, David Schwappach, Juerg Bernhard, David Bowen, Jaroslav Čermák, Avinash G Dinmohamed, Corien Eeltink, Sabrina Eggmann, Pierre Fenaux, Ulrich Germing, Manuel Haschke, Eva Hellstrom-Lindberg, Monika Heger, Arjan A van de Loosdrecht, Jakob Passweg, Michael Pfeilstöcker, Uwe Platzbecker, Luca Malcovati, António Medina de Almeida, Moshe Mittelman, Christine Morgenthaler, David P Steensma, Valeria Santini, Reinhard Stauder, Argiris Symeonidis, Sämi Schär, Charlotte Maddox, Theo de Witte, Julia Bohlius, Nicolas Bonadies
Myelodysplastic syndromes (MDSs) represent a heterogeneous group of hematological stem cell disorders with an increasing burden on health care systems. Evidence-based MDS guidelines and recommendations (G/Rs) are published but do not necessarily translate into better quality of care if adherence is not maintained in daily clinical practice. Guideline-based indicators (GBIs) are measurable elements for the standardized assessment of quality of care and, thus far, have not been developed for adult MDS patients...
August 25, 2020: Blood Advances
#24
JOURNAL ARTICLE
Taulant Muka, Marija Glisic, Jelena Milic, Sanne Verhoog, Julia Bohlius, Wichor Bramer, Rajiv Chowdhury, Oscar H Franco
To inform evidence-based practice in health care, guidelines and policies require accurate identification, collation, and integration of all available evidence in a comprehensive, meaningful, and time-efficient manner. Approaches to evidence synthesis such as carefully conducted systematic reviews and meta-analyses are essential tools to summarize specific topics. Unfortunately, not all systematic reviews are truly systematic, and their quality can vary substantially. Since well-conducted evidence synthesis typically involves a complex set of steps, we believe formulating a cohesive, step-by-step guide on how to conduct a systemic review and meta-analysis is essential...
January 2020: European Journal of Epidemiology
#25
MULTICENTER STUDY
Eliane Rohner, Lukas Bütikofer, Kurt Schmidlin, Mazvita Sengayi, Mhairi Maskew, Janet Giddy, Katayoun Taghavi, Richard D Moore, James J Goedert, M John Gill, Michael J Silverberg, Gypsyamber D'Souza, Pragna Patel, Jessica L Castilho, Jeremy Ross, Annette Sohn, Firouze Bani-Sadr, Ninon Taylor, Vassilios Paparizos, Fabrice Bonnet, Annelies Verbon, Jörg Janne Vehreschild, Frank A Post, Caroline Sabin, Amanda Mocroft, Fernando Dronda, Niels Obel, Sophie Grabar, Vincenzo Spagnuolo, Eugenia Quiros-Roldan, Cristina Mussini, José M Miro, Laurence Meyer, Barbara Hasse, Deborah Konopnicki, Bernardino Roca, Diana Barger, Gary M Clifford, Silvia Franceschi, Matthias Egger, Julia Bohlius
We compared invasive cervical cancer (ICC) incidence rates in Europe, South Africa, Latin and North America among women living with HIV who initiated antiretroviral therapy (ART) between 1996 and 2014. We analyzed cohort data from the International Epidemiology Databases to Evaluate AIDS (IeDEA) and the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord. We used flexible parametric survival models to determine regional ICC rates and risk factors for incident ICC. We included 64,231 women from 45 countries...
February 1, 2020: International Journal of Cancer. Journal International du Cancer
#26
JOURNAL ARTICLE
Julia Bohlius, Kari Bohlke, Alejandro Lazo-Langner
No abstract text is available yet for this article.
July 2019: Journal of Oncology Practice
#27
JOURNAL ARTICLE
Tafadzwa Dhokotera, Julia Bohlius, Adrian Spoerri, Matthias Egger, Jabulani Ncayiyana, Victor Olago, Elvira Singh, Mazvita Sengayi
Introduction: The impact of South Africa's high human immunodeficiency virus (HIV) burden on cancer risk is not fully understood, particularly in the context of antiretroviral treatment (ART) availability. We examined national cancer trends and excess cancer risk in people living with HIV (PLHIV) compared to those who are HIV-negative. Methods: We used probabilistic record linkage to match cancer records provided by the National Cancer Registry to HIV data provided by the National Health Laboratory Service (NHLS)...
2019: Infectious Agents and Cancer
#28
JOURNAL ARTICLE
P Koehler, M Stecher, O A Cornely, D Koehler, M J G T Vehreschild, J Bohlius, H Wisplinghoff, J J Vehreschild
OBJECTIVES: Candidaemia is a serious hazard to hospitalized patients, but European epidemiological data are restricted to national studies focusing on Northern Europe, population-based surveillance programmes or studies conducted in distinct local areas. The aim was to provide current data on the overall burden and epidemiological development of candidaemia in Europe. METHODS: A Web of Knowledge™ search was carried out from January 2000 to February 2019. Appropriate data were collected on total cases, study duration, incidence, species distribution and/or mortality rates...
October 2019: Clinical Microbiology and Infection
#29
REVIEW
Julia Bohlius, Kari Bohlke, Roberto Castelli, Benjamin Djulbegovic, Maryam B Lustberg, Massimo Martino, Giannis Mountzios, Namrata Peswani, Laura Porter, Tiffany N Tanaka, Gianluca Trifirò, Hushan Yang, Alejandro Lazo-Langner
PURPOSE: To update the American Society of Clinical Oncology (ASCO)/American Society of Hematology (ASH) recommendations for use of erythropoiesis-stimulating agents (ESAs) in patients with cancer. METHODS: PubMed and the Cochrane Library were searched for randomized controlled trials (RCTs) and meta-analyses of RCTs in patients with cancer published from January 31, 2010, through May 14, 2018. For biosimilar ESAs, the literature search was expanded to include meta-analyses and RCTs in patients with cancer or chronic kidney disease and cohort studies in patients with cancer due to limited RCT evidence in the cancer setting...
April 23, 2019: Blood Advances
#30
JOURNAL ARTICLE
Julia Bohlius, Kari Bohlke, Roberto Castelli, Benjamin Djulbegovic, Maryam B Lustberg, Massimo Martino, Giannis Mountzios, Namrata Peswani, Laura Porter, Tiffany N Tanaka, Gianluca Trifirò, Hushan Yang, Alejandro Lazo-Langner
PURPOSE: To update the American Society of Clinical Oncology (ASCO)/American Society of Hematology (ASH) recommendations for use of erythropoiesis-stimulating agents (ESAs) in patients with cancer. METHODS: PubMed and the Cochrane Library were searched for randomized controlled trials (RCTs) and meta-analyses of RCTs in patients with cancer published from January 31, 2010, through May 14, 2018. For biosimilar ESAs, the literature search was expanded to include meta-analyses and RCTs in patients with cancer or chronic kidney disease and cohort studies in patients with cancer due to limited RCT evidence in the cancer setting...
May 20, 2019: Journal of Clinical Oncology
#31
JOURNAL ARTICLE
Lucas Affentranger, Julia Bohlius, Mahmoud Hallal, Nicolas Bonadies
Anemic patients with lower risk myelodysplastic syndromes are frequently treated with erythropoiesis stimulating agents (ESA), eventually in combination with granulocyte colony stimulating factor (G-CSF). However, the evidence for the efficacy of a combined treatment remains controversial. The goal of our analysis was to assess the available evidence for a combined treatment. We performed a systematic review and identified only nine eligible studies. In two randomized controlled trials (n = 98), erythroid response rates were 33% and 40% after low-/standard-doses of ESA alone (10,000-30,000 rHuEPO equivalents/week) versus 65% and 73% after combination treatment...
April 2019: Critical Reviews in Oncology/hematology
#32
JOURNAL ARTICLE
Marie-Josèphe Horner, Steady Chasimpha, Adrian Spoerri, Jessie Edwards, Julia Bohlius, Hannock Tweya, Petros Tembo, Franklin Nkhambule, Eddie Moffo Phiri, William C Miller, Kennedy Malisita, Sam Phiri, Charles Dzamalala, Andrew F Olshan, Satish Gopal
Background: With antiretroviral therapy (ART), AIDS-defining cancer incidence has declined and non-AIDS defining cancers are now more frequent among HIV-infected populations in high-income countries. In sub-Saharan Africa, limited epidemiological data describe cancer burden among ART users. Methods: We used probabilistic algorithms to link cases from the population-based cancer registry with electronic medical records supporting ART delivery in the Malawi's two largest HIV cohorts, Lighthouse Trust (LT; 2007-2010) and Queen Elizabeth Central Hospital (QECH; 2000-2010)...
November 17, 2018: Clinical Infectious Diseases
#33
JOURNAL ARTICLE
Julia Bohlius, Caroline Foster, Gita Naidu, Mazvita Sengayi, Anna Turkova
PURPOSE OF REVIEW: Adults living with HIV have an increased risk of malignancy yet there is little data for adolescents and young adults. We reviewed recently published cancer epidemiology, treatment, and outcome data for adolescents and young adults living with HIV (AYALHIV) aged 10 to less than 25 years between 2016 and 2017. RECENT FINDINGS: AYALHIV are at increased risk of developing cancer compared to their uninfected peers. Kaposi sarcoma and non-Hodgkin lymphoma occur most frequently with variation by geographical region...
May 2018: Current Opinion in HIV and AIDS
#34
REVIEW
Eliane Rohner, Michael Grabik, Thomy Tonia, Peter Jüni, Frank Pétavy, Francesco Pignatti, Julia Bohlius
Since 2010, the European Medicines Agency (EMA) has provided access to clinical study reports (CSRs). We requested CSRs for randomized controlled trials (RCTs) of erythropoiesis-stimulating agents (ESAs) in cancer patients from EMA and identified RCT publications with literature searches. We assessed CSR availability and completeness, the impact of unreported and unpublished data obtained from CSRs on the effects of ESAs on quality of life (QoL) of cancer patients, and discrepancies between data reported in the public domain and in CSRs...
2017: PloS One
#35
JOURNAL ARTICLE
M M Sengayi, D Kielkowski, M Egger, L Dreosti, J Bohlius
BACKGROUND: When South Africa (SA) implemented its antiretroviral therapy (ART) programme in 2004, the model for treating HIV-positive Kaposi's sarcoma (KS) patients shifted from symptomatic palliation to potential cure. OBJECTIVE: To evaluate survival and changes over time in AIDS-KS patients treated at a tertiary academic hospital oncology unit (the Steve Biko Academic Hospital medical oncology unit) in Pretoria, SA, in the context of ART availability in SA. METHODS: We conducted a retrospective review of electronic and paper records of KS patients who accessed cancer care between May 2004 and September 2012...
September 22, 2017: South African Medical Journal
#36
JOURNAL ARTICLE
Aggrey Semeere, Esther Freeman, Megan Wenger, David Glidden, Mwebesa Bwana, Micheal Kanyesigye, Fredrick Chite Asirwa, Elyne Rotich, Naftali Busakhala, Emmanuel Oga, Elima Jedy-Agba, Vivian Kwaghe, Kenneth Iregbu, Clement Adebamowo, Antoine Jaquet, Francois Dabis, Sam Phiri, Julia Bohlius, Matthias Egger, Constantin T Yiannoutsos, Kara Wools-Kaloustian, Jeffrey Martin
BACKGROUND: Throughout most of sub-Saharan Africa (and, indeed, most resource-limited areas), lack of death registries prohibits linkage of cancer diagnoses and precludes the most expeditious approach to determining cancer survival. Instead, estimation of cancer survival often uses clinical records, which have some mortality data but are replete with patients who are lost to follow-up (LTFU), some of which may be caused by undocumented death. The end result is that accurate estimation of cancer survival is rarely performed...
September 2, 2017: BMC Cancer
#37
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: We compared Kaposi sarcoma (KS) risk in adults who started antiretroviral therapy (ART) across the Asia-Pacific, South Africa, Europe, Latin, and North America. METHODS: We included cohort data of human immunodeficiency virus (HIV)-positive adults who started ART after 1995 within the framework of 2 large collaborations of observational HIV cohorts. We present incidence rates and adjusted hazard ratios (aHRs). RESULTS: We included 208140 patients from 57 countries...
October 15, 2017: Clinical Infectious Diseases
#38
JOURNAL ARTICLE
Eliane Rohner, Mazvita Sengayi, Bridgette Goeieman, Pamela Michelow, Cynthia Firnhaber, Mhairi Maskew, Julia Bohlius
Data on invasive cervical cancer (ICC) incidence in HIV-positive women and the effect of cervical cancer screening in sub-Saharan Africa are scarce. We estimated i) ICC incidence rates in women (≥18 years) who initiated antiretroviral therapy (ART) at the Themba Lethu Clinic (TLC) in Johannesburg, South Africa, between 2004 and 2011 and ii) the effect of a Pap-based screening program. We included 10,640 women; median age at ART initiation: 35 years [interquartile range (IQR) 30-42], median CD4 count at ART initiation: 113 cells/µL (IQR 46-184)...
August 1, 2017: International Journal of Cancer. Journal International du Cancer
#39
REVIEW
Elvira Singh, Gita Naidu, Mary-Ann Davies, Julia Bohlius
PURPOSE OF REVIEW: HIV-infected children are at an increased risk of developing cancer. Many of the cancers in HIV-infected children are linked to immunosuppression and oncogenic coinfections. Worldwide most HIV-infected children live in sub-Saharan Africa, but cancer data for this population are scarce. In this article, we review the current literature on the epidemiology and prevention of cancer in HIV-infected children. RECENT FINDINGS: Combined antiretroviral therapy (cART) reduces the risk of developing cancer in HIV-infected children...
January 2017: Current Opinion in HIV and AIDS
#40
JOURNAL ARTICLE
Mazvita Sengayi, Adrian Spoerri, Matthias Egger, Danuta Kielkowski, Tamaryn Crankshaw, Christie Cloete, Janet Giddy, Julia Bohlius
The surveillance of HIV-related cancers in South Africa is hampered by the lack of systematic collection of cancer diagnoses in HIV cohorts and the absence of HIV status in cancer registries. To improve cancer ascertainment and estimate cancer incidence, we linked records of adults (aged ≥ 16 years) on antiretroviral treatment (ART) enrolled at Sinikithemba HIV clinic, McCord Hospital in KwaZulu-Natal (KZN) with the cancer records of public laboratories in KZN province using probabilistic record linkage (PRL) methods...
September 15, 2016: International Journal of Cancer. Journal International du Cancer
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