Junyu Wang, Chaojie Yang, Zhixin Liang, Junping Sun, Mingyue Zhang, Shaofu Qiu, Xinying Du, Xi He, Xiaoying Pang, Xidong Ma, Mei Xie, Xinjie Han, Ru Fan, Enlu Zhou, Hairong Yu, Danyang She, Hongbin Song, Jianxin Wang
Human adenovirus (HAdV) infection is a major cause of respiratory disease, yet no antiviral drugs have been approved for its treatment. Herein, we evaluated the antiviral and anti-inflammatory effects of cyclin-dependent protein kinase (CDK) inhibitor indirubin-3'-monoxime (IM) against HAdV infection in cells and a transgenic mouse model. After evaluating its cytotoxicity, cytopathic effect reduction, antiviral replication kinetics, and viral yield reduction assays were performed to assess the anti-HAdV activity of IM...
April 9, 2024: Biomedicine & Pharmacotherapy