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https://www.readbyqxmd.com/read/29454571/feasibility-of-restorative-proctocolectomy-in-patients-with-ulcerative-colitis-associated-lower-rectal-cancer-a-retrospective-study
#1
Shinnosuke Hotta, Yoshifumi Shimada, Mae Nakano, Saki Yamada, Kaoru Abe, Hidehito Oyanagi, Ryoma Yagi, Yosuke Tajima, Masato Nakano, Hitoshi Kameyama, Masayuki Nagahashi, Jun Sakata, Takashi Kobayashi, Toshifumi Wakai
BACKGROUND/OBJECTIVE: Restorative proctocolectomy (RP) may improve quality of life in patients with ulcerative colitis (UC)-associated lower rectal cancer to a greater extent than total proctocolectomy. However, patients with UC-associated cancer often have flat mucosal lesions that make it extremely difficult to endoscopically delineate the tumor margins. Therefore, there is a potential risk of residual tumor and local recurrence after RP in patients with UC-associated lower rectal cancer...
February 14, 2018: Asian Journal of Surgery
https://www.readbyqxmd.com/read/29452860/pancreaticoduodenectomy-in-the-surgical-management-of-primary-retroperitoneal-sarcoma
#2
William W Tseng, Denice D Tsao-Wei, Dario Callegaro, Giovanni Grignani, Lorenzo D'Ambrosio, Sylvie Bonvalot, Cecilia G Ethun, Kenneth Cardona, John T Mullen, Robert J Canter, John E Mullinax, Ricardo J Gonzalez, Frits van Coevorden, Markus Albertsmeier, Kiran K Dhanireddy, Salvatore L Renne, Alessandro Gronchi
BACKGROUND: In retroperitoneal sarcoma (RPS), the optimal extent of resection must balance adequate disease control with potential for morbidity. We sought to study the frequency and outcomes after a Whipple procedure or pancreaticoduodenectomy (PD) in patients undergoing resection for primary RPS. METHODS: Participating referral centers within the Trans-Atlantic Retroperitoneal Sarcoma Working Group provided retrospective data from January 2007 to December 2016 for patients with primary RPS who underwent PD along with the total number of consecutive resections done during the same time period...
February 5, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29448308/perioperative-outcomes-and-survival-following-neoadjuvant-stereotactic-body-radiation-therapy-sbrt-versus-intensity-modulated-radiation-therapy-imrt-in-pancreatic-adenocarcinoma
#3
Brandon C Chapman, Ana Gleisner, Devin Rigg, Cheryl Meguid, Karyn Goodman, Brian Brauer, Csaba Gajdos, Richard D Schulick, Barish H Edil, Martin D McCarter
BACKGROUND AND OBJECTIVES: To compare outcomes in patients receiving neoadjuvant stereotactic body radiation therapy (SBRT) with those receiving intensity-modulated radiation therapy (IMRT) for pancreatic adenocarcinoma. METHODS: We analyzed patients receiving neoadjuvant SBRT for borderline resectable (BRPC) and locally advanced pancreatic cancer (LAPC) (2012-2016). Differences in baseline characteristics, perioperative outcomes, progression-free survival (PFS), and overall survival (OS) were compared...
February 15, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29443760/resection-of-benign-side-branch-intraductal-papillary-mucinous-neoplasm-of-the-pancreas-is-long-term-follow-up-indicated-a-case-report-and-review-of-the-literature
#4
Stefan Fritz, Regina Küper-Steffen, Katharina Feilhauer, Christoph M Sommer, Götz M Richter, René Hennig, Jörg Köninger
RATIONALE: Intraductal papillary mucinous neoplasms of the pancreas (IPMNs) are benign cystic tumors with a relevant risk of malignant transformation over time. Currently, follow-up after surgical resection of benign IPMNs remains controversial. PATIENT CONCERNS: This is a case report of a 68-year-old male who underwent pancreatic head resection for a multicystic side-branch IPMN with low-grade epithelial dysplasia in March 2009 at the Katharinenhospital Stuttgart, Germany...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29434873/mechanisms-by-which-cxcr4-cxcl12-cause-metastatic-behavior-in-pancreatic-cancer
#5
Jianbo Zhang, Chengxin Liu, Xinkai Mo, Huan Shi, Sheng Li
C-X-C motif chemokine receptor (CXCR) 4/CXCL12 is associated with tumor invasion and metastasis in pancreatic cancer. The present study aimed to investigate the possible mechanisms behind this process by studying the association between the expression of CXCR4 and numerous molecular markers. A total of 60 patients with pancreatic cancer who had been treated with radical surgery between July 2012 and February 2016 were included in the present study. The expression of CXCR4/CXCL12 in primary pancreatic cancer lesions, tissues adjacent to cancerous tissue, non-cancerous pancreatic tissues and in the surrounding lymph nodes was evaluated by immunohistochemistry...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434161/the-role-of-endoscopic-ultrasound-guided-drainage-for-autoimmune-pancreatitis-associated-pancreatic-cysts-a-report-of-five-cases-and-a-literature-review
#6
Kenjiro Yamamoto, Takao Itoi, Atsushi Sofuni, Takayoshi Tsuchiya, Shujiro Tsuji, Reina Tanaka, Ryosuke Tonozuka, Mitsuyoshi Honjo, Shuntaro Mukai, Kentaro Kamada, Mitsuru Fujita, Yasutsugu Asai, Yukitoshi Matsunami, Yuichi Nagakawa
Objective Autoimmune pancreatitis (AIP) has been recognized as a benign disease, which that shows a prompt response to corticosteroid treatment (CST). It was previously believed to not be associated with cyst formation; however, a few cases of AIP-associated pancreatic cyst (PC) have been reported. Some cases were reported to have been effectively treated by CST, while others were refractory to CST. Many of the patients received interventional treatment. Until now, there has been no consensus on the therapeutic strategies for AIP-associated PC...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29430219/disease-control-on-lanreotide-autogel%C3%A2-120-mg-in-a-patient-with-metastatic-gastrinoma-a-case-report
#7
Maridi Aerts, Hendrik Reynaert
Gastrinomas are functionally active pancreatic neuroendocrine tumors (NETs) secreting gastrin and are associated with local or regional metastases in 60% of the cases. Somatostatin analogs (SSAs) are currently recommended as a first-line treatment for the symptomatic treatment of NETs. Although antiproliferative activity of SSAs has been demonstrated in various cancer types in several in vivo and in vitro studies, clinical benefits with SSAs have been only achieved in a small proportion of patients. We report a disease control on a long-acting SSA lanreotide in a patient with metastatic gastrinoma...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29428099/strategies-for-pancreatic-anastomosis-after-pancreaticoduodenectomy-what-really-matters
#8
REVIEW
Jin Xu, Shun-Rong Ji, Bo Zhang, Quan-Xing Ni, Xian-Jun Yu
BACKGROUND: The postoperative pancreatic fistula rate remains approximately 10-20% even in institutions treating a high-volume of pancreatic cases. The best strategy to restore the continuity between the pancreatic remnant and the digestive tract is still in debate. DATA SOURCES: Studies were identified by searching PubMed for studies published between January 1934 (when pancreaticogastrostomy was technically feasible) and December 2016. The following search terms were used: "duct-to-mucosa", "invagination", "pancreaticojejunostomy", "pancreaticogastrostomy," and "pancreaticoduodenectomy"...
February 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29423434/prospective-evaluation-of-eus-guided-fine-needle-biopsy-in-pancreatic-mass-lesions
#9
M H Larsen, C W Fristrup, S Detlefsen, M B Mortensen
Background and study aim : Due to the scarcity of specific data on endoscopic ultrasound (EUS)-guided fine-needle biopsies (SharkCore) FNB in the evaluation of pancreatic lesions, we performed a prospective study of the diagnostic performance of EUS SharkCore FNB in patients with pancreatic lesions. The aim of this study was to evaluate the diagnostic accuracy. Patients and methods : Single-center prospective study of 41 consecutive patients referred for EUS-FNB from October 2015 to April 2016 at our center...
February 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29421807/the-clinical-management-of-main-duct-intraductal-papillary-mucinous-neoplasm-of-the-pancreas
#10
Chiara Dal Borgo, Giampaolo Perri, Alex Borin, Giovanni Marchegiani, Roberto Salvia, Claudio Bassi
BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas comprise a heterogeneous group of intraductal mucin-producing neoplasms representing a typical adenoma-to-carcinoma sequence. The involvement of the main pancreatic duct (MPD) is a feature of paramount importance, directly related to a more aggressive biology and a higher malignancy rate. METHOD: We review and discuss the clinical management of IPMNs with a MPD involvement, recalling the different consensus guidelines and addressing recent controversies in literature, presenting the current clinical practice in Verona Pancreas Institute...
February 8, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29417755/safety-signal-detection-and-evaluation-in-clinical-development-programs-a-case-study-of-tofacitinib
#11
Gorana Dasic, Thomas Jones, Vera Frajzyngier, Ricardo Rojo, Ann Madsen, Hernan Valdez
Adverse events are anticipated during a clinical development program. Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We describe here the process undertaken by Pfizer to investigate a safety signal for pancreatic cancer with tofacitinib. Potential cases of pancreatic cancer across indications from Pfizer's clinical trials and safety databases were identified and underwent in-depth case review and external expert consultation. The magnitude of the signal was quantified...
February 2018: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/29417182/simultaneous-common-bile-duct-clearance-and-laparoscopic-cholecystectomy-experience-of%C3%A2-a-one-stage-approach
#12
Shahin Mohseni, John Ivarsson, Rebecka Ahl, Sinan Dogan, Sten Saar, Arvo Reinsoo, Teesi Sepp, Karl-Gunnar Isand, Edvard Garder, Ilmar Kaur, Heiti Ruus, Peep Talving
INTRODUCTION: The timing and optimal method for common bile duct (CBD) clearance and laparoscopic cholecystectomy remains controversial. Several different approaches are available in clinical practice. The current study presents the experience of two European hospitals of simultaneous laparoscopic cholecystectomy (LC) and intra-operative endoscopic retrograde cholangiopacreatography (IO-ERCP) done by surgeons. METHODS: Retrospective analysis of all consecutive patients subjected to LC + IO-ERCP during their index admission between 4/2014 and 9/2016...
February 7, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29415489/identification-of-pancreatic-injury-in-patients-with-elevated-amylase-or-lipase-level-using-a-decision-tree-classifier-a-cross-sectional-retrospective-analysis-in-a-level-i-trauma-center
#13
Cheng-Shyuan Rau, Shao-Chun Wu, Peng-Chen Chien, Pao-Jen Kuo, Yi-Chun Chen, Hsiao-Yun Hsieh, Ching-Hua Hsieh, Hang-Tsung Liu
BACKGROUND: In trauma patients, pancreatic injury is rare; however, if undiagnosed, it is associated with high morbidity and mortality rates. Few predictive models are available for the identification of pancreatic injury in trauma patients with elevated serum pancreatic enzymes. In this study, we aimed to construct a model for predicting pancreatic injury using a decision tree (DT) algorithm, along with data obtained from a population-based trauma registry in a Level I trauma center...
February 6, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29409663/penta-therapy-for-severe-acute-hyperlipidemic-pancreatitis-a-retrospective-chart-review-over-a-10-year-period
#14
Jian Lu, Yun Xie, Jiang Du, Mei Kang, Wei Jin, Yan Li, Hui Xie, Ruijie Cheng, Rui Tian, Ruilan Wang
INTRODUCTION: The purpose of our study is to evaluate the efficacy of penta-therapy for HL-SAP in a retrospective study. METHODS: Retrospective study between January 2007 and December 2016 in a hospital intensive care unit. HL-SAP patients were assigned to conventional treatment alone (the control group) or conventional treatment with the experimental protocol (the penta-therapy group) consists of blood purification, antihyperlipidemic agents, low-molecular weight heparin, insulin, covering the whole abdomen with Pixiao (a traditional Chinese medicine)...
February 3, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29409310/electrohydraulic-lithotripsy-for-difficult-bile-duct-stones-under-endoscopic-retrograde-cholangiopancreatography-and-peroral-transluminal-cholangioscopy-guidance
#15
Rieko Kamiyama, Takeshi Ogura, Atsushi Okuda, Akira Miyano, Nobu Nishioka, Miyuki Imanishi, Wataru Takagi, Kazuhide Higuchi
Background/Aims: Electrohydraulic lithotripsy (EHL) under endoscopic retrograde cholangiopancreatography (ERCP) guidance can be an option to treat difficult stones. Recently, a digital, single-operator cholangioscope (SPY-DS) has become available. Peroral transluminal cholangioscopy (PTLC) using SPY-DS has also been reported. In this retrospective study, the technical feasibility and clinical effectiveness of EHL for difficult bile duct stones under ERCP guidance and under PTLC guidance was examined...
February 8, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29409303/slow-pull-using-a-fanning-technique-is-more-useful-than-the-standard-suction-technique-in-eus-guided-fine-needle-aspiration-in-pancreatic-masses
#16
Jae Min Lee, Hong Sik Lee, Jong Jin Hyun, Jung Min Lee, In Kyung Yoo, Seung Han Kim, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Yoon Tae Jeen, Hoon Jai Chun, Soon Ho Um, Chang Duck Kim
Background/Aims: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is useful for obtaining pancreatic mass samples. The combination of modified techniques (i.e., slow-pull technique and fanning technique) may improve the quality of the sample obtained by EUS-FNA. We investigated the effectiveness of a combined slow-pull fanning technique in EUS-FNA for pancreatic mass. Methods: This prospective comparative study investigated EUS-FNA performed for pancreatic solid masses between August 2015 and July 2016...
February 8, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29405026/-care-plan-for-resuming-the-physical-activity-of-patients-with-pancreatic-cancer-and-diabetes-after-surgery
#17
Hui-Ting Yang, Mei-Chih Wu, Shiow-Ching Shun
Many barriers influence the ability of postoperative cancer patients to reengage in normal physical activities. Training programs have been shown to be effective in helping restore physical activity in patients and in reducing the care burdens of family members. Nurses cannot use physical activity guidelines in their care plan to assess individual needs. The clinical practice guidelines for physical activity in survivorship were published by the National Comprehensive Cancer Network (NCCN) in 2016. These guidelines are used to assess patients' physical status, curable factors, physical barriers, and risk of postoperative pancreatic cancer and diabetes...
February 2018: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29399276/risk-factors-for-hepatic-steatosis-in-adults-with-cystic-fibrosis-similarities-to-non-alcoholic-fatty-liver-disease
#18
Fares Ayoub, Cesar Trillo-Alvarez, Giuseppe Morelli, Jorge Lascano
AIM: To investigate the clinical, biochemical and imaging characteristics of adult cystic fibrosis (CF) patients with hepatic steatosis as compared to normal CF controls. METHODS: We performed a retrospective review of adult CF patients in an academic outpatient setting during 2016. Baseline characteristics, genetic mutation analysis as well as laboratory values were collected. Abdominal imaging (ultrasound, computed tomography, magnetic resonance) was used to determine presence of hepatic steatosis...
January 27, 2018: World Journal of Hepatology
https://www.readbyqxmd.com/read/29398424/pasireotide-does-not-prevent-postoperative-pancreatic-fistula-a-prospective-study
#19
Irmina A Elliott, Amanda M Dann, Razmik Ghukasyan, Lauren Damato, Mark D Girgis, Jonathan C King, O J Hines, Howard A Reber, Timothy R Donahue
BACKGROUND: Pancreatic fistula is a major cause of morbidity after pancreas surgery. In 2014, a single-center, randomized-controlled trial found pasireotide decreased pancreatic fistula rates. However, this finding has not been validated, nor has pasireotide been widely adopted. METHODS: A single-arm study in 111 consecutive patients undergoing pancreatic resection April 2015-October 2016 was conducted. Beginning immediately before surgery, patients received 900 μg subcutaneous pasireotide twice daily for up to seven days...
February 2, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29396900/effects-of-early-antiplatelet-therapy-after-splenectomy-with-gastro-oesophageal-devascularization
#20
Jin-Bao Zhou, Bao-Yang Luo, Chi-Wen Liu, Feng Zhu
BACKGROUND: This study aimed to explore the effects of early antiplatelet therapy (APT) for portal vein thrombosis (PVT) in patients with cirrhotic portal hypertension after splenectomy with gastro-oesophageal devascularization. METHODS: We retrospectively analysed 139 patients who underwent splenectomy with gastro-oesophageal devascularization for portal hypertension due to cirrhosis between April 2010 and December 2016. Based on the post-operative platelet values, we used two different APT regimens: APT was started when platelet counts were increased to 200 × 109 /L or above (group A, n = 64) or 300 × 109 /L or above (group B, n = 75)...
February 3, 2018: ANZ Journal of Surgery
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