keyword
MENU ▼
Read by QxMD icon Read
search

Aminoacid

keyword
https://www.readbyqxmd.com/read/28522351/effect-of-early-supplemental-parenteral-nutrition-in-the-paediatric-icu-a-preplanned-observational-study-of-post-randomisation-treatments-in-the-pepanic-trial
#1
Ilse Vanhorebeek, Sascha Verbruggen, Michaël P Casaer, Jan Gunst, Pieter J Wouters, Jan Hanot, Gonzalo Garcia Guerra, Dirk Vlasselaers, Koen Joosten, Greet Van den Berghe
BACKGROUND: Large randomised controlled trials have shown that early supplemental parenteral nutrition in patients admitted to adult and paediatric intensive care units (PICUs) is harmful. Overdosing of energy with too little protein was suggested as a potential reason for this. This study analysed which macronutrient was associated with harm caused by early supplemental parenteral nutrition in the Paediatric Early versus Late Parenteral Nutrition In Critical Illness (PEPaNIC) randomised trial...
May 15, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28496185/-gardos-channelopathy-a-variant-of-hereditary-stomatocytosis-with-complex-molecular-regulation
#2
Elisa Fermo, Anna Bogdanova, Polina Petkova-Kirova, Anna Zaninoni, Anna Paola Marcello, Asya Makhro, Pascal Hänggi, Laura Hertz, Jens Danielczok, Cristina Vercellati, Nadia Mirra, Alberto Zanella, Agostino Cortelezzi, Wilma Barcellini, Lars Kaestner, Paola Bianchi
The Gardos channel is a Ca(2+) sensitive, K(+) selective channel present in several tissues including RBCs, where it is involved in cell volume regulation. Recently, mutations at two different aminoacid residues in KCNN4 have been reported in patients with hereditary xerocytosis. We identified by whole exome sequencing a new family with two members affected by chronic hemolytic anemia carrying mutation R352H in the KCNN4 gene. No additional mutations in genes encoding for RBCs cytoskeletal, membrane or channel proteins were detected...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28493874/srcrxfe12-xo19-nanoceramics-as-an-effective-catalyst-for-desulfurization-of-liquid-fuels-green-sol-gel-synthesis-characterization-magnetic-and-optical-properties
#3
Samira Mandizadeh, Faezeh Soofivand, Samira Bagheri, Masoud Salavati-Niasari
In this work, SrCrxFe12-xO19 (x = 0.0, 0.5, 1.0, 1.5) nanostructures were successfully synthesized by sol-gel auto-combustion method, and different aminoacids were used as green reductants. Various analysis results show that SrCrxFe12-xO19 nanoparticles synthesized successfully.The present study shows that SrCrxFe12-xO19 nanoparticle could be used as adsorbent for the desulfurization of liquid fuels. Increasing of nanoparticles concentration was caused to increase the adsorption rate of sulfur contents of fuel...
2017: PloS One
https://www.readbyqxmd.com/read/28492474/fabrication-of-silicon-nanobelts-and-nanopillars-by-soft-lithography-for-hydrophobic-and-hydrophilic-photonic-surfaces
#4
Estela Baquedano, Ramses V Martinez, José M Llorens, Pablo A Postigo
Soft lithography allows for the simple and low-cost fabrication of nanopatterns with different shapes and sizes over large areas. However, the resolution and the aspect ratio of the nanostructures fabricated by soft lithography are limited by the depth and the physical properties of the stamp. In this work, silicon nanobelts and nanostructures were achieved by combining soft nanolithography patterning with optimized reactive ion etching (RIE) in silicon. Using polymethylmethacrylate (PMMA) nanopatterned layers with thicknesses ranging between 14 and 50 nm, we obtained silicon nanobelts in areas of square centimeters with aspect ratios up to ~1...
May 11, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28488442/stable-benzacridine-pigments-by-oxidative-coupling-of-chlorogenic-acid-with-amino-acids-and-proteins-toward-natural-product-based-green-food-coloring
#5
Mariagrazia Iacomino, Fabian Weber, Maike Gleichenhagen, Valeria Pistorio, Lucia Panzella, Elio Pizzo, Andreas Schieber, Marco d'Ischia, Alessandra Napolitano
The occasional greening of sweet potatoes and other plant tissues observed during cooking or other food processing has been shown to arise from the autoxidative coupling of chlorogenic acid (CGA, 5-caffeoylquinic acid) with amino acid components, leading to trihydroxybenzacridine pigments. To explore the potential of this reaction for food coloring, we report herein the optimized biomimetic preparation of trihydroxybenzacridine pigments from CGA and amino acids such as glycine and lysine, their straightforward purification by gel filtration chromatography, the UHPLC-MS/MS analysis of the purified pigment fraction, and a detailed characterization of the pH-dependent trihydroxybenzacridine chromophore...
May 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28444858/dietary-protein-content-for-an-optimal-diet-a-clinical-view
#6
EDITORIAL
Lidia Santarpia, Franco Contaldo, Fabrizio Pasanisi
The dietary protein role in different clinical nutritional conditions and some physio-pathological perspectives is a current and hot topic to discuss. Recent Proceedings of the Protein Summit 2, joining more than 60 nutrition scientists, health experts, and nutrition educators, suggest to increase plant but, in particular, animal protein intake because richer in leucine and consequently more effective to influence anabolic protein metabolism. The Panel conclusions are in apparent contradiction with the nutritional ecology statements, which strongly sustain the reduction of animal origin foods in the human diet and are currently concerned about the excessive, mainly animal protein intake in western and westernized Countries...
April 25, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28435968/unexpected-proton-mobility-in-the-bulk-phase-of-cholinium-based-ionic-liquids-new-insights-from-theoretical-calculations
#7
Marco Campetella, Maria Montagna, Lorenzo Gontrani, Eleonora Scarpellini, Enrico Bodo
We have explored by means of ab initio molecular dynamics two ionic liquids based on the combination of a choline cation with deprotonated cysteine and aspartic acid anions. While the combination of the strong base choline with various other amino-acids leads to the formation of a highly ionized medium where proton transfer is negligible, the presence of additional protic functions on the SH and COOH groups leads to an unexpected and interesting behavior and to a sizable migration of their acidic protons onto the NH2 basic terminals...
May 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28427960/construct-and-expression-of-recombinant-domains-i-ii-of-dengue-virus-2-and-its-efficacy-to-evaluate-immune-response-in-endemic-area-possible-use-in-prognosis
#8
Alfredo Eduardo Montes-Gómez, Hector Vivanco-Cid, José Bustos-Arriaga, Mussaret Bano Zaidi, Jazmin Garcia-Machorro, Benito Gutierrez-Castañeda, Leticia Cedillo-Barron
The envelope (E) protein from DENV, contain three functional and structural domains (DI, DII and DIII). Some studies suggest that neutralizing antibodies during natural DENV infection are predominantly against DI and DII, in contrast, low proportion of the antibodies were against DIII. Thus it is necessary to establish the proportion of human antibodies against DENV E protein that bind to DI and DII during the normal course of infection; as an indicator of the quality of the antibody response and to further design new vaccine candidates for DENV...
April 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28380333/synthesis-and-characterization-of-a-biocompatible-chitosan-based-hydrogel-cross-linked-via-click-chemistry-for-controlled-drug-release
#9
O Guaresti, C García-Astrain, T Palomares, A Alonso-Varona, A Eceiza, N Gabilondo
A chemically cross-linked chitosan-based hydrogel was successfully synthesized through Diels-Alder (DA) reaction and characterized. The final product was obtained after different steps; on the one hand, furan-modified chitosan (Cs-Fu) was synthesized by the reaction of furfural with the free amino groups of chitosan. On the other hand, highlighting the novelty of the present research, maleimide-functionalized chitosan (Cs-AMI) was prepared by the reaction of a maleimide-modified aminoacid with the amino groups of chitosan through amide coupling...
April 2, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28368217/long-acting-insulin-allergy-in-a-diabetic-child
#10
Carla Mastrorilli, Laura Rizzuti, Antonina Marta Cangelosi, Brunella Iovane, Giovanni Chiari, Carlo Caffarelli
Insulin allergy has been uncommon since the introduction of human recombinant insulin preparations; the prevalence is 2.4%. Insulin injection could elicit immediate reactions, which are usually induced by an IgE-mediated mechanism, within the first hour after drug administration. In the present study, we describe the case of a child who experienced immediate urticaria after long-acting insulin injection. A 9-year-old girl affected by type I diabetes mellitus referred a history of three episodes of urticaria 30 min after insulin subcutaneous injection...
April 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/28359946/use-of-in%C3%A2-vivo-induced-technology-to-identify-antigens-expressed-by-photobacterium-damselae-subsp-piscicida-during-infection-of-senegalese-sole-solea-senegalensis
#11
J A Núñez-Díaz, M Fumanal, E Viguera, M A Moriñigo, M C Balebona
Photobacterium damselae subsp. piscicida (Phdp), the causative agent of photobacteriosis, is an important pathogen in marine aquaculture that affects many different fish species worldwide, including Solea senegalensis, an important fish species for aquaculture in the south of Europe. Bacteria express different repertoires of proteins in response to environmental conditions and when invading a host, sense in vivo environment and adapt by changing the expression of specific proteins. In the case of pathogens, identification of genes with up-regulated expression in vivo compared to in vitro conditions might give an insight into the genes relevant to the bacterial virulence...
May 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28358046/phosphatidylinositol-4-5-bisphosphate-dynamically-regulates-the-k2p-background-k-channel-task-2
#12
María Isabel Niemeyer, L Pablo Cid, Marc Paulais, Jacques Teulon, Francisco V Sepúlveda
Two-pore domain K2P K(+) channels responsible for the background K(+) conductance and the resting membrane potential, are also finely regulated by a variety of chemical, physical and physiological stimuli. Hormones and transmitters acting through Gq protein-coupled receptors (GqPCRs) modulate the activity of various K2P channels but the signalling involved has remained elusive, in particular whether dynamic regulation by membrane PI(4,5)P2, common among other classes of K(+) channels, affects K2P channels is controversial...
March 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28352611/targeting-the-metabolic-reprogramming-that-controls-epithelial-to-mesenchymal-transition-in-aggressive-tumors
#13
REVIEW
Andrea Morandi, Maria Letizia Taddei, Paola Chiarugi, Elisa Giannoni
The epithelial-to-mesenchymal transition (EMT) process allows the trans-differentiation of a cell with epithelial features into a cell with mesenchymal characteristics. This process has been reported to be a key priming event for tumor development and therefore EMT activation is now considered an established trait of malignancy. The transcriptional and epigenetic reprogramming that governs EMT has been extensively characterized and reviewed in the last decade. However, increasing evidence demonstrates a correlation between metabolic reprogramming and EMT execution...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28337209/transcriptional-responses-of-chilean-quinoa-chenopodium-quinoa-willd-under-water-deficit-conditions-uncovers-aba-independent-expression-patterns
#14
Andrea Morales, Andres Zurita-Silva, Jonathan Maldonado, Herman Silva
HIGHLIGHTS R49 genotype displayed best performance on selected physiological parameters and highest tolerance to drought.R49 drought over-represented transcripts has exhibited 19% of genes (306 contigs) that presented no homology to published databases.Expression pattern for canonical responses to drought such as ABA biosynthesis and other genes induced in response to drought were assessed by qPCR. Global freshwater shortage is one of the biggest challenges of our time, often associated to misuse, increased consumption demands and the effects of climate change, paralleled with the desertification of vast areas...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28333105/anti-melanogenic-properties-of-greek-plants-a-novel-depigmenting-agent-from-morus-alba-wood
#15
Eliza Chaita, George Lambrinidis, Christina Cheimonidi, Adamantia Agalou, Dimitris Beis, Ioannis Trougakos, Emmanuel Mikros, Alexios-Leandros Skaltsounis, Nektarios Aligiannis
In therapeutic interventions associated with melanin hyperpigmentation, tyrosinase is regarded as a target enzyme as it catalyzes the rate-limiting steps in mammalian melanogenesis. Since many known agents have been proven to be toxic, there has been increasing impetus to identify alternative tyrosinase inhibitors, especially from natural sources. In this study, we investigated 900 extracts from Greek plants for potential tyrosinase inhibitive properties. Among the five most potent extracts, the methanol extract of Morus alba wood (MAM) demonstrated a significant reduction in intracellular tyrosinase and melanin content in B16F10 melanoma cells...
March 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28300769/aptamers-biomedical-interest-and-applications
#16
EDITORIAL
Cristina Romero-López, Alfredo Berzal-Herranz
Aptamers are short DNA or RNA oligonucleotides specialized in the specific and efficient binding to a target molecule. They are obtained by in vitro selection or evolution processes. It was in 1990 that two independent research groups described the bases of a new in vitro technology for the identification of RNA molecules able to specifically bind to a target [1,2]. Tuerk and Gold established the principals of the in vitro selection process that was named SELEX (Systematic Evolution of Ligands by Exponential enrichment), which is based on iterative cycles of binding, partitioning, and amplification of oligonucleotides from a pool of variant sequences [2]...
March 16, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28283009/-production-and-molecular-characterization-of-plasmodium-falciparum-recombinant-circumsporozoite-protein-with-37-nanp-and-4-nvdp-epitopes
#17
Yunus Uyar, Abdüssamed Akşit, Serkan Karaca, Şirin Sahra Ceylan, Merve Yürük
Malaria is caused by the protozoan parasite Plasmodium, the leading cause of death amongst the parasitic diseases. The disease is transmitted to human by the bites of female Anopheles mosquitoes. According to the World Health Organization (WHO) data, there were an estimated 214 million malaria cases and estimated 438.000 deaths occurred worldwide, in 2015. It is observed that 90% of all the deaths due to malaria occur in Africa. 78% of these cases were children who are under five years old. Intensive malaria interventions helped to reduce malaria incidence by 37% between 2000 and 2015...
January 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28272877/enantioselective-ring-opening-polymerization-of-rac-lactide-dictated-by-densely-substituted-amino-acids
#18
Ana Sanchez-Sanchez, Ivan Rivilla, Maddalen Agirre, Andere Basterretxea, Agustin Etxeberria, Antonio Veloso, Haritz Sardon, David Mecerreyes, Fernando P Cossío
Organocatalysis is becoming an important tool in polymer science because of its versatility and specificity. To date a limited number of organic catalysts have demonstrated the ability to promote stereocontrolled polymerizations. In this work we report one of the first examples of chirality transfer from a catalyst to a polymer in the organocatalyzed ring-opening polymerization (ROP) of rac-lactide (rac-LA). We have polymerized rac-LA using the diastereomeric densely substituted amino acids (2S,3R,4S,5S)-1-methyl-4-nitro-3,5-diphenylpyrrolidine-2-carboxylic acid (endo-6) and (2S,3S,4R,5S)-1-methyl-4-nitro-3,5-diphenylpyrrolidine-2-carboxylic acid (exo-6), combined with 1,8-diazabicyclo[5...
March 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28259834/the-anaerobic-digestion-process-capability-to-produce-biostimulant-the-case-study-of-the-dissolved-organic-matter-dom-vs-auxin-like-property
#19
Barbara Scaglia, Michele Pognani, Fabrizio Adani
Biostimulants improve plant growth by stimulating nutrient uptake and efficiency, improving tolerance to abiotic stress and raising crop quality. Biostimulants are currently only recognised in five categories. However, the recent interest in this sector has led to the identification of some new ones. The aim of this work was to study the auxin-like activity of digestate dissolved organic matter (DOM) obtained from full scale anaerobic digester plants. All DOMs had biostimulant capacity comparable with humic acid and amino acids...
March 2, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28257918/ceftriaxone-mediated-upregulation-of-the-glutamate-transporter-glt-1-contrasts-neurotoxicity-evoked-by-kainate-in-rat-organotypic-spinal-cord-cultures
#20
Dzejla Bajrektarevic, Andrea Nistri
Excitotoxicity is a major pathological trigger of neurodegenerative diseases like amyotrophic lateral sclerosis. This process is caused by excessive release of the transmitter glutamate that overwhelms the capacity of astroglia transporters to maintain a low extracellular level of this aminoacid and strongly stimulates neurons. Using an in vitro model of rat organotypic spinal slice culture, we explored if the excitotoxicity caused by the potent glutamate analogue kainate, widely employed as a paradigm to evoke neurotoxicity in the central nervous system, was prevented by the antibiotic ceftriaxone known to enhance glutamate transporter expression...
March 1, 2017: Neurotoxicology
keyword
keyword
113038
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"