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Growth Hormone AND IGF-1

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https://www.readbyqxmd.com/read/29154428/muscle-wasting-and-sarcopenia-in-heart-failure-and-beyond-update-2017
#1
REVIEW
Jochen Springer, Joshua-I Springer, Stefan D Anker
Sarcopenia (loss of muscle mass and muscle function) is a strong predictor of frailty, disability and mortality in older persons and may also occur in obese subjects. The prevalence of sarcopenia is increased in patients suffering from chronic heart failure. However, there are currently few therapy options. The main intervention is resistance exercise, either alone or in combination with nutritional support, which seems to enhance the beneficial effects of training. Also, testosterone has been shown to increased muscle power and function; however, a possible limitation is the side effects of testosterone...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29153669/maternal-serum-igf-1-igfbp-1-and-3-and-placental-growth-hormone-at-20weeks-gestation-in-pregnancies-complicated-by-preeclampsia
#2
Shutan Liao, Mark H Vickers, Rennae S Taylor, Beatrix Jones, Mhoyra Fraser, Lesley M E McCowan, Philip N Baker, Jo K Perry
OBJECTIVE: To investigate whether maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF) 1 and 2, and IGF binding proteins (IGFBP) 1 and 3 were altered in pregnancies complicated by later preeclampsia (PE). STUDY DESIGN: In a nested case-control study, PE cases (n=71) and matched controls (n=71) were selected from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Maternal serum hormone concentrations at 20weeks of gestation were determined by ELISA...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153202/growth-hormone-as-biomarker-in-heart-failure
#3
REVIEW
Alberto M Marra, Emanuele Bobbio, Roberta D'Assante, Andrea Salzano, Michele Arcopinto, Eduardo Bossone, Antonio Cittadini
The impairment of growth hormone (GH)/insulin growth factor-1(IGF-1) plays a crucial role in chronic heart failure (CHF). Several studies have shown that patients affected by this condition display a more aggressive disease, with impaired functional capacity and poor outcomes. Interestingly, GH replacement therapy represents a possible future therapeutic option in CHF. In this review, the authors focus on the assessment of the main abnormalities in GH/IGF-1 axis in CHF, the underlying molecular background, and their impact on disease progression and outcomes...
January 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29152592/revisiting-the-igf-1r-as-a-breast-cancer-target
#4
Roudy Chiminch Ekyalongo, Douglas Yee
The type I insulin-like growth factor-1 receptor is a well-described target in breast cancer and multiple clinical trials examining insulin-like growth factor-1 receptor have been completed. Unfortunately, monoclonal antibodies and tyrosine kinase inhibitors targeting insulin-like growth factor-1 receptor failed in phase III breast clinical trials for several reasons. First, insulin-like growth factor-1 receptor antibody therapy resulted in hyperglycemia and metabolic syndrome most likely due to disruption of insulin-like growth factor-1 homeostasis and subsequent growth hormone elevation...
2017: NPJ Precis Oncol
https://www.readbyqxmd.com/read/29152285/mexican-case-report-of-a-never-treated-laron-syndrome-patient-evolving-to-metabolic-syndrome-type-2-diabetes-and-stroke
#5
Inma Castilla-Cortazar, Giovana Femat-Roldán, Joel Rodríguez-Rivera, Gabriel A Aguirre, Mariano García-Magariño, Irene Martín-Estal, Luis Espinosa, Carlos Díaz-Olachea
Glucose and lipid profile together with blood pressure should always be considered for low sera-IGF-1 patients. Even when adulthood is reached, IGF-1 therapy in these patients should be pursued as metabolic and protective cellular effects could be triggered. Real incidence of growth hormone insensitivity is still to be uncovered.
November 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29152244/effect-of-dietary-protein-intake-on-the-body-composition-and-metabolic-parameters-of-neutered-dogs
#6
Iris Mayumi Kawauchi, Juliana Toloi Jeremias, Paula Takeara, Danilo Ferreira de Souza, Júlio Cesar de Carvalho Balieiro, Karina Pfrimer, Marcio Antonio Brunetto, Cristiana Fonseca Ferreira Pontieri
Neutering is a common veterinary recommendation and is often associated with obesity development. Thus, the aim of the present study was to evaluate the effects of two different amounts of protein intake by neutered dogs regarding maintenance energy requirement (MER), body composition, and biochemical and hormonal parameters. A total of fourteen healthy adult dogs were fed either a diet containing 59·7 g protein/1000 kcal (4184 kJ) (P60) or a diet with 94·0 g protein/1000 kcal (4184 kJ) (P94) for 26 weeks after neutering to maintain their body weight prior to neutering...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29151078/therapeutic-effect-of-exogenous-ghrelin-in-the-healing-of-gingival-ulcers-is-mediated-by-the-release-of-endogenous-growth-hormone-and-insulin-like-growth-factor-1
#7
J Cieszkowski, Z Warzecha, P Ceranowicz, D Ceranowicz, B Kusnierz-Cabala, M Pedziwiatr, M Dembinski, T Ambrozy, T Kaczmarzyk, M Pihut, M Wieckiewicz, R Olszanecki, A Dembinski
Ghrelin, an acylated 28-amino acid polypeptide, was primary isolated from the stomach, and the stomach is a main source of circulating ghrelin. Ghrelin strongly and dose-dependently stimulates release of growth hormone from the anterior pituitary, as well as increases food intake and fat deposition. Previous studies showed that ghrelin exhibits protective and therapeutic effect in different parts of the gastrointestinal system, including the oral cavity. The aim of present study was to examine the role of growth hormone and insulin-like growth factor-1 (IGF-1) in the healing of gingival ulcers...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29149058/neurotrophic-and-neuroregenerative-effects-of-gh-igf1
#8
Vittorio Emanuele Bianchi, Vittorio Locatelli, Laura Rizzi
INTRODUCTION: Human neurodegenerative diseases increase progressively with age and present a high social and economic burden. Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are both growth factors exerting trophic effects on neuronal regeneration in the central nervous system (CNS) and peripheral nervous system (PNS). GH and IGF-1 stimulate protein synthesis in neurons, glia, oligodendrocytes, and Schwann cells, and favor neuronal survival, inhibiting apoptosis. This study aims to evaluate the effect of GH and IGF-1 on neurons, and their possible therapeutic clinical applications on neuron regeneration in human subjects...
November 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29147569/growth-hormone-insensitivity-mexican-case-report
#9
I Castilla-Cortazar, J R De Ita, G A Aguirre, M García-Magariño, I Martín-Estal, V J Lara-Diaz, M I Elizondo
Herein, we present a 14-year-old patient with short stature (134 cm) referred from Paediatrics to our department for complementary evaluation since growth hormone (GH) treatment failed to show any improvement. He was born premature and small for gestational age. Genital examination classified the patient as Tanner I-II with small penis and testicular size for his age. Biochemical analyses revealed normal GH levels with low serum insulin-like growth factor-1 (IGF-1). Molecular diagnosis confirmed several mutations in IGF1R and IGFALS, and so he was diagnosed with Laron Syndrome or GH insensibility and treated with IGF-1 substitutive therapy...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29144813/diagnosing-and-monitoring-endocrine-dysfunction-diabetes-and-obesity-in-a-cohort-of-adult-survivors-of-childhood-cancer
#10
Victoria Rollins Hudspeth, Stuart Harrison Gold, David Robert Clemmons
OBJECTIVE: 5-year survival for childhood cancer has increased to 80%, resulting in a growing population of adult survivors of childhood cancer (ASOCC). Long-term endocrine dysfunction is as high as 63% when screened in research protocols. The purpose of this study was to evaluate the prevalence of endocrine testing, endocrine dysfunction, diabetes, obesity, and endocrinologist visits outside of a research screening protocol. METHODS: Retrospective chart review was performed for 176 ASOCC who were diagnosed with cancer before age 18, followed at least 10 years, were now at least 18, and had survived to the time of chart review...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29144802/lipid-accumulation-product-visceral-adiposity-index-and-chinese-visceral-adiposity-index-as-markers-of-cardiometabolic-risk-in-adult-growth-hormone-deficiency-patients-a-cross-sectional-study
#11
Xin Xie, Qing Li, Lingmin Zhang, Wei Ren
OBJECTIVE: Adult growth hormone deficiency (AGHD) is associated with cardiometabolic risk factors. Given that cardiovascular disease (CVD) is an important cause of morbidity and mortality in the AGHD population, there is a need for alternative, non-invasive methods of assessing cardiometabolic risk in this population. Chinese visceral adiposity index (CVAI) is a new marker of visceral fat dysfunction that is based on age, body mass index (BMI), waist circumference (WC) and metabolic parameters...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29140440/cord-metabolic-profiles-in-obese-pregnant-women-insights-into-offspring-growth-and-body-composition
#12
Nashita Patel, Christian Hellmuth, Olaf Uhl, Keith Godfrey, Annette Briley, Paul Welsh, Dharmintra Pasupathy, Paul Seed, Berthold Koletzko, Lucilla Poston
Context: Offspring exposed in-utero to maternal obesity have an increased risk of later obesity; however, the underlying mechanisms remain unknown. Objective: To assess the effect of an antenatal lifestyle intervention in obese women on the offspring's cord blood metabolic profile, and examine associations of cord blood metabolic profile with maternal clinical characteristics and offspring anthropometry at birth and age 6 months. Design: Randomised controlled trial and cohort study...
November 13, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29137319/effects-of-growth-hormone-on-cardiac-remodeling-and-soleus-muscle-in-rats-with-aortic-stenosis-induced-heart-failure
#13
Aline R R Lima, Luana U Pagan, Ricardo L Damatto, Marcelo D M Cezar, Camila Bonomo, Mariana J Gomes, Paula F Martinez, Daniele M Guizoni, Dijon H S Campos, Felipe C Damatto, Katashi Okoshi, Marina P Okoshi
Background: Skeletal muscle wasting is often observed in heart failure (HF). The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis is impaired in HF. In this study, we evaluated the effects of GH on soleus muscle and cardiac remodeling in rats with aortic stenosis (AS)-induced HF. Methods: AS was created by placing a stainless-steel clip on the ascending aorta. After clinically detecting HF, GH (2 mg/kg/day) was subcutaneously injected for 14 days (AS-GH group)...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136343/pharmacokinetics-pharmacodynamics-and-safety-of-a-long-acting-human-growth-hormone-mod-4023-in-healthy-japanese-and-caucasian-adults
#14
William G Kramer, Michal Jaron-Mendelson, Ronit Koren, Oren Hershkovitz, Gili Hart
Daily injections of growth hormone (GH) as replacement therapy in GH-deficient (GHD) patients may cause poor compliance and inconvenience. C-terminal peptide-modified human GH (MOD-4023) has been developed for once-weekly administration in GHD adults and children. In the present study, the pharmacokinetics (PK) and pharmacodynamics (PD) of a single subcutaneous dose of MOD-4023 were evaluated in healthy Caucasian and Japanese adults, using a phase 1 double-blind, vehicle-controlled, randomized study design...
November 14, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29133707/impact-of-transsphenoidal-surgery-on-asymptomatic-cardiomyopathy-in-patients-with-acromegaly-a-single-blinded-study
#15
Anirudh Srinivasan, Ajay Bahl, Hemant Bhagat, Pinaki Dutta, Ashutosh Rai, Jagtar S Devgun, Rupinder Kaur, Kanchan Kumar Mukherjee
BACKGROUND: Patients with acromegaly have 2-3 times the expected mortality rates primarily due to cardiovascular risks. Echocardiographic studies showing improvement of cardiac function following transsphenoidal surgery (TSS) are limited. MATERIALS AND METHODS: All patients with acromegaly underwent preoperative echocardiography and tissue Doppler (Philips i33, 3D ECHO) for assessment of cardiac indices. In the prospective group of patients, echocardiography was repeated after 6 months of surgery...
November 2017: Neurology India
https://www.readbyqxmd.com/read/29131127/pleiotropic-effects-of-white-willow-bark-and-1-2-decanediol-on-human-adult-keratinocytes
#16
Eleonora Bassino, Franco Gasparri, Luca Munaron
BACKGROUND: Acne vulgaris is a common skin defect, usually occurring during adolescence, but often it can persist in adults leaving permanent face scarring. Acne is usually treated with topical drugs, oral antibiotics, retinoids, and hormonal therapies, but medicinal plants are increasingly employed. OBJECTIVE: To investigate the protective role of white willow bark (WWB) and 1,2-decanediol (DD) on the damage caused by lipopolysaccharides (LPS) on human adult keratinocytes (HaCaT)...
November 8, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29114882/a-comprehensive-analysis-of-polymorphic-variants-in-steroid-hormone-and-igf-1-metabolism-and-risk-of-in-situ-breast-cancer-results-from-the-breast-and-prostate-cancer-cohort-bpc3-consortium
#17
Myrto Barrdahl, Federico Canzian, Mia M Gaudet, Susan M Gapstur, Antonia Trichopoulou, Kostas Tsilidis, Carla H van Gils, Signe Borgquist, Elisabete Weiderpass, Kay-Tee Khaw, Graham G Giles, Roger L Milne, Loic Le Marchand, Christopher Haiman, Sara Lindström, Peter Kraft, David J Hunter, Regina Ziegler, Stephen J Chanock, Xiaohong R Yang, Julie E Buring, I-Min Lee, Rudolf Kaaks, Daniele Campa
We assessed the association between 1,414 single nucleotide polymorphisms (SNPs) in genes involved in synthesis and metabolism of steroid hormones and IGF-1, and risk of breast cancer in situ (BCIS), with the aim of determining whether any of these were disease specific. This was done using 1,062 BCIS cases and 10,126 controls as well as 6,113 invasive breast cancer cases from the Breast and Prostate Cancer Cohort Consortium (BPC3). Three SNPs showed at least one nominally significant association in homozygous minor versus homozygous major models...
November 7, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29113980/management-of-endocrine-disease-novel-anabolic-treatments-for-osteoporosis
#18
Ernesto Canalis
Skeletal anabolic agents enhance bone formation, which is determined by the number and function of osteoblasts. Signals that influence the differentiation and function of cells of the osteoblast lineage play a role in the mechanism of action of anabolic agents in the skeleton. Wnts induce the differentiation of mesenchymal stem cells toward osteoblasts, and insulin-like growth factor I (IGF-I) enhances the function of mature osteoblasts. The activity of Wnt and IGF-I is controlled by proteins that bind to the growth factor or to its receptors...
November 7, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29113856/has-acromegaly-been-diagnosed-earlier
#19
Hideko Ohno, Yuichiro Yoneoka, Shinya Jinguji, Naoto Watanabe, Masayasu Okada, Yukihiko Fujii
PURPOSE: We investigated whether acromegaly has been diagnosed earlier at the Niigata Medical and Dental University Hospital. METHODS: Patients with acromegaly (n = 81) who underwent their first transsphenoidal surgery from 2006 to 2015 were reviewed. Two groups were compared: those who underwent surgery between 2006 and 2010 (n = 35) and those who underwent surgery between 2011 and 2015 (n = 46). We compared clinical features and serum levels of the growth hormone (GH) and insulin-like growth factor-1 (IGF-1), hypertension (HT) and diabetes mellitus (DM) prevalence between the two groups...
November 4, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29112114/role-of-scaffold-protein-proline-glutamic-acid-and-leucine-rich-protein-1-pelp1-in-the-modulation-of-adrenocortical-cancer-cell-growth
#20
Arianna De Luca, Paola Avena, Rosa Sirianni, Adele Chimento, Francesco Fallo, Catia Pilon, Ivan Casaburi, Vincenzo Pezzi
PELP1 acts as an estrogen receptor (ER) coactivator that exerts an essential role in the ER's functions. ER coregulators have a critical role in the progression and response to hormonal treatment of estrogen-dependent tumors. We previously demonstrated that, in adrenocortical carcinoma (ACC), ERα is upregulated and that estradiol activates the IGF-II/IGF1R signaling pathways defining the role of this functional cross-talk in H295R ACC cell proliferation. The aim of this study was to determine if PELP1 is expressed in ACC and may play a role in promoting the interaction between ERα and IGF1R allowing the activation of pathways important for ACC cell growth...
November 7, 2017: Cells
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