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https://www.readbyqxmd.com/read/27616658/the-significance-of-the-increased-expression-of-phosphorylated-mecp2-in-the-membranes-from-patients-with-proliferative-diabetic-retinopathy
#1
Xiaohua Li, Xiaohui Liu, Haoyi Guo, Zhaoxia Zhao, Yun Sui Li, Guoming Chen
The purpose of this study was to evaluate the correlation of expression of phosphorylated methyl-CpG binding protein 2-Ser421 (MeCP2-S421) and VEGF in the membranes of patients with PDR. We examined the expression of phospho-MeCP2-S80, S421, VEGF and PEDF in surgically excised PDR membranes from 33 patients with diabetes, and idiopathic epiretinal membranes from 11 patients without diabetes, using immunohistochemistry and western blot. The colocalization of MeCP2-S421 with VEGF, PEDF, CD31, GFAP and αSMA was revealed by fluorescent double labeling...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27528260/growth-factors-in-pathogenesis-of-retinal-neurodegeneration-in-diabetes-mellitus-affiliation
#2
Ben-Skowronek Iwona
Neurodegeneration is an initial process in the development of diabetic retinopathy (DR). High quantity of glutamate, oxidative stress, the induction of the renin-angiotensin system (RAS) and the elevated levels of RAGE is crucial element in the retinal neurodegeneration caused by diabetes mellitus. At least , there is emerging proofs to indicate that the equilibrium between the neurotoxic and neuroprotective components will influence on the state of the retinal neurons. Somatostatin (SST), pigment epithelium- derived factor (PEDF), erythropoietin (Epo) are endogenous neuroprotective peptides that are decreased in the eye of diabetic persons and play a essential role in retinal homeostasis...
August 13, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27352351/biological-modulation-of-mouse-rpe-cells-in-response-to-subthreshold-diode-micropulse-laser-treatment
#3
Zhouyue Li, Yanping Song, Xiao Chen, Zhongshan Chen, Qin Ding
Many clinical trials have demonstrated the effectiveness of subthreshold phototherapy with no visible damage in retinal vascular diseases, such as diabetic retinopathy. We aimed primarily to investigate the effect of subthreshold diode micropulse laser (SDM) treatment on mouse retinal pigmented epithelium (RPE) cells. The expression of angiogenesis-modulating cytokines in response to SDM was also explored. The least toxic laser dose was selected by measuring cell viability with MTT assay and 5 % duty cycle (DC) was chosen for use in further experiments...
November 2015: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27080465/the-development-of-diabetic-retinopathy-in-goto-kakizaki-rat-and-the-expression-of-angiogenesis-related-signals
#4
Chen-Yuan Gong, Bin Lu, Yu-Chen Sheng, Zeng-Yang Yu, Jian-Yuan Zhou, Li-Li Ji
The Goto-Kakizaki (GK) rat is a genetic model of type 2 diabetes. Diabetic retinopathy (DR) is a common complication of diabetes. In this study, we observed the development of DR in GK rats and the expression of some angiogenesis-related signals. GK rats were housed for 5, 6 and 7 months. Results of retinal vessels stained by cluster of differentiation 31 (CD31) showed that the number of retinal vessels was increased in GK rats at both 6 and 7 months. Retinal histological observation also evidenced such increase...
April 30, 2016: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/26942449/pepito-driven-pedf-expression-ameliorates-diabetic-retinopathy-hallmarks
#5
Sofia M Calado, Francisco Diaz-Corrales, Gabriela A Silva
Diabetic retinopathy (DR) is one of the major complications of diabetes mellitus. It is characterized by retinal microvascular changes caused by chronic exposure to hyperglycemia, leading to low tissue oxygenation and ultimately to neovascularization. Laser photocoagulation and vitrectomy are the most efficient treatments for DR, but display severe side effects such as the destruction of the healthy retina. Another clinical approach uses antiangiogenic agents to prevent and delay progression of neovascularization, but these require recurrent local administrations that increase the possibility of retinal detachment, vitreous hemorrhage, and cataract formation...
April 2016: Human Gene Therapy Methods
https://www.readbyqxmd.com/read/26692279/a-combination-of-the-main-constituents-of-fufang-xueshuantong-capsules-shows-protective-effects-against-streptozotocin-induced-retinal-lesions-in-rats
#6
Weijie Jian, Suyun Yu, Minke Tang, Huihui Duan, Jianmei Huang
ETHNOPHARMACOLOGICAL RELEVANCE: Fufang Xueshuantong Capsule, an herbal formula licensed for clinical use in China, which is composed of Panax notoginseng (Burkill) F.H. Chen, Salvia miltiorrhiza Bunge, Astragalus membranaceus (Fisch.) Bunge, and Scrophularia ningpoensis Hemsl, has proven effective for the treatment of diabetic retinopathy. However, its bioactive constituents are still ambiguous. In this study, the therapeutic effects of a combination of the main constituents of Fufang Xueshuantong Capsule (cFXT) were evaluated in streptozotocin (STZ)-induced retinal lesions to identify the bioactive constituents...
April 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26319672/the-ethanol-extract-of-zingiber-zerumbet-rhizomes-mitigates-vascular-lesions-in-the-diabetic-retina
#7
Tang-Yao Hong, Thing-Fong Tzeng, Shorong-Shii Liou, I-Min Liu
Diabetic retinopathy (DR) is a common diabetic eye disease which is well-known as the result of microvascular retinal changes. Although the ethanol extract from Zingiber zerumbet (L.) Smith rhizome (EEZZR) has been indicated to ameliorate hyperglycemia in diabetes, its protective effect on DR remains unclear. The aim of this study was to determine the effects of EEZZR on DR in streptozotocin (STZ) diabetic rats. Diabetic rats were treated orally with EEZZR (200, 300 mg/kg per day) or calcium dobesilate (CD; 500 mg/kg per day) for 12 weeks...
January 2016: Vascular Pharmacology
https://www.readbyqxmd.com/read/26004392/low-blood-and-vitreal-bdnf-lxa4-and-altered-th1-th2-cytokine-balance-are-potential-risk-factors-for-diabetic-retinopathy
#8
Kuppan Kaviarasan, Mohanlal Jithu, Mohammad Arif Mulla, Tarun Sharma, Shanmuganathan Sivasankar, Undurti Narasimha Das, Narayanasamy Angayarkanni
OBJECTIVE: The study was conducted to observe the serum and vitreous levels of LXA4, BDNF and Th1/Th2 cytokines in type 2 diabetes mellitus (DM) and changes associated with diabetic retinopathy (DR). Further, the in vitro study was performed to analyze the exposure of BDNF and LXA4 on LPS-induced pro-inflammatory state in ARPE 19 cells. MATERIALS AND METHODS: Totally 114 individuals were recruited in a prospective case control study. Of these, 27 were type 2 DM cases with no complications, 30 cases were type 2 DM with non proliferative diabetic retinopathy (NPDR), 30 were type 2 DM with proliferative diabetic retinopathy (PDR), and 27 were healthy control...
September 2015: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/25686060/proliferative-and-inflammatory-factors-in-the-vitreous-of-patients-with-proliferative-diabetic-retinopathy
#9
V V Chernykh, E V Varvarinsky, E V Smirnov, D V Chernykh, Alexander N Trunov
PURPOSE: The purpose was to measure the concentrations of various cytokines and growth factors (including vascular endothelial growth factor [VEGF] and pigment epithelium-derived factor [PEDF]) in the vitreous of patients with proliferative diabetic retinopathy (PDR) and to investigate interaction between inflammatory and proliferative factors in the genesis of PDR. Materials and Methods : Vitreous samples from 32 eyes with PDR and 25 eyes without diabetes mellitus and signs of DR (control) were collected...
January 2015: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/25562624/pigment-epithelium-derived-factor-inhibits-retinal-microvascular-dysfunction-induced-by-12-15-lipoxygenase-derived-eicosanoids
#10
Ahmed S Ibrahim, Amany M Tawfik, Khaled A Hussein, Sally Elshafey, Shanu Markand, Nasser Rizk, Elia J Duh, Sylvia B Smith, Mohamed Al-Shabrawey
We recently demonstrated that 12/15-lipoxygenase (LOX) derived metabolites, hydroxyeicosatetraenoic acids (HETEs), contribute to diabetic retinopathy (DR) via NADPH oxidase (NOX) and disruption of the balance in retinal levels of the vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF). Here, we test whether PEDF ameliorates retinal vascular injury induced by HETEs and the underlying mechanisms. Furthermore, we pursue the causal relationship between LOX-NOX system and regulation of PEDF expression during DR...
March 2015: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/25352747/effects-of-5-aza-2-deoxycytidine-and-trichostatin-a-on-high-glucose-and-interleukin-1%C3%AE-induced-secretory-mediators-from-human-retinal-endothelial-cells-and-retinal-pigment-epithelial-cells
#11
Manyun Xie, Jingyi Tian, Yan Luo, Liqing Wei, Shaofen Lin, Shibo Tang
PURPOSE: We aimed to elucidate the effects of two epigenetic inhibitors, 5-aza-2'-deoxycytidine (5-aza-dC) and trichostatin A (TSA), on several key secretory mediators of diabetic retinopathy (DR) in human retinal endothelial cells (HRECs) and human retinal pigment epithelial (HRPE) cells treated with high glucose or interleukin-1β (IL-1β). METHODS: HRECs and HRPE cells were incubated in 30 mM D-glucose or 10 ng/ml IL-1β with or without the presence of various concentrations of 5-aza-dC or TSA...
2014: Molecular Vision
https://www.readbyqxmd.com/read/25119659/systemic-administration-of-erythropoietin-inhibits-retinopathy-in-rcs-rats
#12
Weiyong Shen, Sook H Chung, Mohammad R Irhimeh, Shiying Li, So-Ra Lee, Mark C Gillies
OBJECTIVE: Royal College of Surgeons (RCS) rats develop vasculopathy as photoreceptors degenerate. The aim of this study was to examine the effect of erythropoietin (EPO) on retinopathy in RCS rats. METHODS: Fluorescein angiography was used to monitor retinal vascular changes over time. Changes in retinal glia and vasculature were studied by immunostaining. To study the effects of EPO on retinal pathology, EPO (5000 IU/kg) was injected intraperitoneally in 14 week old normal and RCS rats twice a week for 4 weeks...
2014: PloS One
https://www.readbyqxmd.com/read/24924441/melatonin-prevents-retinal-oxidative-stress-and-vascular-changes-in-diabetic-rats
#13
G Ozdemir, Y Ergün, S Bakariş, M Kılınç, H Durdu, E Ganiyusufoğlu
PURPOSE: To evaluate the role of melatonin, an antioxidant agent, in diabetic oxidative stress and vascular damage. METHODS: Diabetes was induced in 21 male Wistar rats by intraperitoneal (IP) administration of streptozotocin and then the rats were equally and randomly allocated to diabetic, melatonin, and vehicle groups. Seven healthy normal rats with similar features comprised the control group as the fourth group. All animals were followed for 12 weeks. The melatonin group received IP melatonin daily and the vehicle group received 2...
August 2014: Eye
https://www.readbyqxmd.com/read/24630762/vitreous-biomarkers-in-diabetic-retinopathy-a-systematic-review-and-meta-analysis
#14
REVIEW
Annie K McAuley, Paul G Sanfilippo, Alex W Hewitt, Helena Liang, Ecosse Lamoureux, Jie Jin Wang, Paul P Connell
The aim of this study was to perform a systematic meta-analysis of biomarkers investigated with diabetic retinopathy (DR) in the vitreous, and to explore the molecular pathway interactions of these markers found to be consistently associated with DR. Relevant databases [PubMed and ISI web of science] were searched for all published articles investigating molecular biomarkers of the vitreous associated with DR. Based on set exclusion/inclusion criteria available data from studies with human vitreous samples were extracted and used for our meta-analysis...
May 2014: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/24204392/protective-effects-of-fufang-xueshuantong-on-diabetic-retinopathy-in-rats
#15
Huihui Duan, Jianmei Huang, Wei Li, Minke Tang
The aim of this study was to evaluate the protective effects of Fufang Xueshuantong (FXT) on diabetic retinopathy in rats induced by streptozotocin (STZ). Diabetes was induced in Sprague-Dawley rats by a single injection of 60 mg/kg STZ. One week after STZ, FXT 0.525 g/kg or 1.05 g/kg was administrated to the rats by intragastric gavage (ig) once daily consecutively for 24 weeks. The control rats and untreated STZ rats received vehicle the same way. At the end of the experiment, the erythrocyte aggregation and blood viscosity were assayed...
2013: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/24195074/functional-and-molecular-characterization-of-ex-vivo-cultured-epiretinal-membrane-cells-from-human-proliferative-diabetic-retinopathy
#16
Zoltán Veréb, Xhevat Lumi, Sofija Andjelic, Mojca Globocnik-Petrovic, Mojca Urbancic, Marko Hawlina, Andrea Facskó, Goran Petrovski
Characterization of the cell surface marker phenotype of ex vivo cultured cells growing out of human fibrovascular epiretinal membranes (fvERMs) from proliferative diabetic retinopathy (PDR) can give insight into their function in immunity, angiogenesis, and retinal detachment. FvERMs from uneventful vitrectomies due to PDR were cultured adherently ex vivo. Surface marker analysis, release of immunity- and angiogenesis-pathway-related factors upon TNF α activation and measurement of the intracellular calcium dynamics upon mechano-stimulation using fluorescent dye Fura-2 were all performed...
2013: BioMed Research International
https://www.readbyqxmd.com/read/23847321/enzyme-induced-vitreolysis-can-alleviate-the-progression-of-diabetic-retinopathy-through-the-hif-1%C3%AE-pathway
#17
COMPARATIVE STUDY
Chuanyin Li, Ping Chen, Jingfa Zhang, Limei Zhang, Xiaolin Huang, Yuting Yao, Xin Che, Xianqun Fan, Shengfang Ge, Zhiliang Wang
PURPOSE: We studied the mechanism by which complete posterior vitreous detachment by enzyme-induced vitreolysis alleviates the progression of diabetic retinopathy. METHODS: We enrolled 50 diabetic rats and 20 normal control rats in this study. The right eyes of these diabetic rats were treated with a hyaluronidase (5 U) plus plasmin (0.25 U) by intravitreous injection (ET group), while the left eyes of diabetic rats (DR group) and eyes of the normal rats (NC group) were injected with balanced saline...
July 2013: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/23372421/prospectives-for-gene-therapy-of-retinal-degenerations
#18
Gabriele Thumann
Retinal degenerations encompass a large number of diseases in which the retina and associated retinal pigment epithelial (RPE) cells progressively degenerate leading to severe visual disorders or blindness. Retinal degenerations can be divided into two groups, a group in which the defect has been linked to a specific gene and a second group that has a complex etiology that includes environmental and genetic influences. The first group encompasses a number of relatively rare diseases with the most prevalent being Retinitis pigmentosa that affects approximately 1 million individuals worldwide...
August 2012: Current Genomics
https://www.readbyqxmd.com/read/23275908/angiogenesis-related-cytokines-in-serum-of-proliferative-diabetic-retinopathy-patients-before-and-after-vitrectomy
#19
Shuang Li, Xun-An Fu, Xiao-Fang Zhou, You-Yan Chen, Wei-Qun Chen
AIM: To evaluate serum concentrations of angiogenesis-related cytokines in proliferative diabetic retinopathy (PDR) before and after vitrectomy. METHODS: Serum samples were collected from 30 PDR patients with varying severity before and after vitrectomy. Serum concentrations of vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF), interleukin-8 (IL-8) and interferon-inducible protein-10 (IP-10) were determined by enzyme-linked immunosorbent assays (ELISA)...
2012: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/22966818/high-glucose-induced-differential-expression-of-lysyl-oxidase-and-its-isoform-in-arpe-19-cells
#20
COMPARATIVE STUDY
Karunakaran Coral, Jagadeesan Madhavan, Rishi Pukhraj, Narayanasamy Angayarkanni
PURPOSE: Lysyl oxidase (LOX) stabilizes the extracellular matrix (ECM) by cross-linking collagen and elastin molecules. In proliferative diabetic retinopathy (PDR), there is ECM remodeling with neovascularization and basement membrane changes. While protease activities are well reported, the role of LOX in the pathogenesis of diabetic retinopathy is less studied. This study was done to see the effect of high glucose on the activity and expression of LOX and its isoforms in ARPE-19 cells...
January 2013: Current Eye Research
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