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https://www.readbyqxmd.com/read/28812124/clozapine-chlorpromazine-and-risperidone-dose-dependently-reduce-emotional-hyperthermia-a-biological-marker-of-salience
#1
William W Blessing, Esther M Blessing, Mazher Mohammed, Youichirou Ootsuka
RATIONALE: We recently introduced a new rat model of emotional hyperthermia in which a salient stimulus activates brown adipose tissue (BAT) thermogenesis and tail artery constriction. Antipsychotic drugs, both classical and second generation, act to reduce excessive assignment of salience to objects and events in the external environment. The close association between salient occurrences and increases in body temperature suggests that antipsychotic drugs may also reduce emotional hyperthermia...
August 15, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28811837/an-interview-with-samuel-shem-author-of-the-house-of-god
#2
Claire Brash
Dr Stephen Bergman, Professor of medical humanities at New York University, writes under the name Samuel Shem. He is an acclaimed author of several novels, plays and textbooks, and his work has been translated into several languages -'The House of God' his first novel has sold over 3 million copies. His work exposes the potential moral challenges of the medical workplace and the connection between values, good relationships and healing. In 2015 he visited the UK for medical humanities academic tour which included keynote talks at the RCGP 2015 Annual Conference and at the Royal Society of Medicine...
July 2017: London Journal of Primary Care
https://www.readbyqxmd.com/read/28810511/estimation-of-the-proximity-of-private-domestic-wells-to-underground-storage-tanks-oklahoma-pilot-study
#3
James W Weaver, Andrew R Murray, Fran V Kremer
For protecting drinking water supplies, the locations of areas with reliance on private domestic wells (hereafter referred to as "wells") and their relationship to contaminant sources need to be determined. A key resource in the U.S. was the 1990 Census where the source of domestic drinking water was a survey question. Two methods are developed to update estimates of the areal density of well use using readily accessible data. The first uses well logs reported to the states and the addition of housing units reported to the Census Bureau at the county, census tract and census block group scales...
August 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28807864/reducing-diagnostic-turnaround-times-of-exome-sequencing-for-families-requiring-timely-diagnoses
#4
Aurélie Bourchany, Christel Thauvin-Robinet, Daphné Lehalle, Ange-Line Bruel, Alice Masurel-Paulet, Nolwenn Jean, Sophie Nambot, Marjorie Willems, Laetitia Lambert, Salima El Chehadeh-Djebbar, Elise Schaefer, Aurélia Jaquette, Judith St-Onge, Charlotte Poe, Thibaud Jouan, Martin Chevarin, Patrick Callier, Anne-Laure Mosca-Boidron, Nicole Laurent, Mathilde Lefebvre, Frédéric Huet, Nada Houcinat, Sébastien Moutton, Christophe Philippe, Frédéric Tran-Mau-Them, Antonio Vitobello, Paul Kuentz, Yannis Duffourd, Jean-Baptiste Rivière, Julien Thevenon, Laurence Faivre
BACKGROUND AND OBJECTIVE: Whole-exome sequencing (WES) has now entered medical practice with powerful applications in the diagnosis of rare Mendelian disorders. Although the usefulness and cost-effectiveness of WES have been widely demonstrated, it is essential to reduce the diagnostic turnaround time to make WES a first-line procedure. Since 2011, the automation of laboratory procedures and advances in sequencing chemistry have made it possible to carry out diagnostic whole genome sequencing from the blood sample to molecular diagnosis of suspected genetic disorders within 50 h...
August 11, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28807664/social-interaction-modulates-the-neuroinflammatory-response-to-global-cerebral-ischemia-in-male-mice
#5
Monica M Gaudier-Diaz, Ning Zhang, Adam H Haines, Surbhi, Min Zhou, A Courtney DeVries
Social isolation is a risk factor for cardiovascular and cerebrovascular diseases, although the underlying mechanisms remain underspecified. Considering the potential of microglia to become sensitized by stressors and their role in neuroinflammation, we hypothesized that social isolation primes microglia, resulting in an exaggerated neuroimmune response to experimental cerebral ischemia. First, major histocompatibility complex II (MHC II) gene expression, an indicator of microglial priming, was compared between mice that were socially isolated or pair-housed...
August 11, 2017: Brain Research
https://www.readbyqxmd.com/read/28807307/significance-of-anti-carla-salivary-iga-antibody-in-first-grazing-season-cattle-naturally-infected-with-gastrointestinal-nematodes
#6
Aurélie Merlin, Richard Shaw, Alain Chauvin, Nathalie Bareille, Christophe Chartier
A carbohydrate larval surface antigen (CarLA) present on infective larvae of all trichostrongylid nematodes is a target antigen for host immunoglobulins (Ig). Levels of anti-CarLA salivary IgA antibody (CarLA-IgA) have been shown to be correlated to the level of protective immunity to GIN in sheep and deer but no information is available in cattle. The first objective of this study was to assess the pattern of CarLA-IgA response in 7 groups (G1-G7) of first grazing season cattle (FGSC) naturally infected with gastrointestinal nematodes...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28807299/seasonality-and-circadian-variation-of-microfilaremia-in-dogs-experimentally-infected-with-dirofilaria-immitis
#7
Léonore Lovis, Mélanie Grandjean, Laurence Overney, Wolfgang Seewald, Heinz Sager
Periodicity, the cyclical rise and fall in microfilaria (mff) numbers in the peripheral blood over time, is observed in many filarial infections. It is correlated with the necessity for these larval stages to be ingested by the blood feeding vector before they can be transmitted to a new vertebrate host. Microfilariae of the dog heartworm Dirofilaria immitis have been described to show periodicity, but the circadian pattern does not seem to be consistent. Most publications describe the lowest mff-concentrations in the peripheral blood in the early morning, while the highest counts occurred either in the afternoon, in the late evening or shortly after midnight...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28807087/allergic-bronchopulmonary-mycosis-due-to-exposure-to-eurotium-herbariorum-after-the-great-east-japan-earthquake
#8
Chiyako Oshikata, Maiko Watanabe, Akemi Saito, Masatsugu Ishida, Seiichi Kobayashi, Rumi Konuma, Yoichi Kamata, Jun Terajima, Junichi Cho, Masaru Yanai, Naomi Tsurikisawa
BACKGROUND: Indoor mold levels typically increase after natural disasters, flooding, and water damage. Eurotium herbariorum is the sexual stage of Aspergillus glaucus. Case Presentation A 66-year-old, Japanese male, ex-smoker had been diagnosed with bronchial asthma when he was five years old; he achieved remission at the age of 13 years. He was displaced from his home during the Great East Japan Earthquake on March 11, 2011 and moved to temporary housing in Miyagi Prefecture in June 2011...
August 15, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28806497/tooth-morphogenesis-and-fgf4-expression-during-development-of-molar-tooth-in-three-muroid-rodents-calomyscus-elburzensis-calomyscidae-mesocricetus-auratus-cricetidae-and-mus-musculus-muridae
#9
Kordiyeh Hamidi, Jamshid Darvish, Maryam M Matin, Athar Sadat Javanmard, C William Kilpatrick
To date, no studies have examined the tooth formation during developmental stages of brush-tailed mice (Calomyscidae) and true hamsters (Cricetidae). Herein, we compared the timing of tooth morphogenesis and FGF4 expression pattern during development of the first lower molar in Goodwin's brush-tailed mouse, Calomyscus elburzensis with two other muroid rodents; the house mouse, Mus musculus (Muridae), model organism for tooth morphogenesis, and the golden hamster, Mesocricetus auratus which shares great similarities in cusp pattern with brush-tailed mice...
August 14, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28805733/first-detection-of-rotavirus-group-c-in-asymptomatic-pigs-of-smallholder-farms-in-east-africa
#10
Joshua Oluoch Amimo, Eunice Magoma Machuka, Edward Okoth
Abstract: Group C rotavirus (RVC) has been described to be a causative agent of gastroenteritis in humans and animals including pigs, cows, and dogs. Fecal samples collected from asymptomatic pigs in smallholder swine farms in Kenya and Uganda were screened for the presence of group C rotaviruses (RVC) using a reverse transcription-polymerase chain reaction assay. A total of 446 samples were tested and 37 were positive (8.3%). A significantly larger (p < 0.05) number of RVC-positive samples was detected in groups of older pigs (5-6 months) than in younger piglets (1-2 months)...
August 14, 2017: Pathogens
https://www.readbyqxmd.com/read/28805703/thermo-hydraulic-analysis-of-heat-storage-filled-with-the-ceramic-bricks-dedicated-to-the-solar-air-heating-system
#11
Magdalena Nemś, Artur Nemś, Jacek Kasperski, Michał Pomorski
This article presents the results of a study into a packed bed filled with ceramic bricks. The designed storage installation is supposed to become part of a heating system installed in a single-family house and eventually to be integrated with a concentrated solar collector adapted to climate conditions in Poland. The system's working medium is air. The investigated temperature ranges and air volume flow rates in the ceramic bed were dictated by the planned integration with a solar air heater. Designing a packed bed of sufficient parameters first required a mathematical model to be constructed and heat exchange to be analyzed, since heat accumulation is a complex process influenced by a number of material properties...
August 12, 2017: Materials
https://www.readbyqxmd.com/read/28805444/contrast-effect-in-spatial-context-robustness-and-practical-significance
#12
Christophe Blaison, Marie-Pierre Fayant, Ursula Hess
Contrary to lay conceptions, unattractive locations can under certain circumstances increase the perceived value of neighboring areas. This phenomenon is akin to a contrast effect. However, extant research on this type of contrast suffers from two limitations. First, the use of repeated measures may inflate the likelihood of observing a contrast effect. Second, there is a lack of meaningful comparisons for gauging the size of the effect. We designed three experiments to address these issues. In each, we assessed how much participants valued places located increasingly far from an unsafe housing block...
August 14, 2017: Journal of Experimental Psychology. Applied
https://www.readbyqxmd.com/read/28802280/detection-and-molecular-identification-of-cryptosporidium-species-in-laboratory-rats-rattus-norvegicus-in-ibadan-nigeria
#13
Adekunle Bamidele Ayinmode, Nkeiruka Fortunate Ogbonna, Giovanni Widmer
To study the occurrence of Cryptosporidium infection in laboratory rats (Rattus norvegicus) raised for experimental usage, 134 faecal samples were obtained from two rearing houses in Ibadan and examined for the presence of Cryptosporidium oocyst using the modified acid fast staining technique. Cryptosporidium species in 2 samples positive for microscopy were further characterized by a nested polymerase chain reaction (PCR) amplifying the 18S rRNA gene. Two of 134 samples were positive for the Cryptosporidium oocysts...
2017: Annals of Parasitology
https://www.readbyqxmd.com/read/28800756/lawsonia-intracellularis-in-the-feces-of-wild-rodents-and-stray-cats-captured-around-equine-farms
#14
Jeong-Min Hwang, Myung-Ji Seo, Jung-Yong Yeh
BACKGROUND: Proliferative enteropathy is a global enteric disease of particular importance in pigs. The causative bacterium, Lawsonia intracellularis, has a wide range of susceptible host species. Recently, L. intracellularis has been recognized as an etiologic agent of an emerging enteric disease in foals called equine proliferative enteropathy (EPE). The presence of L. intracellularis in nonruminant wildlife has raised questions regarding the role of these species in EPE transmission...
August 11, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28799852/adverse-childhood-experiences-and-substance-use-history-among-vulnerable-older-adults-living-in-public-housing
#15
Heather Larkin, Amanda Aykanian, Erica Dean, Eunju Lee
Knowledge is limited on how substance use history is associated with childhood adversities and mental health issues among poor older adults. Previous research on adverse childhood experiences (ACEs) shows strong correlations between accumulated early adversity and later life health risks, including substance use and mental health problems. The current study is among the first to examine the relationship between ACEs, substance use, and anxiety in a sample of older adults living in public housing. Results show that roughly one-third of participants had an ACE score of four or more...
August 11, 2017: Journal of Gerontological Social Work
https://www.readbyqxmd.com/read/28799652/environmental-exposure-of-the-adult-french-population-to-permethrin
#16
Marie Hermant, Olivier Blanchard, Guillaume Perouel, Guillaume Boulanger, Mathilde Merlo, Virginie Desvignes
This work aims to assess the exposure to permethrin of the adult French population from available contamination measurements of outdoor air, indoor air, and settled dust. Priority is given to the assessment of chronic exposure, given the potential of permethrin to induce cancers and/or endocrine disorders. A statistical method was devised to calculate exposure to permethrin by different pathways (inhalation, indirect dust ingestion, and dermal contact). This method considers anthropometric parameters, the population's space-time budget, and recent methods for calculating dermal exposure...
August 11, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28798186/draft-genome-sequence-of-dermatophagoides-pteronyssinus-the-european-house-dust-mite
#17
Rose Waldron, Jamie McGowan, Natasha Gordon, Charley McCarthy, E Bruce Mitchell, Sean Doyle, David A Fitzpatrick
Dermatophagoides pteronyssinus is the European dust mite and a major source of human allergens. Here, we present the first draft genome sequence of the mite, as well as the ab initio gene prediction and functional analyses that will facilitate comparative genomic analyses with other mite species.
August 10, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28795645/the-royal-typographer-and-the-alchemist-john-dee-willem-silvius-and-the-diagrammatic-alchemy-of-the-monas-hieroglyphica
#18
Stephen Clucas
John Dee's Monas Hieroglyphica (1564) was a work which involved a close collaboration between its author and his "singular friend" the Antwerp printer Willem Silvius, in whose house Dee was living whilst he composed the work and saw it through the press. This article considers the reasons why Dee chose to collaborate with Silvius, and the importance of the intellectual culture - and the print trade - of the Low Countries to the development of Dee's outlook. Dee's Monas was probably the first alchemical work which focused exclusively on the diagrammatic representation of the alchemical process, combining diagrams, cosmological schemes, and various forms of tabular grid...
August 10, 2017: Ambix
https://www.readbyqxmd.com/read/28795156/results-of-ultrasound-assisted-brace-casting-for-adolescent-idiopathic-scoliosis
#19
Edmond H Lou, Doug L Hill, Andreas Donauer, Melissa Tilburn, Douglas Hedden, Marc Moreau
BACKGROUND: Four factors have been reported to affect brace treatment outcome: (1) growth or curve based risk, (2) the in-brace correction, (3) the brace wear quantity, and (4) the brace wear quality. The quality of brace design affects the in-brace correction and comfort which indirectly affects the brace wear quantity and quality. This paper reported the immediate benefits and results on using ultrasound (US) to aid orthotists to design braces for the treatment of scoliosis. METHODS: Thirty-four AIS subjects participated in this study with 17 (2 males, 15 females) in the control group and 17 (2 males, 15 females) in the intervention (US) group...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28794183/french-prospective-clinical-evaluation-of-the-aptima%C3%A2-mycoplasma-genitalium-assay-ce-ivd-and-macrolide-resistance-detection-using-three-distinct-assays
#20
Chloé Le Roy, Sabine Pereyre, Nadège Hénin, Cécile Bébéar
The aim of this study was to evaluate the clinical performance of the Aptima® Mycoplasma genitalium CE-IVD (MG-TMA) assay for the detection of Mycoplasma genitalium in clinical male and female samples in comparison with the in-house real-time PCR (in-house PCR) assay routinely used in our laboratory. A total of 1,431 clinical specimens obtained from 1,235 patients were prospectively collected at the Bacteriology Department of Bordeaux University Hospital (France). Additional research-use-only Aptima® M. genitalium TMA assays, Alt1-TMA and Alt2-TMA, were performed on discordant specimens to determine the M...
August 9, 2017: Journal of Clinical Microbiology
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