keyword
https://read.qxmd.com/read/37314175/anillin-and-the-microtubule-bundler-prc1-maintain-myosin-in-the-contractile-ring-to-ensure-completion-of-cytokinesis
#21
JOURNAL ARTICLE
Inês C Santos, Ana M Silva, Reto Gassmann, Ana X Carvalho
Cytokinesis is the last step of cell division, when one cell physically divides into two cells. Cytokinesis is driven by an equatorial contractile ring and signals from antiparallel microtubule bundles (the central spindle) that form between the two masses of segregating chromosomes. Bundling of central spindle microtubules is essential for cytokinesis in cultured cells. Using a temperature-sensitive mutant of SPD-1, the homolog of the microtubule bundler PRC1, we demonstrate that SPD-1 is required for robust cytokinesis in the Caenorhabditis elegans early embryo...
June 15, 2023: Development
https://read.qxmd.com/read/37081903/bending-actin-filaments-twists-of-fate
#22
REVIEW
Mitsutoshi Nakamura, Justin Hui, Susan M Parkhurst
In many cellular contexts, intracellular actomyosin networks must generate directional forces to carry out cellular tasks such as migration and endocytosis, which play important roles during normal developmental processes. A number of different actin binding proteins have been identified that form linear or branched actin, and that regulate these filaments through activities such as bundling, crosslinking, and depolymerization to create a wide variety of functional actin assemblies. The helical nature of actin filaments allows them to better accommodate tensile stresses by untwisting, as well as to bend to great curvatures without breaking...
2023: Faculty reviews
https://read.qxmd.com/read/37051591/screening-anln-and-aspm-as-bladder-urothelial-carcinoma-related-biomarkers-based-on-weighted-gene-co-expression-network-analysis
#23
JOURNAL ARTICLE
Tenghao Yang, Zepai Chi, Guoyuan Liu, Xuwei Hong, Sizhe Cao, Kequan Cheng, Yonghai Zhang
Introduction: Bladder cancer (BLCA) is one of the most common malignancies in the urinary system with a poor prognosis and high treatment costs. Identifying potential prognostic biomarkers is significant for exploring new therapeutic and predictive targets of BLCA. Methods: In this study, we screened differentially expressed genes using the GSE37815 dataset. We then performed a weighted gene co-expression network analysis (WGCNA) to identify the genes correlated with the histologic grade and T stage of BLCA using the GSE32548 dataset...
2023: Frontiers in Genetics
https://read.qxmd.com/read/37007961/identification-and-validation-of-novel-prognostic-biomarkers-and-therapeutic-targets-for-non-small-cell-lung-cancer
#24
JOURNAL ARTICLE
Li-Ting Lai, Yuan-Hui Ren, Ya-Jun Huai, Yu Liu, Ying Liu, Shan-Shan Wang, Jin-Hong Mei
Background: Despite the significant survival benefits of anti-PD-1/PD-L1 immunotherapy, non-small cell lung cancer (NSCLC) remains one of the most common tumors and major causes of cancer-related deaths worldwide. Thus, there is an urgent need to identify new therapeutic targets for this refractory disease. Methods: In this study, microarray datasets GSE27262, GSE75037, GSE102287, and GSE21933 were integrated by Venn diagram. We performed functional clustering and pathway enrichment analyses using R. Through the STRING database and Cytoscape, we conducted protein-protein interaction (PPI) network analysis and identified the key genes, which were verified by the GEPIA2 and UALCAN portal...
2023: Frontiers in Genetics
https://read.qxmd.com/read/36923927/n-6-methyladenosine-modification-of-anln-enhances-hepatocellular-carcinoma-bone-metastasis
#25
JOURNAL ARTICLE
Hao Zheng, Zhang-Jun Cheng, Bo Liang, Zhen-Guang Wang, Yuan-Ping Tao, Sheng-Yu Huang, Jun-Sheng Ni, Hui-Fen Li, Le Yang, Sheng-Xian Yuan, Jennifer Wu, Takumi Kawaguchi, Hrishikesh Samant, Wei-Ping Zhou, Dai-Min Xiang, Yuan Yang
Bones are categorized as the second most prevalent location of extra-hepatic metastasis in Hepatocellular Carcinoma (HCC), which is linked to an extremely poor prognosis due to limited therapeutic options. N6 -methyladenosine (m6 A) is a prominent modification involved in HCC, but the exact mechanisms on how m6 A modifications induce HCC bone metastases (BM) remain unclear. The key modulators responsible for the abundant m6 A RNA modification-induced HCC BM was found to be the METTL3 and YTHDF1 . The expression of Anillin actin-binding protein ( ANLN ) was dramatically higher in HCC with BM tissues, and its messenger RNA (mRNA) stability was enhanced via m6 A epitranscriptomic regulation by METTL3 and YTHDF1 ...
2023: International Journal of Biological Sciences
https://read.qxmd.com/read/36894036/a-therapeutically-targetable-taz-tead2-pathway-drives-the-growth-of-hepatocellular-carcinoma-via-anln-and-kif23
#26
JOURNAL ARTICLE
Yoshinobu Saito, Dingzi Yin, Naoto Kubota, Xiaobo Wang, Aveline Filliol, Helen Remotti, Ajay Nair, Ladan Fazlollahi, Yujin Hoshida, Ira Tabas, Kirk J Wangensteen, Robert F Schwabe
BACKGROUND & AIMS: Despite recent progress, long-term survival remains low for hepatocellular carcinoma (HCC). The most effective HCC therapies target the tumor immune microenvironment (TIME), and there are almost no therapies that directly target tumor cells. Here, we investigated the regulation and function of tumor cell-expressed Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in HCC. METHODS: HCC was induced in mice by Sleeping Beauty-mediated expression of MET, CTNNB1-S45Y, or TAZ-S89A, or by diethylnitrosamine plus CCl4 ...
June 2023: Gastroenterology
https://read.qxmd.com/read/36747616/anillin-related-mid1-as-an-adaptive-and-multimodal-contractile-ring-anchoring-protein-a-simulation-study
#27
Aaron R Hall, Yeol Kyo Choi, Wonpil Im, Dimitrios Vavylonis
The organization of the cytokinetic ring at the cell equator of dividing animal and fungi cells depends crucially on the anillin scaffold proteins. In fission yeast, anillin related Mid1 binds to the plasma membrane and helps anchor and organize a medial broad band of cytokinetic nodes, which are the precursors of the contractile ring. Similar to other anillins, Mid1 contains a C terminal globular domain with two potential regions for membrane binding, the Pleckstrin Homology (PH) and C2 domains, and an N terminal intrinsically disordered region that is strongly regulated by phosphorylation...
January 27, 2023: bioRxiv
https://read.qxmd.com/read/36549590/native-size-exclusion-chromatography-based-mass-spectrometry-sec-ms-reveals-new-components-of-the-early-heat-shock-protein-90-inhibition-response-among-limited-global-changes
#28
JOURNAL ARTICLE
Rahul S Samant, Silvia Batista, Mark Larance, Bugra Ozer, Christopher I Milton, Isabell Bludau, Estelle Wu, Laura Biggins, Simon Andrews, Alexia Hervieu, Harvey E Johnston, Bissan Al-Lazikhani, Angus I Lamond, Paul A Clarke, Paul Workman
The molecular chaperone heat shock protein 90 (HSP90) works in concert with co-chaperones to stabilize its client proteins, which include multiple drivers of oncogenesis and malignant progression. Pharmacologic inhibitors of HSP90 have been observed to exert a wide range of effects on the proteome, including depletion of client proteins, induction of heat shock proteins, dissociation of co-chaperones from HSP90, disruption of client protein signaling networks, and recruitment of the protein ubiquitylation and degradation machinery-suggesting widespread remodeling of cellular protein complexes...
December 19, 2022: Molecular & Cellular Proteomics: MCP
https://read.qxmd.com/read/36540027/contractile-ring-composition-dictates-kinetics-of-in-silico-contractility
#29
JOURNAL ARTICLE
Daniel B Cortes, Paul S Maddox, Francois Nedelec, Amy Shaub Maddox
Constriction kinetics of the cytokinetic ring are expected to depend on dynamic adjustment of contractile ring composition, but the impact of ring component abundance dynamics on ring constriction is understudied. Computational models generally assume that contractile networks maintain constant total amounts of components, which is not always true. To test how compositional dynamics affect constriction kinetics, we first measured F-actin, non-muscle myosin II, septin, and anillin during C. elegans zygotic mitosis...
December 19, 2022: Biophysical Journal
https://read.qxmd.com/read/36526897/targeting-usp10-induces-degradation-of-oncogenic-anln-in-esophageal-squamous-cell-carcinoma
#30
JOURNAL ARTICLE
Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li
Anillin (ANLN) is a mitosis-related protein that promotes contractile ring formation and cytokinesis, but its cell cycle-dependent degradation mechanisms in cancer cells remain unclear. Here, we show that high expression of ANLN promotes cytokinesis and proliferation in esophageal squamous cell carcinoma (ESCC) cells and is associated with poor prognosis in ESCC patients. Furthermore, the findings of the study showed that the deubiquitinating enzyme USP10 interacts with ANLN and positively regulates ANLN protein levels...
December 16, 2022: Cell Death and Differentiation
https://read.qxmd.com/read/36426865/the-role-of-anillin-mid1p-during-medial-division-and-cytokinesis-from-fission-yeast-to-cancer-cells
#31
JOURNAL ARTICLE
Imane M Rezig, Wandiahyel G Yaduma, Gwyn W Gould, Christopher J McInerny
Cytokinesis is the final stage of cell division cycle when cellular constituents are separated to produce two daughter cells. This process is driven by the formation and constriction of a contractile ring. Progression of these events is controlled by mechanisms and proteins that are evolutionary conserved in eukaryotes from fungi to humans. Genetic and molecular studies in different model organisms identified essential cytokinesis genes, with several conserved proteins, including the anillin/Mid1p proteins, constituting the core cytokinetic machinery...
November 25, 2022: Cell Cycle
https://read.qxmd.com/read/36416720/cytokinetic-diversity-in-mammalian-cells-is-revealed-by-the-characterization-of-endogenous-anillin-ect2-and-rhoa
#32
JOURNAL ARTICLE
Mathieu C Husser, Imge Ozugergin, Tiziana Resta, Vincent J J Martin, Alisa J Piekny
Cytokinesis is required to physically separate the daughter cells at the end of mitosis. This crucial process requires the assembly and ingression of an actomyosin ring, which must occur with high fidelity to avoid aneuploidy and cell fate changes. Most of our knowledge of mammalian cytokinesis was generated using over-expressed transgenes in HeLa cells. Over-expression can introduce artefacts, while HeLa are cancerous human cells that have lost their epithelial identity, and the mechanisms controlling cytokinesis in these cells could be vastly different from other cell types...
November 2022: Open Biology
https://read.qxmd.com/read/36359734/midbody-proteins-display-distinct-dynamics-during-cytokinesis
#33
JOURNAL ARTICLE
Ella F J Halcrow, Riccardo Mazza, Anna Diversi, Anton Enright, Pier Paolo D'Avino
The midbody is an organelle that forms between the two daughter cells during cytokinesis. It co-ordinates the abscission of the nascent daughter cells and is composed of a multitude of proteins that are meticulously arranged into distinct temporal and spatial localization patterns. However, very little is known about the mechanisms that regulate the localization and function of midbody proteins. Here, we analyzed the temporal and spatial profiles of key midbody proteins during mitotic exit under normal conditions and after treatment with drugs that affect phosphorylation and proteasome-mediated degradation to decipher the impacts of post-translational modifications on midbody protein dynamics...
October 22, 2022: Cells
https://read.qxmd.com/read/36334838/dorsal-lip-maturation-and-initial-archenteron-extension-depend-on-wnt11-family-ligands
#34
JOURNAL ARTICLE
Elizabeth S Van Itallie, Christine M Field, Timothy J Mitchison, Marc W Kirschner
Wnt11 family proteins are ligands that activate a type of Dishevelled-mediated, non-canonical Wnt signaling pathway. Loss of function causes defects in gastrulation and/or anterior-posterior axis extension in all vertebrates. Non-mammalian vertebrate genomes encode two Wnt11 family proteins whose distinct functions have been unclear. We knocked down Wnt11b and Wnt11, separately and together, in Xenopus laevis. Single morphants exhibited very similar phenotypes of delayed blastopore closure, but they had different phenotypes during the tailbud period...
November 2, 2022: Developmental Biology
https://read.qxmd.com/read/36232775/a-tissue-engineering-acoustophoretic-tea-set-up-for-the-enhanced-osteogenic-differentiation-of-murine-mesenchymal-stromal-cells-mmscs
#35
JOURNAL ARTICLE
Hui Zhang, Nirina Beilfuss, Urszula Zabarylo, Kay Raum, Regina Puts
Quickly developing precision medicine and patient-oriented treatment strategies urgently require novel technological solutions. The randomly cell-populated scaffolds usually used for tissue engineering often fail to mimic the highly anisotropic characteristics of native tissue. In this work, an ultrasound standing-wave-based tissue engineering acoustophoretic (TEA) set-up was developed to organize murine mesenchymal stromal cells (mMSCs) in an in situ polymerizing 3-D fibrin hydrogel. The resultant constructs, consisting of 17 cell layers spaced at 300 µm, were obtained by continuous wave ultrasound applied at a 2...
September 29, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36199577/comprehensive-bioinformatics-analysis-reveals-the-prognostic-value-predictive-value-and-immunological-roles-of-anln-in-human-cancers
#36
JOURNAL ARTICLE
Zhiwei Cui, Jiantao Mo, Ping Song, Lijun Wang, Rongli Wang, Feiyan Cheng, Lihui Wang, Fan Zou, Xin Guan, Nini Zheng, Xinyuan Yang, Wei Wang
Anillin (ANLN) is a unique scaffolding, actin-binding protein, which is essential for the integrity and ingression of the cleavage furrow. It is mainly involved in the cytokinesis process, while its role in various tumors has not been fully addressed and remains largely elusive. To provide a thorough perspective of ANLN's roles among diverse malignancies, we conducted a comprehensive, pan-cancer analysis about ANLN, including but not limited to gene expression levels, prognostic value, biological functions, interacting proteins, immune-related analysis, and predictive value...
2022: Frontiers in Genetics
https://read.qxmd.com/read/36057161/ldha-mediated-metabolic-reprogramming-promoted-cardiomyocyte-proliferation-by-alleviating-ros-and-inducing-m2-macrophage-polarization
#37
JOURNAL ARTICLE
Yijin Chen, Guangkai Wu, Mengsha Li, Michael Hesse, Yusheng Ma, Wei Chen, Haoxiang Huang, Yu Liu, Wenlong Xu, Yating Tang, Hao Zheng, Chuling Li, Zhongqiu Lin, Guojun Chen, Wangjun Liao, Yulin Liao, Jianping Bin, Yanmei Chen
AIMS: Metabolic switching during heart development contributes to postnatal cardiomyocyte (CM) cell cycle exit and loss of regenerative capacity in the mammalian heart. Metabolic control has potential for developing effective CM proliferation strategies. We sought to determine whether lactate dehydrogenase A (LDHA) regulated CM proliferation by inducing metabolic reprogramming. METHODS AND RESULTS: LDHA expression was high in P1 hearts and significantly decreased during postnatal heart development...
October 2022: Redox Biology
https://read.qxmd.com/read/36044846/an-anillin-cin85-sept9-complex-promotes-intercellular-bridge-maturation-required-for-successful-cytokinesis
#38
JOURNAL ARTICLE
Thomas C Panagiotou, Anan Chen, Andrew Wilde
Cleavage of one cell into two is the most dramatic event in the life of a cell. Plasma membrane fission occurs within a narrow intercellular bridge (ICB) between the daughter cells, but the mechanisms underlying ICB formation and maturation are poorly understood. Here we identify CIN85 as an ICB assembly factor and demonstrate its requirement for robust and timely cytokinesis. CIN85 interacts directly with the N-terminal region of anillin and SEPT9 and thereby facilitates SEPT9-containing filament localization to the plasma membrane of the ICB...
August 30, 2022: Cell Reports
https://read.qxmd.com/read/36030492/clinical-implication-and-immunological-landscape-analyses-of-anln-in-pan-cancer-a-new-target-for-cancer-research
#39
JOURNAL ARTICLE
Lan Zhang, Yong Wei, Yan He, Xiaping Wang, Zebo Huang, Libing Sun, Jie Chen, Qingyi Zhu, Xin Zhou
BACKGROUND: Anillin is a F-actin binding protein (ANLN) mainly involved in the process of cytokinesis and known to be dysregulated in diverse cancers. However, the role of ANLN in pan-cancer prognosis and tumor immunity remains unclear. METHODS: Gene expression profiles of 31 solid tumors were downloaded from The Cancer Genome Atlas (TCGA) database. ANLN mRNA and protein expression were quantified using quantitative real-time PCR (qRT-PCR) and immunohistochemistry (IHC)...
February 2023: Cancer Medicine
https://read.qxmd.com/read/35991576/pan-cancer-analysis-of-the-prognostic-and-immunological-role-of-anln-an-onco-immunological-biomarker
#40
JOURNAL ARTICLE
Kejun Liu, Lei Cui, Cunquan Li, Chaofeng Tang, Yiming Niu, Ji Hao, Yang Bu, Bendong Chen
Anillin actin-binding protein (ANLN) is crucially involved in cell proliferation and migration. Moreover, ANLN is significantly in tumor progression in several types of human malignant tumors; however, it remains unclear whether ANLN acts through common molecular pathways within different tumor microenvironments, pathogeneses, prognoses and immunotherapy contexts. Therefore, this study aimed to perform bioinformatics analysis to examine the correlation of ANLN with tumor immune infiltration, immune evasion, tumor progression, immunotherapy, and tumor prognosis...
2022: Frontiers in Genetics
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