Ying Cheng, Zhuying Gao, Tiantian Zhang, Yuhua Wang, Xueqin Xie, Guoqiang Han, Yashu Li, Rong Yin, Yilin Chen, Peipei Wang, Jin Hu, Tong Zhang, Chengli Guo, Jihua Chai, Jing Wang, Manman Cui, Kexin Gao, Weidong Liu, Shuxin Yao, Pengbo Lu, Ziyan Cao, Yanbing Zheng, Jiwei Chang, Zheming Liu, Qibin Song, Weiming Li, Fuling Zhou, Haojian Zhang
N6 -methyladenosine (m6 A) is a common chemical modification for mammalian mRNA and exhibits high dynamics in various biological processes. However, dynamics of m6 A RNA methylome during leukemogenesis remains unknown. Here, we delineate a comprehensive m6 A landscape during acute myeloid leukemia (AML) development and identify PRMT6 as a key for maintaining AML stem cells. We observe an obvious change in m6 A methylome during leukemogenesis and find that protein arginine methyltransferase PRMT6 and m6 A reader IGF2BP2 maintain the function of human and murine leukemia stem cells (LSCs)...
January 5, 2023: Cell Stem Cell