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https://www.readbyqxmd.com/read/29904289/identifying-suspected-familial-chylomicronemia-syndrome
#1
Ronak Rengarajan, Peter A McCullough, Anima Chowdhury, Kristen M Tecson
Familial chylomicronemia syndrome (FCS) is a rare lipid disorder posing significant clinical burdens on patients. Due to its rarity, variety of presentations, and lack of universal diagnostic criteria, patients see an average of five physicians before diagnosis. We screened adults for a triglyceride level ≥1000 mg/dL from September 2015 to September 2016 and a history of pancreatitis and performed a thorough chart review on those who met the criteria. An adjudication panel used a definition that also called for supportive information including history of hypertriglyceridemia or family history of pancreatitis/hypertriglyceridemia...
July 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29903633/incidence-and-reasons-of-pancreatic-resection-in-patients-with-asymptomatic-serous-cystadenoma
#2
Carlo Lombardo, Sara Iacopi, Francesca Menonna, Niccolò Napoli, Emanuele Kauffmann, Juri Bernardini, Andrea Cacciato Insilla, Piero Boraschi, Francescamaria Donati, Carla Cappelli, Daniela Campani, Davide Caramella, Ugo Boggi
BACKGROUND/OBJECTIVES: Despite diagnostic refinements, pancreatic resection (PR) is eventually performed in some patients with asymptomatic serous cystadenoma (A-SCA). The aim of this study was to define incidence and reasons of PR in A-SCA. METHODS: A retrospective analysis of a prospectively maintained database was performed for all the patients referred for pancreatic cystic lesions (PCL) between January 2005 and March 2016. RESULTS: Overall, there were 1488 patients with PCL, including 1271 (85...
June 8, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29903511/non-inferiority-of-open-passive-drains-compared-with-closed-suction-drains-in-pancreatic-surgery-outcomes-a-prospective-observational-study
#3
Giovanni Marchegiani, Giampaolo Perri, Alessandra Pulvirenti, Elisabetta Sereni, Anna Maria Azzini, Giuseppe Malleo, Roberto Salvia, Claudio Bassi
BACKGROUND: Policies concerning the management of operatively placed drains after pancreatic surgery are still under debate. Open passive drains and closed-suction drains are both used currently in clinical practice worldwide, but there are no reliable data regarding potential differences in the postoperative outcomes associated with each drain type. The aim of the present study was to compare open passive drains and closed-suction drains with regard to postoperative contamination of the drainage fluid and overall morbidity and mortality...
June 11, 2018: Surgery
https://www.readbyqxmd.com/read/29898439/the-diagnostic-accuracy-of-cytology-for-the-diagnosis-of-hepatobiliary-and-pancreatic-cancers
#4
Marwan Al-Hajeili, Maryam Alqassas, Astabraq Alomran, Bashaer Batarfi, Bashaer Basunaid, Reem Alshail, Shahad Alaydarous, Rana Bokhary, Mahmoud Mosli
OBJECTIVE: Although cytology testing is considered a valuable method to diagnose tumors that are difficult to access such as hepato-biliary-pancreatic (HBP) malignancies, its diagnostic accuracy remains unclear. We therefore aimed to investigate the diagnostic accuracy of cytology testing for HBP tumors. STUDY DESIGN: We performed a retrospective study of all cytology samples that were used to confirm radiologically detected HBP tumors between 2002 and 2016. The cytology techniques used in our center included fine needle aspiration (FNA), brush cytology, and aspiration of bile...
June 13, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29896571/are-traditional-scoring-systems-for-severity-stratification-of-acute-pancreatitis-sufficient
#5
Thaddaeus Tan Jun Kiat, Sivaraj K Gunasekaran, Sameer P Junnarkar, Jee Keem Low, Winston Woon, Vishal G Shelat
Backgrounds/Aims: Ranson's score (RS) and Glasgow score (GS) have been utilized to stratify the severity of acute pancreatitis (AP). The aim of this study was to validate RS and GS for stratifying the severity of acute pancreatitis and audit our experience of managing AP. Methods: We conducted a retrospective review of patients treated for AP from July 2009 to September 2016. Final severity was determined using the revised Atlanta classification. Mortality and complications were analyzed...
May 2018: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/29895904/long-term-follow-up-of-low-risk-branch-duct-ipmns-of-the-pancreas-is-main-pancreatic-duct-dilatation-the-most-worrisome-feature
#6
Maria Chiara Petrone, Pietro Magnoni, Ilaria Pergolini, Gabriele Capurso, Mariaemilia Traini, Claudio Doglioni, Alberto Mariani, Stefano Crippa, Paolo Giorgio Arcidiacono
OBJECTIVES: The management of branch-duct IPMN remains controversial due to the relatively low rate of malignant degeneration and the uncertain predictive role of high-risk stigmata (HRS) and worrisome features (WFs) identified by the 2012 International Consensus Guidelines. Our aim was to evaluate the evolution of originally low-risk (Fukuoka-negative) BD-IPMNs during a long follow-up period in order to determine whether the appearance of any clinical or morphological variables may be independently associated with the development of malignancy over time...
June 13, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29893751/clinical-impact-of-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-patients-with-resectable-pancreatic-cancer-diagnosing-lymph-node-metastasis-and-predicting-survival
#7
Hyung Rae Kim, Minjung Seo, Yang Won Nah, Hyung Woo Park, Seol Hoon Park
PURPOSE: To evaluate the diagnostic accuracy of fluorine-18-fluorodeoxyglucose PET/computed tomography (F-FDG PET/CT) for lymph node (LN) metastasis and the prognostic significance of F-FDG PET/CT LN parameters in patients with resectable pancreatic cancer. PATIENTS AND METHODS: Patients with resectable pancreatic cancer who underwent staging F-FDG PET/CT between May 2007 and September 2016 were retrospectively enrolled and analyzed through medical record and image re-evaluation...
July 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29890300/application-of-pancreaticojejunostomy-with-one-layer-suture-in-pancreaticoduodenectomy-a-retrospective-cohort-study
#8
Chong Zhong Liu, Jian Kang Zhu, Qianqian Xu, Feng Yue Liu, Ya Dong Wang, Min Zhu
BACKGROUND: Postoperative pancreatic fistula (POPF) is the most common critical complication after pancreaticoduodenectomy (PD) and a primary reason for increased mortality and morbidity after PD. To perform a safe pancreaticojejunostomy (PJ), a fast and simple technique of duct-to-mucosa PJ with one-layer suture was devised at our institution. MATERIALS AND METHODS: We conducted a retrospective analysis of 81 successive cases of PD performed at our hospital from March 2012 to August 2016...
June 8, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29887920/systematic-review-and-meta-analysis-of-diagnostic-accuracy-of-mirnas-in-patients-with-pancreatic-cancer
#9
REVIEW
Xiao Sun, Xiaobin Zhou, Yuan Zhang, Xiaoyan Zhu, Haihua Liu
Background: It is reported that miRNAs are aberrantly expressed in patients with pancreatic cancer. However, the diagnostic value of miRNAs in pancreatic cancer remains controversial. The meta-analysis was to access diagnostic accuracy of miRNAs in pancreatic cancer. Methods: PubMed, Scopus, Web of Science, Chinese National Knowledge Infrastructure (CNKI), WANFANG Data, China Biomedical Literature Database (CBM), and VIP databases were retrieved up to June 30, 2016, to collect articles concerning the diagnosis of miRNAs in pancreatic cancer...
2018: Disease Markers
https://www.readbyqxmd.com/read/29887705/outcome-of-pancreaticoduodenectomy-at-low-volume-centre-in-tier-ii-city-of-india
#10
Kumar Vinchurkar, Vishwanath M Pattanshetti, Manoj Togale, Santosh Hazare, Varadraj Gokak
Currently, pancreaticoduodenectomy (PD) is considered a common and feasibly performed surgery for periampullary tumours, but it is still a high-risk surgical procedure with potential morbidity and mortality rates. Previously, it was emphasised for the need of high-volume centres to perform specialised surgery such as PD. The authors have made an attempt to know the relation between low-volume centre and outcomes of PD. The study was conducted in a Tier-II city referral hospital located in Karnataka, India. A total of 37 patients with suspected periampullary neoplasms underwent surgical exploration with curative intent over a period of 4 years, i...
June 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29887694/32-consecutive-cases-of-whipple-s-operation-with-single-layer-end-to-side-dunking-pancreatojejunostomy-without-any-pancreatic-fistula-our-institutional-experience
#11
Ashutosh Gupta, Sourabh Nandi, Santanu Tiwari, Amit Choraria, Vivek Chaudhary
The aim of this paper is to study the outcome of single-layer end to side dunking pancreatojejunostomy technique in 32 patients of malignant pancreatic disease undergoing Whipple's surgery in a tertiary care oncology centre in India. From January 2013 to January 2016, 32 consecutive patients who underwent pancreatoduodenectomy for malignant diseases were analysed retrospectively. All the patients underwent standard Whipple's operation. Pancreatojejunostomy was established in a single-layer end to side dunking manner with PDS 4-0...
June 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29886024/ivacaftor-treatment-of-cystic-fibrosis-in-children-aged-12-to-24-months-and-with-a-cftr-gating-mutation-arrival-a-phase-3-single-arm-study
#12
Margaret Rosenfeld, Claire E Wainwright, Mark Higgins, Linda T Wang, Charlotte McKee, Daniel Campbell, Simon Tian, Jennifer Schneider, Steve Cunningham, Jane C Davies
BACKGROUND: Ivacaftor is generally safe and effective in patients aged 2 years and older who have cystic fibrosis and specific CFTR mutations. We assessed its use in children aged 12 to <24 months. METHODS: The ARRIVAL study is a phase 3, single-arm, two-part, multicentre study. Eligible children were aged 12 to <24 months at enrolment and had a confirmed diagnosis of cystic fibrosis and a CFTR gating mutation on at least one allele and could participate in one or both parts of the study...
June 6, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29884479/chronologic-changes-in-clinical-and-survival-features-of-pancreatic-ductal-adenocarcinoma-since-2000-a-single-center-experience-with-2-029-patients
#13
Sang Hyun Shin, Song Cheol Kim, Ki-Byung Song, Dae Wook Hwang, Jae Hoon Lee, Kwang-Min Park, Young-Joo Lee
BACKGROUND: To identify chronologic changes in clinical and survival features of pancreatic ductal adenocarcinoma based on diagnosis and treatment strategy development since 2000. METHODS: Among 2,029 patients enrolled in this study, 746 and 1,283 were treated between 2000 and 2009 (group 1) and between 2010 and 2016 (group 2), respectively. We used patient clinicopathologic, biologic, and molecular factors to assess the prognostic factors. RESULTS: Group 2 had a better survival outcome than group 1 (median survival time: 24...
June 5, 2018: Surgery
https://www.readbyqxmd.com/read/29882290/comparison-of-lipase-and-amylase-for-diagnosing-post-operative-pancreatic-fistulae
#14
David Griffith, Thomas Hanna, Kimberley Wong, Alexander Reece-Smith, Somaiah Aroori, Matthew Bowles, David Stell, Christopher Briggs
BACKGROUND: To ascertain if post-operative drain fluid lipase is superior to amylase in routinely detecting clinically significant post-operative pancreatic fistulae (POPF). METHOD: Between January 2015 and March 2016 data were collected on all patients undergoing pancreatic surgery at a regional referral centre. Routine drain fluid analysis was performed on post-operative patients as part of a locally defined enhanced recovery protocol. POPF was diagnosed in accordance with the recently updated International Study Group of Pancreatic Surgery guidance...
June 7, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29880440/adverse-effects-of-immune-checkpoint-therapy-in-cancer-patients-visiting-the-emergency-department-of-a-comprehensive-cancer-center
#15
Imad El Majzoub, Aiham Qdaisat, Kyaw Z Thein, Myint A Win, Myat M Han, Kalen Jacobson, Patrick S Chaftari, Michael Prejean, Cielito Reyes-Gibby, Sai-Ching J Yeung
STUDY OBJECTIVE: Cancer immunotherapy is evolving rapidly and is transforming cancer care. During the last decade, immune checkpoint therapies have been developed to enhance the immune response; however, specific adverse effects related to autoimmunity are increasingly apparent. This study aims to fill the knowledge gap related to the spectrum of immune-related adverse effects among cancer patients visiting emergency departments (EDs). METHODS: We performed a retrospective review of patients treated with immune checkpoint therapy who visited the ED of a comprehensive cancer center between March 1, 2011, and February 29, 2016...
June 4, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29880308/effectiveness-and-safety-of-long-term-treatment-with-sulfonylureas-in-patients-with-neonatal-diabetes-due-to-kcnj11-mutations-an-international-cohort-study
#16
Pamela Bowman, Åsta Sulen, Fabrizio Barbetti, Jacques Beltrand, Pernille Svalastoga, Ethel Codner, Ellen H Tessmann, Petur B Juliusson, Torild Skrivarhaug, Ewan R Pearson, Sarah E Flanagan, Tarig Babiker, Nicholas J Thomas, Maggie H Shepherd, Sian Ellard, Iwar Klimes, Magdalena Szopa, Michel Polak, Dario Iafusco, Andrew T Hattersley, Pål R Njølstad
BACKGROUND: KCNJ11 mutations cause permanent neonatal diabetes through pancreatic ATP-sensitive potassium channel activation. 90% of patients successfully transfer from insulin to oral sulfonylureas with excellent initial glycaemic control; however, whether this control is maintained in the long term is unclear. Sulfonylurea failure is seen in about 44% of people with type 2 diabetes after 5 years of treatment. Therefore, we did a 10-year multicentre follow-up study of a large international cohort of patients with KCNJ11 permanent neonatal diabetes to address the key questions relating to long-term efficacy and safety of sulfonylureas in these patients...
June 4, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29875900/acute-pancreatitis-is-a-very-rare-comorbidity-of-acute-ischemic-stroke
#17
Kiyobumi Ota, Ayako Oniki, Zen Kobayashi, Shoichiro Ishihara, Hiroyuki Tomimitsu, Shuzo Shintani
Background: Although acute pancreatitis is listed among the exclusion criteria for the administration of recombinant tissue plasminogen activator according to the Japanese Guideline for the Management of Stroke, the co-occurrence of acute pancreatitis and acute ischemic stroke has not been investigated. The present study aimed to assess the incidence rate of acute pancreatitis in patients with acute ischemic stroke. Methods: This study consecutively enrolled all patients with ischemic stroke admitted to the Department of Neurology, JA Toride Medical Center between April 2014 and March 2016...
May 2018: Journal of Rural Medicine: JRM
https://www.readbyqxmd.com/read/29872342/stereotactic-body-radiation-therapy-plus-induction-or-adjuvant-chemotherapy-for-early-stage-but-medically-inoperable-pancreatic-cancer-a-propensity-score-matched-analysis-of-a-prospectively-collected-database
#18
Xiaofei Zhu, Fuqi Li, Wenyu Liu, Dongchen Shi, Xiaoping Ju, Yangsen Cao, Yuxin Shen, Fei Cao, Shuiwang Qing, Fang Fang, Zhen Jia, Huojun Zhang
Background: To evaluate and compare the efficacy and safety of stereotactic body radiation therapy (SBRT) plus induction chemotherapy and SBRT plus adjuvant therapy. Methods: Patients with radiographically resectable, biopsy-proven pancreatic cancer were enrolled. Data were prospectively collected from 2012 to 2016. Cox proportional hazards regression was used to identify factors predictive of survival. Propensity score matching analysis was performed to assess the efficacy of SBRT combined with different timing of chemotherapy...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29869080/the-role-of-endoscopic-treatment-of-pancreatic-duct-disruption-in-patients-with-walled-off-pancreatic-necrosis
#19
Mateusz Jagielski, Marian Smoczyński, Krystian Adrych
BACKGROUND: The place of endoscopic techniques in the treatment of main pancreatic duct (MPD) disruption arising in the course of acute necrotizing pancreatitis (ANP) remains unclear. The aim of this study was to describe the findings of endoscopic retrograde pancreatography (ERP) in patients with walled-off necrosis (WON). It was attempted to evaluate the role of endoscopic treatment of pancreatic duct disruption in patients with WON. METHODS: The retrospective analysis of results and complications with particular emphasis to all ERP procedures in the group of 226 patients was conducted, which underwent endoscopic treatment of symptomatic WON between years 2001 and 2016 in the Department of Gastroenterology and Hepatology of Medical University of Gdańsk...
June 4, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29868287/clinicopathologic-characteristics-laboratory-parameters-treatment-protocols-and-outcomes-of-pancreatic-cancer-a-retrospective-cohort-study-of-1433-patients-in-china
#20
Shuisheng Zhang, Xiaozhun Huang, Yuan Tian, Saderbieke Aimaiti, Jianwei Zhang, Jiuda Zhao, Yingtai Chen, Chengfeng Wang
Objectives: The prognosis of people with pancreatic cancer is extremely unfavorable. However, the prognostic factors remain largely undefined. We aimed to perform comprehensive analyses of clinicopathologic characteristics, laboratory parameters, and treatment protocols for exploring their role as prognostic factors of pancreatic cancer. Methods: Patients diagnosed with pancreatic cancer and hospitalized at the China National Cancer Center between April 2006 and May 2016 were enrolled in this retrospective cohort study...
2018: PeerJ
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