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https://www.readbyqxmd.com/read/28338973/inflammation-autoimmunity-and-hypertension-the-essential-role-of-tissue-transglutaminase
#1
Chen Liu, Rodney E Kellems, Yang Xia
Inflammatory cytokines cause hypertension when introduced into animals. Additional evidence indicates that cytokines induce the production of autoantibodies that activate the AT1 angiotensin receptor (AT1R). Extensive evidence shows that these autoantibodies, termed AT1-AA, contribute to hypertension. We review here recent studies showing that cytokine-induced hypertension and AT1-AA production require the ubiquitous enzyme, tissue transglutaminase (TG2). We consider 3 mechanisms by which TG2 may contribute to hypertension...
March 13, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28328971/mapping-the-n-linked-glycosites-of-rice-oryza-sativa-l-germinating-embryos
#2
Jiezheng Ying, Juan Zhao, Yuxuan Hou, Yifeng Wang, Jiehua Qiu, Zhiyong Li, Xiaohong Tong, Zhaomei Shi, Jun Zhu, Jian Zhang
Germination is a key event in the angiosperm life cycle. N-glycosylation of proteins is one of the most common post-translational modifications, and has been recognized to be an important regulator of the proteome of the germinating embryo. Here, we report the first N-linked glycosites mapping of rice embryos during germination by using a hydrophilic interaction chromatography (HILIC) glycopeptides enrichment strategy associated with high accuracy mass spectrometry identification. A total of 242 glycosites from 191 unique proteins was discovered...
2017: PloS One
https://www.readbyqxmd.com/read/28323416/one-pot-two-nanoprobe-assay-uncovers-targeted-glycoprotein-biosignature
#3
Mira Anne C Dela Rosa, Wei-Chun Chen, Yi-Ju Chen, Rofeamor P Obena, Chih-Hsiang Chang, Rey Y Capangpangan, Tung-Hung Su, Chi-Ling Chen, Pei-Jer Chen, Yu-Ju Chen
We report a one-pot two-nanoprobe approach coupled to mass spectrometry for simultaneous quantification and post-translational modification (PTM) profiling of targeted protein in biofluid. Using N-glycoprotein as model, the assay employs two nanoprobes, antibody-conjugated SiO2 nanoparticles and lectin-conjugated magnetic Fe3O4 nanoparticles, to achieve target glycoprotein isolation from biofluid and subsequent glycopeptide enrichment in a single tube. As demonstrated on α-fetoprotein (AFP), a serum biomarker for hepatocellular carcinoma (HCC), the assay has high purification specificity (20 glycopeptides) with 2-fold and 10-fold superior total glycopeptide intensity compared to non-one-pot method (9 glycopeptides) or without enrichment (6 glycopeptides), respectively...
March 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28321987/cephalometric-findings-among-children-with-velopharyngeal-dysfunction-following-adenoidectomy-a-retrospective-study
#4
Firas Kassem, Yaniv Ebner, Ben Nageris, Nezar Watted, Ari DeRowe, Ariela Nachmani
OBJECTIVES: To characterize the craniofacial structure by cephalometry, especially the skull base and nasopharyngeal space, in children who underwent adenoidectomy and developed persistent velopharyngeal dysfunction (VPD). DESIGN: Retrospective study. SETTING: Speech and swallowing clinic of a single academic hospital. PARTICIPANTS: 39 children with persistent VPD following adenoidectomy (mean age 8.0±3.6 years) and a control group of 80 healthy children...
March 21, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28320309/correlated-duplications-and-losses-in-the-evolution-of-palmitoylation-writer-and-eraser-families
#5
Stijn Wittouck, Vera van Noort
BACKGROUND: Protein post-translational modifications (PTMs) change protein properties. Each PTM type is associated with domain families that apply the modification (writers), remove the modification (erasers) and bind to the modified sites (readers) together called toolkit domains. The evolutionary origin and diversification remains largely understudied, except for tyrosine phosphorylation. Protein palmitoylation entails the addition of a palmitoyl fatty acid to a cysteine residue. This PTM functions as a membrane anchor and is involved in a range of cellular processes...
March 20, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28319808/identifying-regulatory-posttranslational-modifications-of-pd-l1-a-focus-on-monoubiquitinaton
#6
Henrick Horita, Andy Law, Soonjin Hong, Kim Middleton
A set of high-affinity, high-specificity posttranslational modification (PTM) enrichment tools was developed to generate an unbiased snapshot of four key PTM profiles (tyrosine phosphorylation, acetylation, ubiquitination, and SUMOylation 2/3) for the clinically important protein programmed cell death ligand 1 (PD-L1). The results showed that epidermal growth factor (EGF) treatment induced tyrosine phosphorylation, acetylation, and ubiquitination of PD-L1. Further characterization of EGF-induced PD-L1 ubiquitination revealed a significant increase in mono- and multiubiquitination of PD-L1 that occurred on glycosylated PD-L1...
March 16, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28317354/-comparing-study-on-the-hyoid-bone-position-after-treatment-of-class-%C3%A2-malocclusion-using-improved-appliance-fr-%C3%A2
#7
Zhu Yuanping, Duan Yinzhong
OBJECTIVE: This study aims to compare the changes of hyoid bone position before and after treatment of Angle class Ⅲ malocclusion using improved appliance FR Ⅲ. METHODS: Forty patients with Angle class Ⅲ malocclusion were chosen and divided into two groups, namely, experimental and control. Each group had 20 patients. The young patients in the experi-mental group were treated using improved appliance FR Ⅲ, whereas those in the control group were treated using classic appliance FR Ⅲ...
August 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28295345/the-viral-protein-gp120-decreases-the-acetylation-of-neuronal-tubulin-potential-mechanism-of-neurotoxicity
#8
Valeria Avdoshina, Seamus P Caragher, Erin D Wenzel, Francesca Taraballi, Italo Mocchetti, G Jean Harry
The human immunodeficiency virus (HIV) envelope protein gp120 promotes axonal damage and neurite pruning, similar to that observed in HIV positive subjects with neurocognitive disorders. Thus, gp120 has been used to examine molecular and cellular pathways underlying HIV-mediated neuronal dysfunction. Gp120 binds to tubulin beta III, a component of neuronal microtubules. Microtubule function, which modulates the homeostasis of neurons, is regulated by polymerization and post-translational modifications. Based on these considerations, we tested the hypothesis that gp120 induces dynamic instability of neuronal microtubules...
March 10, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28293301/histone-peptide-microarray-screen-of-chromo-and-tudor-domains-defines-new-histone-lysine-methylation-interactions
#9
Erin K Shanle, Stephen A Shinsky, Joseph B Bridgers, Narkhyun Bae, Cari Sagum, Krzysztof Krajewski, Scott B Rothbart, Mark T Bedford, Brian D Strahl
BACKGROUND: Histone posttranslational modifications (PTMs) function to regulate chromatin structure and function in part through the recruitment of effector proteins that harbor specialized "reader" domains. Despite efforts to elucidate reader domain-PTM interactions, the influence of neighboring PTMs and the target specificity of many reader domains is still unclear. The aim of this study was to use a high-throughput histone peptide microarray platform to interrogate 83 known and putative histone reader domains from the chromo and Tudor domain families to identify their interactions and characterize the influence of neighboring PTMs on these interactions...
2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28292250/computational-prediction-of-protein-epsilon-lysine-acetylation-sites-based-on-a-feature-selection-method
#10
JianZhao Gao, Xue-Wen Tao, Jia Zhao, Yuan-Ming Feng, Yu-Dong Cai, Ning Zhang
Lysine acetylation, as one type of post-translational modifications (PTM), plays key roles in cellular regulations and can be involved in a variety of human diseases. However, it is often high-cost and time-consuming to use traditional experimental approaches to identify the lysine acetylation sites. Therefore, effective computational methods should be developed to predict the acetylation sites. In this study, we developed a position-specific method for epsilon lysine acetylation site prediction. Various kinds of features such as position specific scoring matrix (PSSM), amino acid factors (AAF), and disorders were incorporated...
March 13, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28289734/regulatory-mechanisms-of-hsp90
#11
Chrisostomos Prodromou
The ability of Hsp90 to activate a disparate clientele implicates this chaperone in diverse biological processes. To accommodate such varied roles, Hsp90 requires a variety of regulatory mechanisms that are coordinated in order to modulate its activity appropriately. Amongst these, the master-regulator heat shock factor 1 (HSF1) is critically important in upregulating Hsp90 during stress, but is also responsible, through interaction with specific transcription factors (such as STAT1 and Strap/p300) for the integration of a variety of biological signals that ultimately modulate Hsp90 expression...
January 30, 2017: Biochemistry & Molecular Biology Journal
https://www.readbyqxmd.com/read/28287136/a-dual-pathogenic-mechanism-links-tau-acetylation-to-sporadic-tauopathy
#12
Hanna Trzeciakiewicz, Jui-Heng Tseng, Connor M Wander, Victoria Madden, Ashutosh Tripathy, Chao-Xing Yuan, Todd J Cohen
Tau acetylation has recently emerged as a dominant post-translational modification (PTM) in Alzheimer's disease (AD) and related tauopathies. Mass spectrometry studies indicate that tau acetylation sites cluster within the microtubule (MT)-binding region (MTBR), suggesting acetylation could regulate both normal and pathological tau functions. Here, we combined biochemical and cell-based approaches to uncover a dual pathogenic mechanism mediated by tau acetylation. We show that acetylation specifically at residues K280/K281 impairs tau-mediated MT stabilization, and enhances the formation of fibrillar tau aggregates, highlighting both loss and gain of tau function...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28282126/tuning-the-rectification-ratio-by-changing-the-electronic-nature-open-shell-and-closed-shell-in-donor-acceptor-self-assembled-monolayers
#13
Manuel Souto, Li Yuan, Dayana C Morales, Li Jiang, Imma Ratera, Christian A Nijhuis, Jaume Veciana
This Communication describes the mechanism of charge transport across self-assembled monolayers (SAMs) of two donor-acceptor systems consisting of a polychlorotriphenylmethyl (PTM) electron-acceptor moiety linked to an electron-donor ferrocene (Fc) unit supported by ultraflat template-stripped Au and contacted by a eutectic alloy of gallium and indium top contacts. The electronic and supramolecular structures of these SAMs were well characterized. The PTM unit can be switched between the nonradical and radical forms, which influences the rectification behavior of the junction...
March 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28280500/post-translational-modifications-in-regulation-of-chloroplast-function-recent-advances
#14
REVIEW
Magda Grabsztunowicz, Minna M Koskela, Paula Mulo
Post-translational modifications (PTMs) of proteins enable fast modulation of protein function in response to metabolic and environmental changes. Phosphorylation is known to play a major role in regulating distribution of light energy between the Photosystems (PS) I and II (state transitions) and in PSII repair cycle. In addition, thioredoxin-mediated redox regulation of Calvin cycle enzymes has been shown to determine the efficiency of carbon assimilation. Besides these well characterized modifications, recent methodological progress has enabled identification of numerous other types of PTMs in various plant compartments, including chloroplasts...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28280049/seedlings-lacking-the-ptm-protein-do-not-show-a-genomes-uncoupled-gun-mutant-phenotype
#15
Mike T Page, Sylwia M Kacprzak, Nobuyoshi Mochizuki, Haruko Okamoto, Alison G Smith, Matthew J Terry
No abstract text is available yet for this article.
March 9, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28275799/-changes-of-hard-tissues-in-patients-with-functional-and-skeletal-angel-class-%C3%A2-malocclusion-after-fr%C3%A2-appliance-treatment
#16
Nan Zhang, Sun Wang, Wei Zheng, Min Chen, Yu-Feng Shen, Hong-Juan Yan
PURPOSE: To compare changes of hard tissues before and after treatment of functional and skeletal Angle Class Ⅲ malocclusion with FRⅢ appliance. METHODS: Thirty patients with functional and skeletal Angel Class Ⅲ malocclusion were selected and treated with FRⅢ appliance. SPSS 22.0 software package was performed for statistical analysis. RESULTS: After treatment, there was no significant difference in SNA, S-Ptm, ANS-Ptm and Go-Po (P>0...
December 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28272507/scrutiny-of-mycobacterium-tuberculosis-19-kda-antigen-proteoforms-provides-new-insights-in-the-lipoglycoprotein-biogenesis-paradigm
#17
Julien Parra, Julien Marcoux, Isabelle Poncin, Stéphane Canaan, Jean Louis Herrmann, Jérôme Nigou, Odile Burlet-Schiltz, Michel Rivière
Post-translational modifications (PTMs) are essential processes conditioning the biophysical properties and biological activities of the vast majority of mature proteins. However, occurrence of several distinct PTMs on a same protein dramatically increases its molecular diversity. The comprehensive understanding of the functionalities resulting from any particular PTM association requires a highly challenging full structural description of the PTM combinations. Here, we report the in-depth exploration of the natural structural diversity of the M...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28270257/new-developments-in-probing-and-targeting-protein-acylation-in-malaria-leishmaniasis-and-african-sleeping-sickness
#18
Markus Ritzefeld, Megan H Wright, Edward W Tate
Infections by protozoan parasites, such as Plasmodium falciparum or Leishmania donovani, have a significant health, social and economic impact and threaten billions of people living in tropical and sub-tropical regions of developing countries worldwide. The increasing range of parasite strains resistant to frontline therapeutics makes the identification of novel drug targets and the development of corresponding inhibitors vital. Post-translational modifications (PTMs) are important modulators of biology and inhibition of protein lipidation has emerged as a promising therapeutic strategy for treatment of parasitic diseases...
March 8, 2017: Parasitology
https://www.readbyqxmd.com/read/28262227/gender-related-differences-in-the-outcome-of-patients-with-venous-thromboembolism-and-thrombophilia
#19
Inna Tzoran, Emmanouil Papadakis, Benjamin Brenner, Reina Valle, Luciano López-Jiménez, Fernando García-Bragado, Antoni Riera-Mestre, Aurora Villalobos, Roberto Quintavalla, Manuel Monreal
BACKGROUND: In patients with venous thromboembolism (VTE) and factor V Leiden (FVL) or prothrombin 20210G-A mutation (PTM), the influence of gender on outcome has not been consistently studied. METHODS: We used the RIETE (Registro Informatizado Enfermedad TromboEmbolica) database to assess the existence of gender differences in the rate of VTE recurrences (deep vein thrombosis [DVT] or pulmonary embolism [PE]) or major bleeding during the course of anticoagulation and after its discontinuation in FVL and PTM carriers...
March 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28256318/experimental-design-optimization-of-reverse-osmosis-purification-of-pretreatedolive-mill-wastewater
#20
J M Ochando-Pulido, A Martinez-Ferez
The management of the effluents generated by olive oil industries, commonly known as olive mills, represents an ever increasing problem still unresolved. The core of the present work was the modelling and optimization of a reverse osmosis (RO) membrane operation for the purification of a tertiary-treated olive mill wastewater stream (OMW2TT). Statistical multifactorial analysis showed all the studied variables including the operating pressure (PTM), crossflow velocity (vt) and operating temperature (T) remarkably influence the permeate flux yielded by the selected membrane (p-value practically equal to zero), confirming a statistically significant relationship among the variables considered at 95% confidence level...
February 27, 2017: Science of the Total Environment
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