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https://www.readbyqxmd.com/read/29775837/predator-based-psychosocial-stress-model-of-ptsd-differentially-influences-voluntary-ethanol-consumption-depending-on-methodology
#1
Phillip R Zoladz, Eric D Eisenmann, Robert M Rose, Brooke A Kohls, Brandon L Johnson, Kiera L Robinson, Megan E Heikkila, Kasey E Mucher, Madelaine R Huntley
Post-traumatic stress disorder (PTSD) is a debilitating psychological disorder typified by diagnostic symptom clusters including hyperarousal, avoidance, negative cognitions and mood, and intrusive re-experiencing of the traumatic event. Patients with PTSD have been reported to self-medicate with alcohol to ameliorate hyperarousal symptoms associated with the disorder. Research utilizing rodent models of PTSD to emulate this behavioral phenomenon has thus far yielded inconsistent results. In the present study, we examined the effects of a predator-based psychosocial stress model of PTSD on voluntary ethanol consumption...
January 8, 2018: Alcohol
https://www.readbyqxmd.com/read/29771349/study-of-lymphoedema-of-non-filarial-origin-in-the-northwest-region-of-cameroon-spatial-distribution-profiling-of-cases-and-socio-economic-aspects-of-podoconiosis
#2
Samuel Wanji, Jonas A Kengne-Ouafo, Kebede Deribe, Ayok M Tembei, Abdel Jelil Njouendou, Dizzel Bita Tayong, David D Sofeu-Feugaing, Fabrice R Datchoua-Poutcheu, Jorge Cano, Emanuele Giorgi, Yolande F Longang-Tchounkeu, Peter A Enyong, Melanie J Newport, Gail Davey
Background: Although podoconiosis is endemic in Cameroon, little is known about its epidemiology and spatial distribution. Methods: This cross-sectional, population-based study enrolled all adults (≥15 y) residing in the districts of the northwest region of Cameroon for 10 or more years. Participants were interviewed and had a physical examination. The study outcomes were prevalence estimates of lymphoedema and podoconiosis. House-to-house screening was conducted by Community Health Implementers (CHIs)...
May 16, 2018: International Health
https://www.readbyqxmd.com/read/29768288/caffeine-sodium-benzoate-for-electroconvulsive-therapy-augmentation
#3
Kevin M Bozymski, Teresa G Potter, Vasu Venkatachalam, Ananda K Pandurangi, Ericka L Crouse
OBJECTIVES: Because of an ongoing manufacturer shortage of injectable caffeine sodium benzoate (CSB), patients at our health system were given CSB compounded in-house to increase seizure response during electroconvulsive therapy (ECT). Therefore, we aimed to evaluate its effectiveness and safety as an ECT augmentation agent. METHODS: Medical records of patients who received compounded CSB at Virginia Commonwealth University Health System were reviewed to identify adults receiving it as part of an index ECT treatment course between June 2012 and December 2016...
May 15, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29765825/early-career-surgical-practice-for-cerebellopontine-angle-tumors-in-the-era-of-radiosurgery
#4
Giannantonio Spena, Tommaso Sorrentino, Roberto Altieri, Luca Redaelli de Zinis, Roberto Stefini, Pier Paolo Panciani, Marco Fontanella
We analyzed the outcomes of patients with large cerebellopontine angle (CPA) tumors treated by a skull-base team in which two surgeons (one neurosurgeon and one otological surgeon) were in the beginning of their careers (<40 years old). Data of patients operated on between April 2012 and March 2016 were reviewed. All factors related to surgical training were considered. Thirty-one patients had vestibular schwannomas, while 26 had meningiomas. Mean tumor diameter was 30.6 mm (range, 23-49 mm) for schwannomas and 35 mm (range, 22-51 mm) for meningiomas...
June 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29764677/a-novel-in-house-mixed-mode-solid-phase-extraction-of-urine-for-the-determination-of-16-basic-drugs-by-hplc-ion-trap-ms
#5
Giacomo Musile, Lucia Cenci, Elena Piletska, Rossella Gottardo, Alessandra M Bossi, Federica Bortolotti
The aim of the present work was to develop a novel in-house mixed-mode SPE sorbent to be used for the HPLC-Ion TrapMS determination of 16 basic drugs in urine. By using a computational modelling, a virtual monomer library was screened identifying three suitable functional monomers, methacrylic acid (MAA), itaconic acid (IA) and 2-acrylamide-2-methylpropane sulfonic acid (AMPSA), respectively. Three different sorbents were then synthetized based on these monomers, and using as cross-linker trimethylolpropane trimethacrylate (TMPTMA)...
May 9, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29764425/mobility-patterns-and-associated-factors-among-pregnant-internal-migrant-women-in-china-a-cross-sectional-study-from-a-national-monitoring-survey
#6
Ying Ji, Xiaoping Zhao, Zhili Wang, Shenglan Liu, Yang Shen, Chun Chang
BACKGROUND: Residential instability during pregnancy has been linked to poor health outcomes. As a first step toward providing better health care to pregnant migrant women, the size and characteristics of this population and factors associated with mobility during pregnancy should be studied. METHODS: Using the "Monitoring Data of Chinese Migrants" for 2012, from the Chinese National Population and Family Planning Commission, this study explored mobility patterns during pregnancy and associated factors among migrants within China...
May 15, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29763792/impact-assessment-of-pollutants-from-waste-related-operations-as-a-feature-of-holistic-logistic-tool
#7
Vlastimír Nevrlý, Radovan Šomplák, Jiří Gregor, Martin Pavlas, Jiří Jaromír Klemeš
Waste management has still been a developing and progressing field, which demands continual improvements in waste transportation as well as proper selection of locations and technical operation of new treatment facilities. Most of research papers on waste management planning have been dealing with optimisation of network flows, thus minimising the cost and improving economic criteria. The shortest paths to treatment facilities are considered together with detailed analysis of their operation including heat and electricity demands in their vicinity...
May 12, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29763532/palliative-care-occupies-growing-presence-in-ed
#8
(no author information available yet)
As the benefits of palliative care become more evident in clinical trials, there is growing interest in making such resources available to patients at an earlier stage, such as the ED. However, experts note that emergency staff first must identify available resources and make sure that providers have the primary palliative care skills needed to effectively introduce the topic to appropriate patients and families. Research shows that initiating the call for a palliative care consult while the patient is in the ED can deliver quality-of-life benefits even three months later...
June 2017: ED Management: the Monthly Update on Emergency Department Management
https://www.readbyqxmd.com/read/29761454/an-introduction-to-the-saccharomyces-genome-database-sgd
#9
Olivia W Lang, Robert S Nash, Sage T Hellerstedt, Stacia R Engel
The Saccharomyces Genome Database (SGD) is a well-established, key resource for researchers studying Saccharomyces cerevisiae. In addition to updating and maintaining the official genomic sequence of this highly studied organism, SGD provides integrated data regarding gene functions and phenotypes, which are extracted from the published literature. The vast amount and variety of data housed in the database can prove challenging to navigate for the first-time user. Therefore, this chapter serves as an introduction describing how to search the database in order to discover new information...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29759659/the-global-development-and-clinical-efficacy-of-sublingual-tablet-immunotherapy-for-allergic-diseases
#10
REVIEW
Hendrik Nolte, Jennifer Maloney
Allergy immunotherapy (AIT) is a treatment option for respiratory allergy that is complementary to pharmacotherapy, with a distinct mechanism of action. Alternative methods to subcutaneous administration of AIT that enable patients to safely self-administer AIT is considered an unmet clinical need. The sublingual immunotherapy tablet (SLIT-tablet) is an orally disintegrating pharmaceutical formulation (oral lyophilisate) containing standardized allergens. SLIT-tablets have been developed for sublingual immunotherapy (SLIT) of cedar-pollen, grass-pollen, ragweed-pollen, tree-pollen, and house dust mite allergies...
May 12, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29759056/housing-and-employment-outcomes-for-mental-health-self-direction-participants
#11
Bevin Croft, Nilüfer İsvan, Susan L Parish, Kevin J Mahoney
OBJECTIVE: In self-direction, participants control individual budgets, allocating service dollars according to needs and preferences within program parameters to meet self-defined recovery goals. Mental health self-direction is associated with enhanced wellness and recovery outcomes at lower or similar cost than traditional service arrangements. This study compared outcomes of housing independence and employment between individuals who participated in self-direction and those who did not...
May 15, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29758182/exploratory-behavior-is-linked-to-stress-physiology-and-social-network-centrality-in-free-living-house-finches-haemorhous-mexicanus
#12
Sahnzi C Moyers, James S Adelman, Damien R Farine, Ignacio T Moore, Dana M Hawley
Animal personality has been linked to individual variation in both stress physiology and social behaviors, but few studies have simultaneously examined covariation between personality traits, stress hormone levels, and behaviors in free-living animals. We investigated relationships between exploratory behavior (one aspect of animal personality), stress physiology, and social and foraging behaviors in wild house finches (Haemorhous mexicanus). We conducted novel environment assays after collecting samples of baseline and stress-induced plasma corticosterone concentrations from a subset of house finches...
May 11, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29756618/intraparotid-facial-nerve-schwannoma-two-case-reports-and-a-review-of-the-literature
#13
M Simone, E Vesperini, C Viti, A Camaioni, L Lepanto, F Raso
Schwannomas are rare benign tumours that arise from Schwann cells. The most known and studied is the intracranial vestibular schwannoma, even if it is not the most frequent. More often schwannomas arise from peripheral sensitive nerves, and the vagous is most involved among the cranial nerves. Intraparotid schwannomas account for just 10% of all facial involvement, so they are an extremely rare localisation. At present, there are less than 100 cases described in the literature. We performed a retrospective analysis of parotidectomy in two Italian hospitals and present two cases of intraparotid schwannoma and a review of the literature...
February 2018: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29755194/time-course-of-salmonella-shedding-and-antibody-response-in-naturally-infected-pigs-during-grower-finisher-stage
#14
Saranya Nair, Abdolvahab Farzan, Terry L O'Sullivan, Robert M Friendship
A longitudinal trial was conducted to determine the course of Salmonella shedding and antibody response in naturally infected grower-finisher pigs. Ten-week-old pigs ( n = 45) were transferred from a farm with history of salmonellosis and housed at a research facility. Weekly fecal samples (weeks 1 to 11) as well as tissue samples at slaughter were cultured for Salmonella. Serum samples were tested for presence of Salmonella antibody by enzyme-linked immunosorbent assay (ELISA). Data were analyzed using a multilevel mixed-effects logistic regression model...
April 2018: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/29753614/a-22-year-follow-up-reveals-a-variable-disease-severity-in-early-onset-facioscapulohumeral-dystrophy
#15
Rianne J M Goselink, Caroline R van Kernebeek, Karlien Mul, Richard J L F Lemmers, Silvère M van der Maarel, Oebele F Brouwer, Nicol Voermans, George W Padberg, Corrie E Erasmus, Baziel G M van Engelen
AIM: To assess the long-term natural course of early-onset facioscapulohumeral dystrophy (FSHD), which is important for patient management and trial-readiness, and is currently lacking. METHODS: We had the unique opportunity to evaluate 10 patients with early-onset FSHD after 22 years follow-up. Patients underwent a semi-structured interview, physical examination and additional genotyping. RESULTS: Nine initial study participants (median age 37 years) were included, one patient died shortly after first publication...
May 3, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29748457/distribution-and-larval-breeding-habitats-of-aedes-mosquito-species-in-residential-areas-of-northwest-ethiopia
#16
Getachew Ferede Endalew, Moges Tiruneh, Ebba Abate, Wondmeneh Jemberie, Yitayih Wondimeneh, Demekech Damtie, Belay Tessema
Objectives: Aedes mosquito is a vector for transmitting many arboviruses. Knowledge of this vector breeding habitat is vital for implementing appropriate interventions. Thus, this study was aimed to determine the breeding habitats and presence of Aedes mosquito species in the study areas. Methods: House to house cross- sectional survey of Aedes mosquito breeding habitats was carried out in Metema and Humera, Ethiopia, in August 2017. All available water-holding containers present in and around the houses were inspected for the presence of immature stages of Aedes mosquitoes, and they were collected and reared to the adult stage for species identification...
April 23, 2018: Epidemiology and Health
https://www.readbyqxmd.com/read/29746855/the-first-multi-zoo-application-of-an-allostatic-load-index-to-western-lowland-gorillas-gorilla-gorilla-gorilla
#17
Ashley N Edes, Barbara A Wolfe, Douglas E Crews
Vertebrate stress responses are highly adaptive biological functions, maximizing survival probability in life-threatening situations. However, experiencing repeated and/or chronic stressors can generate physiological dysregulation and lead to disease. Because stress responses are multi-systemic and involve a wide range of physiological functions, identifying responses to stressors is best accomplished using integrated biomarker models. Allostatic load, defined as the physiological dysregulation that accumulates over the lifespan due to stressful experiences, is one such model...
May 7, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29743115/geographical-distribution-and-relative-risk-of-anjozorobe-virus-thailand-orthohantavirus-infection-in-black-rats-rattus-rattus-in-madagascar
#18
Vololoniaina Raharinosy, Marie-Marie Olive, Fehivola Mandanirina Andriamiarimanana, Soa Fy Andriamandimby, Jean-Pierre Ravalohery, Seta Andriamamonjy, Claudia Filippone, Danielle Aurore Doll Rakoto, Sandra Telfer, Jean-Michel Heraud
BACKGROUND: Hantavirus infection is a zoonotic disease that is associated with hemorrhagic fever with renal syndrome and cardiopulmonary syndrome in human. Anjozorobe virus, a representative virus of Thailand orthohantavirus (THAIV), was recently discovered from rodents in Anjozorobe-Angavo forest in Madagascar. To assess the circulation of hantavirus at the national level, we carried out a survey of small terrestrial mammals from representative regions of the island and identified environmental factors associated with hantavirus infection...
May 9, 2018: Virology Journal
https://www.readbyqxmd.com/read/29743053/pdxliver-a-database-of-liver-cancer-patient-derived-xenograft-mouse-models
#19
Sheng He, Bo Hu, Chao Li, Ping Lin, Wei-Guo Tang, Yun-Fan Sun, Fang-You-Min Feng, Wei Guo, Jia Li, Yang Xu, Qian-Lan Yao, Xin Zhang, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Yi-Xue Li, Hong Li, Xin-Rong Yang
BACKGROUND: Liver cancer is the second leading cause of cancer-related deaths and characterized by heterogeneity and drug resistance. Patient-derived xenograft (PDX) models have been widely used in cancer research because they reproduce the characteristics of original tumors. However, the current studies of liver cancer PDX mice are scattered and the number of available PDX models are too small to represent the heterogeneity of liver cancer patients. To improve this situation and to complement available PDX models related resources, here we constructed a comprehensive database, PDXliver, to integrate and analyze liver cancer PDX models...
May 9, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29740188/prenatal-consultation-perspectives-on-training-relevance-and-utilization-among-pediatric-subspecialty-program-directors
#20
Phoebe Danziger, Naomi Laventhal
OBJECTIVE: To characterize the experience and training of house officers in prenatal consultation, and to assess program directors' perceptions regarding adequacy of training, and relevance and utilization of prenatal consultation in their field. STUDY DESIGN: An online survey was distributed to program directors of all ACGME-accredited programs in the United States in relevant pediatric subspecialties. RESULTS: Ninety-five percent (142/150) of respondents agreed that prenatal consultation from their field can impact decision-making, yet 46% (69/149) believe their prenatal consult services are underutilized...
May 8, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
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