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https://www.readbyqxmd.com/read/27917802/transient-neurological-symptoms-after-spinal-anesthesia
#1
Muhammet Gozdemir, Bunyamin Muslu, Huseyin Sert, Burhanettin Usta, Ruveyda Irem Demircioglu, Hulya Kasikara
PURPOSE: The aim of this study was to investigate the incidence of transient neurological symptoms (TNS) after spinal anesthesia with levobupivacaine, bupivacaine, articaine or lidocaine. METHODS: The patients (n=400) were randomly assigned to receive spinal anesthesia with levobupivacaine, bupivacaine, articaine or isobaric lidocaine. Onsets of sensory and motor block were recorded. On postoperative days 1, 2 and 3, patients were interviewed by an investigator blinded to the spinal anaesthetic agent used...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27908600/adenoma-recurrence-after-piecemeal-colonic-emr-is-predictable-the-sydney-emr-recurrence-tool
#2
David J Tate, Lobke Desomer, Amir Klein, Gregor Brown, Luke F Hourigan, Eric Yt Lee, Alan Moss, Donald Ormonde, Spiro Raftopoulos, Rajvinder Singh, Stephen J Williams, Simon Zanati, Karen Byth, Michael J Bourke
BACKGROUND AND AIMS: Endoscopic mucosal resection (EMR) is the primary treatment of large laterally spreading colonic lesions (LSL). Residual or recurrent adenoma (RRA) is a major limitation. We aimed to identify a robust method to stratify risk of RRA. METHODS: Prospective multicenter data on consecutive LSL ≥ 20mm removed by piecemeal EMR from eight Australian tertiary centers was included (September 2008 until May 2016). A logistic regression model for endoscopically determined recurrence (EDR) was created on a randomly selected half of the cohort to yield the Sydney EMR Recurrence Tool (SERT), a 4-point score to stratify the incidence of RRA based on characteristics of the index EMR...
November 28, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27897987/atmospheric-correction-of-satellite-gf-1-wfv-imagery-and-quantitative-estimation-of-suspended-particulate-matter-in-the-yangtze-estuary
#3
Pei Shang, Fang Shen
The Multispectral Wide Field of View (WFV) camera on the Chinese GF-1 satellite, launched in 2013, has advantages of high spatial resolution (16 m), short revisit period (4 days) and wide scene swath (800 km) compared to the Landsat-8/OLI, which make it an ideal means of monitoring spatial-temporal changes of Suspended Particulate Matter (SPM) in large estuaries like the Yangtze Estuary. However, a lack of proper atmospheric correction methods has limited its application in water quality assessment. We propose an atmospheric correction method based on a look up table coupled by the atmosphere radiative transfer model (6S) and the water semi-empirical radiative transfer (SERT) model for inversion of water-leaving reflectance from GF-1 top-of-atmosphere radiance, and then retrieving SPM concentration from water-leaving radiance reflectance of the Yangtze Estuary and its adjacent sea...
November 25, 2016: Sensors
https://www.readbyqxmd.com/read/27882537/neurochemical-and-behavioral-effects-of-hypidone-hydrochloride-yl-0919-a-novel-combined-selective-serotonin-reuptake-inhibitor-and-partial-5-ht1a-agonist
#4
Li-Ming Zhang, Xiao-Yun Wang, Nan Zhao, Yu-Lu Wang, Xiao-Xu Hu, Yu-Hua Ran, Yan-Qin Liu, You-Zhi Zhang, Ri-Fang Yang, Yun-Feng Li
The purpose of the present study was to investigate the pharmacology of hypidone hydrochloride (YL-0919), a novel selective serotonin reuptake inhibitor (SSRI) and 5-hydroxytryptamine (5-HT)1A receptor agonist with high affinity for serotonin transporter (SERT) and 5-HT1A receptors. YL-0919 promoted [(35) S]GTPγ S binding at 85% of the magnitude of the full 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), suggesting that YL-0919 is a high-efficacy partial agonist of 5-HT1A receptors...
November 24, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27874199/glucose-and-lipids-levels-with-lanreotide-autogel-120-mg-in-treatment-na%C3%A3-ve-patients-with-acromegaly-data-from-the-primarys-study
#5
Philippe J Caron, Stephan Petersenn, Aude Houchard, Caroline Sert, John S Bevan
OBJECTIVE: Impaired glycaemic control, characteristic of acromegaly, can be exacerbated by treatment with somatostatin analogues (SSAs), particularly those with multireceptor activity. We present data from the PRIMARYS study on the impact of the SSA lanreotide, associated with tumour volume and hormonal improvements, on glucose and other metabolic parameters in acromegaly. DESIGN: PRIMARYS was a 48-week open-label single-arm phase-3b study of lanreotide autogel 120mg/4 weeks...
November 22, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27865645/discovery-of-smp-304-a-novel-benzylpiperidine-derivative-with-serotonin-transporter-inhibitory-activity-and-5-ht1a-weak-partial-agonistic-activity-showing-the-antidepressant-like-effect
#6
Hidefumi Yoshinaga, Shuji Masumoto, Koji Koyama, Naoya Kinomura, Yuji Matsumoto, Taro Kato, Satoko Baba, Kenji Matsumoto, Tomoko Horisawa, Hitomi Oki, Kazuki Yabuuchi, Toru Kodo
We report the discovery of a novel benzylpiperidine derivative with serotonin transporter (SERT) inhibitory activity and 5-HT1A receptor weak partial agonistic activity showing the antidepressant-like effect. The 3-methoxyphenyl group and the phenethyl group of compound 1, which has weak SERT binding activity, but potent 5-HT1A binding activity, were optimized, leading to compound 35 with potent and balanced dual SERT and 5-HT1A binding activity, but also potent CYP2D6 inhibitory activity. Replacement of the methoxy group in the left part of compound 35 with a larger alkoxy group, such as ethoxy, isopropoxy or methoxy-ethoxy group ameliorated CYP2D6 inhibition, giving SMP-304 as a candidate...
October 29, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27826242/fluoxetine-prevents-a%C3%AE-1-42-induced-toxicity-via-a-paracrine-signaling-mediated-by-transforming-growth-factor-%C3%AE-1
#7
Filippo Caraci, Fabio Tascedda, Sara Merlo, Cristina Benatti, Simona F Spampinato, Antonio Munafò, Gian Marco Leggio, Ferdinando Nicoletti, Nicoletta Brunello, Filippo Drago, Maria Angela Sortino, Agata Copani
Selective reuptake inhibitors (SSRIs), such as fluoxetine and sertraline, increase circulating Transforming-Growth-Factor-β1 (TGF-β1) levels in depressed patients, and are currently studied for their neuroprotective properties in Alzheimer's disease. TGF-β1 is an anti-inflammatory cytokine that exerts neuroprotective effects against β-amyloid (Aβ)-induced neurodegeneration. In the present work, the SSRI, fluoxetine, was tested for the ability to protect cortical neurons against 1 μM oligomeric Aβ1-42-induced toxicity...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27782890/pediatric-small-bowel-transplantation-a-single-center-experience-from-turkey
#8
Cem Tuğmen, Maşallah Baran, İsmail Sert, Ayşe Berna Anıl, Eyüp Kebapçı, Sait Murat Doğan, Selçuk Kılınç, Gaye Aydın, Ayşe Gülden Diniz, Mustafa Ölmez, İbrahim Pirim, Cezmi Karaca
BACKGROUND/AIMS: Small bowel transplantation (SBTx) is a treatment option for patients with serious parenteral nutrition-related problems in intestinal failure. İzmir Tepecik Training Research Hospital Organ Transplantation Center is still the only pediatric intestinal transplant center in Turkey. MATERIAL AND METHODS: This study was approved by the local ethics committee. Patients' data were analyzed from the medical charts and the hospital digital database. Seven isolated SBTxs were performed in six children between 2010 and 2016...
September 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/27759558/a-novel-technique-of-subclavian-artery-cannulation-for-venoarterial-extracorporeal-membrane-oxygenation
#9
Umit Kervan, Sinan Sabit Kocabeyoglu, Dogan Emre Sert, Emre Aygün, Kemal Kavasoglu, Mehmet Karahan, Ertekin Utku Unal, Mustafa Pac
OBJECTIVES: The common femoral artery is the standard site for immediate vascular access when initiating adult venoarterial extracorporeal membrane oxygenation. However, this approach is fraught with problems such as femoral artery occlusion, distal limb ischemia, reperfusion injury resulting in compartment syndrome, retroperitoneal hemorrhage, thrombosis, embolization, and most importantly, pulmonary edema. Here, we show our preference of using the subclavian artery with a side graft as a different cannulation technique for outflow of extracorporeal membrane oxygenation, which can avoid complications associated with different access techniques...
October 14, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27744678/discovery-of-indazoles-as-potent-orally-active-dual-neurokinin-1-receptor-antagonists-and-serotonin-transporter-inhibitors-for-the-treatment-of-depression
#10
Andrew P Degnan, George O Tora, Hong Huang, David A Conlon, Carl D Davis, Umesh M Hanumegowda, Xiaoping Hou, Yi Hsiao, Joanna Hu, Rudolph Krause, Yu-Wen Li, Amy E Newton, Rick L Pieschl, Joseph Raybon, Thorsten Rosner, Jung-Hui Sun, Matthew T Taber, Sarah J Taylor, Michael K Wong, Huiping Zhang, Nicholas J Lodge, Joanne J Bronson, John E Macor, Kevin W Gillman
Combination studies of neurokinin 1 (NK1) receptor antagonists and serotonin-selective reuptake inhibitors (SSRIs) have shown promise in preclinical models of depression. Such a combination may offer important advantages over the current standard of care. Herein we describe the discovery and optimization of an indazole-based chemotype to provide a series of potent dual NK1 receptor antagonists/serotonin transporter (SERT) inhibitors to overcome issues of ion channel blockade. This effort culminated in the identification of compound 9, an analog that demonstrated favorable oral bioavailability, excellent brain uptake, and robust in vivo efficacy in a validated depression model...
October 17, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27716426/mean-platelet-volume-in-children-with-hepatitis-a
#11
Fatih Akın, Ahmet Sert, Şükrü Arslan
BACKGROUND: Mean platelet volume (MPV), which is commonly used as a measure of platelet size, indicates the rate of platelet production and platelet activation. We aimed to evaluate the mean platelet volume in children with hepatitis A. METHODS: In this retrospective case-controlled study, the study population consisted of 62 children with hepatitis A and 62 healthy control subjects. RESULTS: MPV values, aspartate transaminase (AST), and alanine transaminase (ALT) levels on admission were significantly increased in patients with hepatitis A when compared to controls whereas white blood cell (WBC) counts were significantly lower...
October 6, 2016: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/27665061/the-allosteric-citalopram-binding-site-differentially-interferes-with-neuronal-firing-rate-and-sert-trafficking-in-serotonergic-neurons
#12
Friederike Matthäus, Nasser Haddjeri, Connie Sánchez, Yasmina Martí, Senda Bahri, Renaud Rovera, Patrick Schloss, Thorsten Lau
Citalopram is a clinically applied selective serotonin re-uptake inhibitor for antidepressant pharmacotherapy. It consists of two enantiomers, S-citalopram (escitalopram) and R-citalopram, of which escitalopram exerts the antidepressant therapeutic effect and has been shown to be one of the most efficient antidepressants, while R-citalopram antagonizes escitalopram via an unknown molecular mechanism that may depend on binding to a low-affinity allosteric binding site of the serotonin transporter. However, the precise mechanism of antidepressant regulation of the serotonin transporter by citalopram enantiomers still remains elusive...
September 21, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27662825/addressing-culture-gender-and-power-with-asian-american-couples-application-of-socio-emotional-relationship-therapy
#13
Jessica ChenFeng, Lana Kim, Yuwei Wu, Carmen Knudson-Martin
Asian Americans juggle the intersections of multiple social identities and societal discourses as they respond to experiences of immigration, marginalization, and patriarchy, integrate collectivist and individualistic family values, and form families and intimate relationships. In this study we examine what we have learned as we apply Socio-Emotional Relationship Therapy (SERT) with heterosexual couples of Asian heritage. SERT begins with sociocultural attunement and the assumption that relationships should mutually support each partner...
September 24, 2016: Family Process
https://www.readbyqxmd.com/read/27591973/perinatal-exposure-to-the-selective-serotonin-reuptake-inhibitor-citalopram-alters-spatial-learning-and-memory-anxiety-depression-and-startle-in-sprague-dawley-rats
#14
Jenna L N Sprowles, Jillian R Hufgard, Arnold Gutierrez, Rebecca A Bailey, Sarah A Jablonski, Michael T Williams, Charles V Vorhees
Selective serotonin reuptake inhibitors (SSRIs) block the serotonin (5-HT) reuptake transporter (SERT) and increase synaptic 5-HT. 5-HT is also important in brain development; hence when SSRIs are taken during pregnancy there exists the potential for these drugs to affect CNS ontogeny. Prenatal SSRI exposure has been associated with an increased prevalence of autism spectrum disorder (ASD), and peripheral 5-HT is elevated in some ASD patients. Perinatal SSRI exposure in rodents has been associated with increased depression and anxiety-like behavior, decreased sociability, and impaired learning in the offspring, behaviors often seen in ASD...
November 2016: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/27586978/-effect-of-ginsenoside-pre-treatment-on-5-hydroxytryptamine-system-in-sd-rats-with-myocardial-infarction-and-depression
#15
M Y Liu, L J Zhang, M C Liu
OBJECTIVE: To evaluate the effect of ginsenoside pre-treatment on serotonin (5-hydroxytryptamine, 5-HT), 5-HT2A receptor (5-HT2AR), and 5-HT transporter (serotonin transporter, SERT) in serum, platelet lysate and brain tissue homogenates in SD rats with myocardial infarction (MI) or depression. METHODS: Eighty SD rats were randomized treated with ginsenoside or normal saline(NS). After 4 weeks, the rats were, then, randomized to four subgroups: the MI, the depression, the MI in combination with depression and sham subgroups...
September 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/27524685/synthesis-characterization-and-monoamine-transporter-activity-of-the-new-psychoactive-substance-mexedrone-and-its-n-methoxy-positional-isomer-n-methoxymephedrone
#16
Gavin McLaughlin, Noreen Morris, Pierce V Kavanagh, John D Power, Geraldine Dowling, Brendan Twamley, John O'Brien, Brian Talbot, Donna Walther, John S Partilla, Michael H Baumann, Simon D Brandt
3-Methoxy-2-(methylamino)-1-(4-methylphenyl)propan-1-one (mexedrone) appeared in 2015 and was advertised by UK Internet retailers as a non-controlled mephedrone derivative (2-(methylamino)-1-(4-methylphenyl)propan-1-one), which was of particular interest to countries who operate generic drugs legislation. This study describes the synthesis and analytical characterization of mexedrone and differentiation from its isomer, N-methoxymephedrone, which was predicted to be a suitable candidate before the identity of mexedrone was revealed...
August 15, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27499056/treatment-with-the-selective-serotonin-reuptake-inhibitor-fluoxetine-attenuates-the-fish-hypoxia-response
#17
Jennifer M Panlilio, Sara Marin, Marissa B Lobl, M Danielle McDonald
The selective serotonin reuptake inhibitor (SSRI) fluoxetine (FLX), the active ingredient of the antidepressant drug Prozac, inhibits reuptake of the neurotransmitter, serotonin (5-HT; 5-hydroxytryptamine), into cells by the 5-HT transporter (SERT). Given the role of 5-HT in oxygen detection and the cardiovascular and ventilatory responses of fish to hypoxia, we hypothesized that treatment of the Gulf toadfish, Opsanus beta, with FLX would interfere with their response to hypoxia. Toadfish treated intra-arterially with 3...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27493135/effect-of-serotonin-transporter-5-httlpr-polymorphism-on-gastrointestinal-intolerance-to-metformin-a-godarts-study
#18
Tanja Dujic, Kaixin Zhou, Roger Tavendale, Colin N A Palmer, Ewan R Pearson
OBJECTIVE: The mechanism causing gastrointestinal intolerance to metformin treatment is unknown. We have previously shown that reduced-function alleles of organic cation transporter 1 (OCT1) are associated with increased intolerance to metformin. Considering recent findings that serotonin reuptake transporter (SERT) might also be involved in metformin intestinal absorption, and the role of serotonin in gastrointestinal physiology, in this study we investigated the association between a common polymorphism in the SERT gene and metformin gastrointestinal intolerance...
August 4, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27458594/spontaneous-calcaneal-fracture-in-patients-with-diabetic-foot-ulcer-four-cases-report-and-review-of-literature
#19
Mehtap Evran, Murat Sert, Tamer Tetiker, Gamze Akkuş, Ömer Sunkar Biçer
Spontaneous calcaneal fractures in diabetic patients without obvious trauma may occur, sometimes accompanying diabetic foot ulcers. In the current study we report four cases who were hospitalized for diabetic foot ulcer with concomitant calcaneal fractures. There were four diabetic patients (one type 1 and three type 2) who registered with diabetic foot ulcers with coexisting calcaneal fractures, all of which were classified as Type A according to Essex Lopresti Calcaneal Fracture Classification. Two of the patients with renal failure were in a routine dialysis program, as well as vascular compromise and osteomyelitis in all of the patients...
July 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/27391165/phase-i-metabolites-of-mephedrone-display-biological-activity-as-substrates-at-monoamine-transporters
#20
F P Mayer, L Wimmer, O Dillon-Carter, J S Partilla, N V Burchardt, M D Mihovilovic, M H Baumann, H H Sitte
BACKGROUND AND PURPOSE: 4-Methyl-N-methylcathinone (mephedrone) is a synthetic stimulant that acts as a substrate-type releaser at transporters for dopamine (DAT), noradrenaline (NET) and 5-HT (SERT). Upon systemic administration, mephedrone is metabolized to several phase I compounds: the N-demethylated metabolite, 4-methylcathinone (nor-mephedrone); the ring-hydroxylated metabolite, 4-hydroxytolylmephedrone (4-OH-mephedrone); and the reduced keto-metabolite, dihydromephedrone. EXPERIMENTAL APPROACH: We used in vitro assays to compare the effects of mephedrone and synthetically prepared metabolites on transporter-mediated uptake and release in HEK293 cells expressing human monoamine transporters and in rat brain synaptosomes...
September 2016: British Journal of Pharmacology
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