Bochuan Deng, Jiao Zhang, Xiang Zhang, Dan Wang, Lu Cheng, Ping Su, Tingli Yu, Guangjun Bao, Guofeng Li, Liang Hong, Xiaokang Miao, Wenle Yang, Rui Wang, Junqiu Xie
Renal fibrosis is a complex pathological process that contributes to the development of chronic kidney disease due to various risk factors. Conservative treatment to curb progression without dialysis or renal transplantation is widely applicable, but its effectiveness is limited. Here, the inhibitory effect of the novel peptide DR3penA (DHα-(4-pentenyl)-AlaNPQIR-NH2 ), which was developed by our group, on renal fibrosis was assessed in cells and mice with established fibrosis and fibrosis triggered by transforming growth factor-β1 (TGF-β1), unilateral ureteral obstruction, and repeated low-dose cisplatin...
April 12, 2024: ACS Pharmacology & Translational Science