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https://www.readbyqxmd.com/read/29871537/-express-plastic-change-of-prefrontal-cortex-mediates-anxiety-like-behaviors-associated-with-chronic-pain-in-neuropathic-rats
#1
Kangning Sang, Chaofei Bao, Yushi Xin, Shunan Hu, Xian Gao, Yongsheng Wang, Mark Bodner, Yongdi Zhou, Xiaowei Dong
Clinical studies show that anxiety and chronic pain are concomitant. The neural basis for the comorbidity is unclear. The prefrontal cortex (PFC) has been recognized as a critical area for affective disorders and chronic pain modulation. In this study, we examined the role of the PFC in the pathogenesis of anxiety associated with chronic pain in a rat model of neuropathic pain with spare nerve injury (SNI). The SNI rats showed apparent anxiety-like behaviors in both open field (OF) test and elevated-plus maze (EPM) test 8 weeks after surgery...
January 1, 2018: Molecular Pain
https://www.readbyqxmd.com/read/29867377/evidence-for-sprouting-of-dopamine-and-serotonin-axons-in-the-pallidum-of-parkinsonian-monkeys
#2
Dave Gagnon, Lara Eid, Dymka Coudé, Carl Whissel, Thérèse Di Paolo, André Parent, Martin Parent
This light and electron microscopie immunohistochemical quantitative study aimed at determining the state of the dopamine (DA) and serotonin (5-HT) innervations of the internal (GPi) and external (GPe) segments of the pallidum in cynomolgus monkeys ( Macaca fascicularis ) rendered parkinsonian by systemic injections of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In contrast to the prominent DA denervation of striatum, the GPi in MPTP monkeys was found to be markedly enriched in DA (TH+) axon varicosities...
2018: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29859284/mir-132-regulated-olfactory-bulb-proteins-linked-to-olfactory-learning-in-greater-short-nosed-fruit-bat-cynopterus-sphinx
#3
Murugan Mukilan, David Mary Rajathei, Edwin Jeyaraj, Nagarajan Kayalvizhi, Koilmani Emmanuvel Rajan
Earlier, we showed that micro RNA-132 (miR-132) regulate the immediate early genes (IEGs) in the olfactory bulb (OB) of fruit bat Cynopterus sphinx during olfactory learning. This study was designed to examine whether the miR-132 regulate other proteins in OB during olfactory learning. To test this, miR-132 anti-sense oligodeoxynucleotide (AS-ODN) was delivered to the OB and then trained to novel odor. The 2-dimensional gel electrophoresis analysis showed that inhibition of miR-132 altered olfactory training induced expression of 321 proteins...
May 30, 2018: Gene
https://www.readbyqxmd.com/read/29803758/increase-in-chromogranin-a-and-serotonin-positive-cells-in-pouch-mucosa-of-patients-with-ulcerative-colitis-undergoing-proctocolectomy
#4
Paolo Giuffrida, Alessandro Vanoli, Elena Biletta, Catherine Klersy, Gaetano Bergamaschi, Gianluca M Sampietro, Sandro Ardizzone, Ombretta Luinetti, Michele Martino, Marco Vincenzo Lenti, Nicola Aronico, Marco Curti, Rachele Manca, Paolo Fociani, Marta Truffi, Fabio Corsi, Gino Roberto Corazza, Antonio Di Sabatino
BACKGROUND: Inflammatory bowel disease (IBD) is associated with neuroendocrine cell hyperplasia. AIMS: We investigated neuroendocrine cells in J-pouches of patients with ulcerative colitis undergoing restorative proctocolectomy and ileal pouch-anal anastomosis. METHODS: Sections from pouch biopsies of 17 patients and ileal biopsies of 17 active IBD patients and 16 controls were processed by immunohistochemistry for chromogranin A (CgA) and serotonin...
April 28, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29802653/serotonin-transporter-inhibition-during-neonatal-period-induces-sex-dependent-effects-on-mitochondrial-bioenergetics-in-the-rat-brainstem
#5
Tercya Lucidi Araujo Silva, Glauber Rudá Feitoza Braz, Severina Cassia de Andrade Silva, Anderson Apolônio da Silva Pedroza, Cristiane de Moura Freitas, Diorginis José Soares Ferreira, Aline Isabel da Silva, Claudia Jacques Lagranha
The serotonin reuptake is mainly regulated by the serotonin transporters (SERTs), which are abundantly found in the raphe nuclei, located in the brainstem. Previous studies have shown that dysfunction in the SERT has been associated with several disorders, including depression and cardiovascular diseases. In this manuscript, we aimed to investigate how gender and the treatment with a serotonin selective reuptake inhibitor (SSRI) could affect mitochondrial bioenergetics and oxidative stress in the brainstem of male and female rats...
May 26, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29785547/analysis-of-factors-affecting-outcomes-of-pregnancy-complicated-by-echinococcus-an-algorithm-for-approach-and-management
#6
Sebahattin Celik, Ozan Okyay, Erbil Karaman, Özlem Z Sert, Numan Cim, Tuba Y Okyay
PURPOSE: The management of hydatid disease (HD) co-occurring with pregnancy remains a challenge for physicians. We aimed to determine factors that were related to fetal and maternal outcomes in HD complicated pregnancies and then develop an approach/treatment algorithm. METHOD: All patients at the participating hospitals were first analyzed to determine whether they had HD. Only patients diagnosed with HD during the course of their pregnancy were included. Certain cyst-related factors (diameter, localization, increase in size, and viability) and certain pregnancy-related factors (treatments, gestational week, maternal co-morbidities, and delivery type) were investigated...
May 21, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29728201/experimental-weight-gain-increases-ambulatory-blood-pressure-in-healthy-subjects-implications-of-visceral-fat-accumulation
#7
Naima Covassin, Fatima H Sert-Kuniyoshi, Prachi Singh, Abel Romero-Corral, Diane E Davison, Francisco Lopez-Jimenez, Michael D Jensen, Virend K Somers
OBJECTIVE: To examine whether experimentally induced weight gain raises ambulatory blood pressure (BP) in healthy subjects and identify any relationship between changes in BP and changes in regional fat distribution. PATIENTS AND METHODS: Twenty-six normal weight subjects were randomized to 8 weeks of weight gain through overfeeding (n=16; age, 30.4±6.6 years) or to weight maintenance (controls; n=10; age, 27.1±7.7 years) between July 2004 and August 2010. Measures of body composition via dual energy X-ray absorptiometry and computed tomography, circulating biomarkers, and 24-hour ambulatory BP were obtained at baseline and after the 8-week experimental phase...
May 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29723540/tnf%C3%AE-dependent-anhedonia-and-upregulation-of-hippocampal-serotonin-transporter-activity-in-a-mouse-model-of-collagen-induced-arthritis
#8
Eric Brown, Conor J Mc Veigh, Leilani Santos, Martina Gogarty, Heidi Kaastrup Müller, Betina Elfving, David J Brayden, Jana Haase
The serotonin transporter (SERT) facilitates high affinity reuptake of 5-HT from the extracellular fluid and dysregulation of transporter function has been implicated in a range of mood disorders including depression. Recent studies have linked immune system activation to depression as well as to altered serotonin transporter activity. Advancing previous studies, which have mainly focussed on acute effects of immune system activation, in this study we used collagen-induced arthritis (CIA) in mice as a model of chronic inflammatory disease, to investigate the effect of prolonged inflammation on brain SERT function and behaviour...
April 30, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29692142/-fractal-features-of-soil-particle-size-in-the-process-of-desertification-in-desert-grassland-of-ningxia-china
#9
Xin Yan, Hui An
The variation of soil properties, the fractal dimension of soil particle size, and the relationships between fractal dimension of soil particle size and soil properties in the process of desertification in desert grassland of Ningxia were discussed. The results showed that the fractal dimension (D) at different desertification stages in desert grassland varied greatly, the value of D was between 1.69 and 2.62. Except for the 10-20 cm soil layer, the value of D gradually declined with increa sing desertification of desert grassland at 0-30 cm soil layer...
October 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29688474/increase-in-processing-factors-is-involved-in-skewed-microrna-expression-in-patients-with-ulcerative-colitis-who-develop-small-intestine-inflammation-after-pouch-surgery
#10
Hadas Sherman Horev, Keren M Rabinowitz, Hofit Elad, Revital Barkan, Shay Ben-Shachar, Metsada Pasmanik Chor, Iris Dotan
Background: A large-scale increase in microRNA (miRNA) expression was observed in patients with ulcerative colitis who underwent pouch surgery and developed inflammation of the pouch (pouchitis). In this study, we assessed miRNA expression in these patients and investigated how regulation of its expression changes in the setting of pouchitis. Methods: Autologous samples that included mucosal biopsies, peripheral blood cells, and plasma were collected from the patients...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29668991/the-onset-and-progression-of-chronic-colitis-parallels-increased-mucosal-serotonin-release-via-enterochromaffin-cell-hyperplasia-and-downregulation-of-the-serotonin-reuptake-transporter
#11
Rhian Stavely, Sarah Fraser, Shilpa Sharma, Ahmed A Rahman, Vanesa Stojanovska, Samy Sakkal, Vasso Apostolopoulos, Paul Bertrand, Kulmira Nurgali
Background: Serotonin (5-hydroxytryptamine, 5-HT) has been linked with several inflammation-associated intestinal diseases, including ulcerative colitis (UC). The largest pool of 5-HT in the body is in enterochromaffin (EC) cells located throughout the intestinal tract. EC cells are mechanosensitive and detect noxious stimuli, inducing secretion of 5-HT, which plays an important role in enteric reflexes and immunomodulation. In this study, we evaluated intestinal 5-HT levels in the Winnie mouse model of spontaneous chronic colitis, which closely replicates UC...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29667320/flotillin-1-interacts-with-the-serotonin-transporter-and-modulates-chronic-corticosterone-response
#12
S N Reisinger, E Kong, B Molz, T Humberg, S Sideromenos, A Cicvaric, T Steinkellner, J-W Yang, M Cabatic, F J Monje, H H Sitte, B J Nichols, D D Pollak
Aberrant serotonergic neurotransmission in the brain is considered at the core of the pathophysiological mechanisms involved in neuropsychiatric disorders. Gene by environment interactions contribute to the development of depression and involve modulation of the availability and functional activity of the serotonin transporter (SERT). Using behavioral and in vivo electrophysiological approaches together with biochemical, molecular-biological and molecular imaging tools we establish Flotillin-1 (Flot1) as a novel protein interacting with SERT and demonstrate its involvement in the response to chronic corticosterone (CORT) treatment...
April 18, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29644713/deuterium-substituted-2-2-dimethylamino-methyl-4-18-f-fluoropropoxy-phenylthio-benzenamine-as-a-serotonin-transporter-imaging-agent
#13
Futao Liu, Lin Zhu, Seok Rye Choi, Karl Plössl, Zhihao Zha, Hank F Kung
Positron emission tomography imaging of serotonin transporter (SERT) is useful for studying brain diseases with altered serotonergic function. A deuterated imaging agent, ([18 F]2-((2-((bis(methyl-d3 )amino)methyl)-4-(3-fluoropropoxy-1,1,2,2,3,3-d6 )phenyl)thio)aniline, [18 F]D12FPBM, [18 F]1), was prepared as a new chemical entity. The deuterated agent, 1, showed excellent binding affinity to SERT; Ki was 0.086 nM, comparable with the undeuterated FPBM. In vivo biodistribution studies in rats with [18 F]1 showed good brain uptake (1...
April 12, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29614501/the-serotonin-transporter-gene-polymorphisms-and-risk-of-ischemic-stroke
#14
Janne Kaergaard Mortensen, Kristian Lundsgaard Kraglund, Søren Paaske Johnsen, Ole Mors, Grethe Andersen, Henriette N Buttenschøn
INTRODUCTION: Serotonin is known as a neurotransmitter; however, it also plays an important role in platelet aggregation as it is released upon platelet activation. The serotonin transporter (SERT) is responsible for the uptake of serotonin into platelets. Functional polymorphisms in the SERT gene may influence platelet activity, as they result in different levels of transporters and thereby different levels of serotonin in platelets. SERT gene polymorphisms have thus been associated with the risk of myocardial infarction...
2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29609092/does-fluoxetine-exposure-affect-hypoxia-tolerance-in-the-gulf-toadfish-opsanus-beta
#15
Molly H B Amador, Kevin L Schauer, M Danielle McDonald
Due to ineffective wastewater treatment technologies, pharmaceuticals such as the selective serotonin reuptake inhibitors (SSRIs)-a common class of antidepressants which inhibit the serotonin transporter (SERT)-can be found in surface waters and marine receiving waters near wastewater effluents. Understanding how exposure to these chemicals might impact non-target organisms, especially combined with other environmental stressors like hypoxia, is essential in order to thoroughly evaluate environmental risk. It was hypothesized that both acute and chronic exposure to the SSRI fluoxetine (FLX) would interfere with the metabolic hypoxia response of the Gulf toadfish, Opsanus beta...
June 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29551185/susceptibility-and-severity-of-cancer-related-fatigue-in-colorectal-cancer-patients-is-associated-with-slc6a4-gene-single-nucleotide-polymorphism-rs25531-a-g-genotype
#16
Xi Ouyang, Guanping Zhang, Hua Pan, Jun Huang
PURPOSE: To explore the correlation between the SERT gene promoter single nucleotide polymorphisms (SNPs) rs25531 and rs956304 and the cancer-related fatigue (CRF) of colon and rectal cancer, and also to analyze the correlation of the interaction of genetic and non-genetic factors. METHOD: A sample of 568 colon and rectal cancer patients were recruited from the Second Affiliated Hospital of Nanchang University from October 2013 to December 2015. The Chinese version of the Brief Fatigue Inventory (BFI-C) was used to evaluate the CRF...
April 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29542343/interplay-between-the-key-proteins-of-serotonin-system-in-ssri-antidepressants-efficacy
#17
Alexander V Kulikov, Raul R Gainetdinov, Evgeni Ponimaskin, Allan V Kalueff, Vladimir S Naumenko, Nina K Popova
Selective serotonin reuptake inhibitors (SSRIs) are the most effective and most used antidepressant drugs. Acting by inhibiting serotonin (5-HT) transporter, SSRIs display a typical 3-4-week delay in their therapeutic effects, with nearly 40% of depressed patients remaining treatment-resistant. Recent evidence suggests complex interplay between 5-HT receptors and key proteins of 5-HT metabolism in molecular mechanisms of such delay and resistance to SSRIs. Area covered: This paper concentrates on the interplay between 5-HT receptors in the delay of therapeutic effect of SSRIs, and the interaction between tryptophan hydroxylase 2 and 5-HT transporter in the SSRI resistance...
April 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29505786/deep-brain-stimulation-and-fluoxetine-exert-different-long-term-changes-in-the-serotonergic-system
#18
Julien Volle, Tatiana Bregman, Brian Scott, Mustansir Diwan, Roger Raymond, Paul J Fletcher, José N Nobrega, Clement Hamani
Both selective serotonin reuptake inhibitors (SSRIs) and ventromedial prefrontal cortex (vmPFC) deep brain stimulation (DBS) modulate serotonergic activity. We compared the acute (1 day) and long-term (12 days) effects of vmPFC stimulation and fluoxetine on serotonin (5-HT) release and receptor expression in rats. Samples to measure serotonin levels were collected from the hippocampus using microdialysis. Serotonin transporter (SERT), 5-HT1A and 5-HT1B mRNA were measured using in situ hybridization. [3 H]8-OH-DPAT and [125 I]cyanopindolol autoradiography were used to measure 5-HT1A and 5-HT1B binding...
March 2, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29502734/corrosion-potential-in-artificial-saliva-and-possible-genotoxic-and-cytotoxic-damage-in-buccal-epithelial-cells-of-patients-who-underwent-ni-cr-based-porcelain-fused-to-metal-fixed-dental-prostheses
#19
Gülce Alp, Gonca Çakmak, Murat Sert, Yavuz Burgaz
Nickel-chromium(Ni-Cr) based alloys account for the majority of the porcelain-fused-to-metal fixed dental prostheses(PFM-FDPs) on account of their superior properties despite both nickel and chromium being known as human carcinogens. Understanding the genotoxicity and the cytotoxicity alongside the characteristics of corrosion behavior of the alloy is vital for understanding their biocompatibility. This study has evaluated whether the Ni-Cr based alloys corroded in artificial saliva by analyzing alloy decomposition at different pH levels and immersion durations(7, 14, 21, and 28 days) using inductively coupled plasma-optic emission spectrophotometry(ICP-OES)...
March 2018: Mutation Research
https://www.readbyqxmd.com/read/29500932/development-and-validation-of-an-lc-esi-ms-ms-method-for-the-quantification-of-d-84-reboxetine-and-citalopram-for-their-use-in-ms-binding-assays-addressing-the-monoamine-transporters-hdat-hsert-and-hnet
#20
Patrick Neiens, Angela De Simone, Anna Ramershoven, Georg Höfner, Lars Allmendinger, Klaus T Wanner
MS Binding Assays represent a label-free alternative to radioligand binding assays. In this study, we present an LC-ESI-MS/MS method for the quantification of (R,R)-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol [(R,R)-D-84, (R,R)-1], (S,S)-reboxetine [(S,S)-2], and (S)-citalopram [(S)-3] employed as highly selective nonlabeled reporter ligands in MS Binding Assays addressing the dopamine [DAT, (R,R)-D-84], norepinephrine [NET, (S,S)-reboxetine] and serotonin transporter [SERT, (S)-citalopram], respectively...
March 3, 2018: Biomedical Chromatography: BMC
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